22 – 23 September 2017 | Halle (Saale)

Genome Editing – Challenges for the FutureAnnual Meeting 2017

Invitation and Programme

ML – Member of Leopoldina

Thursday, 21 September 2017

9:00 am – 1:00 pm | Meeting of the Presidium (by invitation only)

2:30 – 5:30 pm | Meeting of the Senate (by invitation only)

Friday, 22 September 2017

6:30 – 7:30 pm | General Assembly of Leopoldina Members (by invitation only)

1

Friday, 22 September 2017

9:00 am – 1:00 pm | Opening Ceremony*

Musical Intermezzi HallensiaQuartett

Welcome Address Gunnar Berg ML, Halle (Saale) Vice-President of the Academy

Speech Jörg Hacker ML, Halle (Saale) President of the Academy

Awards Jörg Hacker ML, Halle (Saale) President of the Academy

- Cothenius-Medal- Carus-Medal- Schleiden-Medal- Mendel-Medal- Leopoldina Prize for Junior Scientists- Georg-Uschmann-Award for the History of Science

10:20 – 10:50 am | Coffee Break

Welcome Address Jörg Hacker ML, Halle (Saale) President of the Academy

Short Welcoming Speech Armin Willingmann Minister for Economy, Science and DigitalisationofthestateofSachsen-Anhalt

Short Welcoming Speech GeorgSchütte StateSecretaryattheFederalMinistryofEducationand Research

* The Opening Ceremony as well as the scientific presentations given in German will be translated simultaneously.

2

Speech The responsibility of science towards politics and the public Rolf-Dieter Heuer ML, Bad Honnef

11:50 – 12:00 am | Break

Introduction Jörg Hacker ML, Halle (Saale) President of the Academy

Keynote Lecture Evolution – natural or man-made Ernst-Ludwig Winnacker ML, München

1:00 – 2:00 pm | Lunch

3

Scientific Session I | Basics of Programmable Gene Scissors

Chair: Franz Hofmann ML, München

2:00 – 2:45 pm TALENs – Programmable gene scissors for plants* Jens Boch, Hannover

2:45 – 3:30 pm CRISPR-Cas9 – A game changer in genome engineering: Origins and overview EmmanuelleCharpentierML,Berlin

3:30 – 4:15 pm Stem cell technology, gene editing and disease research Rudolf Jaenisch ML, Cambridge, MA (USA)

4:15 – 4:45 pm | Coffee Break

Scientific Session II | Genome Editing in Clinical Context

Chair: Claus R. Bartram ML, Heidelberg

4:45 – 5:30 pm Correction of Duchenne Muscular Dystrophy by genomic editing Eric Olson, Dallas (USA)

5:30 – 6:15 pm Genome editing for the treatment of HIV infections* Boris Fehse, Hamburg

8:15 pm | Leopoldina Lecture

Chair: Jörg Hacker ML, Halle (Saale)

How the genes determine our lives, and why women and men are different* Axel Meyer ML, Konstanz

4

Saturday, 23 September 2017

Scientific Session III | Application Prospects

Chair: MartinLohseML,Berlin

8:30 – 9:15 am The implications of CRISPR-based gene-drive systems Ethan Bier, San Diego (USA)

9:15 – 10:00 am T.B.A

10:00 – 10:45 am Precision surgery in plant genomes: methods, applications and regulatory consequences* Ralph Bock ML, Potsdam-Golm

10:45 – 11:15 am | Coffee Break

Scientific Session IV | Societal Prospects

Chair: Frank Rösler ML, Hamburg

11:15 – 12:00 am Would there be a market for genetically modified food in Germany? – A social psychological analysis* Wolfgang Stroebe, Groningen (NL)

12:00 – 12:45 pm Pros and cons of genome editing in human embryos Robin Lowell-Badge, London (UK)

12:45 – 2:30 pm | Lunch

5

2:30 – 4:30 pm | Panel Discussion

Chair: Kathrin Zinkant, Süddeutsche Zeitung Berlin

Pros and cons of germline editing and non- heritable somatic gene therapy Claus R. Bartram ML, Heidelberg Silja Vöneky, Freiburg BettinaSchöne-SeifertML,Münster Volker Gerhardt, Berlin BettinaKeller,JungeAkademie,Berlin 4:30 – 5:00 pm | Coffee Break

Scientific Session V | International Legal Perspectives

Chair: Ursula M. Staudinger ML, New York (USA)

5:00 – 5:45 pm Human embryo genome editing: Regulation in Israel and ethical perspectives Ephrat Levy-Lahad, Jerusalem (Israel)

5:45 – 6:30 pm Human embryo genome editing: Regulation in the UK and ethical perspectives AndyGreenfield,Harwell(UK)

6:30 – 7:15 pm Human genome editing in the context of the German Embryo-Protection-Act* Jochen Taupitz ML, Mannheim

6

7:15 pm | Summary

Ulla Bonas ML, Halle (Saale) Vice-President of the Academy

8:30 – 10:00 pm | Conference Dinner (by invitation only)

