GLYCINEShaun Okano

CHEMICAL FORMULA

C2H5NO2

WHAT IS A GLYCINE?

Amino acid Simplest Smallest 2nd most common

Neurotransmitter Proteins

PHYSICAL PROPERTIES

Nonpolar Molecular weight 75.07 White crystalline powder Freely soluble in water

CHEMICAL PROPERTIES Chemical Properties

Aliphatic No nutritional importance

Codes- GGU, GGC, GGA, GGG

ClCH2COOH NH3

+

Glycine (H2NCH2COOH)

+ HCl

NEUROTRANSMITTER

Spinal reflexes Released into

synapse Binds to receptor Membrane permeable

to Cl- ions hyperpolarized

BONDING AND ATTRACTION

Covalent bonds Strong attraction

FUNCTIONS IN THE BODY

Biosynthesis Nucleic acids Bile acids Porphynins

Production of proteins Collagen Phospholipids

Prevent muscle degeneration

History

40 Years ago Discovery within the spinal cord and brainstem

2 Years later Neurotransmitter status

USES

Health of prostate gland Urologic irrigation during surgery

1.5% concentration of Glycine in water Minimize risk of intravascular hemolysis during

TUR

SUMMARY

Smallest and Simplest Amino Acids Hydrogen atom on amine, carboxyl group

Covalent Neurotransmitter Used in urological irrigation

END

Glycine (C2H5NO2) Reference

http://en.wikipedia.org http://

micro.magnet.fsu.edu/aminoacids/pages/glycine.html http://www.benbest.com/science/anatmind/

anatmd10.html#glycine http://www.biology.arizona.edu/biochemistry/

problem_sets/aa/Glycine.html http://www.chemie.fu-berlin.de/chemistry/bio/

aminoacid/glycin_en.html http://www.supplementnews.org/glycine/ http://www.drugs.com/pro/glycine.html http://www.ncbi.nlm.nih.gov/pubmed/16402094