A clinical study on the concept of Jara wsr to Ageing process and its management by Rasayana Yoga

GUIDE CO-GUIDEDr R N Tripathi MD(BHU) Dr HM Shukla MD

Reader Dept of Kayachikitsa Lecturer Dept Of Panchakarma

GOVT AYURVEDIC COLLEGE RAIPUR (CG)

By Dr Nutan Panda

INTRODUCTION

1) Ayurveda deals with physical psychological as well as spiritual well being of an individual

2) The desire to live is common to all living creatures evolved on this graceful planet the Earth

3) Man is a step ahead in the sense desires not only to live but to live a long happy and disease free life as far as possible

ldquoTHE GOAL OF LIFE IS TO DIE YOUNG AS LATE AS POSSIBLErdquo

-Asle Montegue

CRITERIA OF TOPIC SELECTION

1)World shifting from young to old world 2)Incorrect life style ampdietary habits 3)Increase stress in day to day life4)Elderly population in India by 2016 will be 113 million ie10-12 of whole

population The present study undertaken is designed with the hypothesis that

Stress incorrect Life style amp Dietary Habits have found to be major impacts on Ageing

200 YEARS AGO TODAY

COMMUNICABLE DISEASES CHRONIC DISEASE (like HT DM Cancer etc)

5

LIFE EXPECTANCY OF THE WORLDIndia-675-70yrs

6

AUSTRALIA

RUSSIAN FEDERATIONCANADA

ANGOLA amp ZAMBIA

AFHGANISTAN

JAPAN

SWEDAN

UK

INDIA

CHINA

USA

BRAZIL

ARGENTINA

MEXICO

JARA- An Ayurvedic Review

Etymology of Jara

Jara (old age) is from root ldquot`rdquok oksgkukSrdquo by applying the sutra ^^frdquokfnkfnHksMM~- the term indicates to the loss in the period of life span The deduction from the remaining half of the expected duration and every spent year would be considered as a loss in the age

Synonyms of Jara amp Vriddha

LFkfoje~

amp LFkfoja rq o`)Roe~ -The aspect of being old

foL=lk amp folzalrs vkirfrA -The degeneration of the Shareera

OF JARA (Sources Vachaspatyam and Gurubala prabodhika)

o`) amp okZrs o`) -One who has already attained Vriddhiizo amp izxra kSouk[a oksmiddotLsfr izo-One who has crossed his

youth

LFkfoj amp cgq dkya frrdquoBrhfr LFkfoj- One who has stayed for a long time

thu amp thufr olks ghrs thu-One who is attaining deteriorationthkZtju~

amp thrs thkZ tjp -Same meaning

Tku~ amp ordquokhZku~ nrsquokfe Tku~ -One who is at the stage of 90 yearstfjr amp trsquok tkr vL rkjdkA

OF VRIDDHA

INTRODUCTION

1) Ayurveda deals with physical psychological as well as spiritual well being of an individual

2) The desire to live is common to all living creatures evolved on this graceful planet the Earth

3) Man is a step ahead in the sense desires not only to live but to live a long happy and disease free life as far as possible

ldquoTHE GOAL OF LIFE IS TO DIE YOUNG AS LATE AS POSSIBLErdquo

-Asle Montegue

CRITERIA OF TOPIC SELECTION

1)World shifting from young to old world 2)Incorrect life style ampdietary habits 3)Increase stress in day to day life4)Elderly population in India by 2016 will be 113 million ie10-12 of whole

population The present study undertaken is designed with the hypothesis that

Stress incorrect Life style amp Dietary Habits have found to be major impacts on Ageing

200 YEARS AGO TODAY

COMMUNICABLE DISEASES CHRONIC DISEASE (like HT DM Cancer etc)

5

LIFE EXPECTANCY OF THE WORLDIndia-675-70yrs

6

AUSTRALIA

RUSSIAN FEDERATIONCANADA

ANGOLA amp ZAMBIA

AFHGANISTAN

JAPAN

SWEDAN

UK

INDIA

CHINA

USA

BRAZIL

ARGENTINA

MEXICO

JARA- An Ayurvedic Review

Etymology of Jara

Jara (old age) is from root ldquot`rdquok oksgkukSrdquo by applying the sutra ^^frdquokfnkfnHksMM~- the term indicates to the loss in the period of life span The deduction from the remaining half of the expected duration and every spent year would be considered as a loss in the age

Synonyms of Jara amp Vriddha

LFkfoje~

amp LFkfoja rq o`)Roe~ -The aspect of being old

foL=lk amp folzalrs vkirfrA -The degeneration of the Shareera

OF JARA (Sources Vachaspatyam and Gurubala prabodhika)

o`) amp okZrs o`) -One who has already attained Vriddhiizo amp izxra kSouk[a oksmiddotLsfr izo-One who has crossed his

youth

LFkfoj amp cgq dkya frrdquoBrhfr LFkfoj- One who has stayed for a long time

thu amp thufr olks ghrs thu-One who is attaining deteriorationthkZtju~

amp thrs thkZ tjp -Same meaning

Tku~ amp ordquokhZku~ nrsquokfe Tku~ -One who is at the stage of 90 yearstfjr amp trsquok tkr vL rkjdkA

OF VRIDDHA

CRITERIA OF TOPIC SELECTION

1)World shifting from young to old world 2)Incorrect life style ampdietary habits 3)Increase stress in day to day life4)Elderly population in India by 2016 will be 113 million ie10-12 of whole

population The present study undertaken is designed with the hypothesis that

Stress incorrect Life style amp Dietary Habits have found to be major impacts on Ageing

200 YEARS AGO TODAY

COMMUNICABLE DISEASES CHRONIC DISEASE (like HT DM Cancer etc)

5

LIFE EXPECTANCY OF THE WORLDIndia-675-70yrs

6

AUSTRALIA

RUSSIAN FEDERATIONCANADA

ANGOLA amp ZAMBIA

AFHGANISTAN

JAPAN

SWEDAN

UK

INDIA

CHINA

USA

BRAZIL

ARGENTINA

MEXICO

JARA- An Ayurvedic Review

Etymology of Jara

Jara (old age) is from root ldquot`rdquok oksgkukSrdquo by applying the sutra ^^frdquokfnkfnHksMM~- the term indicates to the loss in the period of life span The deduction from the remaining half of the expected duration and every spent year would be considered as a loss in the age

Synonyms of Jara amp Vriddha

LFkfoje~

amp LFkfoja rq o`)Roe~ -The aspect of being old

foL=lk amp folzalrs vkirfrA -The degeneration of the Shareera

OF JARA (Sources Vachaspatyam and Gurubala prabodhika)

o`) amp okZrs o`) -One who has already attained Vriddhiizo amp izxra kSouk[a oksmiddotLsfr izo-One who has crossed his

youth

LFkfoj amp cgq dkya frrdquoBrhfr LFkfoj- One who has stayed for a long time

thu amp thufr olks ghrs thu-One who is attaining deteriorationthkZtju~

amp thrs thkZ tjp -Same meaning

Tku~ amp ordquokhZku~ nrsquokfe Tku~ -One who is at the stage of 90 yearstfjr amp trsquok tkr vL rkjdkA

OF VRIDDHA

LIFE EXPECTANCY OF THE WORLDIndia-675-70yrs

6

AUSTRALIA

RUSSIAN FEDERATIONCANADA

ANGOLA amp ZAMBIA

AFHGANISTAN

JAPAN

SWEDAN

UK

INDIA

CHINA

USA

BRAZIL

ARGENTINA

MEXICO

JARA- An Ayurvedic Review

Etymology of Jara

Jara (old age) is from root ldquot`rdquok oksgkukSrdquo by applying the sutra ^^frdquokfnkfnHksMM~- the term indicates to the loss in the period of life span The deduction from the remaining half of the expected duration and every spent year would be considered as a loss in the age

Synonyms of Jara amp Vriddha

LFkfoje~

amp LFkfoja rq o`)Roe~ -The aspect of being old

foL=lk amp folzalrs vkirfrA -The degeneration of the Shareera

OF JARA (Sources Vachaspatyam and Gurubala prabodhika)

o`) amp okZrs o`) -One who has already attained Vriddhiizo amp izxra kSouk[a oksmiddotLsfr izo-One who has crossed his

youth

LFkfoj amp cgq dkya frrdquoBrhfr LFkfoj- One who has stayed for a long time

thu amp thufr olks ghrs thu-One who is attaining deteriorationthkZtju~

amp thrs thkZ tjp -Same meaning

Tku~ amp ordquokhZku~ nrsquokfe Tku~ -One who is at the stage of 90 yearstfjr amp trsquok tkr vL rkjdkA

OF VRIDDHA

JARA- An Ayurvedic Review

Etymology of Jara

Jara (old age) is from root ldquot`rdquok oksgkukSrdquo by applying the sutra ^^frdquokfnkfnHksMM~- the term indicates to the loss in the period of life span The deduction from the remaining half of the expected duration and every spent year would be considered as a loss in the age

Synonyms of Jara amp Vriddha

LFkfoje~

amp LFkfoja rq o`)Roe~ -The aspect of being old

foL=lk amp folzalrs vkirfrA -The degeneration of the Shareera

OF JARA (Sources Vachaspatyam and Gurubala prabodhika)

o`) amp okZrs o`) -One who has already attained Vriddhiizo amp izxra kSouk[a oksmiddotLsfr izo-One who has crossed his

youth

LFkfoj amp cgq dkya frrdquoBrhfr LFkfoj- One who has stayed for a long time

thu amp thufr olks ghrs thu-One who is attaining deteriorationthkZtju~

amp thrs thkZ tjp -Same meaning

Tku~ amp ordquokhZku~ nrsquokfe Tku~ -One who is at the stage of 90 yearstfjr amp trsquok tkr vL rkjdkA

OF VRIDDHA

Etymology of Jara

Jara (old age) is from root ldquot`rdquok oksgkukSrdquo by applying the sutra ^^frdquokfnkfnHksMM~- the term indicates to the loss in the period of life span The deduction from the remaining half of the expected duration and every spent year would be considered as a loss in the age

Synonyms of Jara amp Vriddha

LFkfoje~

amp LFkfoja rq o`)Roe~ -The aspect of being old

foL=lk amp folzalrs vkirfrA -The degeneration of the Shareera

OF JARA (Sources Vachaspatyam and Gurubala prabodhika)

o`) amp okZrs o`) -One who has already attained Vriddhiizo amp izxra kSouk[a oksmiddotLsfr izo-One who has crossed his

youth

LFkfoj amp cgq dkya frrdquoBrhfr LFkfoj- One who has stayed for a long time

thu amp thufr olks ghrs thu-One who is attaining deteriorationthkZtju~

amp thrs thkZ tjp -Same meaning

Tku~ amp ordquokhZku~ nrsquokfe Tku~ -One who is at the stage of 90 yearstfjr amp trsquok tkr vL rkjdkA

OF VRIDDHA

Synonyms of Jara amp Vriddha

LFkfoje~

amp LFkfoja rq o`)Roe~ -The aspect of being old

foL=lk amp folzalrs vkirfrA -The degeneration of the Shareera

OF JARA (Sources Vachaspatyam and Gurubala prabodhika)

o`) amp okZrs o`) -One who has already attained Vriddhiizo amp izxra kSouk[a oksmiddotLsfr izo-One who has crossed his

youth

LFkfoj amp cgq dkya frrdquoBrhfr LFkfoj- One who has stayed for a long time

thu amp thufr olks ghrs thu-One who is attaining deteriorationthkZtju~

amp thrs thkZ tjp -Same meaning

Tku~ amp ordquokhZku~ nrsquokfe Tku~ -One who is at the stage of 90 yearstfjr amp trsquok tkr vL rkjdkA

OF VRIDDHA

Types of Jara

Kalaja Jara

Jara coming at the proper age is Kalaja Jara(after 60 yrs) It is lsquoParirakshana Kritarsquo means it occurs at the proper age even after following the daily and seasonal regimen mentioned in Swasthavritta This is nothing but chronological Ageing Dhatu kshaya janya jara

Akalaja Jara ndash The Concept of Premature Ageing

lsquo Akalotpanna lakshana Akalajarsquo lsquo Akale jata iti Akalajarsquo means that thing which occurs Akalaja ie before its prescribed time occurs before the proper age due to not taking the proper care of personal hygiene (Swasthavritta) This Akalaja Jara is of greater intensity rapidly progressing one if neglected This is Biological Ageing Marga avarodha janya jara

CAUSES OF JARA ACCORDING TO AYURVEDA

iUFkk lsquokhra dnUukfu okso`)krsquop ksfrdquokrAeul izkfrdwYa p tjkk ip gsroA frac14j-j-l-262frac12

In Ras Ratna Samucchaya The etiological factors of Akalaja Jara described are - Continuous walking after tiredness Intake of unwholesome food Intake of cold substances Staying in cold house Sexual indulgence with an old woman Pressure of mind because of unbearable affairs

Etiological Factors of Ageing Related to Dietary Habitsldquowe are what we eatrdquo

1 Lavana (salt) Amla (sour) Katu (spicy) rasa pradhana2 Kshara (alkali)3 Suska shaka amp Mamsa (dry vegetable amp Meat)4 Tila Samyoga5 Pista Anna6 Viruddha Anna (Incompatible Diet)7 Asatmya Anna (Unfavorable Diet)8 Ruksha Anna (Dry Cereal)9 Abhisyandi Anna10 Klinna amp Guru Anna (Heavy Diet)11 Puti amp Paryushita Anna (Polluted amp Out dated Diet)12 Vishamashana (Improper Eating Habits)13 Adhyashana (Over Eating)

12

Etiological Factors Related to Life style

1 Atimarga Gamana (Excessive Walk)2 Diwa Swapna (Day Sleeping)3 Nitya Stri Sevana (Excessive Intercourse)4 Nitya Madya Sevana (Excessive Intake of Alcohol)5 Vishama Vyayama Sevan (Improper Exercise)

13

The etiological factor of Ageing related to disturbed Mental Health

1 Bhaya (Fear)2 Krodha (Anger)3 Shok (Sorrow)4 Lobha (Greed)5 Moha (Affection)6 Ruksha Vani (Harsh words)7 Kalah Priya Bharya (Quarrelsome Wife)8 Kuputra Kuputri (Maladroit child)

14

Ageing

Srotokharatwa(srotovahani)

Improper absorption amp

assimilation of ahara rasa

Disequilibrium in upchaya amp

apchaya

Rasadhatu kshaya

Uttarotara dhatu kshaya

Ojokshaya

Vata vriddhi

How Vata vriddhi occurs during ageing

Etiopathogenesis of Ageing Disturbances in Manasika Bhava Dosha

Rajas Dushti Tamas satva(Bhaya krodha Shok Lobha Moha )

Mana Dushti AjirnaAgnimandya

Ama

Free radicals Injury to cells

Gradually damage to all over cell

Ageing

Vikrit Agni

DECADE WISE AGEING PROCESS

Vagbhatta was the first one to record such an observation which was followed later by Sharangadhara

ckYa o`f) NfoZeskk RoXn`frdquoV lsquokqdzfodzekSAc`f) desZfUnza psrks thfora nrsquokrks g`lsr AA frac14rsquokk-la-iw-620frac12ckYs o`f)a izHkkeskkRod lsquokqdzkfk=qrhfUnze~Anrsquokdsrdquokq dzekkkfUr eu losZfUnzkfk pAA frac14v-la-lsquokk-825frac12 It is clear that ageing does not occur simultaneously in all the tissues Different

body tissues are affected ageing at different time period Gradual declination of a particular faculty takes place in each decade of life and by the end of decade that particular faculty is lost

Decade Loss of tissuesVagbhata Sharngadhara

I Childhood Childhood ΙΙ Growth Growth ΙΙΙ Complexion Complexion IV Intellect Intellect V Skin Skin VI Reproductive Capacity Vision VII Vision Reproductive Capacity

VIII Hearing Valour IX Mind Knowledge X Sensory amp Motor organs Motor organs XI - Mind XII - Life

CHIEF COMPLAINTS1Twak Parushata (Dryness of skin)2 Slatha sara (Flabbiness of the body)3 Slatha Mamsa (Decreased muscle

tone)4 Slatha Asthi (Bone weakness)5 Slatha Sandhi (Flaccid joint)6 Dhatu Kshaya (Loss of tissues)7 Kayasya Avanamanam (Bending of the

body)8 Vepathu (Tremors)9 Khalitya (Falling of hairs)10 Vali (Wrinkling)11 Palitya (Graying of hairs)12 Kasa (Coughing)13 Shwasa (Short breath)

15 Utsaha hani (Decreased Enthusiasm)

16 Parakrama hani (Decreased Physical Strength)

17 Paurusha hani (Decreased Virility)18 Prabha hani Chhavi Hras (Changes

in Complexion)19 Shukra Kshaya20 Dristi Hras (Diminished Vision)21 Karmendriya hani (Decreased Loco

motor Activities)22 Buddhi hani (Deterioration in

Wisdom)

14 Medha hani (Decreased functions of Intellect) a Grahana (Grasping Power) b Dharana (Retention Power) c Smarana (Memory Power) d Vachana (Speech) e Vijnana (Knowledge)

18

Ageing Process - A Modern Review

History of Geriatrics

Greek word ldquogerosrdquo mean the old age + Iatric mean the medical treatment This is the branch of medicine concerned with the problems of Ageing including physiological pathological and psychological problems Nascher was the first to coin the term Geriatrics He published a paper in New York medical journal in1909 and a textbook on it in 1914 Thus Geriatric came to be recognized as a special branch in first decade of 20th century

ldquoThe processes that occur during life which culminate in changes that decrease an individuals ability to cope with biological changesrdquo

Definition of Ageing

GERIATRICS - A branch of medicine dealing exclusively with the problems of ageing and the diseases of the elderly It is derived from the Greek root ldquoger- gero- gerontordquo meaning ldquoold agerdquo or ldquothe agedrdquo

SYNONYMS OF AGEING

Senescence is the process by which the capacity for cell division growth and function is lost over time ultimately leading to an incompatibility with life ie the process of senescence terminates in death

Senility This term is from the Latin origin lsquosenilitusrsquo which means the period of physical and mental deterioration associated with old age

Senium Identical to the term senility one more term senium is also used in the medical field it is marked by the deterioration and weakness that may accompany the age advancement

Geria This also indicates the old age

CLASSIFICATION OF AGE

AGE

Chronological age - number of years lived

Biological age ndash age by body function

Psychological age ndash age how individuals feels it

CHRONOLOGICAL CATEGORIES bullYoung-Old - (ages 65 - 74) Set Old Age

bullMiddle-Old - (ages 75 - 84) Old Old Age

bullOld-Old - (age 85 and older) Ripe Old Age

oIMPROPER DIET Acidic foodsFood additives Food additives are added to improve the shelf life and stability of processed and smoked foods but these are not body friendlyFood preparation oily food preparation

oIMPROPER LIFESTYLEoSmokingoAlcoholoIrregular sleeping patternoPhysical inactivity or improper exercise

oSTRESS oEXOGENOUS AGENTS

bullEnvironmental pollution - People living in any metropolitan area are exposed to pollution and if regularly commute in traffic jams or live near any industrial areas body is exposed to more harmful air particles and increased production of free radicalsbullPesticides - pesticides causes more oxidative stress in the bodybullSun exposurebullX-rays

DRUG ABUSE

CLASSIFICATION OF CAUSES OF AGEING

EFFECT OF STRESS ON BODY SYSTEMS

Some Theories of Ageing are given below1048781 Waste Accumulation Theory1048781 Limited Number of Cell Divisions Theory1048781 Hay flick Limit Theory1048781 Death Hormone Theory (DECO)1048781 Thymic -Stimulating Theory1048781 Mitochondrial Theory1048781 Errors and Repairs Theory1048781 Redundant DNA Theory1048781 Cross-Linkage Theory1048781 Autoimmune Theory1048781 Caloric Restriction Theory1048781 Gene Mutation Theory1048781 The Rate of Living Theory1048781 Order to Disorder Theory1048781 The Telomerase Theory of Ageing1048781 Neuro Endocrine theory or Weak Link Theory1048781 Free Radical Theory of Ageing

25

FREE RADICAL THEORYFree radical is a term used to describe any molecule that differs from conventional molecules in that it possesses a free electron a property that makes it react with other molecules in highly volatile and destructive ways The changes induced by free radicals are believed to be a major cause of Ageing disease development orand death

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

CAUSES OF JARA ACCORDING TO AYURVEDA

iUFkk lsquokhra dnUukfu okso`)krsquop ksfrdquokrAeul izkfrdwYa p tjkk ip gsroA frac14j-j-l-262frac12

In Ras Ratna Samucchaya The etiological factors of Akalaja Jara described are - Continuous walking after tiredness Intake of unwholesome food Intake of cold substances Staying in cold house Sexual indulgence with an old woman Pressure of mind because of unbearable affairs

Etiological Factors of Ageing Related to Dietary Habitsldquowe are what we eatrdquo

1 Lavana (salt) Amla (sour) Katu (spicy) rasa pradhana2 Kshara (alkali)3 Suska shaka amp Mamsa (dry vegetable amp Meat)4 Tila Samyoga5 Pista Anna6 Viruddha Anna (Incompatible Diet)7 Asatmya Anna (Unfavorable Diet)8 Ruksha Anna (Dry Cereal)9 Abhisyandi Anna10 Klinna amp Guru Anna (Heavy Diet)11 Puti amp Paryushita Anna (Polluted amp Out dated Diet)12 Vishamashana (Improper Eating Habits)13 Adhyashana (Over Eating)

12

Etiological Factors Related to Life style

1 Atimarga Gamana (Excessive Walk)2 Diwa Swapna (Day Sleeping)3 Nitya Stri Sevana (Excessive Intercourse)4 Nitya Madya Sevana (Excessive Intake of Alcohol)5 Vishama Vyayama Sevan (Improper Exercise)

13

The etiological factor of Ageing related to disturbed Mental Health

1 Bhaya (Fear)2 Krodha (Anger)3 Shok (Sorrow)4 Lobha (Greed)5 Moha (Affection)6 Ruksha Vani (Harsh words)7 Kalah Priya Bharya (Quarrelsome Wife)8 Kuputra Kuputri (Maladroit child)

14

Ageing

Srotokharatwa(srotovahani)

Improper absorption amp

assimilation of ahara rasa

Disequilibrium in upchaya amp

apchaya

Rasadhatu kshaya

Uttarotara dhatu kshaya

Ojokshaya

Vata vriddhi

How Vata vriddhi occurs during ageing

Etiopathogenesis of Ageing Disturbances in Manasika Bhava Dosha

Rajas Dushti Tamas satva(Bhaya krodha Shok Lobha Moha )

Mana Dushti AjirnaAgnimandya

Ama

Free radicals Injury to cells

Gradually damage to all over cell

Ageing

Vikrit Agni

DECADE WISE AGEING PROCESS

Vagbhatta was the first one to record such an observation which was followed later by Sharangadhara

ckYa o`f) NfoZeskk RoXn`frdquoV lsquokqdzfodzekSAc`f) desZfUnza psrks thfora nrsquokrks g`lsr AA frac14rsquokk-la-iw-620frac12ckYs o`f)a izHkkeskkRod lsquokqdzkfk=qrhfUnze~Anrsquokdsrdquokq dzekkkfUr eu losZfUnzkfk pAA frac14v-la-lsquokk-825frac12 It is clear that ageing does not occur simultaneously in all the tissues Different

body tissues are affected ageing at different time period Gradual declination of a particular faculty takes place in each decade of life and by the end of decade that particular faculty is lost

Decade Loss of tissuesVagbhata Sharngadhara

I Childhood Childhood ΙΙ Growth Growth ΙΙΙ Complexion Complexion IV Intellect Intellect V Skin Skin VI Reproductive Capacity Vision VII Vision Reproductive Capacity

VIII Hearing Valour IX Mind Knowledge X Sensory amp Motor organs Motor organs XI - Mind XII - Life

CHIEF COMPLAINTS1Twak Parushata (Dryness of skin)2 Slatha sara (Flabbiness of the body)3 Slatha Mamsa (Decreased muscle

tone)4 Slatha Asthi (Bone weakness)5 Slatha Sandhi (Flaccid joint)6 Dhatu Kshaya (Loss of tissues)7 Kayasya Avanamanam (Bending of the

body)8 Vepathu (Tremors)9 Khalitya (Falling of hairs)10 Vali (Wrinkling)11 Palitya (Graying of hairs)12 Kasa (Coughing)13 Shwasa (Short breath)

15 Utsaha hani (Decreased Enthusiasm)

16 Parakrama hani (Decreased Physical Strength)

17 Paurusha hani (Decreased Virility)18 Prabha hani Chhavi Hras (Changes

in Complexion)19 Shukra Kshaya20 Dristi Hras (Diminished Vision)21 Karmendriya hani (Decreased Loco

motor Activities)22 Buddhi hani (Deterioration in

Wisdom)

14 Medha hani (Decreased functions of Intellect) a Grahana (Grasping Power) b Dharana (Retention Power) c Smarana (Memory Power) d Vachana (Speech) e Vijnana (Knowledge)

18

Ageing Process - A Modern Review

History of Geriatrics

Greek word ldquogerosrdquo mean the old age + Iatric mean the medical treatment This is the branch of medicine concerned with the problems of Ageing including physiological pathological and psychological problems Nascher was the first to coin the term Geriatrics He published a paper in New York medical journal in1909 and a textbook on it in 1914 Thus Geriatric came to be recognized as a special branch in first decade of 20th century

ldquoThe processes that occur during life which culminate in changes that decrease an individuals ability to cope with biological changesrdquo

Definition of Ageing

GERIATRICS - A branch of medicine dealing exclusively with the problems of ageing and the diseases of the elderly It is derived from the Greek root ldquoger- gero- gerontordquo meaning ldquoold agerdquo or ldquothe agedrdquo

SYNONYMS OF AGEING

Senescence is the process by which the capacity for cell division growth and function is lost over time ultimately leading to an incompatibility with life ie the process of senescence terminates in death

Senility This term is from the Latin origin lsquosenilitusrsquo which means the period of physical and mental deterioration associated with old age

Senium Identical to the term senility one more term senium is also used in the medical field it is marked by the deterioration and weakness that may accompany the age advancement

Geria This also indicates the old age

CLASSIFICATION OF AGE

AGE

Chronological age - number of years lived

Biological age ndash age by body function

Psychological age ndash age how individuals feels it

CHRONOLOGICAL CATEGORIES bullYoung-Old - (ages 65 - 74) Set Old Age

bullMiddle-Old - (ages 75 - 84) Old Old Age

bullOld-Old - (age 85 and older) Ripe Old Age

oIMPROPER DIET Acidic foodsFood additives Food additives are added to improve the shelf life and stability of processed and smoked foods but these are not body friendlyFood preparation oily food preparation

oIMPROPER LIFESTYLEoSmokingoAlcoholoIrregular sleeping patternoPhysical inactivity or improper exercise

oSTRESS oEXOGENOUS AGENTS

bullEnvironmental pollution - People living in any metropolitan area are exposed to pollution and if regularly commute in traffic jams or live near any industrial areas body is exposed to more harmful air particles and increased production of free radicalsbullPesticides - pesticides causes more oxidative stress in the bodybullSun exposurebullX-rays

