GIT BLEEDING
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GASTROINTESTINAL
BLEEDING
By - CHARAN TEJASVIMl-608
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ARTERIAL SUPPLY
• Mostly by anterior branch of abdominal aorta
Celiac trunk - Foregut
• left gastic artery
• splenic artery
• common hepatic artery
Superior Mesenteric
Artery - Midgut• inferior
pancreaticoduodenal artery
• jejunal and ileal arteries
• middle colic artery
• right colic artery
• ileocolic artery
Inferior Mesenteric
Artery - Hindgut
• sigmoid arteries
• superior rectal artery
• Left colic artery
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PORTAL VEIN
Union of splenic vein and sup. Mesentric
vein• Tributaries ; -right and left
gastric veins -cystic veins -para umbilical veins• Portal vein drains to
inferior vena cava (systemic system) through hepatic vein
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INTRODUCTION
• Can be divided into 2 clinical syndromes:-- upper GI bleed
(pharynx to ligament of Treitz)- lower GI bleed
(ligament of Treitz to rectum)
LIGAMENT OF TREITZ
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UPPER GASTROINTESTINAL BLEEDING
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EPIDEMIOLOGY
• Upper GI bleed remains a major medical problem.
• About 75% of patient presenting to the emergency room with GI bleeding have an upper source.
• In-hospital mortality of 5% can be expected.
• The most common cause are peptic ulcer, erosions, Mallory-Weiss tear & esophageal varices.
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CLINICAL FEATURES
• Haematemesis : vomiting of blood (fresh and red or digested and black).
• Melaena : passage of loose, black tarry stools with a characteristic foul smell.
• Coffee ground vomiting : blood clot in the vomitus.
• Hematochezia : passage of bright red blood per rectum (if the haemorrhage is severe).
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CLINICAL FEATURES
• Haematemesis without malaena is generally due to lesions proximal to the ligament of Treitz, since blood entering the GIT below the duodenum rarely enters the stomach.
• Malaena without haematemesis is usually due to lesions distal to the pylorus
• Approximately 60mL of blood is required to produced a single black stool.
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AETIOLOGY
Oesophagus-Oesophageal varices-Oesophageal CA-Reflux oesophagitis-Mallory-Weiss syndrome
-Haemophilia-Leukemia-Thrombocytopenia-Anti-coagulant therapy
Stomach-Gastric ulcer-Erosive gastritis-Gastric CA-gastric lymphoma-gastric leiomyoma-Dielafoy’s syndrome
Duodenum-Duodenal ulcer-Duodenitis-Periampullary tumour-Aorto-duodenal fistula
LOCAL
GENERAL
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OESOPHAGEAL VARICES• Abnormal dilatation of
subepithelial and submucosal veins due to increased venous pressure from portal hypertension (collateral exist between portal system and azygous vein via lower oesophageal venous plexus).
• Most commonly : lower esophagus.11/81
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Esophageal varices: a view of the everted
esophagus and gastroesophageal junction, showing
dilated submucosal veins (varices).
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OESOPHAGEAL VARICES• Management
- blood transfusion- endoscopic variceal injection with sclerosant or banding.- Sengstaken Blakmore tube
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MALLORY-WEISS TEAR
• Longitudinal tears at the oesophagogastric junction.
• may occur after any event that provokes a sudden rise in intragastric pressure or gastric prolapse into the esophagus.
Precipitating factors:- hiatus hernia- retching & vomiting- straining- hiccuping- coughing- blunt abdominal trauma - cardiopulmonary resuscitation 14/81
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MALLORY-WEISS TEAR: MANAGEMENT
- Bleeding from MWTs stops spontaneously in 80-90% of patients - A contact thermal modality, such as multipolar electrocoagulation (MPEC) or heater probe. - Epinephrine injection -reduces or stops bleeding via a mechanism of vasoconstriction and tamponade - Endoscopic band ligation - Endoscopic hemoclipping
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ESOPHAGEAL CANCER• 8th most common cancer seen
throughout the world.• 40% occur in the middle 3rd of
the oesophagus and are squamous carcinomas.
• adenoCA (45%) occur in the lower 3rd of the oesophagus and at the cardia.
• Tumours of the upper 3rd are rare (15%) 16/81
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PEPTIC ULCER: COMPLICATION
• Haemorrhage- posterior duodenal ulcer erode the gastroduodenal artery- lesser curve gastric ulcers erode the left gastric artery
• Perforation- generalized peritonitis- signs of peritonitis
• Pyloric obstruction- profuse vomiting, LOW, dehydrated, weakness, constipation
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EROSIVE GASTRITIS
• Acute mucosal inflammatory process
• Accompanied by hemorrhage into the mucosa and sloughing of the superficial epithelium (erosion).
