7/29/2019 Gluten-Casein Peptides Test

1/2

Benets of Testing

The Great Plains Laboratory, Inc. (GPL)

ffers the Gluten/Casein Peptides Test

which can help determine the inability

o digest wheat, rye, barley, and milk

roteins. These undigested proteins

alled peptides are associated with GI,

eurological, and neuro-developmental

isorders. The Gluten/CaseinPeptides Test measures levels of both

asomporhin and gliadorphin.

GPLs simple and accurate Gluten/

Casein Peptides Test uses the ELISA

method, which is highly specic to the

anogram level, or one-billionth of a

ram. To accomplish this, casomorphin

nd gliadorphin are custom-synthesized

o be able to dene the very sensitive

tandard curve that is required. This

est is a very useful tool in determining

whether dietary modications should beart of an integrated treatment plan, or

whether the diet should be maintained if

is currently used. It is also important to

dentify potential symptoms of yeast and

ungal overgrowth. Digestive enzymes

may improve these symptoms especially

fter accidental diet infractions.

The Gluten/Casein Peptides Test

etermines sensitivities even when

patient has no IgE or IgG allergic

eactions to these foods. If either of the

eptide results is abnormal, both gluten

from gliadorphin) and casein (from

asomorphin) should be eliminated.

f you suspect that you or your child has

bnormal levels of peptides, contact

GPL to obtain a test kit.

Casomorphin is one of the peptides

produced from casein, a major protein in

all mammalian milk. Digestion of gluten

in wheat also produces peptides of

similar size, one of which is gliadorphin.

Because of structural similarity, these

peptides are presumed to affect the

brain similarly. Both casomorphin and

gliadorphin are 7-amino acid peptides

with a beginning N-terminal sequencetyr-pro (for tyrosine and proline) with an

additional pro in positions 4 and 6 (see

below). Matching amino acid residues

are bolded.

1 2 3 4 5 6 7

Casomorphin: tyr-pro-phe-pro-gly-pro-ile

Gliadorphin: tyr-pro-gln-pro-gln-pro-phe

Several studies have linked high

levels of opiate peptides in urine with

gastrointestinal (GI), neurological, andneuro-developmental disorders.

Negative symptoms from excess

casein and gluten peptides range from

constipation to drowsiness and poor

concentration. Other symptoms include

cravings for wheat and dairy products,

and discomfort after eating them.

Elimination Diet

How does the gluten-free, casein-free

(GFCF) diet work, and who might ben

from undertaking such radical changeeating?

Some individuals have difculty brea

down peptides, small protein fragmen

that engage in cell-to-cell signaling a

interact with opiate receptors.

Because the diet is so demanding, it

ideal to be certain that someone has

peptide problem before starting the d

This is why testing for peptides can b

very helpful.

An enzyme nicknamed DPPIV isrequired to break down the peptides

can be inhibited by yeast by-products

and mercury exposure. Although DDP

containing enzymes are available

and are very useful, the diet alone is

suggested for the initial phase. A gra

approach to the GFCF diet usually w

best.

Because casein and gluten peptides

function as opiates, a withdrawal rea

similar to that of a drug addict may oc

when these foods are removed from diet.

Gluten/Casein Peptides TestTesting for food sensitivities is the rst step

n developing an integrated treatment plan

Gluten/Casein Peptides Tesuten-Casein Peptides Test Brochure

/11

7/29/2019 Gluten-Casein Peptides Test

2/2

The Great Plains Laboratory, Inc.

William Shaw, Ph.D Director 11813 W. 77th Street, Lenexa, KS 66214 (913) 341-8949 Fax (913) 341-6207

Specimen Requirements

mL of urine is the absolute minimum required. 10 mL of urine is preferred. The

atient must discontinue consumption of soy and soy proteins one week prior to

ample collection. Soy bean oil and soy lecithin are considered acceptable. Firstmorning urine before food and drink is preferred.

Testing Procedure

Contact The Great Plains Laboratory, Inc. via phone, fax, e-mail, or on our website.

to order a test kit.

Fill out the Test Requisition Form, have this form signed by a medical practitioner..

Indicate the payment method or insurance information on the Test Requisition Form..

Follow the instructions to collect the sample..

Send the sample with the paperwork in the pre-paid express overnight envelope.

included in the test kit (shipping cost is included in the price for U.S. clients).

The results will be mailed with a detailed explanation to the patient and medical.practitioner in approximately one to three weeks after receiving your sample, unless

the practitioner has specifed otherwise.

A free phone consultation with our nutritional consultant is available to practitioners.

and patients upon request.

Recommended for the

following disorders:

AD(H)D

AIDS

Alzheimers Disease

Arthritis

Autism Spectrum Disorders

Chronic Fatigue Syndrome

Colitis & Crohns Disease

Depression

Diarrhea/Constipation

Down Syndrome

Fibromyalgia

Movement Disorders

Multiple Sclerosis

OCD

Psychoses

Schizophrenia

Tic Disorder

Tourette Syndrome

Gluten/Casein Peptides Tesuten-Casein Peptides Test Brochure

/11