DRUG ABUSE

CLASSIFICATION OF CAUSES OF AGEING

EFFECT OF STRESS ON BODY SYSTEMS

Some Theories of Ageing are given below1048781 Waste Accumulation Theory1048781 Limited Number of Cell Divisions Theory1048781 Hay flick Limit Theory1048781 Death Hormone Theory (DECO)1048781 Thymic -Stimulating Theory1048781 Mitochondrial Theory1048781 Errors and Repairs Theory1048781 Redundant DNA Theory1048781 Cross-Linkage Theory1048781 Autoimmune Theory1048781 Caloric Restriction Theory1048781 Gene Mutation Theory1048781 The Rate of Living Theory1048781 Order to Disorder Theory1048781 The Telomerase Theory of Ageing1048781 Neuro Endocrine theory or Weak Link Theory1048781 Free Radical Theory of Ageing

25

FREE RADICAL THEORYFree radical is a term used to describe any molecule that differs from conventional molecules in that it possesses a free electron a property that makes it react with other molecules in highly volatile and destructive ways The changes induced by free radicals are believed to be a major cause of Ageing disease development orand death

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

Etiological Factors of Ageing Related to Dietary Habitsldquowe are what we eatrdquo

1 Lavana (salt) Amla (sour) Katu (spicy) rasa pradhana2 Kshara (alkali)3 Suska shaka amp Mamsa (dry vegetable amp Meat)4 Tila Samyoga5 Pista Anna6 Viruddha Anna (Incompatible Diet)7 Asatmya Anna (Unfavorable Diet)8 Ruksha Anna (Dry Cereal)9 Abhisyandi Anna10 Klinna amp Guru Anna (Heavy Diet)11 Puti amp Paryushita Anna (Polluted amp Out dated Diet)12 Vishamashana (Improper Eating Habits)13 Adhyashana (Over Eating)

12

Etiological Factors Related to Life style

1 Atimarga Gamana (Excessive Walk)2 Diwa Swapna (Day Sleeping)3 Nitya Stri Sevana (Excessive Intercourse)4 Nitya Madya Sevana (Excessive Intake of Alcohol)5 Vishama Vyayama Sevan (Improper Exercise)

13

The etiological factor of Ageing related to disturbed Mental Health

1 Bhaya (Fear)2 Krodha (Anger)3 Shok (Sorrow)4 Lobha (Greed)5 Moha (Affection)6 Ruksha Vani (Harsh words)7 Kalah Priya Bharya (Quarrelsome Wife)8 Kuputra Kuputri (Maladroit child)

14

Ageing

Srotokharatwa(srotovahani)

Improper absorption amp

assimilation of ahara rasa

Disequilibrium in upchaya amp

apchaya

Rasadhatu kshaya

Uttarotara dhatu kshaya

Ojokshaya

Vata vriddhi

How Vata vriddhi occurs during ageing

Etiopathogenesis of Ageing Disturbances in Manasika Bhava Dosha

Rajas Dushti Tamas satva(Bhaya krodha Shok Lobha Moha )

Mana Dushti AjirnaAgnimandya

Ama

Free radicals Injury to cells

Gradually damage to all over cell

Ageing

Vikrit Agni

DECADE WISE AGEING PROCESS

Vagbhatta was the first one to record such an observation which was followed later by Sharangadhara

ckYa o`f) NfoZeskk RoXn`frdquoV lsquokqdzfodzekSAc`f) desZfUnza psrks thfora nrsquokrks g`lsr AA frac14rsquokk-la-iw-620frac12ckYs o`f)a izHkkeskkRod lsquokqdzkfk=qrhfUnze~Anrsquokdsrdquokq dzekkkfUr eu losZfUnzkfk pAA frac14v-la-lsquokk-825frac12 It is clear that ageing does not occur simultaneously in all the tissues Different

body tissues are affected ageing at different time period Gradual declination of a particular faculty takes place in each decade of life and by the end of decade that particular faculty is lost

Decade Loss of tissuesVagbhata Sharngadhara

I Childhood Childhood ΙΙ Growth Growth ΙΙΙ Complexion Complexion IV Intellect Intellect V Skin Skin VI Reproductive Capacity Vision VII Vision Reproductive Capacity

VIII Hearing Valour IX Mind Knowledge X Sensory amp Motor organs Motor organs XI - Mind XII - Life

CHIEF COMPLAINTS1Twak Parushata (Dryness of skin)2 Slatha sara (Flabbiness of the body)3 Slatha Mamsa (Decreased muscle

tone)4 Slatha Asthi (Bone weakness)5 Slatha Sandhi (Flaccid joint)6 Dhatu Kshaya (Loss of tissues)7 Kayasya Avanamanam (Bending of the

body)8 Vepathu (Tremors)9 Khalitya (Falling of hairs)10 Vali (Wrinkling)11 Palitya (Graying of hairs)12 Kasa (Coughing)13 Shwasa (Short breath)

15 Utsaha hani (Decreased Enthusiasm)

16 Parakrama hani (Decreased Physical Strength)

17 Paurusha hani (Decreased Virility)18 Prabha hani Chhavi Hras (Changes

in Complexion)19 Shukra Kshaya20 Dristi Hras (Diminished Vision)21 Karmendriya hani (Decreased Loco

motor Activities)22 Buddhi hani (Deterioration in

Wisdom)

14 Medha hani (Decreased functions of Intellect) a Grahana (Grasping Power) b Dharana (Retention Power) c Smarana (Memory Power) d Vachana (Speech) e Vijnana (Knowledge)

18

Ageing Process - A Modern Review

History of Geriatrics

Greek word ldquogerosrdquo mean the old age + Iatric mean the medical treatment This is the branch of medicine concerned with the problems of Ageing including physiological pathological and psychological problems Nascher was the first to coin the term Geriatrics He published a paper in New York medical journal in1909 and a textbook on it in 1914 Thus Geriatric came to be recognized as a special branch in first decade of 20th century

ldquoThe processes that occur during life which culminate in changes that decrease an individuals ability to cope with biological changesrdquo

Definition of Ageing

GERIATRICS - A branch of medicine dealing exclusively with the problems of ageing and the diseases of the elderly It is derived from the Greek root ldquoger- gero- gerontordquo meaning ldquoold agerdquo or ldquothe agedrdquo

SYNONYMS OF AGEING

Senescence is the process by which the capacity for cell division growth and function is lost over time ultimately leading to an incompatibility with life ie the process of senescence terminates in death

Senility This term is from the Latin origin lsquosenilitusrsquo which means the period of physical and mental deterioration associated with old age

Senium Identical to the term senility one more term senium is also used in the medical field it is marked by the deterioration and weakness that may accompany the age advancement

Geria This also indicates the old age

CLASSIFICATION OF AGE

AGE

Chronological age - number of years lived

Biological age ndash age by body function

Psychological age ndash age how individuals feels it

CHRONOLOGICAL CATEGORIES bullYoung-Old - (ages 65 - 74) Set Old Age

bullMiddle-Old - (ages 75 - 84) Old Old Age

bullOld-Old - (age 85 and older) Ripe Old Age

oIMPROPER DIET Acidic foodsFood additives Food additives are added to improve the shelf life and stability of processed and smoked foods but these are not body friendlyFood preparation oily food preparation

oIMPROPER LIFESTYLEoSmokingoAlcoholoIrregular sleeping patternoPhysical inactivity or improper exercise

oSTRESS oEXOGENOUS AGENTS

bullEnvironmental pollution - People living in any metropolitan area are exposed to pollution and if regularly commute in traffic jams or live near any industrial areas body is exposed to more harmful air particles and increased production of free radicalsbullPesticides - pesticides causes more oxidative stress in the bodybullSun exposurebullX-rays

DRUG ABUSE

CLASSIFICATION OF CAUSES OF AGEING

EFFECT OF STRESS ON BODY SYSTEMS

Some Theories of Ageing are given below1048781 Waste Accumulation Theory1048781 Limited Number of Cell Divisions Theory1048781 Hay flick Limit Theory1048781 Death Hormone Theory (DECO)1048781 Thymic -Stimulating Theory1048781 Mitochondrial Theory1048781 Errors and Repairs Theory1048781 Redundant DNA Theory1048781 Cross-Linkage Theory1048781 Autoimmune Theory1048781 Caloric Restriction Theory1048781 Gene Mutation Theory1048781 The Rate of Living Theory1048781 Order to Disorder Theory1048781 The Telomerase Theory of Ageing1048781 Neuro Endocrine theory or Weak Link Theory1048781 Free Radical Theory of Ageing

25

FREE RADICAL THEORYFree radical is a term used to describe any molecule that differs from conventional molecules in that it possesses a free electron a property that makes it react with other molecules in highly volatile and destructive ways The changes induced by free radicals are believed to be a major cause of Ageing disease development orand death

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

Etiological Factors Related to Life style

1 Atimarga Gamana (Excessive Walk)2 Diwa Swapna (Day Sleeping)3 Nitya Stri Sevana (Excessive Intercourse)4 Nitya Madya Sevana (Excessive Intake of Alcohol)5 Vishama Vyayama Sevan (Improper Exercise)

13

The etiological factor of Ageing related to disturbed Mental Health

1 Bhaya (Fear)2 Krodha (Anger)3 Shok (Sorrow)4 Lobha (Greed)5 Moha (Affection)6 Ruksha Vani (Harsh words)7 Kalah Priya Bharya (Quarrelsome Wife)8 Kuputra Kuputri (Maladroit child)

14

Ageing

Srotokharatwa(srotovahani)

Improper absorption amp

assimilation of ahara rasa

Disequilibrium in upchaya amp

apchaya

Rasadhatu kshaya

Uttarotara dhatu kshaya

Ojokshaya

Vata vriddhi

How Vata vriddhi occurs during ageing

Etiopathogenesis of Ageing Disturbances in Manasika Bhava Dosha

Rajas Dushti Tamas satva(Bhaya krodha Shok Lobha Moha )

Mana Dushti AjirnaAgnimandya

Ama

Free radicals Injury to cells

Gradually damage to all over cell

Ageing

Vikrit Agni

DECADE WISE AGEING PROCESS

Vagbhatta was the first one to record such an observation which was followed later by Sharangadhara

ckYa o`f) NfoZeskk RoXn`frdquoV lsquokqdzfodzekSAc`f) desZfUnza psrks thfora nrsquokrks g`lsr AA frac14rsquokk-la-iw-620frac12ckYs o`f)a izHkkeskkRod lsquokqdzkfk=qrhfUnze~Anrsquokdsrdquokq dzekkkfUr eu losZfUnzkfk pAA frac14v-la-lsquokk-825frac12 It is clear that ageing does not occur simultaneously in all the tissues Different

body tissues are affected ageing at different time period Gradual declination of a particular faculty takes place in each decade of life and by the end of decade that particular faculty is lost

Decade Loss of tissuesVagbhata Sharngadhara

I Childhood Childhood ΙΙ Growth Growth ΙΙΙ Complexion Complexion IV Intellect Intellect V Skin Skin VI Reproductive Capacity Vision VII Vision Reproductive Capacity

VIII Hearing Valour IX Mind Knowledge X Sensory amp Motor organs Motor organs XI - Mind XII - Life

CHIEF COMPLAINTS1Twak Parushata (Dryness of skin)2 Slatha sara (Flabbiness of the body)3 Slatha Mamsa (Decreased muscle

tone)4 Slatha Asthi (Bone weakness)5 Slatha Sandhi (Flaccid joint)6 Dhatu Kshaya (Loss of tissues)7 Kayasya Avanamanam (Bending of the

body)8 Vepathu (Tremors)9 Khalitya (Falling of hairs)10 Vali (Wrinkling)11 Palitya (Graying of hairs)12 Kasa (Coughing)13 Shwasa (Short breath)

15 Utsaha hani (Decreased Enthusiasm)

16 Parakrama hani (Decreased Physical Strength)

17 Paurusha hani (Decreased Virility)18 Prabha hani Chhavi Hras (Changes

in Complexion)19 Shukra Kshaya20 Dristi Hras (Diminished Vision)21 Karmendriya hani (Decreased Loco

motor Activities)22 Buddhi hani (Deterioration in

Wisdom)

14 Medha hani (Decreased functions of Intellect) a Grahana (Grasping Power) b Dharana (Retention Power) c Smarana (Memory Power) d Vachana (Speech) e Vijnana (Knowledge)

18

Ageing Process - A Modern Review

History of Geriatrics

Greek word ldquogerosrdquo mean the old age + Iatric mean the medical treatment This is the branch of medicine concerned with the problems of Ageing including physiological pathological and psychological problems Nascher was the first to coin the term Geriatrics He published a paper in New York medical journal in1909 and a textbook on it in 1914 Thus Geriatric came to be recognized as a special branch in first decade of 20th century

ldquoThe processes that occur during life which culminate in changes that decrease an individuals ability to cope with biological changesrdquo

Definition of Ageing

GERIATRICS - A branch of medicine dealing exclusively with the problems of ageing and the diseases of the elderly It is derived from the Greek root ldquoger- gero- gerontordquo meaning ldquoold agerdquo or ldquothe agedrdquo

SYNONYMS OF AGEING

Senescence is the process by which the capacity for cell division growth and function is lost over time ultimately leading to an incompatibility with life ie the process of senescence terminates in death

Senility This term is from the Latin origin lsquosenilitusrsquo which means the period of physical and mental deterioration associated with old age

Senium Identical to the term senility one more term senium is also used in the medical field it is marked by the deterioration and weakness that may accompany the age advancement

Geria This also indicates the old age

CLASSIFICATION OF AGE

AGE

Chronological age - number of years lived

Biological age ndash age by body function

Psychological age ndash age how individuals feels it

CHRONOLOGICAL CATEGORIES bullYoung-Old - (ages 65 - 74) Set Old Age

bullMiddle-Old - (ages 75 - 84) Old Old Age

bullOld-Old - (age 85 and older) Ripe Old Age

oIMPROPER DIET Acidic foodsFood additives Food additives are added to improve the shelf life and stability of processed and smoked foods but these are not body friendlyFood preparation oily food preparation

oIMPROPER LIFESTYLEoSmokingoAlcoholoIrregular sleeping patternoPhysical inactivity or improper exercise

oSTRESS oEXOGENOUS AGENTS

bullEnvironmental pollution - People living in any metropolitan area are exposed to pollution and if regularly commute in traffic jams or live near any industrial areas body is exposed to more harmful air particles and increased production of free radicalsbullPesticides - pesticides causes more oxidative stress in the bodybullSun exposurebullX-rays

DRUG ABUSE

CLASSIFICATION OF CAUSES OF AGEING

EFFECT OF STRESS ON BODY SYSTEMS

Some Theories of Ageing are given below1048781 Waste Accumulation Theory1048781 Limited Number of Cell Divisions Theory1048781 Hay flick Limit Theory1048781 Death Hormone Theory (DECO)1048781 Thymic -Stimulating Theory1048781 Mitochondrial Theory1048781 Errors and Repairs Theory1048781 Redundant DNA Theory1048781 Cross-Linkage Theory1048781 Autoimmune Theory1048781 Caloric Restriction Theory1048781 Gene Mutation Theory1048781 The Rate of Living Theory1048781 Order to Disorder Theory1048781 The Telomerase Theory of Ageing1048781 Neuro Endocrine theory or Weak Link Theory1048781 Free Radical Theory of Ageing

25

FREE RADICAL THEORYFree radical is a term used to describe any molecule that differs from conventional molecules in that it possesses a free electron a property that makes it react with other molecules in highly volatile and destructive ways The changes induced by free radicals are believed to be a major cause of Ageing disease development orand death

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

The etiological factor of Ageing related to disturbed Mental Health

1 Bhaya (Fear)2 Krodha (Anger)3 Shok (Sorrow)4 Lobha (Greed)5 Moha (Affection)6 Ruksha Vani (Harsh words)7 Kalah Priya Bharya (Quarrelsome Wife)8 Kuputra Kuputri (Maladroit child)

14

Ageing

Srotokharatwa(srotovahani)

Improper absorption amp

assimilation of ahara rasa

Disequilibrium in upchaya amp

apchaya

Rasadhatu kshaya

Uttarotara dhatu kshaya

Ojokshaya

Vata vriddhi

How Vata vriddhi occurs during ageing

Etiopathogenesis of Ageing Disturbances in Manasika Bhava Dosha

Rajas Dushti Tamas satva(Bhaya krodha Shok Lobha Moha )

Mana Dushti AjirnaAgnimandya

Ama

Free radicals Injury to cells

Gradually damage to all over cell

Ageing

Vikrit Agni

DECADE WISE AGEING PROCESS

Vagbhatta was the first one to record such an observation which was followed later by Sharangadhara

ckYa o`f) NfoZeskk RoXn`frdquoV lsquokqdzfodzekSAc`f) desZfUnza psrks thfora nrsquokrks g`lsr AA frac14rsquokk-la-iw-620frac12ckYs o`f)a izHkkeskkRod lsquokqdzkfk=qrhfUnze~Anrsquokdsrdquokq dzekkkfUr eu losZfUnzkfk pAA frac14v-la-lsquokk-825frac12 It is clear that ageing does not occur simultaneously in all the tissues Different

body tissues are affected ageing at different time period Gradual declination of a particular faculty takes place in each decade of life and by the end of decade that particular faculty is lost

Decade Loss of tissuesVagbhata Sharngadhara

I Childhood Childhood ΙΙ Growth Growth ΙΙΙ Complexion Complexion IV Intellect Intellect V Skin Skin VI Reproductive Capacity Vision VII Vision Reproductive Capacity

VIII Hearing Valour IX Mind Knowledge X Sensory amp Motor organs Motor organs XI - Mind XII - Life

CHIEF COMPLAINTS1Twak Parushata (Dryness of skin)2 Slatha sara (Flabbiness of the body)3 Slatha Mamsa (Decreased muscle

tone)4 Slatha Asthi (Bone weakness)5 Slatha Sandhi (Flaccid joint)6 Dhatu Kshaya (Loss of tissues)7 Kayasya Avanamanam (Bending of the

body)8 Vepathu (Tremors)9 Khalitya (Falling of hairs)10 Vali (Wrinkling)11 Palitya (Graying of hairs)12 Kasa (Coughing)13 Shwasa (Short breath)

15 Utsaha hani (Decreased Enthusiasm)

16 Parakrama hani (Decreased Physical Strength)

17 Paurusha hani (Decreased Virility)18 Prabha hani Chhavi Hras (Changes

in Complexion)19 Shukra Kshaya20 Dristi Hras (Diminished Vision)21 Karmendriya hani (Decreased Loco

motor Activities)22 Buddhi hani (Deterioration in

Wisdom)

14 Medha hani (Decreased functions of Intellect) a Grahana (Grasping Power) b Dharana (Retention Power) c Smarana (Memory Power) d Vachana (Speech) e Vijnana (Knowledge)

18

Ageing Process - A Modern Review

History of Geriatrics

Greek word ldquogerosrdquo mean the old age + Iatric mean the medical treatment This is the branch of medicine concerned with the problems of Ageing including physiological pathological and psychological problems Nascher was the first to coin the term Geriatrics He published a paper in New York medical journal in1909 and a textbook on it in 1914 Thus Geriatric came to be recognized as a special branch in first decade of 20th century

ldquoThe processes that occur during life which culminate in changes that decrease an individuals ability to cope with biological changesrdquo

Definition of Ageing

GERIATRICS - A branch of medicine dealing exclusively with the problems of ageing and the diseases of the elderly It is derived from the Greek root ldquoger- gero- gerontordquo meaning ldquoold agerdquo or ldquothe agedrdquo

SYNONYMS OF AGEING

Senescence is the process by which the capacity for cell division growth and function is lost over time ultimately leading to an incompatibility with life ie the process of senescence terminates in death

Senility This term is from the Latin origin lsquosenilitusrsquo which means the period of physical and mental deterioration associated with old age

Senium Identical to the term senility one more term senium is also used in the medical field it is marked by the deterioration and weakness that may accompany the age advancement

Geria This also indicates the old age

CLASSIFICATION OF AGE

AGE

Chronological age - number of years lived

Biological age ndash age by body function

Psychological age ndash age how individuals feels it

CHRONOLOGICAL CATEGORIES bullYoung-Old - (ages 65 - 74) Set Old Age

bullMiddle-Old - (ages 75 - 84) Old Old Age

bullOld-Old - (age 85 and older) Ripe Old Age

oIMPROPER DIET Acidic foodsFood additives Food additives are added to improve the shelf life and stability of processed and smoked foods but these are not body friendlyFood preparation oily food preparation

oIMPROPER LIFESTYLEoSmokingoAlcoholoIrregular sleeping patternoPhysical inactivity or improper exercise

oSTRESS oEXOGENOUS AGENTS

bullEnvironmental pollution - People living in any metropolitan area are exposed to pollution and if regularly commute in traffic jams or live near any industrial areas body is exposed to more harmful air particles and increased production of free radicalsbullPesticides - pesticides causes more oxidative stress in the bodybullSun exposurebullX-rays

DRUG ABUSE

CLASSIFICATION OF CAUSES OF AGEING

EFFECT OF STRESS ON BODY SYSTEMS

Some Theories of Ageing are given below1048781 Waste Accumulation Theory1048781 Limited Number of Cell Divisions Theory1048781 Hay flick Limit Theory1048781 Death Hormone Theory (DECO)1048781 Thymic -Stimulating Theory1048781 Mitochondrial Theory1048781 Errors and Repairs Theory1048781 Redundant DNA Theory1048781 Cross-Linkage Theory1048781 Autoimmune Theory1048781 Caloric Restriction Theory1048781 Gene Mutation Theory1048781 The Rate of Living Theory1048781 Order to Disorder Theory1048781 The Telomerase Theory of Ageing1048781 Neuro Endocrine theory or Weak Link Theory1048781 Free Radical Theory of Ageing

25

FREE RADICAL THEORYFree radical is a term used to describe any molecule that differs from conventional molecules in that it possesses a free electron a property that makes it react with other molecules in highly volatile and destructive ways The changes induced by free radicals are believed to be a major cause of Ageing disease development orand death

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

Ageing

Srotokharatwa(srotovahani)

Improper absorption amp

assimilation of ahara rasa

Disequilibrium in upchaya amp

apchaya

Rasadhatu kshaya

Uttarotara dhatu kshaya

Ojokshaya

Vata vriddhi

How Vata vriddhi occurs during ageing

Etiopathogenesis of Ageing Disturbances in Manasika Bhava Dosha

Rajas Dushti Tamas satva(Bhaya krodha Shok Lobha Moha )

Mana Dushti AjirnaAgnimandya

Ama

Free radicals Injury to cells

Gradually damage to all over cell

Ageing

Vikrit Agni

DECADE WISE AGEING PROCESS

Vagbhatta was the first one to record such an observation which was followed later by Sharangadhara

ckYa o`f) NfoZeskk RoXn`frdquoV lsquokqdzfodzekSAc`f) desZfUnza psrks thfora nrsquokrks g`lsr AA frac14rsquokk-la-iw-620frac12ckYs o`f)a izHkkeskkRod lsquokqdzkfk=qrhfUnze~Anrsquokdsrdquokq dzekkkfUr eu losZfUnzkfk pAA frac14v-la-lsquokk-825frac12 It is clear that ageing does not occur simultaneously in all the tissues Different

body tissues are affected ageing at different time period Gradual declination of a particular faculty takes place in each decade of life and by the end of decade that particular faculty is lost

Decade Loss of tissuesVagbhata Sharngadhara

I Childhood Childhood ΙΙ Growth Growth ΙΙΙ Complexion Complexion IV Intellect Intellect V Skin Skin VI Reproductive Capacity Vision VII Vision Reproductive Capacity

VIII Hearing Valour IX Mind Knowledge X Sensory amp Motor organs Motor organs XI - Mind XII - Life

CHIEF COMPLAINTS1Twak Parushata (Dryness of skin)2 Slatha sara (Flabbiness of the body)3 Slatha Mamsa (Decreased muscle

tone)4 Slatha Asthi (Bone weakness)5 Slatha Sandhi (Flaccid joint)6 Dhatu Kshaya (Loss of tissues)7 Kayasya Avanamanam (Bending of the

body)8 Vepathu (Tremors)9 Khalitya (Falling of hairs)10 Vali (Wrinkling)11 Palitya (Graying of hairs)12 Kasa (Coughing)13 Shwasa (Short breath)

15 Utsaha hani (Decreased Enthusiasm)

16 Parakrama hani (Decreased Physical Strength)

17 Paurusha hani (Decreased Virility)18 Prabha hani Chhavi Hras (Changes

in Complexion)19 Shukra Kshaya20 Dristi Hras (Diminished Vision)21 Karmendriya hani (Decreased Loco

motor Activities)22 Buddhi hani (Deterioration in

Wisdom)

14 Medha hani (Decreased functions of Intellect) a Grahana (Grasping Power) b Dharana (Retention Power) c Smarana (Memory Power) d Vachana (Speech) e Vijnana (Knowledge)

18

Ageing Process - A Modern Review

History of Geriatrics

Greek word ldquogerosrdquo mean the old age + Iatric mean the medical treatment This is the branch of medicine concerned with the problems of Ageing including physiological pathological and psychological problems Nascher was the first to coin the term Geriatrics He published a paper in New York medical journal in1909 and a textbook on it in 1914 Thus Geriatric came to be recognized as a special branch in first decade of 20th century

ldquoThe processes that occur during life which culminate in changes that decrease an individuals ability to cope with biological changesrdquo

Definition of Ageing

GERIATRICS - A branch of medicine dealing exclusively with the problems of ageing and the diseases of the elderly It is derived from the Greek root ldquoger- gero- gerontordquo meaning ldquoold agerdquo or ldquothe agedrdquo

SYNONYMS OF AGEING

Senescence is the process by which the capacity for cell division growth and function is lost over time ultimately leading to an incompatibility with life ie the process of senescence terminates in death

Senility This term is from the Latin origin lsquosenilitusrsquo which means the period of physical and mental deterioration associated with old age

Senium Identical to the term senility one more term senium is also used in the medical field it is marked by the deterioration and weakness that may accompany the age advancement

Geria This also indicates the old age

CLASSIFICATION OF AGE

AGE

Chronological age - number of years lived

Biological age ndash age by body function

Psychological age ndash age how individuals feels it

CHRONOLOGICAL CATEGORIES bullYoung-Old - (ages 65 - 74) Set Old Age

bullMiddle-Old - (ages 75 - 84) Old Old Age

bullOld-Old - (age 85 and older) Ripe Old Age

oIMPROPER DIET Acidic foodsFood additives Food additives are added to improve the shelf life and stability of processed and smoked foods but these are not body friendlyFood preparation oily food preparation

oIMPROPER LIFESTYLEoSmokingoAlcoholoIrregular sleeping patternoPhysical inactivity or improper exercise

oSTRESS oEXOGENOUS AGENTS

bullEnvironmental pollution - People living in any metropolitan area are exposed to pollution and if regularly commute in traffic jams or live near any industrial areas body is exposed to more harmful air particles and increased production of free radicalsbullPesticides - pesticides causes more oxidative stress in the bodybullSun exposurebullX-rays