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EROSIVE GASTRITIS: AETIOLOGY
- NSAIDs- alcohol- smoking- chemotherapy- uraemia- stress - ischaemia and shock- suicide attempts - mechanical trauma- distal gastrectomy
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EROSIVE GASTRITIS: CLINICAL FEATURES
- asymptomatic- epigastric pain with nausea & vomiting- haematemesis and melaena- fatal blood loss
It is one of the major causes of haemetemesis, particularly in alcoholic!
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GASTRIC CANCER
- adenomatous polyps- leiomyoma- neurogenic tumour- fibromata- lipoma
- gastric adenocarcinoma (90%)- lymphomas- smooth muscle tumour
BENIGN GASTRIC NEOPLASM
GASTRIC CARCINOMA
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GASTRIC CANCER
Early signs -Indigestion -Flatulence -DyspepsiaLate signs - LOW -anemia -dysphagia -vomiting -epigastric/back pain - epigastric mass -sign of metastases (jaundice, ascites, diarrhoea, intestinal obstruction)
• Radical total gastrectomy• Palliative resection• Palliative bypass
CLINICAL FEATURESTREATMENT
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DIEULAFOY’S DISEASE
• Rare – erosion of mucosa overlying artery in stomach causes necrosis arterial wall & resultant hemorrhage.
• Gastric arterial venous abnormality
• covered by normal mucosa
• profuse bleeding coming from an area of apparently normal mucosa.
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DUODENITIS
- aspirin, - NSAIDs- high acid secretion
- Symptoms are similar to peptic ulcer disease
- stomach pain- bleeding from the intestine- nausea & vomiting
- intestinal obstruction(rare)
AETIOLOGY
CLINICAL FEATURE
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DUODENITIS
- endoscopy, may
be some redness and nodules in the wall of the small intestine.
- Sometimes, it can be more severe and there may be shallow, eroded areas in the wall of the intestine, along with some bleeding
-stop all medications that can make things worse (aspirin & NSAIDS)
-H2 receptor blockers (ranitidine/cimetidine) or proton pump inhibitors (omeprazole) reduce the acid secretion by the stomach
INVESTIGATION MANAGEMENT
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INVESTIGATIONS
- Complete blood count - Liver function test- Coagulation profile- Renal profile- EGDS
- Barium meal / Double-contrast barium meal
- Ultrasound- CT scan
BASELINE INVESTIGATION
IMAGING
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Acute Upper Gastrointestinal Bleed
Resuscitation and Risk Assessment
Routine Blood Test
Endoscopy (within 24 hrs)
Varices Peptic Ulcer No obvious cause
Management Varices
Major SRH Minor SRH Minor Bleed
Major Bleed
Eradicate H.pylori &
Risk Reduction
Endoscopic Treatment
Failure
Surgical
Other colonoscopy or
angiography
OVERVIEW:MANAGEMENT OF UPPER GI BLEED
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RESUSCITATION
• airway and oxygen• Correct clotting abnormalities• Blood Transfusion• Monitor• Insert urinary catheter and monitor
hourly urine output if shocked.• Consider a CVP line to monitor CVP
and guide fluid replacement.• Organize a CXR, ECG, and check
arterial blood gases in high-risk patient.
• Arrange an urgent endoscopy.• Notify surgeon of all severe bleeds on
admission.28/81
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DETECTION & ENDOSCOPIC• Used to detect the site of
bleeding.• May also be used in a therapeutic
capacity (active bleeding from the ulcer, the presence of a visible vessel, adherent clot overlying the ulcer)
• Injection sclerotherapy is used commonly. Other method include the use of heat probes and lasers.