DRUG ABUSE

CLASSIFICATION OF CAUSES OF AGEING

EFFECT OF STRESS ON BODY SYSTEMS

Some Theories of Ageing are given below1048781 Waste Accumulation Theory1048781 Limited Number of Cell Divisions Theory1048781 Hay flick Limit Theory1048781 Death Hormone Theory (DECO)1048781 Thymic -Stimulating Theory1048781 Mitochondrial Theory1048781 Errors and Repairs Theory1048781 Redundant DNA Theory1048781 Cross-Linkage Theory1048781 Autoimmune Theory1048781 Caloric Restriction Theory1048781 Gene Mutation Theory1048781 The Rate of Living Theory1048781 Order to Disorder Theory1048781 The Telomerase Theory of Ageing1048781 Neuro Endocrine theory or Weak Link Theory1048781 Free Radical Theory of Ageing

25

FREE RADICAL THEORYFree radical is a term used to describe any molecule that differs from conventional molecules in that it possesses a free electron a property that makes it react with other molecules in highly volatile and destructive ways The changes induced by free radicals are believed to be a major cause of Ageing disease development orand death

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

Etiopathogenesis of Ageing Disturbances in Manasika Bhava Dosha

Rajas Dushti Tamas satva(Bhaya krodha Shok Lobha Moha )

Mana Dushti AjirnaAgnimandya

Ama

Free radicals Injury to cells

Gradually damage to all over cell

Ageing

Vikrit Agni

DECADE WISE AGEING PROCESS

Vagbhatta was the first one to record such an observation which was followed later by Sharangadhara

ckYa o`f) NfoZeskk RoXn`frdquoV lsquokqdzfodzekSAc`f) desZfUnza psrks thfora nrsquokrks g`lsr AA frac14rsquokk-la-iw-620frac12ckYs o`f)a izHkkeskkRod lsquokqdzkfk=qrhfUnze~Anrsquokdsrdquokq dzekkkfUr eu losZfUnzkfk pAA frac14v-la-lsquokk-825frac12 It is clear that ageing does not occur simultaneously in all the tissues Different

body tissues are affected ageing at different time period Gradual declination of a particular faculty takes place in each decade of life and by the end of decade that particular faculty is lost

Decade Loss of tissuesVagbhata Sharngadhara

I Childhood Childhood ΙΙ Growth Growth ΙΙΙ Complexion Complexion IV Intellect Intellect V Skin Skin VI Reproductive Capacity Vision VII Vision Reproductive Capacity

VIII Hearing Valour IX Mind Knowledge X Sensory amp Motor organs Motor organs XI - Mind XII - Life

CHIEF COMPLAINTS1Twak Parushata (Dryness of skin)2 Slatha sara (Flabbiness of the body)3 Slatha Mamsa (Decreased muscle

tone)4 Slatha Asthi (Bone weakness)5 Slatha Sandhi (Flaccid joint)6 Dhatu Kshaya (Loss of tissues)7 Kayasya Avanamanam (Bending of the

body)8 Vepathu (Tremors)9 Khalitya (Falling of hairs)10 Vali (Wrinkling)11 Palitya (Graying of hairs)12 Kasa (Coughing)13 Shwasa (Short breath)

15 Utsaha hani (Decreased Enthusiasm)

16 Parakrama hani (Decreased Physical Strength)

17 Paurusha hani (Decreased Virility)18 Prabha hani Chhavi Hras (Changes

in Complexion)19 Shukra Kshaya20 Dristi Hras (Diminished Vision)21 Karmendriya hani (Decreased Loco

motor Activities)22 Buddhi hani (Deterioration in

Wisdom)

14 Medha hani (Decreased functions of Intellect) a Grahana (Grasping Power) b Dharana (Retention Power) c Smarana (Memory Power) d Vachana (Speech) e Vijnana (Knowledge)

18

Ageing Process - A Modern Review

History of Geriatrics

Greek word ldquogerosrdquo mean the old age + Iatric mean the medical treatment This is the branch of medicine concerned with the problems of Ageing including physiological pathological and psychological problems Nascher was the first to coin the term Geriatrics He published a paper in New York medical journal in1909 and a textbook on it in 1914 Thus Geriatric came to be recognized as a special branch in first decade of 20th century

ldquoThe processes that occur during life which culminate in changes that decrease an individuals ability to cope with biological changesrdquo

Definition of Ageing

GERIATRICS - A branch of medicine dealing exclusively with the problems of ageing and the diseases of the elderly It is derived from the Greek root ldquoger- gero- gerontordquo meaning ldquoold agerdquo or ldquothe agedrdquo

SYNONYMS OF AGEING

Senescence is the process by which the capacity for cell division growth and function is lost over time ultimately leading to an incompatibility with life ie the process of senescence terminates in death

Senility This term is from the Latin origin lsquosenilitusrsquo which means the period of physical and mental deterioration associated with old age

Senium Identical to the term senility one more term senium is also used in the medical field it is marked by the deterioration and weakness that may accompany the age advancement

Geria This also indicates the old age

CLASSIFICATION OF AGE

AGE

Chronological age - number of years lived

Biological age ndash age by body function

Psychological age ndash age how individuals feels it

CHRONOLOGICAL CATEGORIES bullYoung-Old - (ages 65 - 74) Set Old Age

bullMiddle-Old - (ages 75 - 84) Old Old Age

bullOld-Old - (age 85 and older) Ripe Old Age

oIMPROPER DIET Acidic foodsFood additives Food additives are added to improve the shelf life and stability of processed and smoked foods but these are not body friendlyFood preparation oily food preparation

oIMPROPER LIFESTYLEoSmokingoAlcoholoIrregular sleeping patternoPhysical inactivity or improper exercise

oSTRESS oEXOGENOUS AGENTS

bullEnvironmental pollution - People living in any metropolitan area are exposed to pollution and if regularly commute in traffic jams or live near any industrial areas body is exposed to more harmful air particles and increased production of free radicalsbullPesticides - pesticides causes more oxidative stress in the bodybullSun exposurebullX-rays

DRUG ABUSE

CLASSIFICATION OF CAUSES OF AGEING

EFFECT OF STRESS ON BODY SYSTEMS

Some Theories of Ageing are given below1048781 Waste Accumulation Theory1048781 Limited Number of Cell Divisions Theory1048781 Hay flick Limit Theory1048781 Death Hormone Theory (DECO)1048781 Thymic -Stimulating Theory1048781 Mitochondrial Theory1048781 Errors and Repairs Theory1048781 Redundant DNA Theory1048781 Cross-Linkage Theory1048781 Autoimmune Theory1048781 Caloric Restriction Theory1048781 Gene Mutation Theory1048781 The Rate of Living Theory1048781 Order to Disorder Theory1048781 The Telomerase Theory of Ageing1048781 Neuro Endocrine theory or Weak Link Theory1048781 Free Radical Theory of Ageing

25

FREE RADICAL THEORYFree radical is a term used to describe any molecule that differs from conventional molecules in that it possesses a free electron a property that makes it react with other molecules in highly volatile and destructive ways The changes induced by free radicals are believed to be a major cause of Ageing disease development orand death

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

DECADE WISE AGEING PROCESS

Vagbhatta was the first one to record such an observation which was followed later by Sharangadhara

ckYa o`f) NfoZeskk RoXn`frdquoV lsquokqdzfodzekSAc`f) desZfUnza psrks thfora nrsquokrks g`lsr AA frac14rsquokk-la-iw-620frac12ckYs o`f)a izHkkeskkRod lsquokqdzkfk=qrhfUnze~Anrsquokdsrdquokq dzekkkfUr eu losZfUnzkfk pAA frac14v-la-lsquokk-825frac12 It is clear that ageing does not occur simultaneously in all the tissues Different

body tissues are affected ageing at different time period Gradual declination of a particular faculty takes place in each decade of life and by the end of decade that particular faculty is lost

Decade Loss of tissuesVagbhata Sharngadhara

I Childhood Childhood ΙΙ Growth Growth ΙΙΙ Complexion Complexion IV Intellect Intellect V Skin Skin VI Reproductive Capacity Vision VII Vision Reproductive Capacity

VIII Hearing Valour IX Mind Knowledge X Sensory amp Motor organs Motor organs XI - Mind XII - Life

CHIEF COMPLAINTS1Twak Parushata (Dryness of skin)2 Slatha sara (Flabbiness of the body)3 Slatha Mamsa (Decreased muscle

tone)4 Slatha Asthi (Bone weakness)5 Slatha Sandhi (Flaccid joint)6 Dhatu Kshaya (Loss of tissues)7 Kayasya Avanamanam (Bending of the

body)8 Vepathu (Tremors)9 Khalitya (Falling of hairs)10 Vali (Wrinkling)11 Palitya (Graying of hairs)12 Kasa (Coughing)13 Shwasa (Short breath)

15 Utsaha hani (Decreased Enthusiasm)

16 Parakrama hani (Decreased Physical Strength)

17 Paurusha hani (Decreased Virility)18 Prabha hani Chhavi Hras (Changes

in Complexion)19 Shukra Kshaya20 Dristi Hras (Diminished Vision)21 Karmendriya hani (Decreased Loco

motor Activities)22 Buddhi hani (Deterioration in

Wisdom)

14 Medha hani (Decreased functions of Intellect) a Grahana (Grasping Power) b Dharana (Retention Power) c Smarana (Memory Power) d Vachana (Speech) e Vijnana (Knowledge)

18

Ageing Process - A Modern Review

History of Geriatrics

Greek word ldquogerosrdquo mean the old age + Iatric mean the medical treatment This is the branch of medicine concerned with the problems of Ageing including physiological pathological and psychological problems Nascher was the first to coin the term Geriatrics He published a paper in New York medical journal in1909 and a textbook on it in 1914 Thus Geriatric came to be recognized as a special branch in first decade of 20th century

ldquoThe processes that occur during life which culminate in changes that decrease an individuals ability to cope with biological changesrdquo

Definition of Ageing

GERIATRICS - A branch of medicine dealing exclusively with the problems of ageing and the diseases of the elderly It is derived from the Greek root ldquoger- gero- gerontordquo meaning ldquoold agerdquo or ldquothe agedrdquo

SYNONYMS OF AGEING

Senescence is the process by which the capacity for cell division growth and function is lost over time ultimately leading to an incompatibility with life ie the process of senescence terminates in death

Senility This term is from the Latin origin lsquosenilitusrsquo which means the period of physical and mental deterioration associated with old age

Senium Identical to the term senility one more term senium is also used in the medical field it is marked by the deterioration and weakness that may accompany the age advancement

Geria This also indicates the old age

CLASSIFICATION OF AGE

AGE

Chronological age - number of years lived

Biological age ndash age by body function

Psychological age ndash age how individuals feels it

CHRONOLOGICAL CATEGORIES bullYoung-Old - (ages 65 - 74) Set Old Age

bullMiddle-Old - (ages 75 - 84) Old Old Age

bullOld-Old - (age 85 and older) Ripe Old Age

oIMPROPER DIET Acidic foodsFood additives Food additives are added to improve the shelf life and stability of processed and smoked foods but these are not body friendlyFood preparation oily food preparation

oIMPROPER LIFESTYLEoSmokingoAlcoholoIrregular sleeping patternoPhysical inactivity or improper exercise

oSTRESS oEXOGENOUS AGENTS

bullEnvironmental pollution - People living in any metropolitan area are exposed to pollution and if regularly commute in traffic jams or live near any industrial areas body is exposed to more harmful air particles and increased production of free radicalsbullPesticides - pesticides causes more oxidative stress in the bodybullSun exposurebullX-rays

DRUG ABUSE

CLASSIFICATION OF CAUSES OF AGEING

EFFECT OF STRESS ON BODY SYSTEMS

Some Theories of Ageing are given below1048781 Waste Accumulation Theory1048781 Limited Number of Cell Divisions Theory1048781 Hay flick Limit Theory1048781 Death Hormone Theory (DECO)1048781 Thymic -Stimulating Theory1048781 Mitochondrial Theory1048781 Errors and Repairs Theory1048781 Redundant DNA Theory1048781 Cross-Linkage Theory1048781 Autoimmune Theory1048781 Caloric Restriction Theory1048781 Gene Mutation Theory1048781 The Rate of Living Theory1048781 Order to Disorder Theory1048781 The Telomerase Theory of Ageing1048781 Neuro Endocrine theory or Weak Link Theory1048781 Free Radical Theory of Ageing

25

FREE RADICAL THEORYFree radical is a term used to describe any molecule that differs from conventional molecules in that it possesses a free electron a property that makes it react with other molecules in highly volatile and destructive ways The changes induced by free radicals are believed to be a major cause of Ageing disease development orand death

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

CHIEF COMPLAINTS1Twak Parushata (Dryness of skin)2 Slatha sara (Flabbiness of the body)3 Slatha Mamsa (Decreased muscle

tone)4 Slatha Asthi (Bone weakness)5 Slatha Sandhi (Flaccid joint)6 Dhatu Kshaya (Loss of tissues)7 Kayasya Avanamanam (Bending of the

body)8 Vepathu (Tremors)9 Khalitya (Falling of hairs)10 Vali (Wrinkling)11 Palitya (Graying of hairs)12 Kasa (Coughing)13 Shwasa (Short breath)

15 Utsaha hani (Decreased Enthusiasm)

16 Parakrama hani (Decreased Physical Strength)

17 Paurusha hani (Decreased Virility)18 Prabha hani Chhavi Hras (Changes

in Complexion)19 Shukra Kshaya20 Dristi Hras (Diminished Vision)21 Karmendriya hani (Decreased Loco

motor Activities)22 Buddhi hani (Deterioration in

Wisdom)

14 Medha hani (Decreased functions of Intellect) a Grahana (Grasping Power) b Dharana (Retention Power) c Smarana (Memory Power) d Vachana (Speech) e Vijnana (Knowledge)

18

Ageing Process - A Modern Review

History of Geriatrics

Greek word ldquogerosrdquo mean the old age + Iatric mean the medical treatment This is the branch of medicine concerned with the problems of Ageing including physiological pathological and psychological problems Nascher was the first to coin the term Geriatrics He published a paper in New York medical journal in1909 and a textbook on it in 1914 Thus Geriatric came to be recognized as a special branch in first decade of 20th century

ldquoThe processes that occur during life which culminate in changes that decrease an individuals ability to cope with biological changesrdquo

Definition of Ageing

GERIATRICS - A branch of medicine dealing exclusively with the problems of ageing and the diseases of the elderly It is derived from the Greek root ldquoger- gero- gerontordquo meaning ldquoold agerdquo or ldquothe agedrdquo

SYNONYMS OF AGEING

Senescence is the process by which the capacity for cell division growth and function is lost over time ultimately leading to an incompatibility with life ie the process of senescence terminates in death

Senility This term is from the Latin origin lsquosenilitusrsquo which means the period of physical and mental deterioration associated with old age

Senium Identical to the term senility one more term senium is also used in the medical field it is marked by the deterioration and weakness that may accompany the age advancement

Geria This also indicates the old age

CLASSIFICATION OF AGE

AGE

Chronological age - number of years lived

Biological age ndash age by body function

Psychological age ndash age how individuals feels it

CHRONOLOGICAL CATEGORIES bullYoung-Old - (ages 65 - 74) Set Old Age

bullMiddle-Old - (ages 75 - 84) Old Old Age

bullOld-Old - (age 85 and older) Ripe Old Age

oIMPROPER DIET Acidic foodsFood additives Food additives are added to improve the shelf life and stability of processed and smoked foods but these are not body friendlyFood preparation oily food preparation

oIMPROPER LIFESTYLEoSmokingoAlcoholoIrregular sleeping patternoPhysical inactivity or improper exercise

oSTRESS oEXOGENOUS AGENTS

bullEnvironmental pollution - People living in any metropolitan area are exposed to pollution and if regularly commute in traffic jams or live near any industrial areas body is exposed to more harmful air particles and increased production of free radicalsbullPesticides - pesticides causes more oxidative stress in the bodybullSun exposurebullX-rays

DRUG ABUSE

CLASSIFICATION OF CAUSES OF AGEING

EFFECT OF STRESS ON BODY SYSTEMS

Some Theories of Ageing are given below1048781 Waste Accumulation Theory1048781 Limited Number of Cell Divisions Theory1048781 Hay flick Limit Theory1048781 Death Hormone Theory (DECO)1048781 Thymic -Stimulating Theory1048781 Mitochondrial Theory1048781 Errors and Repairs Theory1048781 Redundant DNA Theory1048781 Cross-Linkage Theory1048781 Autoimmune Theory1048781 Caloric Restriction Theory1048781 Gene Mutation Theory1048781 The Rate of Living Theory1048781 Order to Disorder Theory1048781 The Telomerase Theory of Ageing1048781 Neuro Endocrine theory or Weak Link Theory1048781 Free Radical Theory of Ageing

25

FREE RADICAL THEORYFree radical is a term used to describe any molecule that differs from conventional molecules in that it possesses a free electron a property that makes it react with other molecules in highly volatile and destructive ways The changes induced by free radicals are believed to be a major cause of Ageing disease development orand death

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

Ageing Process - A Modern Review

History of Geriatrics

Greek word ldquogerosrdquo mean the old age + Iatric mean the medical treatment This is the branch of medicine concerned with the problems of Ageing including physiological pathological and psychological problems Nascher was the first to coin the term Geriatrics He published a paper in New York medical journal in1909 and a textbook on it in 1914 Thus Geriatric came to be recognized as a special branch in first decade of 20th century

ldquoThe processes that occur during life which culminate in changes that decrease an individuals ability to cope with biological changesrdquo

Definition of Ageing

GERIATRICS - A branch of medicine dealing exclusively with the problems of ageing and the diseases of the elderly It is derived from the Greek root ldquoger- gero- gerontordquo meaning ldquoold agerdquo or ldquothe agedrdquo

SYNONYMS OF AGEING

Senescence is the process by which the capacity for cell division growth and function is lost over time ultimately leading to an incompatibility with life ie the process of senescence terminates in death

Senility This term is from the Latin origin lsquosenilitusrsquo which means the period of physical and mental deterioration associated with old age

Senium Identical to the term senility one more term senium is also used in the medical field it is marked by the deterioration and weakness that may accompany the age advancement

Geria This also indicates the old age

CLASSIFICATION OF AGE

AGE

Chronological age - number of years lived

Biological age ndash age by body function

Psychological age ndash age how individuals feels it

CHRONOLOGICAL CATEGORIES bullYoung-Old - (ages 65 - 74) Set Old Age

bullMiddle-Old - (ages 75 - 84) Old Old Age

bullOld-Old - (age 85 and older) Ripe Old Age

oIMPROPER DIET Acidic foodsFood additives Food additives are added to improve the shelf life and stability of processed and smoked foods but these are not body friendlyFood preparation oily food preparation

oIMPROPER LIFESTYLEoSmokingoAlcoholoIrregular sleeping patternoPhysical inactivity or improper exercise

oSTRESS oEXOGENOUS AGENTS

bullEnvironmental pollution - People living in any metropolitan area are exposed to pollution and if regularly commute in traffic jams or live near any industrial areas body is exposed to more harmful air particles and increased production of free radicalsbullPesticides - pesticides causes more oxidative stress in the bodybullSun exposurebullX-rays

DRUG ABUSE

CLASSIFICATION OF CAUSES OF AGEING

EFFECT OF STRESS ON BODY SYSTEMS

Some Theories of Ageing are given below1048781 Waste Accumulation Theory1048781 Limited Number of Cell Divisions Theory1048781 Hay flick Limit Theory1048781 Death Hormone Theory (DECO)1048781 Thymic -Stimulating Theory1048781 Mitochondrial Theory1048781 Errors and Repairs Theory1048781 Redundant DNA Theory1048781 Cross-Linkage Theory1048781 Autoimmune Theory1048781 Caloric Restriction Theory1048781 Gene Mutation Theory1048781 The Rate of Living Theory1048781 Order to Disorder Theory1048781 The Telomerase Theory of Ageing1048781 Neuro Endocrine theory or Weak Link Theory1048781 Free Radical Theory of Ageing

25

FREE RADICAL THEORYFree radical is a term used to describe any molecule that differs from conventional molecules in that it possesses a free electron a property that makes it react with other molecules in highly volatile and destructive ways The changes induced by free radicals are believed to be a major cause of Ageing disease development orand death

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

History of Geriatrics

Greek word ldquogerosrdquo mean the old age + Iatric mean the medical treatment This is the branch of medicine concerned with the problems of Ageing including physiological pathological and psychological problems Nascher was the first to coin the term Geriatrics He published a paper in New York medical journal in1909 and a textbook on it in 1914 Thus Geriatric came to be recognized as a special branch in first decade of 20th century

ldquoThe processes that occur during life which culminate in changes that decrease an individuals ability to cope with biological changesrdquo

Definition of Ageing

GERIATRICS - A branch of medicine dealing exclusively with the problems of ageing and the diseases of the elderly It is derived from the Greek root ldquoger- gero- gerontordquo meaning ldquoold agerdquo or ldquothe agedrdquo

SYNONYMS OF AGEING

Senescence is the process by which the capacity for cell division growth and function is lost over time ultimately leading to an incompatibility with life ie the process of senescence terminates in death

Senility This term is from the Latin origin lsquosenilitusrsquo which means the period of physical and mental deterioration associated with old age

Senium Identical to the term senility one more term senium is also used in the medical field it is marked by the deterioration and weakness that may accompany the age advancement

Geria This also indicates the old age

CLASSIFICATION OF AGE

AGE

Chronological age - number of years lived

Biological age ndash age by body function

Psychological age ndash age how individuals feels it

CHRONOLOGICAL CATEGORIES bullYoung-Old - (ages 65 - 74) Set Old Age

bullMiddle-Old - (ages 75 - 84) Old Old Age

bullOld-Old - (age 85 and older) Ripe Old Age

oIMPROPER DIET Acidic foodsFood additives Food additives are added to improve the shelf life and stability of processed and smoked foods but these are not body friendlyFood preparation oily food preparation

oIMPROPER LIFESTYLEoSmokingoAlcoholoIrregular sleeping patternoPhysical inactivity or improper exercise

oSTRESS oEXOGENOUS AGENTS

bullEnvironmental pollution - People living in any metropolitan area are exposed to pollution and if regularly commute in traffic jams or live near any industrial areas body is exposed to more harmful air particles and increased production of free radicalsbullPesticides - pesticides causes more oxidative stress in the bodybullSun exposurebullX-rays

DRUG ABUSE

CLASSIFICATION OF CAUSES OF AGEING

EFFECT OF STRESS ON BODY SYSTEMS

Some Theories of Ageing are given below1048781 Waste Accumulation Theory1048781 Limited Number of Cell Divisions Theory1048781 Hay flick Limit Theory1048781 Death Hormone Theory (DECO)1048781 Thymic -Stimulating Theory1048781 Mitochondrial Theory1048781 Errors and Repairs Theory1048781 Redundant DNA Theory1048781 Cross-Linkage Theory1048781 Autoimmune Theory1048781 Caloric Restriction Theory1048781 Gene Mutation Theory1048781 The Rate of Living Theory1048781 Order to Disorder Theory1048781 The Telomerase Theory of Ageing1048781 Neuro Endocrine theory or Weak Link Theory1048781 Free Radical Theory of Ageing

25

FREE RADICAL THEORYFree radical is a term used to describe any molecule that differs from conventional molecules in that it possesses a free electron a property that makes it react with other molecules in highly volatile and destructive ways The changes induced by free radicals are believed to be a major cause of Ageing disease development orand death

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

ldquoThe processes that occur during life which culminate in changes that decrease an individuals ability to cope with biological changesrdquo

Definition of Ageing

GERIATRICS - A branch of medicine dealing exclusively with the problems of ageing and the diseases of the elderly It is derived from the Greek root ldquoger- gero- gerontordquo meaning ldquoold agerdquo or ldquothe agedrdquo

SYNONYMS OF AGEING

Senescence is the process by which the capacity for cell division growth and function is lost over time ultimately leading to an incompatibility with life ie the process of senescence terminates in death

Senility This term is from the Latin origin lsquosenilitusrsquo which means the period of physical and mental deterioration associated with old age

Senium Identical to the term senility one more term senium is also used in the medical field it is marked by the deterioration and weakness that may accompany the age advancement

Geria This also indicates the old age

CLASSIFICATION OF AGE

AGE

Chronological age - number of years lived

Biological age ndash age by body function

Psychological age ndash age how individuals feels it

CHRONOLOGICAL CATEGORIES bullYoung-Old - (ages 65 - 74) Set Old Age

bullMiddle-Old - (ages 75 - 84) Old Old Age

bullOld-Old - (age 85 and older) Ripe Old Age

oIMPROPER DIET Acidic foodsFood additives Food additives are added to improve the shelf life and stability of processed and smoked foods but these are not body friendlyFood preparation oily food preparation

oIMPROPER LIFESTYLEoSmokingoAlcoholoIrregular sleeping patternoPhysical inactivity or improper exercise

oSTRESS oEXOGENOUS AGENTS

bullEnvironmental pollution - People living in any metropolitan area are exposed to pollution and if regularly commute in traffic jams or live near any industrial areas body is exposed to more harmful air particles and increased production of free radicalsbullPesticides - pesticides causes more oxidative stress in the bodybullSun exposurebullX-rays

DRUG ABUSE

CLASSIFICATION OF CAUSES OF AGEING

EFFECT OF STRESS ON BODY SYSTEMS

Some Theories of Ageing are given below1048781 Waste Accumulation Theory1048781 Limited Number of Cell Divisions Theory1048781 Hay flick Limit Theory1048781 Death Hormone Theory (DECO)1048781 Thymic -Stimulating Theory1048781 Mitochondrial Theory1048781 Errors and Repairs Theory1048781 Redundant DNA Theory1048781 Cross-Linkage Theory1048781 Autoimmune Theory1048781 Caloric Restriction Theory1048781 Gene Mutation Theory1048781 The Rate of Living Theory1048781 Order to Disorder Theory1048781 The Telomerase Theory of Ageing1048781 Neuro Endocrine theory or Weak Link Theory1048781 Free Radical Theory of Ageing

25

FREE RADICAL THEORYFree radical is a term used to describe any molecule that differs from conventional molecules in that it possesses a free electron a property that makes it react with other molecules in highly volatile and destructive ways The changes induced by free radicals are believed to be a major cause of Ageing disease development orand death

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

CLASSIFICATION OF AGE

AGE

Chronological age - number of years lived

Biological age ndash age by body function

Psychological age ndash age how individuals feels it

CHRONOLOGICAL CATEGORIES bullYoung-Old - (ages 65 - 74) Set Old Age

bullMiddle-Old - (ages 75 - 84) Old Old Age

bullOld-Old - (age 85 and older) Ripe Old Age

oIMPROPER DIET Acidic foodsFood additives Food additives are added to improve the shelf life and stability of processed and smoked foods but these are not body friendlyFood preparation oily food preparation

oIMPROPER LIFESTYLEoSmokingoAlcoholoIrregular sleeping patternoPhysical inactivity or improper exercise

oSTRESS oEXOGENOUS AGENTS

bullEnvironmental pollution - People living in any metropolitan area are exposed to pollution and if regularly commute in traffic jams or live near any industrial areas body is exposed to more harmful air particles and increased production of free radicalsbullPesticides - pesticides causes more oxidative stress in the bodybullSun exposurebullX-rays

DRUG ABUSE

CLASSIFICATION OF CAUSES OF AGEING

EFFECT OF STRESS ON BODY SYSTEMS

Some Theories of Ageing are given below1048781 Waste Accumulation Theory1048781 Limited Number of Cell Divisions Theory1048781 Hay flick Limit Theory1048781 Death Hormone Theory (DECO)1048781 Thymic -Stimulating Theory1048781 Mitochondrial Theory1048781 Errors and Repairs Theory1048781 Redundant DNA Theory1048781 Cross-Linkage Theory1048781 Autoimmune Theory1048781 Caloric Restriction Theory1048781 Gene Mutation Theory1048781 The Rate of Living Theory1048781 Order to Disorder Theory1048781 The Telomerase Theory of Ageing1048781 Neuro Endocrine theory or Weak Link Theory1048781 Free Radical Theory of Ageing

25

FREE RADICAL THEORYFree radical is a term used to describe any molecule that differs from conventional molecules in that it possesses a free electron a property that makes it react with other molecules in highly volatile and destructive ways The changes induced by free radicals are believed to be a major cause of Ageing disease development orand death

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

oIMPROPER DIET Acidic foodsFood additives Food additives are added to improve the shelf life and stability of processed and smoked foods but these are not body friendlyFood preparation oily food preparation

oIMPROPER LIFESTYLEoSmokingoAlcoholoIrregular sleeping patternoPhysical inactivity or improper exercise

oSTRESS oEXOGENOUS AGENTS

bullEnvironmental pollution - People living in any metropolitan area are exposed to pollution and if regularly commute in traffic jams or live near any industrial areas body is exposed to more harmful air particles and increased production of free radicalsbullPesticides - pesticides causes more oxidative stress in the bodybullSun exposurebullX-rays

DRUG ABUSE

CLASSIFICATION OF CAUSES OF AGEING

EFFECT OF STRESS ON BODY SYSTEMS

Some Theories of Ageing are given below1048781 Waste Accumulation Theory1048781 Limited Number of Cell Divisions Theory1048781 Hay flick Limit Theory1048781 Death Hormone Theory (DECO)1048781 Thymic -Stimulating Theory1048781 Mitochondrial Theory1048781 Errors and Repairs Theory1048781 Redundant DNA Theory1048781 Cross-Linkage Theory1048781 Autoimmune Theory1048781 Caloric Restriction Theory1048781 Gene Mutation Theory1048781 The Rate of Living Theory1048781 Order to Disorder Theory1048781 The Telomerase Theory of Ageing1048781 Neuro Endocrine theory or Weak Link Theory1048781 Free Radical Theory of Ageing

25

FREE RADICAL THEORYFree radical is a term used to describe any molecule that differs from conventional molecules in that it possesses a free electron a property that makes it react with other molecules in highly volatile and destructive ways The changes induced by free radicals are believed to be a major cause of Ageing disease development orand death

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

EFFECT OF STRESS ON BODY SYSTEMS

Some Theories of Ageing are given below1048781 Waste Accumulation Theory1048781 Limited Number of Cell Divisions Theory1048781 Hay flick Limit Theory1048781 Death Hormone Theory (DECO)1048781 Thymic -Stimulating Theory1048781 Mitochondrial Theory1048781 Errors and Repairs Theory1048781 Redundant DNA Theory1048781 Cross-Linkage Theory1048781 Autoimmune Theory1048781 Caloric Restriction Theory1048781 Gene Mutation Theory1048781 The Rate of Living Theory1048781 Order to Disorder Theory1048781 The Telomerase Theory of Ageing1048781 Neuro Endocrine theory or Weak Link Theory1048781 Free Radical Theory of Ageing

25

FREE RADICAL THEORYFree radical is a term used to describe any molecule that differs from conventional molecules in that it possesses a free electron a property that makes it react with other molecules in highly volatile and destructive ways The changes induced by free radicals are believed to be a major cause of Ageing disease development orand death

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

Some Theories of Ageing are given below1048781 Waste Accumulation Theory1048781 Limited Number of Cell Divisions Theory1048781 Hay flick Limit Theory1048781 Death Hormone Theory (DECO)1048781 Thymic -Stimulating Theory1048781 Mitochondrial Theory1048781 Errors and Repairs Theory1048781 Redundant DNA Theory1048781 Cross-Linkage Theory1048781 Autoimmune Theory1048781 Caloric Restriction Theory1048781 Gene Mutation Theory1048781 The Rate of Living Theory1048781 Order to Disorder Theory1048781 The Telomerase Theory of Ageing1048781 Neuro Endocrine theory or Weak Link Theory1048781 Free Radical Theory of Ageing

25

FREE RADICAL THEORYFree radical is a term used to describe any molecule that differs from conventional molecules in that it possesses a free electron a property that makes it react with other molecules in highly volatile and destructive ways The changes induced by free radicals are believed to be a major cause of Ageing disease development orand death

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

FREE RADICAL THEORYFree radical is a term used to describe any molecule that differs from conventional molecules in that it possesses a free electron a property that makes it react with other molecules in highly volatile and destructive ways The changes induced by free radicals are believed to be a major cause of Ageing disease development orand death

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

EFFECT OF FREE RADICAL DAMAGE

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

Free Radical Ama

Stress Disturbed Manasika Bhava

Exogenous Causes- Pollutants dangerousChemicals certain products

Paryavaran pradushan Mithya Ahara Vihara

Endogenous Causes- Due to deficiency of certainenzymes

Mandagni

AtomMolecule containing one or more unpairedelectron

Apachyamana

Inassimilable to body components amp exist in free state

Visha Rupam

Cause damage to cell membrane amp destroy cellsleads to putrefaction amp foul smell generation

Durgandhatvam Suktatvam

Quickly interact with healthy molecules of the bodythus setting chain reaction

Reaction of aam vish with normal cells Aashukari

Impaired action of Free Radicals Scavengers Dhatvagni Daurbalya

Increased production at the site Ama Sanchaya

Circulation in the body Prasara

Starts reacting to the weak cell membrane Sthana sanshraya at thesite of Khavaigunya

Production of Sign amp Symptoms of Ageing Production of Sign amp Symptoms of Jara

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

CHANGES OCCURING DURING AGEING

29

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

30

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

31

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

32

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

33

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

Selected Age-related Changes and their consequences

34

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

ANTI AGEING THERAPIES1 Deprenyl2 Human Growth Hormone3 DHEA4 Melatonin5 Acetyl-L-Car nitine6 Coenzyme Q107 Alpha Lipoic Acid8 Cysteine and Procysteine9 NADH10 Lycopene11 Vitamin E12 Vitamin B5 (Pantothenic Acid) 13 Vitamin B6 (Pyridoxine) 14 Synthetic Antioxidants15 Levodopa (L- Dopa) 16 Calorie Restriction (can be correlate with ldquoastha aahar

vidhi visheshytanrdquo)

35

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

CONCEPT OF RASAYANA

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

ldquoRasasya Ayanam Rasayanamrdquo jlL vua izkika jlkue~ frac14jk-fu-frac12

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

RASAYANA

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

jlkurU=a uke o LFkkiuekq esZkkcydja jksxkigjke leFkZapA frac14lq-lw-172frac12 Rasayana Tantra is one which deals with delaying of ageing process increasing of intellect and strength prolongation of life and curing of disorders

DEFINATION

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

CLASSIFICATIONS No Classification Types Of Rasayana1 Main division Dravyabhuta

Rasayana Adravyabhutas Rasayana

2 As per method of use (Charak)

Kuti Praveshika Vatatapika Droni- praveshik

3 As per Scope of use Kamya Rasayana Prana Kamya Medha Kamya Shri Kamya

NaimittikaRasayana Ajasrika Rasayana

4 As per content of Rasayana

Ahara Rasayana (Dietary Rasayana)

Aushadha Rasayana(Medicinal Rasayana)

Achara Rasayana (Conduct of Rasayana)

5 Specific Rasayana drugs amp measures

Medhya Rasayana Achara Rasayana Buddhi Medha

Vardhaka Ayu Vardhaka

6 According toPrabhava

Samshodhana Rasayana

Samshamana Rasayana

7 According toSatmya

Ritu Satmya Aadana Kala Visarga Kala

Desh Satmya Sadharana Desha Jangala Desha Anupa Desha

8 According to Sapta Dhatus

(1)Rasa (2) Rakta (3) Mamsa (4) Meda (5) Asthi (6) Majja (7) Shukra

9 According to Modern Medical Science

To Promote Immunity

To improve metabolism

To improve endocrine and exocrine secretions

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

Four Modes of Action of Rasayana

Rasayana basically promotes the nutrition through four modes They are1 By directly enriching the nutritional intake of the body through

increasing the consumption of Amalki Satavarai Milk Ghee etc

2 ON AGNI By improving Agni ie digestion and metabolism through Bhallataka Pippali etc thereby promoting nutrition

3 SROTOVISHODHANA By promoting the capability of Srotas or microcirculatory channels in the body through herbs like Haritaki Guggulu Tulsi and so on

4 By its VISHAGHNA property

PROBABLE MODE OF ACTION OF RASAYANA

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

Procedure amp effect of Rasayana intake SodhankarmaSrotonirmalta Peyadikarma Dhatu suddhi Dhatwagni deepti RASAYAN PRAYOGA

Improved quality of dhatus

OJOVRIDDHI

Longevity and health Immunity Mental competence

REJUVENATION41

Kayagni deepti

ldquoYajj jara vyadhi vidhvasi bheshajam tad rasayanamrdquo

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

The word Rasayana =Rasa +AyanaRasa means the Rasa dhatu and the remaining dhatu Rakta Mamsa Meda Asthi Majja and Sukra

Ayana Ayana means the road a path a way and a movement ldquoRasasya Ayanam Rasayanam ldquo ldquoLabho payo sashtanam rasadinam rasayanamrdquo(chchi1)

The Therapy which gives the benefit of good Rasa is Rasayana Hence it is the therapy by which one gets the Rasa Raktadi Dhatus of optimum quality

In short Rasayana -1048781 Gives Long life1048781 Delays Ageing and death1048781 Increase intelligence memory and luster1048781 Excellence in the body tissues1048781 Increases the immunity1048781 Removes diseases1048781 Gaining ldquoMokshardquo (Final Entity) and ldquoDivya Lakshanardquo

EFFECT OF RASAYANA

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

RASAYANA YOGA GHNA VATIThe Rasayana yoga for research work comprises of six medicines viz

References for above 1 to 5 medicine are taken from ldquoMEDICINAL PLANTS IN GERIATRIC HEALTH CARErdquo an evidence based approach of Central Council for Research in Ayurveda and Siddha (CCRAS)

44

1) Ashwagandha

2) Aamalki

3) Bala

4) Guduchi

5) Yashtimadhu

6) Vanshalochan

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

PHARMACOLOGICAL ACTIVITIES OF DRUGS

CNSdepressant Hypolipidemic Antiatherosclerotic Antimicrobial Antioxidant Immunomodulator Hypoglycemic Anti-inflammatory Antitumor

2)Ashwagandha -(Withania somnifera)

Hypotensive Immunomodulator Adaptogenic Antistress CNSdepressant Antioxidant Analgesic Antiarthritic Cardioprotective Antiageing Psychotropic

RASA - MADHURA KASAYA TIKTA KATUGUNA - GURU RUKSHA SHEETAVEERYA - SHEETAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA -TRIDOSA SHAMAKA PITTA

RASA - TIKTAKATUMADHURGUNA - LAGHUSNIGDHAVEERYA - USHNAVIPAKA - MADHURPRABHAVA - RASAYANADOSA-PRABHAVA - KAPHAVATA SHAMAK

45

1) Aamalki-(Embelica officinale)

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

Hypoglycemia Antihyperglycemic CNSdepressant antistress Hepatoprotective antiarthritic Antiallergic Immunostimulant Antidiabetic Adaptogenic Antioxidant Diuretic4)Bala-(Sida cordifolia)

Antioxidant Thyroregulatory Hepatoprotective Immunomodulatory Antihypertensive Hypoglycemic Adaptogenic

RASA - KASAYA TIKTAGUNA - GURU SNEEGDHAVEERYA - USHNAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- TRIDOSA SHAMAKA

RASA - MADHURAGUNA - LAGHU SNEEGDHAPICHILAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

46

3)Guduchi-(Tinosporia cordifolia)

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

5)Yashtimadhu-(Glycirrihza glabra)

Hypolipidaemic Antiatherosclerotic Hypotensive Hepato- protective Antiexudative Antioxidant Anti-inflammatory

6)Vanshalochana-(Bambusa arundinacea)

Antidiarrhoel Antiparalytic Carminative Expectorant It is cooling nutritive stimulant digestive aphrodisiac and febrifuge agent It is known to help in chronic and general debility cough and indigestion

RASA - MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURAPRABHAVA - RASAYANADOSA-PRABHAVA- VATA PITTA SHAMAKA

RASA - KASAYA MADHURAGUNA - GURU SNEEGDHAVEERYA - SHITAVIPAKA - MADHURADOSA-PRABHAVA- VATA PITTA SHAMAKA

47

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

DRUG PROPERTIESDRUGS PRABHAVA KARMA DOSHAGHNATA

Amalki RasayanaVrishya

RasayanaHridyaVrishya NadibalyaDeepaniya Medhya Anulomana Shramahara Balya Vayasthāpana Jivaniya Sarvadoshahara Nadi-Indriya Balaprada Rochana

Tridhosh shamak Esp Pitta-shamaka

Ashwagandha

RasayanaVrishya

Balya Brihana Rasayana Vajikarana Nidrajanan Vata Kapha Shamak

Bala VrishyaRasayana

Balya Vatahara Hridya Shukral Prajasthapan Vata- pitta shamak

Guduchi VrishyaRasayana

Rasayana Deepana Pachana Balya Medhya Raktashodhana Vayasthapana VrishyaPathya Shukra dourbalya Dhatukrita Shramahara Mutrajanana

Tridhosh shamak

Yashti madhu RasayanaVrishya

Rasayana Balya Nadibalya Medhya KeshyaSwaryaVedanasthapana

Vata -pitta Shamak

Vanshalochana

Balya Brihana

Vrishya Shamak Trishnanigrahana Grahi Hridya Shwasahara Mootrala Jwarghna Balya Brimhan

Vata- pitta Shamak

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA

S No RASA PROPERTIES PERCENTAGE

1 RASA MadhuraAmlaKatuTiktaKashaya

3846 0769 1538 2307 1538

2 GUNA GuruLaghuSheetaSnigdhaRukshaPicchilaTikshna

2000200006672667133306670667

3 VEERYA SheetaUshna

66673333

4 VIPAKA Madhura 10000

5 DOSHAGHNATA Tridosha ShamakaVata-Pitta ShamakaKapha-Vata Shamaka

250050002500

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

Action of Rasayana Yoga Ghana Vati

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

Vaya Sthapana Brihana Balya Rasayana Deepan Pachana Vata Shamaka

properties Vrishya Hridya

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

RASAYANA YOGA GHANA VATI VEHICAL

RASAYANA YOGA GHANA VATI MILK

Milk pacifies vitiated Vata and Pitta Dosas As the milk is having identical properties of Ojas it promotes Ojas The Cowrsquos milk acts as Rasayana Tarpaka Jivaniya Hridya Ahladakara and Buddhi prabodhaka

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

Importance of Anupan ( cowrsquos milk) In Ayurveda Cowrsquos milk is much appreciated for the therapeutic purposes and

also in preparation of the formulation as a media The Go- dugdha possesses properties like Madhuram Jivaniyam Prinanam Rasayanam Brihanam Vrishyam Medhya Balya Dipaniya Shonita pittaharam Shreshtham etc

Chemical Composition of milk 873 water 39 milk fat 88 solids- not fat Protein ndash 325 Lactose ndash 46 Minerals ndash 065 - Ca P Mg K Na Zn CO Fe Cu sulphates bicarbonates

Acid ndash 018 - citrates formats acetate lactate oxalate Enzymes ndash peroxidase catalase phosphatase lipase Gases ndash oxygen nitrogen Vitamins ndash A C D thiamine riboflavin others

52

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

(1)According to Rasa - Main content is Madhura rasa (3846) which helps to increase dhatus especially saumya dhatus which form the major portion of the body After Madhura Tikta rasa is the predominant one (2307)in present compound formulationTikta rasa is having properties of Agnideepana Pachana Srotoshodhana amp Rasayana prabhava in dhatu nourishment process Katu rasa (1538) by svabhava is agnideepaka Pachaka Srotoshodhaka amp Kaphanashaka

(2)According to Guna-it has got the predominance of Snigdha(2667)So it is Bala Varna vardhaka and Vajikar After Snigdha guna Guru guna(2000) is predominant It causes brimhana and it is Balya amp provide poshana These guna are mainly used in pacifying the Vata prakopa amp Kapahavardhan

(3)According to Vipaka - It is mainly Madhura (100) causes the expulsion of mala amp mutra from the body amp releases the toxins amp it is Shukral in nature

(5)According to Veerya - Most of the contents have Sheeta veerya (6667) which acts as prahladana Kledana amp Stambhana Balya Prasadana amp Jeevaniya It is Kapha amp Vata Shamaka

(6) According to Doshakarma - It works as Vata-Pitta Shamaka (5000) also tridosha shamaka (2500)Thus it helps maintain doshic imbalance in the body amp make person healthy

MODE OF ACTION OF RASAYANA YOGA GHANA VATI

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

CLINICAL STUDY

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

AIM AND OBJECTIVES1)To study the conceptual basis of ageing (jara) according to Ayurveda and different theories of ageing according to modern medical science

2) To evaluate the efficacy of Rasayana yoga clinically in the management of ageing

3)To evaluate the role of main causes of ageingndash Physical amp Mental Stress Improper Life Style amp Dietary Habits and medication of the proper Rasayana Drugs at proper time in a proper way

4) To access the effect of Rasayana Dravya on different age group clinically

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

Clinical Study

MATERIAL

THE PATIENTS WERE SELECTED FROM OPD and IPD of Kayachikitsa Department of Govt Ayurvedic college amp hospital Raipur(CG)

MethodsSim

ple RandomSampling methods

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

SELECTION EXCLUSION CRITERIA bullThe patients having sign and symptoms mentioned as per Ayurvedic and Modern literatures Multiple and simple random sampling method has been adopted for the selection of 60 uncomplicated casesbullAge incidence-The Patients between 40 to 70 years of agebullSex- Patients of either sex were includedbullDuration of illness ndash Not more than 3 years bullHabitat-Both urban and rural areas were selectedbullReligion Occupation Caste Socio-economic status-No barbullPatient willing to follow up regularly

(1)Patients of age group below 40 and above 70 years(2)Patients with severe cardiac disease Pulmonary Tuberculosis Severe hypertension and DM HIV Hepatitis B etc(3)Patients with malignant carcinoma(4)Pregnant amp lactating mothers

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

CRITERIA OF DIAGNOSISHaving the Signs and Symptoms of Jara as described in Ayurvedic texts

The routine hematological and urine examination was carried out in selected patients to exclude any other pathology as well as to assess the present condition of the patient

Detailed history was taken and physical examination was done on the basis of a special Proforma incorporating all the signs and Symptoms of the disease

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

1 Indigestion2 Altered Bowel pattern3 Altered Sleep pattern4 Palpitation5 Anger6 Irritability7 Early Menopause8 Altered Urinary Symptoms9 Recurrent Infections10 Fatigue11 Weakness12 Loss of Hearing13 Weakening of Teeth

ASSOCIATED SYMPTOMS

59

HEALTH PARAMETERS

(DIAGNOSTIC CRITERIA) (a) Walking Time (b) Handgrip Power (c) Foot Pressure (d) Short Term Memory (e) Long Term Memory (f) Breath Holding Time (g) Pulse BP Temperature amp Weight All these vital data are recorded before amp after treatment As per above sign amp symptoms patient examination

proforma will be prepared amp patients will be selected for trial

60

CLINICAL STUDY

It will be undertaken on following parameters-

A) Number of patients- 60(sixty) patients will be selected for randomized clinical trial

B) Place of selection of patients- Patients will be selected from the OPD amp IPD of Govt Auto Ayurvedic College Hospital Raipur Chhattisgarh

C)Criteria for selection of the patient- i) Patient between 40 -70 yrs age group will taken for present study ii) Patients will be selected on the basis of sign amp symptoms available in Ayurveda

texts viz Charak Samhita Sushrut Samhita amp Ashtang Samgraha

61

GROUPINGS ldquoIn all the three groups Haritaki Churna ndash 5 gms is used during samanya

samsodhan with luke warm water for Koshtha amp Srotas Shuddhi before starting the medicationrdquo

1) Group A 20(twenty) patients will be taken between 40 -50 yrs age group and will be given Rasayan yoga orally

Drug dose 1 gm BD Anupana Milk Duration 02(Two) Months 2) Group B 20(twenty) patients will be taken between 51 -60yrs age group and will

be given Rasayan yoga orally Drug dose 1 gm BD Anupana Milk Duration 02(Two) Months

3) Group C 20 (twenty) patients will be taken between 61-70yrs age group and will be given Rasayan yoga orally

Drug dose 1 gm BD Anupana Milk Duration 02(Two) Months

62

Investigations

The Routine haematological examination of blood like Hb TLC DLCMCH MCHC MPV MCVESR were done

Routine amp microscopic urine analysis were carried out to detect the involvement of kidneys and to exclude the urinary tract infectious conditions like veneral disease syphilis etc

Serum of the patients were tested for HDL LDL Triglyceride Creatinine Albumin Globulin AG Ratio blood urea Blood Sugar (Fasting ampPP) Total protein Total cholesterol

20 1917

01

3

0

5

10

15

20

No o

f pat

ient

s

Completed LAMA

Status

Status wise distribution

Group A Group B Group C

12

8

9

11

13

7

0

5

10

15

20

No o

f pat

ient

s40-50 51-60 61-70

Age Group

Age amp sex wise distribution

Group C F

Group C M

Group B F

Group B M

Group A F

Group A M

OBSERVATIONS

8

11

7

12

9

13

02468

101214

No

o

f p

atie

nts

Female Male

Sex group

Sex wise distribution

Group A Group B Group C

1715

14

23 3

1 1 20 1 1

0 0 00

5

10

15

20

No

o

f p

ate

ints

Hindu Muslim Christian Sikh Other

Religion group

Religion wise distribution

Group A Group B Group C

2 1 1

1815

11

04

7

0 0 1

0

5

10

15

20

No o

f pat

ient

s

Umarried Married Widow Divorce

Marital status

Marital status wise distribution

Group A Group B Group C

1

34

34

3

7

5

7

56

4 4

2 2

01234567

No o

f pat

ient

s

Illite

rate

Prim

ary

High

Sec

Grad

uate PG

Education

Education wise distribution

Group A

Group B

Group C

75 6

1315

14

0

5

10

15No

of p

atie

nts

Rural UrbanResidence group

Residence wise distribution

Group A Group B Group C

5

6

54

3

0

6 6

0

4 43

0 0

7

11

5

01234567

No o

f pat

ient

s

Hous

ehold

Labo

urer

Serv

ice

Buise

ness

Retir

ed

Unem

ploye

d

occupation

Occupation wise distribution

Group A

Group B

Group C

43

43

23

89

7

43

21

34

0

2

4

6

8

10

No

o

f p

ati

en

ts

Poor Lowermiddle

Middle Uppermiddle

Rich

Socio-economic status

Socio-economic wise distribution

Group A Group B Group C

1412

15

68

5

0

5

10

15No

of p

atie

nts

Vegetarian MixedType of diet

Type of diet wise distribution

Group A Group B Group C

16

13

9

12 119

2020 20

1918

1617

1412

65 6

02468

101214161820

No

of P

atie

nts

Veg

etab

les

Frui

ts

Cer

eals

Pul

ses

Junk

food

Dry

food

Type of food

Food taking wise distribution

Group A

Group B

Group C

647

12 10 13

8

10

7

17 16

15

6

109

000 0

0

0

79

10

02468

1012141618

No

o

f P

ati

en

ts

Type of oil amp Ghee

consumption of oil amp Ghee wise distribution

Group A

Group B

Group C

1920

17

8 83

101210

58 8

0 0 00

5

10

15

20No

of p

atie

nts

Tea Coffe Colddrink

Milk Other

Supplementary diet group

Supplementary diet wise distribution

Group A Group B Group C

2

4

6

8 8

6 64

2

6 6

3

01

0012345678

No o

f pat

ient

s

Tobb

aco

chew

Smok

ing

Alco

hol

Panm

asal

a

Seda

tives

Addiction

Addiction wise distribution

Group A

Group B

Group C

181817 1615

16

201818

1412 12

35 6

2 3 3

0

5

10

15

20

No

o

f p

ati

en

ts

Madhra Amla Lavana Katu Tikta Kashaya

Type of Ahara Rasa

Dominant Rasa of Ahara wise distribution

Group A Group B Group C

12 1210

8 8

11

1312

1012

14

98

1213

121313

0

2

4

6

8

10

12

14N

o

of

pat

ien

ts

Guru Laghu Sheeta Ushna Snigdha Ruksha

Type of Ahara Guna

Dominant Guna of Ahara wise distribution

Group A Group B Group C

02468

101214161820

No

o

f p

atie

nts

Group A Group B Group C

Types of Ayogya ahara vidhi

Ayogya Ahara Vidhi wise distribution

Anushna

Asnigdha

Amatravata

Ajirne

Viryaviruddha

Anishtadesha

AnishtaupakaranaAnmanaska

AtmanamAnabhikshyaAtidrutta

Ativilambita

9

67

11

8 87

86

0

2

4

6

8

10

12No

f pa

tient

s

Samashana Vishmashana AdhyashanaDiet habit

Diet habit wise distribution

Group A Group B Group C

53 2

64

2

9

13

16

02468

10121416

No o

f pat

ient

s

Mridu Madhyam Krura

Type of Kostha

Kostha wise distribution

Group A Group B Group C

34

2

56

4

88

13

111 110 1 0

002468

101214

No

o

f p

ati

en

ts

Exercise group

Exercise wise distribution

GroupA

GroupB

GroupC

5 5

2

18 1817

1110

13

32 2

7

9

15

1010

13 13

12

9

0

2

4

6

8

10

12

14

16

18N

o o

f p

ati

en

ts

Nidra group

Nidra wise distribution

GroupA

GroupB

GroupC

64 5

1416 15

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Dincharya group

Dincharya Palana wise distribution

Group A Group B Group C

9

12

14

11

86

024

68

101214

No

o

f p

atein

ts

Samyaka AsamyakaRatricharya group

Ratricharya wise distribution

Group A Group B Group C

47

9

16

1311

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Ritucharya group

Ritucharya Palana wise distribution

Group A Group B Group C

34 4

17 16 16

0

5

10

15

20

No

o

f p

atie

nts

Samyaka Asamyaka

Sadvritta group

Sadvritta Palana wise distribution

Group A Group B Group C

9

12

15

4 4

1

7

4 4

0 0 0 0 0 0

02468

10121416

No

o

f p

ati

en

ts

Sharirika prakriti

Sharirika prakriti wise distribution

Group A

Group B

Group C

2

4

2

8 76

10 9

12

0

2

4

6

8

10

12

No

o

f p

ati

ents

Rajasika Tamsika Rajasika-Tamsika

Manasika prakriti

Manasika Prakriti wise distribution

Group A Group B Group C

34 3

8

54

9

1113

0

2

4

6

8

10

12

14

No

o

f p

ati

en

ts

Pravara Madhyama Avara

Type of Sara

Sara wise distribution

Group A Group B Group C

42 2

6 54

10

1314

024

68

101214

No

of

pat

ien

ts

Pravara Madhyama Avara

Type of satva

Satva wise distribution

Group A Group B Group C

5

3 3

76

78

1110

0

2

4

6

8

10

12

No

o

f p

ati

en

ts

Pravara Madhyama AvaraType of samhanana

Samhanana wise distribution

Group A Group B Group C

5

3 3

1113

12

4 4 5

0

2

4

6

8

10

12

14

No

o

f p

atie

nts

Pravara Madhyama AvaraType of pramana

Pramana wise distribution

Group A Group B Group C

23 3

121010

6 7 7

0

2

4

6

8

10

12

No

o

f p

atie

nts

Pravara Madhyama Avara

Type of satmya

Satmya wise distribution

Group A Group B Group C

10

41

57

4 5

9

15

02468

10121416

No

o

f p

atien

ts

Pravara Madhyama AvaraVyayamshakti

Vyayamshakti wise distribution

Group A Group B Group C

10

1314

21 1

65 4

21 1

0

2

4

6

8

10

12

14N

o o

f pat

ient

s

Mandagni Tikshnagni Vishmagni Samagni

Type of agni

Agni wise distribution

Group A Group B Group C

7

54

109

6

3

6

10

0

2

4

6

8

10

No o

f pat

ient

sPravara Madhyam Avara

Abhyavarana shakti

Abhyavarana shakti wise distribution

Group A Group B Group C

75

3

78

76

7

10

0

2

4

6

8

10

No

of p

atie

nts

Pravara Madhyam Avara

Jarana Shakti

Jarana shakti wise distribution

Group A Group B Group C

0

2

4

6

8

10

12

14

16

18

20N

o o

f p

ati

en

ts

chief complaints

Chief complaints wise distribution

Group A

Group B

Group C

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

CLINICAL STUDY

It will be undertaken on following parameters-

A) Number of patients- 60(sixty) patients will be selected for randomized clinical trial