• Angiography in whom endoscopy does not identify the bleeding point. Limitation: can only detect active bleeding of greater than 1mL/min. 29/81
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FORREST CLASSIFICATION FOR BLEEDING PEPTIC ULCER
– Ia: Spurting Bleeding– Ib: Non spurting active bleeding– IIa: visible vessel (no active
bleeding)– IIb: Non bleeding ulcer with
overlying clot (no visible vessel)– IIc: Ulcer with hematin covered
base– III: Clean ulcer ground (no clot,
no vessel)
Min
or S
RHM
ajor
SRH
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MANAGEMENT
• H2 receptor antagonist - cimetidine, ranitidine• Proton pump inhibitors – omeprazole, lanzoprazole• H. pylori irradication• Triple regimen – proton pump inhibitor + 2 antibiotics given for 1
week (elimination rate > 90%) e.g. Omeprazol + metronidazole/amoxycillin + clarithromycin
• GU – remove ulcer, gastrin secreting zone – Billroth I gastrectomy• DU – Polya or Billroth II gastrectomy – Vagotomy
MEDICAL
SURGICAL
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UPPER GI BLEED:RISK FACTORS FOR DEATH
1. Advanced AGE2. SHOCK on admission(pulse rate >100 beats/min; systolic
blood pressure < 100mmHg)3. COMORBIDITY (particularly hepatic or renal failure and
disseminated malignancy)4. Diagnosis (worst PROGNOSIS for advanced upper
gastrointestinal malignancy)5. ENDOSCOPIC FINDINGS (active, spurting haemorrhage from
peptic ulcer; non-bleeding visible vessel)6. RECURRENT BLEEDING (increases mortality 10 times)
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GASTROINTESTINAL BLEEDING
LOWER
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LOWER GI BLEED: AETIOLOGY
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• 1) Hemorrhoids• 2) Diverticulosis • 3) Arteriovenous
malformations• 4) Polyps• 5) Inflammatory bowel disease • 6) Infectious gastroenteritis• 7) Meckel diverticulum
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INVESTIGATION
1. Full Blood Count (FBC)2. BUSE3. Coagulation profile4. Cross-matched (Transfusion)
1. Scintigraphy -Radioactive test using Technetium-99m (99mTc)-
Labelled red cells -diagnose ongoing bleeding at a rate as low as 0.1
mL/min
2. Mesenteric angiography -Can detect bleeding at a rate of more than 0.5 mL/min.
LABORATORY
IMAGING
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IMAGING
3. Helical CT scan
4.Colonoscopy5.Proctosigmoidoscopy• Exclude an anorectal source of
bleeding
6.Esophagoduodenoscopy• To exclude upper GI bleeding
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IMAGING
7. Double-contrast barium enema
• Elective evaluation of unexplained lower GI bleeding
• Do not use in the acute hemorrhage
phase 8. Small bowel enema• Often valuable in investigation of long-
term, unexplained lower GI bleeding
Example of barium enema study showing ulcerative colitis of the colon
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Colorectal polyps
• Adenomatous polyps and adenomas
• Has malignant potential
• Morphology: -polypoid and
pedunculated-dome-shaped and sessile
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MANAGEMENT
• Subtotal colectomy & ileorectal anastomosis
• Panproctocolectomy & ileotomy / ileal pouch
• Follow-up colonoscopies - an adenomatous polyp is found / a
colorectal cancer has been treated -intervals depend on number, size & pathology of polyps
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ADENOCARCINOMA OF COLON & RECTUM
• Common > 60 years old• Common site- sigmoid
colon, rectum• Clinical features: -altered bowel habit &
large bowel obstruction -rectal bleeding -iron deficiency
anaemia -tenesmus -perforation -anorexia & weight
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ANGIODYSPLASIA
• 1 or multiple small mucosal or submucosal vascular malformation.
• > 60 years old• Common site : ascending colon
and caecum• Malformations consist of dilated
tortuous submucosal veins• In severe cases, the mucosa is
replaced by massive dilated deformed vessels
• Clinical features: -acute / chronic rectal bleeding -iron deficiency anaemia
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ISCHAEMIC COLITIS
• Elderly• Transient ischaemia of a
segment of a large bowel, followed by sloughing of mucosa
• Common site –splenic flexure• Clinical features: -abdominal pain -rectal bleeding ( dark red) -1-3x over 12 hours• Complication- fibrotic sticture
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HAEMORRHOIDS
• M > F• Female- late pregnancy,
puerperium• Supine lithotomy position- 3 ,7,
11 o’clock positions
• Classification: 1st degree : never prolapse 2nd degree: prolapse during
defaecation but return spontaneously
3rd degree : remain prolapse but can be reduced digitally
4th degree : long-standing
prolapse cannot be reduced
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ANAL FISSURE
• Longitudinal tear in mucosa & skin of anal canal
• M > F• Common site: midline in posterior
anal margin• Clinical features: - acute pain during defaecation - fresh bleeding at defaecation
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DIVERTICULAR DISEASE• Rare < 40 years old• F > M• Causes: -Chronic lack of dietary fibre -Genetic• Common site: sigmoid colon• Clinical features: -diverticulosis
(asymptomatic) -chronic grumbling
diverticular pain (chronic constipation & episodic diarrhoea)
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MANAGEMENT
1. Vasoconstrictive agents: vasopressin
2. Therapeutic embolization: -Embolic agents: Autologous clot, Gelfoam, polyvinyl alcohol, microcoils,
ethanolamine, and oxidized cellulose
-Selective angiography
3. Endoscopic therapy: -Diathermy / laser coagulation-Short term control of bleeding during resuscitation
• The bleeding point is localized, perform a limited segmental resection of the small or large bowel
• Poor prognostic features: -age over 60 years -chronic history -relapse on full medical
treatment -serious coexisting
medical conditions -> 4 units of blood
transfusion required during resuscitation
MEDICAL SURGICAL
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