B) Place of selection of patients- Patients will be selected from the OPD amp IPD of Govt Auto Ayurvedic College Hospital Raipur Chhattisgarh

C)Criteria for selection of the patient- i) Patient between 40 -70 yrs age group will taken for present study ii) Patients will be selected on the basis of sign amp symptoms available in Ayurveda

texts viz Charak Samhita Sushrut Samhita amp Ashtang Samgraha

61

GROUPINGS ldquoIn all the three groups Haritaki Churna ndash 5 gms is used during samanya

samsodhan with luke warm water for Koshtha amp Srotas Shuddhi before starting the medicationrdquo

1) Group A 20(twenty) patients will be taken between 40 -50 yrs age group and will be given Rasayan yoga orally

Drug dose 1 gm BD Anupana Milk Duration 02(Two) Months 2) Group B 20(twenty) patients will be taken between 51 -60yrs age group and will

be given Rasayan yoga orally Drug dose 1 gm BD Anupana Milk Duration 02(Two) Months

3) Group C 20 (twenty) patients will be taken between 61-70yrs age group and will be given Rasayan yoga orally

Drug dose 1 gm BD Anupana Milk Duration 02(Two) Months

62

Investigations

The Routine haematological examination of blood like Hb TLC DLCMCH MCHC MPV MCVESR were done

Routine amp microscopic urine analysis were carried out to detect the involvement of kidneys and to exclude the urinary tract infectious conditions like veneral disease syphilis etc

Serum of the patients were tested for HDL LDL Triglyceride Creatinine Albumin Globulin AG Ratio blood urea Blood Sugar (Fasting ampPP) Total protein Total cholesterol

20 1917

01

3

0

5

10

15

20

No o

f pat

ient

s

Completed LAMA

Status

Status wise distribution

Group A Group B Group C

12

8

9

11

13

7

0

5

10

15

20

No o

f pat

ient

s40-50 51-60 61-70

Age Group

Age amp sex wise distribution

Group C F

Group C M

Group B F

Group B M

Group A F

Group A M

OBSERVATIONS

8

11

7

12

9

13

02468

101214

No

o

f p

atie

nts

Female Male

Sex group

Sex wise distribution

Group A Group B Group C

1715

14

23 3

1 1 20 1 1

0 0 00

5

10

15

20

No

o

f p

ate

ints

Hindu Muslim Christian Sikh Other

Religion group

Religion wise distribution

Group A Group B Group C

2 1 1

1815

11

04

7

0 0 1

0

5

10

15

20

No o

f pat

ient

s

Umarried Married Widow Divorce

Marital status

Marital status wise distribution

Group A Group B Group C

1

34

34

3

7

5

7

56

4 4

2 2

01234567

No o

f pat

ient

s

Illite

rate

Prim

ary

High

Sec

Grad

uate PG

Education

Education wise distribution

Group A

Group B

Group C

75 6

1315

14

0

5

10

15No

of p

atie

nts

Rural UrbanResidence group

Residence wise distribution

Group A Group B Group C

5

6

54

3

0

6 6

0

4 43

0 0

7

11

5

01234567

No o

f pat

ient

s

Hous

ehold

Labo

urer

Serv

ice

Buise

ness

Retir

ed

Unem

ploye

d

occupation

Occupation wise distribution

Group A

Group B

Group C

43

43

23

89

7

43

21

34

0

2

4

6

8

10

No

o

f p

ati

en

ts

Poor Lowermiddle

Middle Uppermiddle

Rich

Socio-economic status

Socio-economic wise distribution

Group A Group B Group C

1412

15

68

5

0

5

10

15No

of p

atie

nts

Vegetarian MixedType of diet

Type of diet wise distribution

Group A Group B Group C

16

13

9

12 119

2020 20

1918

1617

1412

65 6

02468

101214161820

No

of P

atie

nts

Veg

etab

les

Frui

ts

Cer

eals

Pul

ses

Junk

food

Dry

food

Type of food

Food taking wise distribution

Group A

Group B

Group C

647

12 10 13

8

10

7

17 16

15

6

109

000 0

0

0

79

10

02468

1012141618

No

o

f P

ati

en

ts

Type of oil amp Ghee

consumption of oil amp Ghee wise distribution

Group A

Group B

Group C

1920

17

8 83

101210

58 8

0 0 00

5

10

15

20No

of p

atie

nts

Tea Coffe Colddrink

Milk Other

Supplementary diet group

Supplementary diet wise distribution

Group A Group B Group C

2

4

6

8 8

6 64

2

6 6

3

01

0012345678

No o

f pat

ient

s

Tobb

aco

chew

Smok

ing

Alco

hol

Panm

asal

a

Seda

tives

Addiction

Addiction wise distribution

Group A

Group B

Group C

181817 1615

16

201818

1412 12

35 6

2 3 3

0

5

10

15

20

No

o

f p

ati

en

ts

Madhra Amla Lavana Katu Tikta Kashaya

Type of Ahara Rasa

Dominant Rasa of Ahara wise distribution

Group A Group B Group C

12 1210

8 8

11

1312

1012

14

98

1213

121313

0

2

4

6

8

10

12

14N

o

of

pat

ien

ts

Guru Laghu Sheeta Ushna Snigdha Ruksha

Type of Ahara Guna

Dominant Guna of Ahara wise distribution

Group A Group B Group C

02468

101214161820

No

o

f p

atie

nts

Group A Group B Group C

Types of Ayogya ahara vidhi

Ayogya Ahara Vidhi wise distribution

Anushna

Asnigdha

Amatravata

Ajirne

Viryaviruddha

Anishtadesha

AnishtaupakaranaAnmanaska

AtmanamAnabhikshyaAtidrutta

Ativilambita

9

67

11

8 87

86

0

2

4

6

8

10

12No

f pa

tient

s

Samashana Vishmashana AdhyashanaDiet habit

Diet habit wise distribution

Group A Group B Group C

53 2

64

2

9

13

16

02468

10121416

No o

f pat

ient

s

Mridu Madhyam Krura

Type of Kostha

Kostha wise distribution

Group A Group B Group C

34

2

56

4

88

13

111 110 1 0

002468

101214

No

o

f p

ati

en

ts

Exercise group

Exercise wise distribution

GroupA

GroupB

GroupC

5 5

2

18 1817

1110

13

32 2

7

9

15

1010

13 13

12

9

0

2

4

6

8

10

12

14

16

18N

o o

f p

ati

en

ts

Nidra group

Nidra wise distribution

GroupA

GroupB

GroupC

64 5

1416 15

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Dincharya group

Dincharya Palana wise distribution

Group A Group B Group C

9

12

14

11

86

024

68

101214

No

o

f p

atein

ts

Samyaka AsamyakaRatricharya group

Ratricharya wise distribution

Group A Group B Group C

47

9

16

1311

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Ritucharya group

Ritucharya Palana wise distribution

Group A Group B Group C

34 4

17 16 16

0

5

10

15

20

No

o

f p

atie

nts

Samyaka Asamyaka

Sadvritta group

Sadvritta Palana wise distribution

Group A Group B Group C

9

12

15

4 4

1

7

4 4

0 0 0 0 0 0

02468

10121416

No

o

f p

ati

en

ts

Sharirika prakriti

Sharirika prakriti wise distribution

Group A

Group B

Group C

2

4

2

8 76

10 9

12

0

2

4

6

8

10

12

No

o

f p

ati

ents

Rajasika Tamsika Rajasika-Tamsika

Manasika prakriti

Manasika Prakriti wise distribution

Group A Group B Group C

34 3

8

54

9

1113

0

2

4

6

8

10

12

14

No

o

f p

ati

en

ts

Pravara Madhyama Avara

Type of Sara

Sara wise distribution

Group A Group B Group C

42 2

6 54

10

1314

024

68

101214

No

of

pat

ien

ts

Pravara Madhyama Avara

Type of satva

Satva wise distribution

Group A Group B Group C

5

3 3

76

78

1110

0

2

4

6

8

10

12

No

o

f p

ati

en

ts

Pravara Madhyama AvaraType of samhanana

Samhanana wise distribution

Group A Group B Group C

5

3 3

1113

12

4 4 5

0

2

4

6

8

10

12

14

No

o

f p

atie

nts

Pravara Madhyama AvaraType of pramana

Pramana wise distribution

Group A Group B Group C

23 3

121010

6 7 7

0

2

4

6

8

10

12

No

o

f p

atie

nts

Pravara Madhyama Avara

Type of satmya

Satmya wise distribution

Group A Group B Group C

10

41

57

4 5

9

15

02468

10121416

No

o

f p

atien

ts

Pravara Madhyama AvaraVyayamshakti

Vyayamshakti wise distribution

Group A Group B Group C

10

1314

21 1

65 4

21 1

0

2

4

6

8

10

12

14N

o o

f pat

ient

s

Mandagni Tikshnagni Vishmagni Samagni

Type of agni

Agni wise distribution

Group A Group B Group C

7

54

109

6

3

6

10

0

2

4

6

8

10

No o

f pat

ient

sPravara Madhyam Avara

Abhyavarana shakti

Abhyavarana shakti wise distribution

Group A Group B Group C

75

3

78

76

7

10

0

2

4

6

8

10

No

of p

atie

nts

Pravara Madhyam Avara

Jarana Shakti

Jarana shakti wise distribution

Group A Group B Group C

0

2

4

6

8

10

12

14

16

18

20N

o o

f p

ati

en

ts

chief complaints

Chief complaints wise distribution

Group A

Group B

Group C

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

GROUPINGS ldquoIn all the three groups Haritaki Churna ndash 5 gms is used during samanya

samsodhan with luke warm water for Koshtha amp Srotas Shuddhi before starting the medicationrdquo

1) Group A 20(twenty) patients will be taken between 40 -50 yrs age group and will be given Rasayan yoga orally

Drug dose 1 gm BD Anupana Milk Duration 02(Two) Months 2) Group B 20(twenty) patients will be taken between 51 -60yrs age group and will

be given Rasayan yoga orally Drug dose 1 gm BD Anupana Milk Duration 02(Two) Months

3) Group C 20 (twenty) patients will be taken between 61-70yrs age group and will be given Rasayan yoga orally

Drug dose 1 gm BD Anupana Milk Duration 02(Two) Months

62

Investigations

The Routine haematological examination of blood like Hb TLC DLCMCH MCHC MPV MCVESR were done

Routine amp microscopic urine analysis were carried out to detect the involvement of kidneys and to exclude the urinary tract infectious conditions like veneral disease syphilis etc

Serum of the patients were tested for HDL LDL Triglyceride Creatinine Albumin Globulin AG Ratio blood urea Blood Sugar (Fasting ampPP) Total protein Total cholesterol

20 1917

01

3

0

5

10

15

20

No o

f pat

ient

s

Completed LAMA

Status

Status wise distribution

Group A Group B Group C

12

8

9

11

13

7

0

5

10

15

20

No o

f pat

ient

s40-50 51-60 61-70

Age Group

Age amp sex wise distribution

Group C F

Group C M

Group B F

Group B M

Group A F

Group A M

OBSERVATIONS

8

11

7

12

9

13

02468

101214

No

o

f p

atie

nts

Female Male

Sex group

Sex wise distribution

Group A Group B Group C

1715

14

23 3

1 1 20 1 1

0 0 00

5

10

15

20

No

o

f p

ate

ints

Hindu Muslim Christian Sikh Other

Religion group

Religion wise distribution

Group A Group B Group C

2 1 1

1815

11

04

7

0 0 1

0

5

10

15

20

No o

f pat

ient

s

Umarried Married Widow Divorce

Marital status

Marital status wise distribution

Group A Group B Group C

1

34

34

3

7

5

7

56

4 4

2 2

01234567

No o

f pat

ient

s

Illite

rate

Prim

ary

High

Sec

Grad

uate PG

Education

Education wise distribution

Group A

Group B

Group C

75 6

1315

14

0

5

10

15No

of p

atie

nts

Rural UrbanResidence group

Residence wise distribution

Group A Group B Group C

5

6

54

3

0

6 6

0

4 43

0 0

7

11

5

01234567

No o

f pat

ient

s

Hous

ehold

Labo

urer

Serv

ice

Buise

ness

Retir

ed

Unem

ploye

d

occupation

Occupation wise distribution

Group A

Group B

Group C

43

43

23

89

7

43

21

34

0

2

4

6

8

10

No

o

f p

ati

en

ts

Poor Lowermiddle

Middle Uppermiddle

Rich

Socio-economic status

Socio-economic wise distribution

Group A Group B Group C

1412

15

68

5

0

5

10

15No

of p

atie

nts

Vegetarian MixedType of diet

Type of diet wise distribution

Group A Group B Group C

16

13

9

12 119

2020 20

1918

1617

1412

65 6

02468

101214161820

No

of P

atie

nts

Veg

etab

les

Frui

ts

Cer

eals

Pul

ses

Junk

food

Dry

food

Type of food

Food taking wise distribution

Group A

Group B

Group C

647

12 10 13

8

10

7

17 16

15

6

109

000 0

0

0

79

10

02468

1012141618

No

o

f P

ati

en

ts

Type of oil amp Ghee

consumption of oil amp Ghee wise distribution

Group A

Group B

Group C

1920

17

8 83

101210

58 8

0 0 00

5

10

15

20No

of p

atie

nts

Tea Coffe Colddrink

Milk Other

Supplementary diet group

Supplementary diet wise distribution

Group A Group B Group C

2

4

6

8 8

6 64

2

6 6

3

01

0012345678

No o

f pat

ient

s

Tobb

aco

chew

Smok

ing

Alco

hol

Panm

asal

a

Seda

tives

Addiction

Addiction wise distribution

Group A

Group B

Group C

181817 1615

16

201818

1412 12

35 6

2 3 3

0

5

10

15

20

No

o

f p

ati

en

ts

Madhra Amla Lavana Katu Tikta Kashaya

Type of Ahara Rasa

Dominant Rasa of Ahara wise distribution

Group A Group B Group C

12 1210

8 8

11

1312

1012

14

98

1213

121313

0

2

4

6

8

10

12

14N

o

of

pat

ien

ts

Guru Laghu Sheeta Ushna Snigdha Ruksha

Type of Ahara Guna

Dominant Guna of Ahara wise distribution

Group A Group B Group C

02468

101214161820

No

o

f p

atie

nts

Group A Group B Group C

Types of Ayogya ahara vidhi

Ayogya Ahara Vidhi wise distribution

Anushna

Asnigdha

Amatravata

Ajirne

Viryaviruddha

Anishtadesha

AnishtaupakaranaAnmanaska

AtmanamAnabhikshyaAtidrutta

Ativilambita

9

67

11

8 87

86

0

2

4

6

8

10

12No

f pa

tient

s

Samashana Vishmashana AdhyashanaDiet habit

Diet habit wise distribution

Group A Group B Group C

53 2

64

2

9

13

16

02468

10121416

No o

f pat

ient

s

Mridu Madhyam Krura

Type of Kostha

Kostha wise distribution

Group A Group B Group C

34

2

56

4

88

13

111 110 1 0

002468

101214

No

o

f p

ati

en

ts

Exercise group

Exercise wise distribution

GroupA

GroupB

GroupC

5 5

2

18 1817

1110

13

32 2

7

9

15

1010

13 13

12

9

0

2

4

6

8

10

12

14

16

18N

o o

f p

ati

en

ts

Nidra group

Nidra wise distribution

GroupA

GroupB

GroupC

64 5

1416 15

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Dincharya group

Dincharya Palana wise distribution

Group A Group B Group C

9

12

14

11

86

024

68

101214

No

o

f p

atein

ts

Samyaka AsamyakaRatricharya group

Ratricharya wise distribution

Group A Group B Group C

47

9

16

1311

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Ritucharya group

Ritucharya Palana wise distribution

Group A Group B Group C

34 4

17 16 16

0

5

10

15

20

No

o

f p

atie

nts

Samyaka Asamyaka

Sadvritta group

Sadvritta Palana wise distribution

Group A Group B Group C

9

12

15

4 4

1

7

4 4

0 0 0 0 0 0

02468

10121416

No

o

f p

ati

en

ts

Sharirika prakriti

Sharirika prakriti wise distribution

Group A

Group B

Group C

2

4

2

8 76

10 9

12

0

2

4

6

8

10

12

No

o

f p

ati

ents

Rajasika Tamsika Rajasika-Tamsika

Manasika prakriti

Manasika Prakriti wise distribution

Group A Group B Group C

34 3

8

54

9

1113

0

2

4

6

8

10

12

14

No

o

f p

ati

en

ts

Pravara Madhyama Avara

Type of Sara

Sara wise distribution

Group A Group B Group C

42 2

6 54

10

1314

024

68

101214

No

of

pat

ien

ts

Pravara Madhyama Avara

Type of satva

Satva wise distribution

Group A Group B Group C

5

3 3

76

78

1110

0

2

4

6

8

10

12

No

o

f p

ati

en

ts

Pravara Madhyama AvaraType of samhanana

Samhanana wise distribution

Group A Group B Group C

5

3 3

1113

12

4 4 5

0

2

4

6

8

10

12

14

No

o

f p

atie

nts

Pravara Madhyama AvaraType of pramana

Pramana wise distribution

Group A Group B Group C

23 3

121010

6 7 7

0

2

4

6

8

10

12

No

o

f p

atie

nts

Pravara Madhyama Avara

Type of satmya

Satmya wise distribution

Group A Group B Group C

10

41

57

4 5

9

15

02468

10121416

No

o

f p

atien

ts

Pravara Madhyama AvaraVyayamshakti

Vyayamshakti wise distribution

Group A Group B Group C

10

1314

21 1

65 4

21 1

0

2

4

6

8

10

12

14N

o o

f pat

ient

s

Mandagni Tikshnagni Vishmagni Samagni

Type of agni

Agni wise distribution

Group A Group B Group C

7

54

109

6

3

6

10

0

2

4

6

8

10

No o

f pat

ient

sPravara Madhyam Avara

Abhyavarana shakti

Abhyavarana shakti wise distribution

Group A Group B Group C

75

3

78

76

7

10

0

2

4

6

8

10

No

of p

atie

nts

Pravara Madhyam Avara

Jarana Shakti

Jarana shakti wise distribution

Group A Group B Group C

0

2

4

6

8

10

12

14

16

18

20N

o o

f p

ati

en

ts

chief complaints

Chief complaints wise distribution

Group A

Group B

Group C

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

Investigations

The Routine haematological examination of blood like Hb TLC DLCMCH MCHC MPV MCVESR were done

Routine amp microscopic urine analysis were carried out to detect the involvement of kidneys and to exclude the urinary tract infectious conditions like veneral disease syphilis etc

Serum of the patients were tested for HDL LDL Triglyceride Creatinine Albumin Globulin AG Ratio blood urea Blood Sugar (Fasting ampPP) Total protein Total cholesterol

20 1917

01

3

0

5

10

15

20

No o

f pat

ient

s

Completed LAMA

Status

Status wise distribution

Group A Group B Group C

12

8

9

11

13

7

0

5

10

15

20

No o

f pat

ient

s40-50 51-60 61-70

Age Group

Age amp sex wise distribution

Group C F

Group C M

Group B F

Group B M

Group A F

Group A M

OBSERVATIONS

8

11

7

12

9

13

02468

101214

No

o

f p

atie

nts

Female Male

Sex group

Sex wise distribution

Group A Group B Group C

1715

14

23 3

1 1 20 1 1

0 0 00

5

10

15

20

No

o

f p

ate

ints

Hindu Muslim Christian Sikh Other

Religion group

Religion wise distribution

Group A Group B Group C

2 1 1

1815

11

04

7

0 0 1

0

5

10

15

20

No o

f pat

ient

s

Umarried Married Widow Divorce

Marital status

Marital status wise distribution

Group A Group B Group C

1

34

34

3

7

5

7

56

4 4

2 2

01234567

No o

f pat

ient

s

Illite

rate

Prim

ary

High

Sec

Grad

uate PG

Education

Education wise distribution

Group A

Group B

Group C

75 6

1315

14

0

5

10

15No

of p

atie

nts

Rural UrbanResidence group

Residence wise distribution

Group A Group B Group C

5

6

54

3

0

6 6

0

4 43

0 0

7

11

5

01234567

No o

f pat

ient

s

Hous

ehold

Labo

urer

Serv

ice

Buise

ness

Retir

ed

Unem

ploye

d

occupation

Occupation wise distribution

Group A

Group B

Group C

43

43

23

89

7

43

21

34

0

2

4

6

8

10

No

o

f p

ati

en

ts

Poor Lowermiddle

Middle Uppermiddle

Rich

Socio-economic status

Socio-economic wise distribution

Group A Group B Group C

1412

15

68

5

0

5

10

15No

of p

atie

nts

Vegetarian MixedType of diet

Type of diet wise distribution

Group A Group B Group C

16

13

9

12 119

2020 20

1918

1617

1412

65 6

02468

101214161820

No

of P

atie

nts

Veg

etab

les

Frui

ts

Cer

eals

Pul

ses

Junk

food

Dry

food

Type of food

Food taking wise distribution

Group A

Group B

Group C

647

12 10 13

8

10

7

17 16

15

6

109

000 0

0

0

79

10

02468

1012141618

No

o

f P

ati

en

ts

Type of oil amp Ghee

consumption of oil amp Ghee wise distribution

Group A

Group B

Group C

1920

17

8 83

101210

58 8

0 0 00

5

10

15

20No

of p

atie

nts

Tea Coffe Colddrink

Milk Other

Supplementary diet group

Supplementary diet wise distribution

Group A Group B Group C

2

4

6

8 8

6 64

2

6 6

3

01

0012345678

No o

f pat

ient

s

Tobb

aco

chew

Smok

ing

Alco

hol

Panm

asal

a

Seda

tives

Addiction

Addiction wise distribution

Group A

Group B

Group C

181817 1615

16

201818

1412 12

35 6

2 3 3

0

5

10

15

20

No

o

f p

ati

en

ts

Madhra Amla Lavana Katu Tikta Kashaya

Type of Ahara Rasa

Dominant Rasa of Ahara wise distribution

Group A Group B Group C

12 1210

8 8

11

1312

1012

14

98

1213

121313

0

2

4

6

8

10

12

14N

o

of

pat

ien

ts

Guru Laghu Sheeta Ushna Snigdha Ruksha

Type of Ahara Guna

Dominant Guna of Ahara wise distribution

Group A Group B Group C

02468

101214161820

No

o

f p

atie

nts

Group A Group B Group C

Types of Ayogya ahara vidhi

Ayogya Ahara Vidhi wise distribution

Anushna

Asnigdha

Amatravata

Ajirne

Viryaviruddha

Anishtadesha

AnishtaupakaranaAnmanaska

AtmanamAnabhikshyaAtidrutta

Ativilambita

9

67

11

8 87

86

0

2

4

6

8

10

12No

f pa

tient

s

Samashana Vishmashana AdhyashanaDiet habit

Diet habit wise distribution

Group A Group B Group C

53 2

64

2

9

13

16

02468

10121416

No o

f pat

ient

s

Mridu Madhyam Krura

Type of Kostha

Kostha wise distribution

Group A Group B Group C

34

2

56

4

88

13

111 110 1 0

002468

101214

No

o

f p

ati

en

ts

Exercise group

Exercise wise distribution

GroupA

GroupB

GroupC

5 5

2

18 1817

1110

13

32 2

7

9

15

1010

13 13

12

9

0

2

4

6

8

10

12

14

16

18N

o o

f p

ati

en

ts

Nidra group

Nidra wise distribution

GroupA

GroupB

GroupC

64 5

1416 15

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Dincharya group

Dincharya Palana wise distribution

Group A Group B Group C

9

12

14

11

86

024

68

101214

No

o

f p

atein

ts

Samyaka AsamyakaRatricharya group

Ratricharya wise distribution

Group A Group B Group C

47

9

16

1311

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Ritucharya group

Ritucharya Palana wise distribution

Group A Group B Group C

34 4

17 16 16

0

5

10

15

20

No

o

f p

atie

nts

Samyaka Asamyaka

Sadvritta group

Sadvritta Palana wise distribution

Group A Group B Group C

9

12

15

4 4

1

7

4 4

0 0 0 0 0 0

02468

10121416

No

o

f p

ati

en

ts

Sharirika prakriti

Sharirika prakriti wise distribution

Group A

Group B

Group C

2

4

2

8 76

10 9

12

0

2

4

6

8

10

12

No

o

f p

ati

ents

Rajasika Tamsika Rajasika-Tamsika

Manasika prakriti

Manasika Prakriti wise distribution

Group A Group B Group C

34 3

8

54

9

1113

0

2

4

6

8

10

12

14

No

o

f p

ati

en

ts

Pravara Madhyama Avara

Type of Sara

Sara wise distribution

Group A Group B Group C

42 2

6 54

10

1314

024

68

101214

No

of

pat

ien

ts

Pravara Madhyama Avara

Type of satva

Satva wise distribution

Group A Group B Group C

5

3 3

76

78

1110

0

2

4

6

8

10

12

No

o

f p

ati

en

ts

Pravara Madhyama AvaraType of samhanana

Samhanana wise distribution

Group A Group B Group C

5

3 3

1113

12

4 4 5

0

2

4

6

8

10

12

14

No

o

f p

atie

nts

Pravara Madhyama AvaraType of pramana

Pramana wise distribution

Group A Group B Group C

23 3

121010

6 7 7

0

2

4

6

8

10

12

No

o

f p

atie

nts

Pravara Madhyama Avara

Type of satmya

Satmya wise distribution

Group A Group B Group C

10

41

57

4 5

9

15

02468

10121416

No

o

f p

atien

ts

Pravara Madhyama AvaraVyayamshakti

Vyayamshakti wise distribution

Group A Group B Group C

10

1314

21 1

65 4

21 1

0

2

4

6

8

10

12

14N

o o

f pat

ient

s

Mandagni Tikshnagni Vishmagni Samagni

Type of agni

Agni wise distribution

Group A Group B Group C

7

54

109

6

3

6

10

0

2

4

6

8

10

No o

f pat

ient

sPravara Madhyam Avara

Abhyavarana shakti

Abhyavarana shakti wise distribution

Group A Group B Group C

75

3

78

76

7

10

0

2

4

6

8

10

No

of p

atie

nts

Pravara Madhyam Avara

Jarana Shakti

Jarana shakti wise distribution

Group A Group B Group C

0

2

4

6

8

10

12

14

16

18

20N

o o

f p

ati

en

ts

chief complaints

Chief complaints wise distribution

Group A

Group B

Group C

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

20 1917

01

3

0

5

10

15

20

No o

f pat

ient

s

Completed LAMA

Status

Status wise distribution

Group A Group B Group C

12

8

9

11

13

7

0

5

10

15

20

No o

f pat

ient

s40-50 51-60 61-70

Age Group

Age amp sex wise distribution

Group C F

Group C M

Group B F

Group B M

Group A F

Group A M

OBSERVATIONS

8

11

7

12

9

13

02468

101214

No

o

f p

atie

nts

Female Male

Sex group

Sex wise distribution

Group A Group B Group C

1715

14

23 3

1 1 20 1 1

0 0 00

5

10

15

20

No

o

f p

ate

ints

Hindu Muslim Christian Sikh Other

Religion group

Religion wise distribution

Group A Group B Group C

2 1 1

1815

11

04

7

0 0 1

0

5

10

15

20

No o

f pat

ient

s

Umarried Married Widow Divorce

Marital status

Marital status wise distribution

Group A Group B Group C

1

34

34

3

7

5

7

56

4 4

2 2

01234567

No o

f pat

ient

s

Illite

rate

Prim

ary

High

Sec

Grad

uate PG

Education

Education wise distribution

Group A

Group B

Group C

75 6

1315

14

0

5

10

15No

of p

atie

nts

Rural UrbanResidence group

Residence wise distribution

Group A Group B Group C

5

6

54

3

0

6 6

0

4 43

0 0

7

11

5

01234567

No o

f pat

ient

s

Hous

ehold

Labo

urer

Serv

ice

Buise

ness

Retir

ed

Unem

ploye

d

occupation

Occupation wise distribution

Group A

Group B

Group C

43

43

23

89

7

43

21

34

0

2

4

6

8

10

No

o

f p

ati

en

ts

Poor Lowermiddle

Middle Uppermiddle

Rich

Socio-economic status

Socio-economic wise distribution

Group A Group B Group C

1412

15

68

5

0

5

10

15No

of p

atie

nts

Vegetarian MixedType of diet

Type of diet wise distribution

Group A Group B Group C

16

13

9

12 119

2020 20

1918

1617

1412

65 6

02468

101214161820

No

of P

atie

nts

Veg

etab

les

Frui

ts

Cer

eals

Pul

ses

Junk

food

Dry

food

Type of food

Food taking wise distribution

Group A

Group B

Group C

647

12 10 13

8

10

7

17 16

15

6

109

000 0

0

0

79

10

02468

1012141618

No

o

f P

ati

en

ts

Type of oil amp Ghee

consumption of oil amp Ghee wise distribution

Group A

Group B

Group C

1920

17

8 83

101210

58 8

0 0 00

5

10

15

20No

of p

atie

nts

Tea Coffe Colddrink

Milk Other

Supplementary diet group

Supplementary diet wise distribution

Group A Group B Group C

2

4

6

8 8

6 64

2

6 6

3

01

0012345678

No o

f pat

ient

s

Tobb

aco

chew

Smok

ing

Alco

hol

Panm

asal

a

Seda

tives

Addiction

Addiction wise distribution

Group A

Group B

Group C

181817 1615

16

201818

1412 12

35 6

2 3 3

0

5

10

15

20

No

o

f p

ati

en

ts

Madhra Amla Lavana Katu Tikta Kashaya

Type of Ahara Rasa

Dominant Rasa of Ahara wise distribution

Group A Group B Group C

12 1210

8 8

11

1312

1012

14

98

1213

121313

0

2

4

6

8

10

12

14N

o

of

pat

ien

ts

Guru Laghu Sheeta Ushna Snigdha Ruksha

Type of Ahara Guna

Dominant Guna of Ahara wise distribution

Group A Group B Group C

02468

101214161820

No

o

f p

atie

nts

Group A Group B Group C

Types of Ayogya ahara vidhi

Ayogya Ahara Vidhi wise distribution

Anushna

Asnigdha

Amatravata

Ajirne

Viryaviruddha

Anishtadesha

AnishtaupakaranaAnmanaska

AtmanamAnabhikshyaAtidrutta

Ativilambita

9

67

11

8 87

86

0

2

4

6

8

10

12No

f pa

tient

s

Samashana Vishmashana AdhyashanaDiet habit

Diet habit wise distribution

Group A Group B Group C

53 2

64

2

9

13

16

02468

10121416

No o

f pat

ient

s

Mridu Madhyam Krura

Type of Kostha

Kostha wise distribution

Group A Group B Group C

34

2

56

4

88

13

111 110 1 0

002468

101214

No

o

f p

ati

en

ts

Exercise group

Exercise wise distribution

GroupA

GroupB

GroupC

5 5

2

18 1817

1110

13

32 2

7

9

15

1010

13 13

12

9

0

2

4

6

8

10

12

14

16

18N

o o

f p

ati

en

ts

Nidra group

Nidra wise distribution

GroupA

GroupB

GroupC

64 5

1416 15

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Dincharya group

Dincharya Palana wise distribution

Group A Group B Group C

9

12

14

11

86

024

68

101214

No

o

f p

atein

ts

Samyaka AsamyakaRatricharya group

Ratricharya wise distribution

Group A Group B Group C

47

9

16

1311

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Ritucharya group

Ritucharya Palana wise distribution

Group A Group B Group C

34 4

17 16 16

0

5

10

15

20

No

o

f p

atie

nts

Samyaka Asamyaka

Sadvritta group

Sadvritta Palana wise distribution

Group A Group B Group C

9

12

15

4 4

1

7

4 4

0 0 0 0 0 0

02468

10121416

No

o

f p

ati

en

ts

Sharirika prakriti

Sharirika prakriti wise distribution

Group A

Group B

Group C

2

4

2

8 76

10 9

12

0

2

4

6

8

10

12

No

o

f p

ati

ents

Rajasika Tamsika Rajasika-Tamsika

Manasika prakriti

Manasika Prakriti wise distribution

Group A Group B Group C

34 3

8

54

9

1113

0

2

4

6

8

10

12

14

No

o

f p

ati

en

ts

Pravara Madhyama Avara

Type of Sara

Sara wise distribution

Group A Group B Group C

42 2

6 54

10

1314

024

68

101214

No

of

pat

ien

ts

Pravara Madhyama Avara

Type of satva

Satva wise distribution

Group A Group B Group C

5

3 3

76

78

1110

0

2

4

6

8

10

12

No

o

f p

ati

en

ts

Pravara Madhyama AvaraType of samhanana

Samhanana wise distribution

Group A Group B Group C

5

3 3

1113

12

4 4 5

0

2

4

6

8

10

12

14

No

o

f p

atie

nts

Pravara Madhyama AvaraType of pramana

Pramana wise distribution

Group A Group B Group C

23 3

121010

6 7 7

0

2

4

6

8

10

12

No

o

f p

atie

nts

Pravara Madhyama Avara

Type of satmya

Satmya wise distribution

Group A Group B Group C

10

41

57

4 5

9

15

02468

10121416

No

o

f p

atien

ts

Pravara Madhyama AvaraVyayamshakti

Vyayamshakti wise distribution

Group A Group B Group C

10

1314

21 1

65 4

21 1

0

2

4

6

8

10

12

14N

o o

f pat

ient

s

Mandagni Tikshnagni Vishmagni Samagni

Type of agni

Agni wise distribution

Group A Group B Group C

7

54

109

6

3

6

10

0

2

4

6

8

10

No o

f pat

ient

sPravara Madhyam Avara

Abhyavarana shakti

Abhyavarana shakti wise distribution

Group A Group B Group C

75

3

78

76

7

10

0

2

4

6

8

10

No

of p

atie

nts

Pravara Madhyam Avara

Jarana Shakti

Jarana shakti wise distribution

Group A Group B Group C

0

2

4

6

8

10

12

14

16

18

20N

o o

f p

ati

en

ts

chief complaints

Chief complaints wise distribution

Group A

Group B

Group C

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

8

11

7

12

9

13

02468

101214

No

o

f p

atie

nts

Female Male

Sex group

Sex wise distribution

Group A Group B Group C

1715

14

23 3

1 1 20 1 1

0 0 00

5

10

15

20

No

o

f p

ate

ints

Hindu Muslim Christian Sikh Other

Religion group

Religion wise distribution

Group A Group B Group C

2 1 1

1815

11

04

7

0 0 1

0

5

10

15

20

No o

f pat

ient

s

Umarried Married Widow Divorce

Marital status

Marital status wise distribution

Group A Group B Group C

1

34

34

3

7

5

7

56

4 4

2 2

01234567

No o

f pat

ient

s

Illite

rate

Prim

ary

High

Sec

Grad

uate PG

Education

Education wise distribution

Group A

Group B

Group C

75 6

1315

14

0

5

10

15No

of p

atie

nts

Rural UrbanResidence group

Residence wise distribution

Group A Group B Group C

5

6

54

3

0

6 6

0

4 43

0 0

7

11

5

01234567

No o

f pat

ient

s

Hous

ehold

Labo

urer

Serv

ice

Buise

ness

Retir

ed

Unem

ploye

d

occupation

Occupation wise distribution

Group A

Group B

Group C

43

43

23

89

7

43

21

34

0

2

4

6

8

10

No

o

f p

ati

en

ts

Poor Lowermiddle

Middle Uppermiddle

Rich

Socio-economic status

Socio-economic wise distribution

Group A Group B Group C

1412

15

68

5

0

5

10

15No

of p

atie

nts

Vegetarian MixedType of diet

Type of diet wise distribution

Group A Group B Group C

16

13

9

12 119

2020 20

1918

1617

1412

65 6

02468

101214161820

No

of P

atie

nts

Veg

etab

les

Frui

ts

Cer

eals

Pul

ses

Junk

food

Dry

food

Type of food

Food taking wise distribution

Group A

Group B

Group C

647

12 10 13

8

10

7

17 16

15

6

109

000 0

0

0

79

10

02468

1012141618

No

o

f P

ati

en

ts

Type of oil amp Ghee

consumption of oil amp Ghee wise distribution

Group A

Group B

Group C

1920

17

8 83

101210

58 8

0 0 00

5

10

15

20No

of p

atie

nts

Tea Coffe Colddrink

Milk Other

Supplementary diet group

Supplementary diet wise distribution

Group A Group B Group C

2

4

6

8 8

6 64

2

6 6

3

01

0012345678

No o

f pat

ient

s

Tobb

aco

chew

Smok

ing

Alco

hol

Panm

asal

a

Seda

tives

Addiction

Addiction wise distribution

Group A

Group B

Group C

181817 1615

16

201818

1412 12

35 6

2 3 3

0

5

10

15

20

No

o

f p

ati

en

ts

Madhra Amla Lavana Katu Tikta Kashaya

Type of Ahara Rasa

Dominant Rasa of Ahara wise distribution

Group A Group B Group C

12 1210

8 8

11

1312

1012

14

98

1213

121313

0

2

4

6

8

10

12

14N

o

of

pat

ien

ts

Guru Laghu Sheeta Ushna Snigdha Ruksha

Type of Ahara Guna

Dominant Guna of Ahara wise distribution

Group A Group B Group C

02468

101214161820

No

o

f p

atie

nts

Group A Group B Group C

Types of Ayogya ahara vidhi

Ayogya Ahara Vidhi wise distribution

Anushna

Asnigdha

Amatravata

Ajirne

Viryaviruddha

Anishtadesha

AnishtaupakaranaAnmanaska

AtmanamAnabhikshyaAtidrutta

Ativilambita

9

67

11

8 87

86

0

2

4

6

8

10

12No

f pa

tient

s

Samashana Vishmashana AdhyashanaDiet habit

Diet habit wise distribution

Group A Group B Group C

53 2

64

2

9

13

16

02468

10121416

No o

f pat

ient

s

Mridu Madhyam Krura

Type of Kostha

Kostha wise distribution

Group A Group B Group C

34

2

56

4

88

13

111 110 1 0

002468

101214

No

o

f p

ati

en

ts

Exercise group

Exercise wise distribution

GroupA

GroupB

GroupC

5 5

2

18 1817

1110

13

32 2

7

9

15

1010

13 13

12

9

0

2

4

6

8

10

12

14

16

18N

o o

f p

ati

en

ts

Nidra group

Nidra wise distribution

GroupA

GroupB

GroupC

64 5

1416 15

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Dincharya group

Dincharya Palana wise distribution

Group A Group B Group C

9

12

14

11

86

024

68

101214

No

o

f p

atein

ts

Samyaka AsamyakaRatricharya group

Ratricharya wise distribution

Group A Group B Group C

47

9

16

1311

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Ritucharya group

Ritucharya Palana wise distribution

Group A Group B Group C

34 4

17 16 16

0

5

10

15

20

No

o

f p

atie

nts

Samyaka Asamyaka

Sadvritta group

Sadvritta Palana wise distribution

Group A Group B Group C

9

12

15

4 4

1

7

4 4

0 0 0 0 0 0

02468

10121416

No

o

f p

ati

en

ts

Sharirika prakriti

Sharirika prakriti wise distribution

Group A

Group B

Group C

2

4

2

8 76

10 9

12

0

2

4

6

8

10

12

No

o

f p

ati

ents

Rajasika Tamsika Rajasika-Tamsika

Manasika prakriti

Manasika Prakriti wise distribution

Group A Group B Group C

34 3

8

54

9

1113

0

2

4

6

8

10

12

14

No

o

f p

ati

en

ts

Pravara Madhyama Avara

Type of Sara

Sara wise distribution

Group A Group B Group C

42 2

6 54

10

1314

024

68

101214

No

of

pat

ien

ts

Pravara Madhyama Avara

Type of satva

Satva wise distribution

Group A Group B Group C

5

3 3

76

78

1110

0

2

4

6

8

10

12

No

o

f p

ati

en

ts

Pravara Madhyama AvaraType of samhanana

Samhanana wise distribution

Group A Group B Group C

5

3 3

1113

12

4 4 5

0

2

4

6

8

10

12

14

No

o

f p

atie

nts

Pravara Madhyama AvaraType of pramana

Pramana wise distribution

Group A Group B Group C

23 3

121010

6 7 7

0

2

4

6

8

10

12

No

o

f p

atie

nts

Pravara Madhyama Avara

Type of satmya

Satmya wise distribution

Group A Group B Group C

10

41

57

4 5

9

15

02468

10121416

No

o

f p

atien

ts

Pravara Madhyama AvaraVyayamshakti

Vyayamshakti wise distribution

Group A Group B Group C

10

1314

21 1

65 4

21 1

0

2

4

6

8

10

12

14N

o o

f pat

ient

s

Mandagni Tikshnagni Vishmagni Samagni

Type of agni

Agni wise distribution

Group A Group B Group C

7

54

109

6

3

6

10

0

2

4

6

8

10

No o

f pat

ient

sPravara Madhyam Avara

Abhyavarana shakti

Abhyavarana shakti wise distribution

Group A Group B Group C

75

3

78

76

7

10

0

2

4

6

8

10

No

of p

atie

nts

Pravara Madhyam Avara

Jarana Shakti

Jarana shakti wise distribution

Group A Group B Group C

0

2

4

6

8

10

12

14

16

18

20N

o o

f p

ati

en

ts

chief complaints

Chief complaints wise distribution

Group A

Group B

Group C

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

75 6

1315

14

0

5

10

15No

of p

atie

nts

Rural UrbanResidence group

Residence wise distribution

Group A Group B Group C

5

6

54

3

0

6 6

0

4 43

0 0

7

11

5

01234567

No o

f pat

ient

s

Hous

ehold

Labo

urer

Serv

ice

Buise

ness

Retir

ed

Unem

ploye

d

occupation

Occupation wise distribution

Group A

Group B

Group C

43

43

23

89

7

43

21

34

0

2

4

6

8

10

No

o

f p

ati

en

ts

Poor Lowermiddle

Middle Uppermiddle

Rich

Socio-economic status

Socio-economic wise distribution

Group A Group B Group C

1412

15

68

5

0

5

10

15No

of p

atie

nts

Vegetarian MixedType of diet

Type of diet wise distribution

Group A Group B Group C

16

13

9

12 119

2020 20

1918

1617

1412

65 6

02468

101214161820

No

of P

atie

nts

Veg

etab

les

Frui

ts

Cer

eals

Pul

ses

Junk

food

Dry

food

Type of food

Food taking wise distribution

Group A

Group B

Group C

647

12 10 13

8

10

7

17 16

15

6

109

000 0

0

0

79

10

02468

1012141618

No

o

f P

ati

en

ts

Type of oil amp Ghee

consumption of oil amp Ghee wise distribution

Group A

Group B

Group C

1920

17

8 83

101210

58 8

0 0 00

5

10

15

20No

of p

atie

nts

Tea Coffe Colddrink

Milk Other

Supplementary diet group

Supplementary diet wise distribution

Group A Group B Group C

2

4

6

8 8

6 64

2

6 6

3

01

0012345678

No o

f pat

ient

s

Tobb

aco

chew

Smok

ing

Alco

hol

Panm

asal

a

Seda

tives

Addiction

Addiction wise distribution

Group A

Group B

Group C

181817 1615

16

201818

1412 12

35 6

2 3 3

0

5

10

15

20

No

o

f p

ati

en

ts

Madhra Amla Lavana Katu Tikta Kashaya

Type of Ahara Rasa

Dominant Rasa of Ahara wise distribution

Group A Group B Group C

12 1210

8 8

11

1312

1012

14

98

1213

121313

0

2

4

6

8

10

12

14N

o

of

pat

ien

ts

Guru Laghu Sheeta Ushna Snigdha Ruksha

Type of Ahara Guna

Dominant Guna of Ahara wise distribution

Group A Group B Group C

02468

101214161820

No

o

f p

atie

nts

Group A Group B Group C

Types of Ayogya ahara vidhi

Ayogya Ahara Vidhi wise distribution

Anushna

Asnigdha

Amatravata

Ajirne

Viryaviruddha

Anishtadesha

AnishtaupakaranaAnmanaska

AtmanamAnabhikshyaAtidrutta

Ativilambita

9

67

11

8 87

86

0

2

4

6

8

10

12No

f pa

tient

s

Samashana Vishmashana AdhyashanaDiet habit

Diet habit wise distribution

Group A Group B Group C

53 2

64

2

9

13

16

02468

10121416

No o

f pat

ient

s

Mridu Madhyam Krura

Type of Kostha

Kostha wise distribution

Group A Group B Group C

34

2

56

4

88

13

111 110 1 0

002468

101214

No

o

f p

ati

en

ts

Exercise group

Exercise wise distribution

GroupA

GroupB

GroupC

5 5

2

18 1817

1110

13

32 2

7

9

15

1010

13 13

12

9

0

2

4

6

8

10

12

14

16

18N

o o

f p

ati

en

ts

Nidra group

Nidra wise distribution

GroupA

GroupB

GroupC

64 5

1416 15

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Dincharya group

Dincharya Palana wise distribution

Group A Group B Group C

9

12

14

11

86

024

68

101214

No

o

f p

atein

ts

Samyaka AsamyakaRatricharya group

Ratricharya wise distribution

Group A Group B Group C

47

9

16

1311

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Ritucharya group

Ritucharya Palana wise distribution

Group A Group B Group C

34 4

17 16 16

0

5

10

15

20

No

o

f p

atie

nts

Samyaka Asamyaka

Sadvritta group

Sadvritta Palana wise distribution

Group A Group B Group C

9

12

15

4 4

1

7

4 4

0 0 0 0 0 0

02468

10121416

No

o

f p

ati

en

ts

Sharirika prakriti

Sharirika prakriti wise distribution

Group A

Group B

Group C

2

4

2

8 76

10 9

12

0

2

4

6

8

10

12

No

o

f p

ati

ents

Rajasika Tamsika Rajasika-Tamsika

Manasika prakriti

Manasika Prakriti wise distribution

Group A Group B Group C

34 3

8

54

9

1113

0

2

4

6

8

10

12

14

No

o

f p

ati

en

ts

Pravara Madhyama Avara

Type of Sara

Sara wise distribution

Group A Group B Group C

42 2

6 54

10

1314

024

68

101214

No

of

pat

ien

ts

Pravara Madhyama Avara

Type of satva

Satva wise distribution

Group A Group B Group C

5

3 3

76

78

1110

0

2

4

6

8

10

12

No

o

f p

ati

en

ts

Pravara Madhyama AvaraType of samhanana

Samhanana wise distribution

Group A Group B Group C

5

3 3

1113

12

4 4 5

0

2

4

6

8

10

12

14

No

o

f p

atie

nts

Pravara Madhyama AvaraType of pramana

Pramana wise distribution

Group A Group B Group C

23 3

121010

6 7 7

0

2

4

6

8

10

12

No

o

f p

atie

nts

Pravara Madhyama Avara

Type of satmya

Satmya wise distribution

Group A Group B Group C

10

41

57

4 5

9

15

02468

10121416

No

o

f p

atien

ts

Pravara Madhyama AvaraVyayamshakti

Vyayamshakti wise distribution

Group A Group B Group C

10

1314

21 1

65 4

21 1

0

2

4

6

8

10

12

14N

o o

f pat

ient

s

Mandagni Tikshnagni Vishmagni Samagni

Type of agni

Agni wise distribution

Group A Group B Group C

7

54

109

6

3

6

10

0

2

4

6

8

10

No o

f pat

ient

sPravara Madhyam Avara

Abhyavarana shakti

Abhyavarana shakti wise distribution

Group A Group B Group C

75

3

78

76

7

10

0

2

4

6

8

10

No

of p

atie

nts

Pravara Madhyam Avara

Jarana Shakti

Jarana shakti wise distribution

Group A Group B Group C

0

2

4

6

8

10

12

14

16

18

20N

o o

f p

ati

en

ts

chief complaints

Chief complaints wise distribution

Group A

Group B

Group C

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

1412

15

68

5

0

5

10

15No

of p

atie

nts

Vegetarian MixedType of diet

Type of diet wise distribution

Group A Group B Group C

16

13

9

12 119

2020 20

1918

1617

1412

65 6

02468

101214161820

No

of P

atie

nts

Veg

etab

les

Frui

ts

Cer

eals

Pul

ses

Junk

food

Dry

food

Type of food

Food taking wise distribution

Group A

Group B

Group C

647

12 10 13

8

10

7

17 16

15

6

109

000 0

0

0

79

10

02468

1012141618

No

o

f P

ati

en

ts

Type of oil amp Ghee

consumption of oil amp Ghee wise distribution

Group A

Group B

Group C

1920

17

8 83

101210

58 8

0 0 00

5

10

15

20No

of p

atie

nts

Tea Coffe Colddrink

Milk Other

Supplementary diet group

Supplementary diet wise distribution

Group A Group B Group C

2

4

6

8 8

6 64

2

6 6

3

01

0012345678

No o

f pat

ient

s

Tobb

aco

chew

Smok

ing

Alco

hol

Panm

asal

a

Seda

tives

Addiction

Addiction wise distribution

Group A

Group B

Group C

181817 1615

16

201818

1412 12

35 6

2 3 3

0

5

10

15

20

No

o

f p

ati

en

ts

Madhra Amla Lavana Katu Tikta Kashaya

Type of Ahara Rasa

Dominant Rasa of Ahara wise distribution

Group A Group B Group C

12 1210

8 8

11

1312

1012

14

98

1213

121313

0

2

4

6

8

10

12

14N

o

of

pat

ien

ts

Guru Laghu Sheeta Ushna Snigdha Ruksha

Type of Ahara Guna

Dominant Guna of Ahara wise distribution

Group A Group B Group C

02468

101214161820

No

o

f p

atie

nts

Group A Group B Group C

Types of Ayogya ahara vidhi

Ayogya Ahara Vidhi wise distribution

Anushna

Asnigdha

Amatravata

Ajirne

Viryaviruddha

Anishtadesha

AnishtaupakaranaAnmanaska

AtmanamAnabhikshyaAtidrutta

Ativilambita

9

67

11

8 87

86

0

2

4

6

8

10

12No

f pa

tient

s

Samashana Vishmashana AdhyashanaDiet habit

Diet habit wise distribution

Group A Group B Group C

53 2

64

2

9

13

16

02468

10121416

No o

f pat

ient

s

Mridu Madhyam Krura

Type of Kostha

Kostha wise distribution

Group A Group B Group C

34

2

56

4

88

13

111 110 1 0

002468

101214

No

o

f p

ati

en

ts

Exercise group

Exercise wise distribution

GroupA

GroupB

GroupC

5 5

2

18 1817

1110

13

32 2

7

9

15

1010

13 13

12

9

0

2

4

6

8

10

12

14

16

18N

o o

f p

ati

en

ts

Nidra group

Nidra wise distribution

GroupA

GroupB

GroupC

64 5

1416 15

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Dincharya group

Dincharya Palana wise distribution

Group A Group B Group C

9

12

14

11

86

024

68

101214

No

o

f p

atein

ts

Samyaka AsamyakaRatricharya group

Ratricharya wise distribution

Group A Group B Group C

47

9

16

1311

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Ritucharya group

Ritucharya Palana wise distribution

Group A Group B Group C

34 4

17 16 16

0

5

10

15

20

No

o

f p

atie

nts

Samyaka Asamyaka

Sadvritta group

Sadvritta Palana wise distribution

Group A Group B Group C

9

12

15

4 4

1

7

4 4

0 0 0 0 0 0

02468

10121416

No

o

f p

ati

en

ts

Sharirika prakriti

Sharirika prakriti wise distribution

Group A

Group B

Group C

2

4

2

8 76

10 9

12

0

2

4

6

8

10

12

No

o

f p

ati

ents

Rajasika Tamsika Rajasika-Tamsika

Manasika prakriti

Manasika Prakriti wise distribution

Group A Group B Group C

34 3

8

54

9

1113

0

2

4

6

8

10

12

14

No

o

f p

ati

en

ts

Pravara Madhyama Avara

Type of Sara

Sara wise distribution

Group A Group B Group C

42 2

6 54

10

1314

024

68

101214

No

of

pat

ien

ts

Pravara Madhyama Avara

Type of satva

Satva wise distribution

Group A Group B Group C

5

3 3

76

78

1110

0

2

4

6

8

10

12

No

o

f p

ati

en

ts

Pravara Madhyama AvaraType of samhanana

Samhanana wise distribution

Group A Group B Group C

5

3 3

1113

12

4 4 5

0

2

4

6

8

10

12

14

No

o

f p

atie

nts

Pravara Madhyama AvaraType of pramana

Pramana wise distribution

Group A Group B Group C

23 3

121010

6 7 7

0

2

4

6

8

10

12

No

o

f p

atie

nts

Pravara Madhyama Avara

Type of satmya

Satmya wise distribution

Group A Group B Group C

10

41

57

4 5

9

15

02468

10121416

No

o

f p

atien

ts

Pravara Madhyama AvaraVyayamshakti

Vyayamshakti wise distribution

Group A Group B Group C

10

1314

21 1

65 4

21 1

0

2

4

6

8

10

12

14N

o o

f pat

ient

s

Mandagni Tikshnagni Vishmagni Samagni

Type of agni

Agni wise distribution

Group A Group B Group C

7

54

109

6

3

6

10

0

2

4

6

8

10

No o

f pat

ient

sPravara Madhyam Avara

Abhyavarana shakti

Abhyavarana shakti wise distribution

Group A Group B Group C

75

3

78

76

7

10

0

2

4

6

8

10

No

of p

atie

nts

Pravara Madhyam Avara

Jarana Shakti

Jarana shakti wise distribution

Group A Group B Group C

0

2

4

6

8

10

12

14

16

18

20N

o o

f p

ati

en

ts

chief complaints

Chief complaints wise distribution

Group A

Group B

Group C

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

1920

17

8 83

101210

58 8

0 0 00

5

10

15

20No

of p

atie

nts

Tea Coffe Colddrink

Milk Other

Supplementary diet group

Supplementary diet wise distribution

Group A Group B Group C

2

4

6

8 8

6 64

2

6 6

3

01

0012345678

No o

f pat

ient

s

Tobb

aco

chew

Smok

ing

Alco

hol

Panm

asal

a

Seda

tives

Addiction

Addiction wise distribution

Group A

Group B

Group C

181817 1615

16

201818

1412 12

35 6

2 3 3

0

5

10

15

20

No

o

f p

ati

en

ts

Madhra Amla Lavana Katu Tikta Kashaya

Type of Ahara Rasa

Dominant Rasa of Ahara wise distribution

Group A Group B Group C

12 1210

8 8

11

1312

1012

14

98

1213

121313

0

2

4

6

8

10

12

14N

o

of

pat

ien

ts

Guru Laghu Sheeta Ushna Snigdha Ruksha

Type of Ahara Guna

Dominant Guna of Ahara wise distribution

Group A Group B Group C

02468

101214161820

No

o

f p

atie

nts

Group A Group B Group C

Types of Ayogya ahara vidhi

Ayogya Ahara Vidhi wise distribution

Anushna

Asnigdha

Amatravata

Ajirne

Viryaviruddha

Anishtadesha

AnishtaupakaranaAnmanaska

AtmanamAnabhikshyaAtidrutta

Ativilambita

9

67

11

8 87

86

0

2

4

6

8

10

12No

f pa

tient

s

Samashana Vishmashana AdhyashanaDiet habit

Diet habit wise distribution

Group A Group B Group C

53 2

64

2

9

13

16

02468

10121416

No o

f pat

ient

s

Mridu Madhyam Krura

Type of Kostha

Kostha wise distribution

Group A Group B Group C

34

2

56

4

88

13

111 110 1 0

002468

101214

No

o

f p

ati

en

ts

Exercise group

Exercise wise distribution

GroupA

GroupB

GroupC

5 5

2

18 1817

1110

13

32 2

7

9

15

1010

13 13

12

9

0

2

4

6

8

10

12

14

16

18N

o o

f p

ati

en

ts

Nidra group

Nidra wise distribution

GroupA

GroupB

GroupC

64 5

1416 15

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Dincharya group

Dincharya Palana wise distribution

Group A Group B Group C

9

12

14

11

86

024

68

101214

No

o

f p

atein

ts

Samyaka AsamyakaRatricharya group

Ratricharya wise distribution

Group A Group B Group C

47

9

16

1311

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Ritucharya group

Ritucharya Palana wise distribution

Group A Group B Group C

34 4

17 16 16

0

5

10

15

20

No

o

f p

atie

nts

Samyaka Asamyaka

Sadvritta group

Sadvritta Palana wise distribution

Group A Group B Group C

9

12

15

4 4

1

7

4 4

0 0 0 0 0 0

02468

10121416

No

o

f p

ati

en

ts

Sharirika prakriti

Sharirika prakriti wise distribution

Group A

Group B

Group C

2

4

2

8 76

10 9

12

0

2

4

6

8

10

12

No

o

f p

ati

ents

Rajasika Tamsika Rajasika-Tamsika

Manasika prakriti

Manasika Prakriti wise distribution

Group A Group B Group C

34 3

8

54

9

1113

0

2

4

6

8

10

12

14

No

o

f p

ati

en

ts

Pravara Madhyama Avara

Type of Sara

Sara wise distribution

Group A Group B Group C

42 2

6 54

10

1314

024

68

101214

No

of

pat

ien

ts

Pravara Madhyama Avara

Type of satva

Satva wise distribution

Group A Group B Group C

5

3 3

76

78

1110

0

2

4

6

8

10

12

No

o

f p

ati

en

ts

Pravara Madhyama AvaraType of samhanana

Samhanana wise distribution

Group A Group B Group C

5

3 3

1113

12

4 4 5

0

2

4

6

8

10

12

14

No

o

f p

atie

nts

Pravara Madhyama AvaraType of pramana

Pramana wise distribution

Group A Group B Group C

23 3

121010

6 7 7

0

2

4

6

8

10

12

No

o

f p

atie

nts

Pravara Madhyama Avara

Type of satmya

Satmya wise distribution

Group A Group B Group C

10

41

57

4 5

9

15

02468

10121416

No

o

f p

atien

ts

Pravara Madhyama AvaraVyayamshakti

Vyayamshakti wise distribution

Group A Group B Group C

10

1314

21 1

65 4

21 1

0

2

4

6

8

10

12

14N

o o

f pat

ient

s

Mandagni Tikshnagni Vishmagni Samagni

Type of agni

Agni wise distribution

Group A Group B Group C

7

54

109

6

3

6

10

0

2

4

6

8

10

No o

f pat

ient

sPravara Madhyam Avara

Abhyavarana shakti

Abhyavarana shakti wise distribution

Group A Group B Group C

75

3

78

76

7

10

0

2

4

6

8

10

No

of p

atie

nts

Pravara Madhyam Avara

Jarana Shakti

Jarana shakti wise distribution

Group A Group B Group C

0

2

4

6

8

10

12

14

16

18

20N

o o

f p

ati

en

ts

chief complaints

Chief complaints wise distribution

Group A

Group B

Group C

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

12 1210

8 8

11

1312

1012

14

98

1213

121313

0

2

4

6

8

10

12

14N

o

of

pat

ien

ts

Guru Laghu Sheeta Ushna Snigdha Ruksha

Type of Ahara Guna

Dominant Guna of Ahara wise distribution

Group A Group B Group C

02468

101214161820

No

o

f p

atie

nts

Group A Group B Group C

Types of Ayogya ahara vidhi

Ayogya Ahara Vidhi wise distribution

Anushna

Asnigdha

Amatravata

Ajirne

Viryaviruddha

Anishtadesha

AnishtaupakaranaAnmanaska

AtmanamAnabhikshyaAtidrutta

Ativilambita

9

67

11

8 87

86

0

2

4

6

8

10

12No

f pa

tient

s

Samashana Vishmashana AdhyashanaDiet habit

Diet habit wise distribution

Group A Group B Group C

53 2

64

2

9

13

16

02468

10121416

No o

f pat

ient

s

Mridu Madhyam Krura

Type of Kostha

Kostha wise distribution

Group A Group B Group C

34

2

56

4

88

13

111 110 1 0

002468

101214

No

o

f p

ati

en

ts

Exercise group

Exercise wise distribution

GroupA

GroupB

GroupC

5 5

2

18 1817

1110

13

32 2

7

9

15

1010

13 13

12

9

0

2

4

6

8

10

12

14

16

18N

o o

f p

ati

en

ts

Nidra group

Nidra wise distribution

GroupA

GroupB

GroupC

64 5

1416 15

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Dincharya group

Dincharya Palana wise distribution

Group A Group B Group C

9

12

14

11

86

024

68

101214

No

o

f p

atein

ts

Samyaka AsamyakaRatricharya group

Ratricharya wise distribution

Group A Group B Group C

47

9

16

1311

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Ritucharya group

Ritucharya Palana wise distribution

Group A Group B Group C

34 4

17 16 16

0

5

10

15

20

No

o

f p

atie

nts

Samyaka Asamyaka

Sadvritta group

Sadvritta Palana wise distribution

Group A Group B Group C

9

12

15

4 4

1

7

4 4

0 0 0 0 0 0

02468

10121416

No

o

f p

ati

en

ts

Sharirika prakriti

Sharirika prakriti wise distribution

Group A

Group B

Group C

2

4

2

8 76

10 9

12

0

2

4

6

8

10

12

No

o

f p

ati

ents

Rajasika Tamsika Rajasika-Tamsika

Manasika prakriti

Manasika Prakriti wise distribution

Group A Group B Group C

34 3

8

54

9

1113

0

2

4

6

8

10

12

14

No

o

f p

ati

en

ts

Pravara Madhyama Avara

Type of Sara

Sara wise distribution

Group A Group B Group C

42 2

6 54

10

1314

024

68

101214

No

of

pat

ien

ts

Pravara Madhyama Avara

Type of satva

Satva wise distribution

Group A Group B Group C

5

3 3

76

78

1110

0

2

4

6

8

10

12

No

o

f p

ati

en

ts

Pravara Madhyama AvaraType of samhanana

Samhanana wise distribution

Group A Group B Group C

5

3 3

1113

12

4 4 5

0

2

4

6

8

10

12

14

No

o

f p

atie

nts

Pravara Madhyama AvaraType of pramana

Pramana wise distribution

Group A Group B Group C

23 3

121010

6 7 7

0

2

4

6

8

10

12

No

o

f p

atie

nts

Pravara Madhyama Avara

Type of satmya

Satmya wise distribution

Group A Group B Group C

10

41

57

4 5

9

15

02468

10121416

No

o

f p

atien

ts

Pravara Madhyama AvaraVyayamshakti

Vyayamshakti wise distribution

Group A Group B Group C

10

1314

21 1

65 4

21 1

0

2

4

6

8

10

12

14N

o o

f pat

ient

s

Mandagni Tikshnagni Vishmagni Samagni

Type of agni

Agni wise distribution

Group A Group B Group C

7

54

109

6

3

6

10

0

2

4

6

8

10

No o

f pat

ient

sPravara Madhyam Avara

Abhyavarana shakti

Abhyavarana shakti wise distribution

Group A Group B Group C

75

3

78

76

7

10

0

2

4

6

8

10

No

of p

atie

nts

Pravara Madhyam Avara

Jarana Shakti

Jarana shakti wise distribution

Group A Group B Group C

0

2

4

6

8

10

12

14

16

18

20N

o o

f p

ati

en

ts

chief complaints

Chief complaints wise distribution

Group A

Group B

Group C

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

9

67

11

8 87

86

0

2

4

6

8

10

12No

f pa

tient

s

Samashana Vishmashana AdhyashanaDiet habit

Diet habit wise distribution

Group A Group B Group C

53 2

64

2

9

13

16

02468

10121416

No o

f pat

ient

s

Mridu Madhyam Krura

Type of Kostha

Kostha wise distribution

Group A Group B Group C

34

2

56

4

88

13

111 110 1 0

002468

101214

No

o

f p

ati

en

ts

Exercise group

Exercise wise distribution

GroupA

GroupB

GroupC

5 5

2

18 1817

1110

13

32 2

7

9

15

1010

13 13

12

9

0

2

4

6

8

10

12

14

16

18N

o o

f p

ati

en

ts

Nidra group

Nidra wise distribution

GroupA

GroupB

GroupC

64 5

1416 15

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Dincharya group

Dincharya Palana wise distribution

Group A Group B Group C

9

12

14

11

86

024

68

101214

No

o

f p

atein

ts

Samyaka AsamyakaRatricharya group

Ratricharya wise distribution

Group A Group B Group C

47

9

16

1311

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Ritucharya group

Ritucharya Palana wise distribution

Group A Group B Group C

34 4

17 16 16

0

5

10

15

20

No

o

f p

atie

nts

Samyaka Asamyaka

Sadvritta group

Sadvritta Palana wise distribution

Group A Group B Group C

9

12

15

4 4

1

7

4 4

0 0 0 0 0 0

02468

10121416

No

o

f p

ati

en

ts

Sharirika prakriti

Sharirika prakriti wise distribution

Group A

Group B

Group C

2

4

2

8 76

10 9

12

0

2

4

6

8

10

12

No

o

f p

ati

ents

Rajasika Tamsika Rajasika-Tamsika

Manasika prakriti

Manasika Prakriti wise distribution

Group A Group B Group C

34 3

8

54

9

1113

0

2

4

6

8

10

12

14

No

o

f p

ati

en

ts

Pravara Madhyama Avara

Type of Sara

Sara wise distribution

Group A Group B Group C

42 2

6 54

10

1314

024

68

101214

No

of

pat

ien

ts

Pravara Madhyama Avara

Type of satva

Satva wise distribution

Group A Group B Group C

5

3 3

76

78

1110

0

2

4

6

8

10

12

No

o

f p

ati

en

ts

Pravara Madhyama AvaraType of samhanana

Samhanana wise distribution

Group A Group B Group C

5

3 3

1113

12

4 4 5

0

2

4

6

8

10

12

14

No

o

f p

atie

nts

Pravara Madhyama AvaraType of pramana

Pramana wise distribution

Group A Group B Group C

23 3

121010

6 7 7

0

2

4

6

8

10

12

No

o

f p

atie

nts

Pravara Madhyama Avara

Type of satmya

Satmya wise distribution

Group A Group B Group C

10

41

57

4 5

9

15

02468

10121416

No

o

f p

atien

ts

Pravara Madhyama AvaraVyayamshakti

Vyayamshakti wise distribution

Group A Group B Group C

10

1314

21 1

65 4

21 1

0

2

4

6

8

10

12

14N

o o

f pat

ient

s

Mandagni Tikshnagni Vishmagni Samagni

Type of agni

Agni wise distribution

Group A Group B Group C

7

54

109

6

3

6

10

0

2

4

6

8

10

No o

f pat

ient

sPravara Madhyam Avara

Abhyavarana shakti

Abhyavarana shakti wise distribution

Group A Group B Group C

75

3

78

76

7

10

0

2

4

6

8

10

No

of p

atie

nts

Pravara Madhyam Avara

Jarana Shakti

Jarana shakti wise distribution

Group A Group B Group C

0

2

4

6

8

10

12

14

16

18

20N

o o

f p

ati

en

ts

chief complaints

Chief complaints wise distribution

Group A

Group B

Group C

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

5 5

2

18 1817

1110

13

32 2

7

9

15

1010

13 13

12

9

0

2

4

6

8

10

12

14

16

18N

o o

f p

ati

en

ts

Nidra group

Nidra wise distribution

GroupA

GroupB

GroupC

64 5

1416 15

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Dincharya group

Dincharya Palana wise distribution

Group A Group B Group C

9

12

14

11

86

024

68

101214

No

o

f p

atein

ts

Samyaka AsamyakaRatricharya group

Ratricharya wise distribution

Group A Group B Group C

47

9

16

1311

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Ritucharya group

Ritucharya Palana wise distribution

Group A Group B Group C

34 4

17 16 16

0

5

10

15

20

No

o

f p

atie

nts

Samyaka Asamyaka

Sadvritta group

Sadvritta Palana wise distribution

Group A Group B Group C

9

12

15

4 4

1

7

4 4

0 0 0 0 0 0

02468

10121416

No

o

f p

ati

en

ts

Sharirika prakriti

Sharirika prakriti wise distribution

Group A

Group B

Group C

2

4

2

8 76

10 9

12

0

2

4

6

8

10

12

No

o

f p

ati

ents

Rajasika Tamsika Rajasika-Tamsika

Manasika prakriti

Manasika Prakriti wise distribution

Group A Group B Group C

34 3

8

54

9

1113

0

2

4

6

8

10

12

14

No

o

f p

ati

en

ts

Pravara Madhyama Avara

Type of Sara

Sara wise distribution

Group A Group B Group C

42 2

6 54

10

1314

024

68

101214

No

of

pat

ien

ts

Pravara Madhyama Avara

Type of satva

Satva wise distribution

Group A Group B Group C

5

3 3

76

78

1110

0

2

4

6

8

10

12

No

o

f p

ati

en

ts

Pravara Madhyama AvaraType of samhanana

Samhanana wise distribution

Group A Group B Group C

5

3 3

1113

12

4 4 5

0

2

4

6

8

10

12

14

No

o

f p

atie

nts

Pravara Madhyama AvaraType of pramana

Pramana wise distribution

Group A Group B Group C

23 3

121010

6 7 7

0

2

4

6

8

10

12

No

o

f p

atie

nts

Pravara Madhyama Avara

Type of satmya

Satmya wise distribution

Group A Group B Group C

10

41

57

4 5

9

15

02468

10121416

No

o

f p

atien

ts

Pravara Madhyama AvaraVyayamshakti

Vyayamshakti wise distribution

Group A Group B Group C

10

1314

21 1

65 4

21 1

0

2

4

6

8

10

12

14N

o o

f pat

ient

s

Mandagni Tikshnagni Vishmagni Samagni

Type of agni

Agni wise distribution

Group A Group B Group C

7

54

109

6

3

6

10

0

2

4

6

8

10

No o

f pat

ient

sPravara Madhyam Avara

Abhyavarana shakti

Abhyavarana shakti wise distribution

Group A Group B Group C

75

3

78

76

7

10

0

2

4

6

8

10

No

of p

atie

nts

Pravara Madhyam Avara

Jarana Shakti

Jarana shakti wise distribution

Group A Group B Group C

0

2

4

6

8

10

12

14

16

18

20N

o o

f p

ati

en

ts

chief complaints

Chief complaints wise distribution

Group A

Group B

Group C

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

47

9

16

1311

02468

10121416

No

o

f p

atie

nts

Samyaka Asamyaka

Ritucharya group

Ritucharya Palana wise distribution

Group A Group B Group C

34 4

17 16 16

0

5

10

15

20

No

o

f p

atie

nts

Samyaka Asamyaka

Sadvritta group

Sadvritta Palana wise distribution

Group A Group B Group C

9

12

15

4 4

1

7

4 4

0 0 0 0 0 0

02468

10121416

No

o

f p

ati

en

ts

Sharirika prakriti

Sharirika prakriti wise distribution

Group A

Group B

Group C

2

4

2

8 76

10 9

12

0

2

4

6

8

10

12

No

o

f p

ati

ents

Rajasika Tamsika Rajasika-Tamsika

Manasika prakriti

Manasika Prakriti wise distribution

Group A Group B Group C

34 3

8

54

9

1113

0

2

4

6

8

10

12

14

No

o

f p

ati

en

ts

Pravara Madhyama Avara

Type of Sara

Sara wise distribution

Group A Group B Group C

42 2

6 54

10

1314

024

68

101214

No

of

pat

ien

ts

Pravara Madhyama Avara

Type of satva

Satva wise distribution

Group A Group B Group C

5

3 3

76

78

1110

0

2

4

6

8

10

12

No

o

f p

ati

en

ts

Pravara Madhyama AvaraType of samhanana

Samhanana wise distribution

Group A Group B Group C

5

3 3

1113

12

4 4 5

0

2

4

6

8

10

12

14

No

o

f p

atie

nts

Pravara Madhyama AvaraType of pramana

Pramana wise distribution

Group A Group B Group C

23 3

121010

6 7 7

0

2

4

6

8

10

12

No

o

f p

atie

nts

Pravara Madhyama Avara

Type of satmya

Satmya wise distribution

Group A Group B Group C

10

41

57

4 5

9

15

02468

10121416

No

o

f p

atien

ts

Pravara Madhyama AvaraVyayamshakti

Vyayamshakti wise distribution

Group A Group B Group C

10

1314

21 1

65 4

21 1

0

2

4

6

8

10

12

14N

o o

f pat

ient

s

Mandagni Tikshnagni Vishmagni Samagni

Type of agni

Agni wise distribution

Group A Group B Group C

7

54

109

6

3

6

10

0

2

4

6

8

10

No o

f pat

ient

sPravara Madhyam Avara

Abhyavarana shakti

Abhyavarana shakti wise distribution

Group A Group B Group C

75

3

78

76

7

10

0

2

4

6

8

10

No

of p

atie

nts

Pravara Madhyam Avara

Jarana Shakti

Jarana shakti wise distribution

Group A Group B Group C

0

2

4

6

8

10

12

14

16

18

20N

o o

f p

ati

en

ts

chief complaints

Chief complaints wise distribution

Group A

Group B

Group C

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

2

4

2

8 76

10 9

12

0

2

4

6

8

10

12

No

o

f p

ati

ents

Rajasika Tamsika Rajasika-Tamsika

Manasika prakriti

Manasika Prakriti wise distribution

Group A Group B Group C

34 3

8

54

9

1113

0

2

4

6

8

10

12

14

No

o

f p

ati

en

ts

Pravara Madhyama Avara

Type of Sara

Sara wise distribution

Group A Group B Group C

42 2

6 54

10

1314

024

68

101214

No

of

pat

ien

ts

Pravara Madhyama Avara

Type of satva

Satva wise distribution

Group A Group B Group C

5

3 3

76

78

1110

0

2

4

6

8

10

12

No

o

f p

ati

en

ts

Pravara Madhyama AvaraType of samhanana

Samhanana wise distribution

Group A Group B Group C

5

3 3

1113

12

4 4 5

0

2

4

6

8

10

12

14

No

o

f p

atie

nts

Pravara Madhyama AvaraType of pramana

Pramana wise distribution

Group A Group B Group C

23 3

121010

6 7 7

0

2

4

6

8

10

12

No

o

f p

atie

nts

Pravara Madhyama Avara

Type of satmya

Satmya wise distribution

Group A Group B Group C

10

41

57

4 5

9

15

02468

10121416

No

o

f p

atien

ts

Pravara Madhyama AvaraVyayamshakti

Vyayamshakti wise distribution

Group A Group B Group C

10

1314

21 1

65 4

21 1

0

2

4

6

8

10

12

14N

o o

f pat

ient

s

Mandagni Tikshnagni Vishmagni Samagni

Type of agni

Agni wise distribution

Group A Group B Group C

7

54

109

6

3

6

10

0

2

4

6

8

10

No o

f pat

ient

sPravara Madhyam Avara

Abhyavarana shakti

Abhyavarana shakti wise distribution

Group A Group B Group C

75

3

78

76

7

10

0

2

4

6

8

10

No

of p

atie

nts

Pravara Madhyam Avara

Jarana Shakti

Jarana shakti wise distribution

Group A Group B Group C

0

2

4

6

8

10

12

14

16

18

20N

o o

f p

ati

en

ts

chief complaints

Chief complaints wise distribution

Group A

Group B

Group C

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

5

3 3

1113

12

4 4 5

0

2

4

6

8

10

12

14

No

o

f p

atie

nts

Pravara Madhyama AvaraType of pramana

Pramana wise distribution

Group A Group B Group C

23 3

121010

6 7 7

0

2

4

6

8

10

12

No

o

f p

atie

nts

Pravara Madhyama Avara

Type of satmya

Satmya wise distribution

Group A Group B Group C

10

41

57

4 5

9

15

02468

10121416

No

o

f p

atien

ts

Pravara Madhyama AvaraVyayamshakti

Vyayamshakti wise distribution

Group A Group B Group C

10

1314

21 1

65 4

21 1

0

2

4

6

8

10

12

14N

o o

f pat

ient

s

Mandagni Tikshnagni Vishmagni Samagni

Type of agni

Agni wise distribution

Group A Group B Group C

7

54

109

6

3

6

10

0

2

4

6

8

10

No o

f pat

ient

sPravara Madhyam Avara

Abhyavarana shakti

Abhyavarana shakti wise distribution

Group A Group B Group C

75

3

78

76

7

10

0

2

4

6

8

10

No

of p

atie

nts

Pravara Madhyam Avara

Jarana Shakti

Jarana shakti wise distribution

Group A Group B Group C

0

2

4

6

8

10

12

14

16

18

20N

o o

f p

ati

en

ts

chief complaints

Chief complaints wise distribution

Group A

Group B

Group C

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

10

1314

21 1

65 4

21 1

0

2

4

6

8

10

12

14N

o o

f pat

ient

s

Mandagni Tikshnagni Vishmagni Samagni

Type of agni

Agni wise distribution

Group A Group B Group C

7

54

109

6

3

6

10

0

2

4

6

8

10

No o

f pat

ient

sPravara Madhyam Avara

Abhyavarana shakti

Abhyavarana shakti wise distribution

Group A Group B Group C

75

3

78

76

7

10

0

2

4

6

8

10

No

of p

atie

nts

Pravara Madhyam Avara

Jarana Shakti

Jarana shakti wise distribution

Group A Group B Group C

0

2

4

6

8

10

12

14

16

18

20N

o o

f p

ati

en

ts

chief complaints

Chief complaints wise distribution

Group A

Group B

Group C

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

0

2

4

6

8

10

12

14

16

18

20N

o o

f p

ati

en

ts

chief complaints

Chief complaints wise distribution

Group A

Group B

Group C

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

0

2

4

6

8

10

12

14

16

18

20

No

o

f p

ati

en

ts

Associated symptoms

Associated symptom wise distribution

Group A Group B Group C

Percentage

90008833

8000

4333

8166

866651668000

9000

7000

9833

9500 5333

Indigetion ConstipationDisturbed sleep PalpitationAnger IrritabilityLoss of hearing Weakning of teethEarly menopause Recurrent infectionFatigue WeaknessAltered urinary symptoms

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

20 20 20

1718

20

1616

1918

17

1414

16

19

13

16

19

4

67

0

2

4

6

8

10

12

14

16

18

20N

o

of

pati

en

ts

Dhatu

Dhatu Kshaya wise distribution

Group A

Group B

Group C

02468

101214161820

No

o

f p

ati

en

ts

Type of Srotas

Srotodushti wise distribution

Group A Group B Group C

79

14

7

11

17

47

9

0

5

10

15

20

No

o

f p

atie

nts

Vyapada Visramsa KshayaType of ojodushti

Ojodushti wise distribution

Group A Group B Group C

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

S No Sign amp Symptoms Before Treatment After Treatment

G0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF RELIEF

1 Twak Parushata 6 5 6 3 26 15 3 2 0 7 7308

2 Slatha sara 0 4 8 8 44 14 3 2 1 10 7727

3 Slatha mamsa 2 3 8 7 40 14 2 2 2 13 6750

4 Slatha Asthi 2 8 5 5 33 14 2 1 3 13 6060

5 Slatha Sandhi 4 7 6 3 28 14 4 1 1 9 6786

6 Dhatu Kshaya 0 12 4 4 32 14 4 2 0 8 7500

7 Kayasya Avanamana

19 1 0 0 1 20 0 0 0 0 10000

8 Vepthu 15 3 1 1 8 18 2 0 0 2 7500

9 Khalitya 0 7 8 5 38 13 2 4 1 13 6579

10 Vali 2 10 5 3 29 13 3 2 2 13 5517

11 Palitya 2 9 7 2 29 14 2 3 1 11 6207

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 20 PATIENT OF JARA ROGA OF ldquoGROUP Ardquo

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

12 Kasa 06 7 6 1 22 14 4 2 0 8 636413 Shwasa 13 5 2 0 9 18 1 1 0 3 666714 MEDHA HANI

i Grahana hahi 1 15 3 1 24 14 4 1 1 9 6250ii Dharana hani 1 16 2 1 23 15 4 1 0 06 7391iii Smarana hani 0 7 10 3 36 13 3 3 1 12 6667iv Vijnana hani 13 3 4 0 11 17 2 1 0 4 6364v Vachana hani 0 0 0 0 0 0 0 0 0 0 0000

15 Utsaha hani 6 5 5 4 27 15 2 1 2 10 629616 Parakrama hani 2 7 6 5 34 13 1 4 2 15 558817 Paurusha hani 19 1 0 0 1 20 0 0 0 0 100

18 Prabaha hani 3 13 3 1 22 15 2 2 1 9 590919 Shukra Kshaya 15 3 2 0 7 16 2 2 0 6 142820 Drishti Hrasa 4 12 4 0 20 6 12 2 0 16 200021 Karmendriya hani 10 6 4 0 14 17 2 1 0 4 714222 Buddhi hani 15 4 1 0 6 18 1 1 0 3 5000

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 19 PATIENT OF JARA ROGA OF ldquoGROUP Brdquo

S No

Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 2 7 6 4 31 10 7 2 0 11 6452

2 Slatha sara 0 5 10 4 37 10 7 1 1 12 6757

3 Slatha mamsa 2 3 9 5 36 11 5 2 1 12 6667

4 Slatha Asthi 1 7 8 3 32 11 6 2 0 10 6875

5 Slatha Sandhi 0 6 8 5 37 12 4 1 2 12 6756

6 Dhatu Kshaya 0 4 11 4 38 10 4 3 2 16 5789

7 Kayasya Avanamana 13 3 2 1 10 15 3 1 0 5 5000

8 Vepthu 11 3 3 2 15 14 3 1 1 8 4667

9 Khalitya 0 6 11 2 34 1 8 8 2 30 1176

10 Vali 0 3 13 3 38 0 7 10 2 33 1316

11 Palitya 0 6 12 1 33 4 4 10 1 27 1818

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

12 Kasa 2 4 9 4 34 11 4 4 0 12 647113 Shwasa 5 5 6 3 26 13 4 2 0 8 692314 MEDHA HANI

i Grahana hahi 0 9 5 5 34 10 3 4 2 17 5000ii Dharana hani 0 12 4 3 29 11 5 2 1 12 5862iii Smarana hani 0 10 7 2 30 10 6 2 1 13 5000iv Vijnana hani 13 2 3 1 11 16 1 1 1 6 4545v Vachana hani 18 1 0 0 1 18 1 0 0 1 0000

15 Utsaha hani 2 9 6 2 27 11 4 3 1 13 518516 Parakrama hani 0 8 7 4 34 10 2 5 2 18 470617 Paurusha hani 14 3 1 1 8 16 2 1 0 4 500018 Prabaha hani 1 13 3 2 25 7 9 2 1 16 360019 Shukra Kshaya 13 3 2 1 10 14 3 1 1 8 200020 Drishti Hrasa 2 9 8 0 25 3 8 8 0 24 40021 Karmendriya hani 9 5 3 2 17 15 2 1 1 7 588222 Buddhi hani 11 5 3 0 11 14 5 0 0 5 5455

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

SHOWING PERCENTAGE OF IMPROVEMENT IN VARIOUS SIGN AND SYMPTOMS AFTER TWO MONTH OF TREATMENT IN 17 PATIENT OF JARA ROGA OF ldquoGROUP Crdquo

SNo Sign amp Symptoms Before Treatment After TreatmentG0 G1 G2 G3 Total G 0 G 1 G 2 G 3 Total OF

RELIEF

1 Twak Parushata 0 3 10 4 35 2 5 7 3 28 2000

2 Slatha sara 0 0 9 8 42 4 9 2 2 19 5476

3 Slatha mamsa 0 2 10 5 37 8 2 6 1 17 5405

4 Slatha Asthi 1 4 7 5 33 6 6 3 2 18 4545

5 Slatha Sandhi 0 3 8 6 37 5 10 1 1 15 5946

6 Dhatu Kshaya 0 0 10 7 41 2 5 6 4 29 2927

7 Kayasya Avanamana 13 1 2 1 8 13 1 2 1 8 0000

8 Vepthu 11 4 2 0 8 13 3 1 0 5 3750

9 Khalitya 0 3 6 8 39 0 3 8 6 37 0513

10 Vali 0 2 11 4 36 0 5 8 4 33 0833

11 Palitya 0 0 7 10 44 0 0 7 10 44 0000

12 Kasa 2 3 7 5 32 8 6 1 2 14 5625

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

13 Shwasa 5 3 8 1 22 11 2 3 1 11 5000

14 MEDHA HANI

i Grahana hahi 0 5 10 2 31 6 9 2 0 13 5806

ii Dharana hani 0 4 12 1 31 7 8 2 0 12 6129

iii Smarana hani 0 6 8 3 31 1 9 6 1 24 2258

iv Vijnana hani 3 5 8 1 24 5 8 3 1 17 2917

v Vachana hani 15 1 1 0 3 15 1 1 0 3 0000

15 Utsaha hani 0 4 12 1 31 11 4 2 0 8 7419

16 Parakrama hani 0 2 13 2 34 10 5 2 0 9 7353

17 Paurusha hani 9 5 2 1 12 13 1 2 1 8 3333

18 Prabaha hani 0 6 9 2 30 2 8 5 2 24 2000

19 Shukra Kshaya 11 3 1 2 11 11 4 1 5 9 1818

20 Drishti Hrasa 0 2 10 5 37 0 2 10 1 37 0000

21 Karmendriya hani 3 3 7 4 29 11 6 0 0 6 7900

22 Buddhi hani6 5 2 1 12 11 4 1 1 9 2500

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

STATISTICAL ANALYSIS OF

DIFFERENT SIGN AND SYMPTOMS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of Relief S D S E T-value

(Paired test)

P value Remarks

1 Twak Parushata130 035 095 7308 083 019 515 lt0001 HS

2 Slatha sara220 050 170 7727 103 023 737 lt0001 HS

3 Slatha mamsa200 065 135 6750 109 024 554 lt0001 HS

4 Slatha Asthi165 065 100 6060 079 018 563 lt0001 HS

5 Slatha Sandhi140 045 095 6786 089 019 479 lt0001 HS

6 Dhatu Kshaya160 040 120 7500 070 016 771 lt0001 HS

7 KayasyaAvanamana005 000 005 10000 022 005 100 gt005 NS

8 Vepthu040 010 030 7500 057 013 235 lt005 Sig

9 Khalitya190 065 125 6579 085 019 657 lt0001 HS

10 Vali145 065 080 5517 069 016 514 lt0001 HS

11 Palitya145 055 090 6207 064 014 628 lt0001 HS

12 Kasa110 040 070 6364 057 013 548 lt0001 HS

13 Shwasa045 015 030 6667 047 011 285 lt001 HS

14 MEDHA HANI

i Grahana hahi120 045 075 6250 055 012 609 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (20) of Group lsquoArsquo

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

ii Dharana hani 115 030 085 7391 049 011 777 lt0001 HS

iii Smarana hani 180 060 120 6667 077 017 699 lt0001 HS

iv Vijnana hani 055 020 035 6364 059 013 266 lt002 Sig

v Vachana hani 000 000 000 0000 000 000 000 gt005 NS

15 Utsaha hani 135 050 085 6296 088 019 434 lt0001 HS

16 Parakrama hani

170 065 105 5588 099 022 470 lt0001 HS

17 Paurusha hani 005 000 005 10000 022 005 100 gt005 NS

18 Prabaha hani 110 045 065 5909 059 013 495 lt0001 HS

19 Shukra Kshaya 035 030 005 1428 022 005 100 gt005 NS

20 Drishti Hrasa 100 080 020 2000 052 012 171 gt005 NS

21Karmendriya

hani070 020 050 7142 068 015 325 lt001 HS

22Buddhi hani

030 015 015 5000 036 008 183 gt005 NS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired

test)

P value Remark

s

1 Twak Parushata 163 058 105 6452 078 018 588 lt0001 HS

2 Slatha sara 195 063 132 6757 082 019 699 lt0001 HS

3 Slatha mamsa 189 068 121 6389 071 016 739 lt0001 HS

4 Slatha Asthi 168 063 105 6250 052 012 875 lt0001 HS

5 Slatha Sandhi 195 068 126 6486 073 016 751 lt0001 HS

6 Dhatu Kshaya 179 084 095 5789 091 020 453 lt0001 HS

7 Kayasya Avanamana 053 026 026 5000 056 013 204 gt005 NS

8 Vepthu 079 042 037 4667 068 016 235 lt005 Sig

9 Khalitya 058 032 026 4545 056 013 204 gt005 NS

10 Vali 200 184 016 1315 037 009 184 gt005 NS

11 Palitya 220 159 061 1818 037 009 184 gt005 NS

12 Kasa 179 063 116 6471 060 014 838 lt0001 HS

13 Shwasa 137 042 095 6923 085 019 4869 lt0001 HS

14 MEDHA HANI

i Grahana hahi 179 089 089 5000 057 013 688 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

iiDharana hani

153 063 089 5862 046 011 850 lt0001 HS

iiiSmarana hani

158 068 089 5000 074 017 528 lt0001 HS

ivVijnana hani

058 032 026 4545 056 013 204 gt005 NS

vVachana hani

005 005 000 0000 _ _ _ _ _

15Utsaha hani

142 068 074 5185 065 015 491 lt0001 HS

16Parakrama hani

179 095 084 4706 077 018 480 lt0001 HS

17Paurusha hani

042 021 021 5000 042 010 219 lt005 Sig

18Prabaha hani

132 084 047 3600 077 018 267 lt002 Sig

19Shukra Kshaya

053 042 011 2000 032 007 145 gt005 NS

20Drishti Hrasa

132 126 005 400 023 005 100 gt005 NS

21Karmendriya

hani089 037 053 5882 069 016 329 lt001 HS

22Buddhi hani

058 026 032 5455 048 011 288 001 HS

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

S

No

Sign amp Symptoms BT

Mean

A T

Mean

D of

Relief

S D S E T-value P value Remarks

1 Twak Parushata 205 164 041 2000 071 017 238 lt005 Sig

2 Slatha sara 253 112 141 5476 079 019 732 lt0001 HS

3 Slatha mamsa 218 100 117 5405 073 018 667 lt0001 HS

4 Slatha Asthi 194 105 088 4545 078 019 466 lt0001 HS

5 Slatha Sandhi 218 088 129 5946 068 017 778 lt0001 HS

6 Dhatu Kshaya 241 170 070 2927 084 020 343 lt001 HS

7 Kayasya Avanamana 047 047 000 0000 _ _ _ _ NS

8 Vepthu 047 029 018 3750 039 009 185 gt005 NS

9 Khalitya 229 211 018 0513 039 009 185 gt005 NS

10 Vali 212 194 018 0833 039 009 185 gt005 NS

11 Palitya 258 258 000 0000 _ _ _ _ NS

12 Kasa 188 082 106 5625 075 018 584 lt0001 HS

13 Shwasa 129 065 065 5000 079 019 339 lt001 HS

14 MEDHA HANI

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

i Grahana hahi 182 077 011 5806 0827 020 528 lt0001 HS

ii Dharana hani 182 071 112 6129 0857 021 537 lt0001 HS

iii Smarana hani 182 141 041 2258 062 015 275 lt002 Sig

iv Vijnana hani 141 124 018 2917 053 013 138 gt005 NS

v Vachana hani 177 177 000 0000 _ _ _ _ NS

15 Utsaha hani 159 053 106 7419 0899 022 485 lt0001 HS

16 Parakrama hani 188 059 129 7353 0849 021 629 lt0001 HS

17 Paurusha hani 071 059 012 3333 033 008 146 gt005 NS

18 Prabaha hani 176 141 035 2000 0606 015 240 lt005 Sig

19 Shukra Kshaya 065 053 011 1818 0332 008 146 gt005 NS

20 Drishti Hrasa 217 218 000 0000 _ _ _ _ NS

21 Karmendriya

hani

176 141 0352000

0606 015 240 lt005 Sig

22 Buddhi hani 065 053 011 1818 0332 008 146 gt005 NS

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

STATISTICAL ANALYSIS OFASSOCIATED SIGN AND

SYMPTOMS

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

S No Associated sign ampSymptoms

Mean Score D ofRelief

S D S E T-value (Paired test)

P value Remarks

BT A T

1 Indigestion 115 030 085 7391 114 025 334 lt001 HS

2 Constipation 145 025 120 8275 070 016 771 lt0001 HS

3 Disturbed sleep 120 030 090 7500 064 014 628 lt0001 HS

4 Palpitation 050 015 035 7000 059 013 266 lt002 Sig

5 Anger 130 050 080 6154 069 016 514 lt0001 HS

6 Irritability 125 050 075 6000 044 009 755 lt0001 HS

7 Loss of Hearing 126 116 011 0873 032 007 146 gt005 NS

8 Weakening of teeth 090 075 015 1667 049 011 137 gt005 NS

9 Early menopause 115 040 075 7826 078 018 427 lt0001 HS

10 Recurrent infection 085 040 045 7059 061 014 331 lt001 HS

11 Fatigue 165 020 145 8788 061 014 1072 lt0001 HS

12 Weakness 130 015 115 8846 059 013 876 lt0001 HS

13 Altered urinary symptoms

045 020 025 5556 044 009 252 002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Associated Sign amp Symptoms -Patients (20) of Group lsquoArsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test)

P value Remarks

1 Indigestion 174 089 084 4827 069 016 533 lt0001 HS

2 Constipation 147 063 084 5714 076 017 480 lt0001 HS

3 Disturbed sleep 147 084 063 4286 089 021 308 lt001 HS

4 Palpitation 053 032 021 3962 054 012 170 gt005 NS

5 Anger 163 089 074 4539 099 023 324 lt001 HS

6 Irritability 163 126 037 2270 049 011 324 lt001 HS

7 Loss of Hearing 053 053 000 000 - - - - NS

8 Weakening of teeth 126 116 011 0873 032 007 146 gt005 NS

9 Early menopause 173 147 026 1503 045 010 254 002 Sig

10 Recurrent infection 116 042 074 6379 073 017 438 lt0001 HS

11 Fatigue 174 015 157 9000 084 019 821 lt0001 HS

12 Weakness 136 037 100 7353 047 011 925 lt0001 HS

13 Altered urinary

symptoms

100 047 053 5300 084 019 272 lt002 Sig

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (19) of Group lsquoBrsquo

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

S No Associated sign ampSymptoms

BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Indigestion 194 135 059 3041 071 017 341 lt001 HS

2 Constipation 200 094 106 5300 129 031 336 lt001 HS

3 Disturbed sleep 182 123 059 3242 094 023 258 002 Sig

4 Palpitation 112 094 018 1607 039 010 185 gt005 NS

5 Anger 147 100 047 3197 062 015 312 lt001 HS

6 Irritability 171 117 053 3099 072 017 304 lt001 HS

7 Loss of Hearing 141 141 000 0000 - - - - NS

8 Weakening of teeth 176 176 000 0000 - - - - NS

9 Early menopause 176 152 024 1364 056 014 173 gt005 NS

10 Recurrent infection 153 088 065 4248 061 015 440 lt0001 HS

11 Fatigue 206 088 118 5728 081 019 599 lt0001 HS

12 Weakness 224 100 124 5536 083 020 613 lt0001 HS

13 Altered urinary symptoms

118 071 047 3983 052 013 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Sign amp Symptoms of the Patients (17) of Group lsquoCrsquo

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

STATISTICAL ANALYSIS OF HEALTH PARAMETERS

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value

(Paired test

P value Remarks

1 Walking time 130 030 100 7308 073 016 6164 lt0001 HS

2 Hand Grip Power (mm hg) 8717 10160 1443 1655 278 160 715 lt0001 HS

3 Foot Pressure(Kg) 2871 3028 157 0546 129 049 321 lt001 HS

4 Short term memory 126 037 089 7063 081 019 482 lt0001 HS

5 Long term Memory 125 100 025 2000 044 010 252 002 Sig

6 Breath holding time(sec) 2816 3016 200 0710 063 026 775 lt0001 HS

7 Pulse (min) 7712 7362 350 0475 194 168 511 lt0001 HS

8 Blood pressure

i Systolic 13064 1268 384 0529 050 025 300 lt001 HS

ii Diastolic 8645 8426 219 0334 078 026 426 lt0001 HS

9 Weight(Kg) 5637 5745 108 0174 127 043 379 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (20) of Group lsquoArsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 158 058 100 6667 075 017 585 lt0001 HS

2 Hand Grip Power (mm hg)

8200 9400 1200 1463 400 179 671 lt0001 HS

3 Foot Pressure(Kg) 2762 290 138 0472 111 039 350 lt001 HS

4 Short term memory 145 095 050 3448 069 015 325 lt001 HS

5 Long term Memory 205 164 041 3905 071 017 238 lt005 Sig

6 Breath holding time(sec)

2517 2812 295 0977 083 029 938 lt0001 HS

7 Pulse (min) 7912 7782 130 0475 194 168 511 lt0001 HS

8 Blood pressurei Systolic 13228 1282 408 0334 078 026 426 lt0001 HS

ii Diastolic 8425 8256 169 1506 105 037 302 lt001 HS

9 Weight(Kg) 5337 55 163 0294 122 043 377 lt001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (19) of Group lsquoBrsquo

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

S No Health parameters BT

Mean

A T

Mean

D of

Relief

S D S E T-value (Paired test

P value Remarks

1 Walking time 235 211 024 1021 043 011 222 gt005 HS

2 Hand Grip Power (mm hg)

7650 8983 1333 1742 695 284 470 lt0001 HS

3 Foot Pressure(Kg) 22 245 250 1136 373 152 164 gt005 NS

4 Short term memory 175 150 025 1429 044 009 252 lt005 Sig

5 Long term Memory 225 205 020 0889 041 009 218 lt005 Sig

6 Breath holding time(sec)

1971 2242 271 1208 20 075 397 lt001 HS

7 Pulse (min) 8150 7833 317 0389 337 138 230 lt005 Sig

8 Blood pressurei Systolic 14150 13975 175 0124 271 096 235 lt005 Sig

ii Diastolic 9400 9286 114 0121 107 040 283 lt002 Sig

9 Weight(Kg) 5171 5314 143 0274 090 034 418 lt0001 HS

Statistical Analysis Showing the Effect of Trial Drug to the Health parameters of the Patients (17) of Group lsquoCrsquo

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

OVER ALL EFFECT OF THERAPY

OF RELIEF EFFECT

MORE THAN 76 Maximum Improvement

51-75 Moderate Improvement

26-50 Mild Improvement

LESS THAN 25 No Improvement

04102023

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

RESULT Group A Group B Group C TotalNo of pts

No of Pts

No of Pts

No of pts

Maximum improvement 76 or more

06 3000 04 2105 02 1176 12 2143

Moderate improvement 51amp75

08 4000 05 2631 03 1765 16 2857

Mild improvement 26amp50

03 1500 06 3157 06 3529 15 2679

No improvement 25 or less

03 1500 04 2105 06 3529 13 2321

Total 20 100 19 100 17 100 56 100

OVER ALL EFFECT OF THE THERAPY ON GROUP lsquoArsquo GROUP lsquoBrsquo AND GROUP lsquoCrsquo PATIENTS OF JARA ROGA

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo

Total effect of therapy on 20 Patients of Jara Roga Of Group A

30

40

15

15

Maximum improvement Moderate improvement Mild improvement Unchanged

GROUP lsquoArsquo

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoBrsquo

GROUP lsquoBrsquo

Total effect of therapy on 19 Patients of Jara Roga Of Group B

21

2632

21

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoCrsquo

GROUP lsquoCrsquo

Total effect of therapy on 17 Patients of Jara Roga Of Group C

12

18

35

35

Maximum improvement Moderate improvement Mild improvement Unchanged

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

GRAPHICAL REPRESENTATION OF THE COMPARATIVE TOTAL EFFECT OF THERAPY ON THE PATIENTS OF JARA ROGA OF GROUP lsquoArsquo GROUP lsquoBrsquoAND GROUP lsquoCrsquo

30

2105

1176

40

2631

1765 15

3157

3529

15

2105

3529

0

5

10

15

20

25

30

35

40

Per

cent

Maximumimprovement

Moderateimprovement

Mildimprovement

Unchanged

Group A

Group B

Group C

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

The thesis entitled A Clinical study on the concept of Jara wsr to ageing process and its management by Rasayana yogardquo Consists of seven sections namelyThe Conceptual ContriveConcept of RasayanaDrug ContriveClinical ContriveDiscussionSummary and ConclusionAddenda

SUMMARY

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

CONCLUSIONCONCEPTUAL STUDY -

bullAkalaja Jara can be treated effectively

bullKala Swabhava Vayu and Virodhaka Bhava play a major role while Desha Ahara Sausthavam (Dietary Habits) Lifestyle and Avighata (disturbed Manasika Bhava-Stress) contribute to the Ageing Process

bullIn the present stressful environment disturbed Manasika Bhava like Shoka Chinta Bhaya etc are observed to be playing a vital role in the etiopathogenesis Premature Ageing

bullStress induced free radicals being highly reactive and unstable damage the cell membrane and cytosol and if unchecked hastens the process of Ageing

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

bullAntioxidants counteract the free radicals by inhibiting the generation of ROS or by directly scavenging or by raising endogenous antioxidant defenses

bullRasayana is being practiced effectively and extensively since ages It has preventive promotive and curative aspects hence best rejuvenator of the body

bullMaximum benefits of Rasayana can be yielded in Purva Vayas or Madhya Vayas

bullRasayana have the properties similar to Adaptogens Antioxidants Immunostimulants Nootropics Anabolics Tonics and other Geriatric remedies

bullThe selected drug Rasayana Yoga Ghana Vati is having the best properties of Rasayana with specific property of Dhatupushtikar (Rejuvenator) type of Rasayana which can slow down the Ageing Process by treating the main symptom Dhatukshaya and it is also Balya

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

CLINICAL STUDY - CONCLUSION CONThellipbullImproper food habit amp life style and Disturbed Manasika Bhava ndash stress are the main causative factors of Premature Ageing

bullSocio-economic status urban habitat and the type of work contribute to the manifestation of Daurbalya

bullVata Pittaja amp Rajasika Prakriti Madhyama amp Avara Sara Avara Sattva were found more prone for the development of Premature Ageing

bullMaximum sign amp symptoms of Ageing are related to DhatukshayaThe Results in three groups based after subjection to analytical statistical techniques reveals that

bullRasayana Yoga Ghana vati with Anupana of Milk Shows better result in Group lsquoArsquo ie40-50 years on cardinal Sign amp symptoms in comparison with other group because of early administration of Rasayana and before all sign and symptoms of ageing appeared Administration of Rasayana in this age group prevents excessive dhatu kshaya and thus prevents premature ageing and complication of normal ageing process

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

bullRasayana yoga Ghana Vati shows less result in Group lsquoCrsquoie61-70 years age group because at this point of age excessive deterioration of body occurs and its very difficult to rectify the dhatu kshaya

bullRasayana yoga Ghana Vati is Vaya sthapana Brihana Balya Rasayana Deepana Pachana Srotoshodhana Vata Shamaka properties Its pharmacodynamic properties prevent excessive degeneration and slow down the process of Dhatu Kshaya and thus prevent Premature ageing

bullAccording to literary profile Jara avastha is Yapya so the medication can provide only symptomatic relief for certain period But in premature ageing if Rasayana is taken at proper age along with good lifestyle and Diet as mentioned in texts as ldquoPoorve vayasi madhye vardquo it can prevent premature ageing

bullThough the trial drug of the present study that is Rasayana Yoga Ghana Vati proves to be effective in sign and symptoms of ageing it shows better result when administered at proper and early age before sign and symptoms of ageing gets aggravated

bullThe results at the end leads to the conclusion that administration of Rasayana Yoga Ghana Vati with milk as Anupana along with proper diet lifestyle free from stress some exercise Yogasans and Medication have certainly a positive role in inducing satisfactory level of benefits in the management of Jara Roga if patients follow advised regime

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip

Thank Uhellip

• Slide 1
• Slide 2
• Slide 3
• INTRODUCTION
• CRITERIA OF TOPIC SELECTION
• LIFE EXPECTANCY OF THE WORLD
• Slide 7
• Slide 8
• Slide 9
• Types of Jara
• Slide 11
• Etiological Factors of Ageing Related to Dietary Habits ldquowe are
• Etiological Factors Related to Life style
• The etiological factor of Ageing related to disturbed Mental H
• Slide 15
• Etiopathogenesis of Ageing
• Slide 17
• CHIEF COMPLAINTS
• Slide 19
• History of Geriatrics
• Slide 21
• Slide 22
• Slide 23
• Slide 24
• Some Theories of Ageing are given below
• Slide 26
• Slide 27
• Slide 28
• CHANGES OCCURING DURING AGEING
• Slide 30
• Slide 31
• Slide 32
• Slide 33
• Slide 34
• ANTI AGEING THERAPIES
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Procedure amp effect of Rasayana intake
• Slide 42
• Slide 43
• RASAYANA YOGA GHNA VATI
• PHARMACOLOGICAL ACTIVITIES OF DRUGS
• Slide 46
• Slide 47
• Slide 48
• RASAYANA YOGA GHANA VATI PERCENTAGE OF RASA PANCHAKA
• Action of Rasayana Yoga Ghana Vati
• RASAYANA YOGA GHANA VATI
• Importance of Anupan ( cowrsquos milk)
• Slide 53
• Slide 54
• Slide 55
• Slide 56
• SELECTION EXCLUSION CRITERIA
• CRITERIA OF DIAGNOSIS
• ASSOCIATED SYMPTOMS
• HEALTH PARAMETERS (DIAGNOSTIC CRITERIA)
• CLINICAL STUDY
• GROUPINGS
• Slide 63
• Slide 64
• Slide 65
• Slide 66
• Slide 67
• Slide 68
• Slide 69
• Slide 70
• Slide 71
• Slide 72
• Slide 73
• Slide 74
• Slide 75
• Slide 76
• Slide 77
• Slide 78
• Slide 79
• Slide 80
• Slide 81
• Slide 82
• Slide 83
• Slide 84
• Slide 85
• Slide 86
• Slide 87
• Slide 88
• Slide 89
• Slide 90
• Slide 91
• Slide 92
• Slide 93
• Slide 94
• Slide 95
• Slide 96
• Slide 97
• Slide 98
• Slide 99
• OVER ALL EFFECT OF THERAPY
• Slide 101
• Slide 102
• Slide 103
• Slide 104
• Slide 105
• Slide 106
• Slide 107
• Slide 108
• Slide 109
• Slide 110
• Thank Uhellip