Venue: DORMERO Kongress- & Kulturzentrum Halle (Saale) Leipziger Straße 76 Franckestraße 1 06110 Halle

7

Social Event

Sunday, 24 September 2017

Excursion to Panorama Museum Bad Frankenhausen(for Academy members and accompanying persons only)

08.15 am Departure in front of the Dorint Hotel Charlottenhof Dorotheenstraße 12, 06108 Halle (Saale)09.30 am Arrival in Bad Frankenhausen10.00 – 11.00 am Guided Tour of the Panorama Museum11.00 – 11.30 am Documentary film „Schlacht am Bild“11.45 am Return to Halle (Saale)1.15 pm Arrival in Halle (Saale) at Dorint Hotel Charlottenhof

This year‘s excursion takes participants to the Panorama Museum in Bad Franken-hausen/Thüringen and should be seen in the context of this year’s Reformation Jubi-lee (1517-2017).On the occasion of the 450th anniversary of the German Peasants‘ War in 1975, a panoramic memorial site was erected on historic grounds, on a battlefield (“Schlacht-berg”). Leipzig’s most important painter, Werner Tübke (1929-2004), designed and painted a 360° depiction of the battle. Tübke was – together with Bernhard Heisig, Heinz Zander and Wolfgang Mattheuer – a member of the “Leipziger Schule” and also served as the rector of the ”Hochschule für Grafik und Buchkunst Leipzig ”. In 1976, he accepted the assignment under the condition that the panorama painting should also show the transition from the medieval to the modern age. The original intention of the GDR‘s cultural policy was to create a memorial site that idealised the Peasants’ War, and particularly the figure of Thomas Müntzer (1489-1525) in the sense of a socialist view of history. Tübke successfully prevented that his art was instrumental-ised in this way. First, he studied Renaissance paintings, made sketches and produced many smaller studies of the final monumental painting. Subsequently, he developed a 1:10 scale model, which later served as a template for the projection of the 360° image. After further preparatory work he began in 1983 with the actual transfer to the big screen. Tübke was temporarily supported by up to five other artists. On 16 Oc-tober 1987 he completed his work and put his signature under the finished unique painting. Due to the monumentality and the craftsmanship, the 14 x 123 meter work of art is also often referred to as the ”Sixtina of the North“.

8

To confirm your participation, we ask you to register with the enclosed reply card.Also, please transfer the amount of 30 € per person to the bank account of theLeopoldina by 31 August 2017. A buffet lunch will not be served.

Please use the following account:

Beneficiary: Akademie LeopoldinaBank: SaalesparkasseIBAN: DE 4180 0537 6203 8606 0855BIC (SWIFT): NOLADE21HAL

9

We would like to thank Alfried Krupp von Bohlen and Halbach-Stiftung for the generous support of the annual meeting.

We would like to thank the Wilhelm and Else Heraeus-Stiftung for theirgenerous support for a programme which enables – in collaboration withGesellschaft Deutscher Naturforscher und Ärzte (GDNÄ) – the participationof secondary school pupils in the Leopoldina Annual Meeting.

10

Hotel Reservation

The Leopoldina has provisionally reserved rooms for participants at the hotels listed below. Participants are advised to make their individual booking under the keyword “Leopoldina” no later than 25th of August 2017. Room booking for speakers and senators will be made by the Leopoldina.

City-Hotel Am WasserturmLessingstraße 8, 06114 Halle (Saale)Tel. +49 (0) 345-298 20, Fax: +49 (0) 345-512 65 43E-Mail: info@city-hotel-halle.deSingle: 66,00 €Walking distance: approx. 20 minutes

Dorint Hotel CharlottenhofDorotheenstraße 12, 06108 Halle (Saale)Tel. +49 (0) 345-292 36 06, Fax: +49 (0) 345-292 31 00E-Mail: reservierung.halle-charlottenhof@dorint.comStandard Single: 91,00 €, Double: 117,00 €, Comfort Single: 101,00 €, Double: 127,00 €Walking distance: approx. 20 minutesTram from Riebeckplatz – Moritzburgring (line 7) approx. 10 min. + 2 min. by foot

B&B-Hotel Halle (Saale)Hallorenring 9, 06108 Halle (Saale)Tel. +49 (0) 345-2795 73 50, Fax: +49 (0) 345-2795 73 69E-Mail: halle-saale@hotelbb.comSingle: 57,50 €, Double: 76,00 €Walking distance: approx. 10 minutes

Other overnight accommodation possibilities can be found at:Stadtmarketing Halle GmbHMarktschlösschenMarktplatz 1306108 Halle (Saale)Tel. +49 (0) 345-122 79 10, Fax: +49 (0) 345-122 79 22E-Mail: info@stadtmarketing-halle.deInternet: www.stadtmarketing-halle.de

11

Venue

Nationale Akademie der Wissenschaften LeopoldinaJägerberg 106108 Halle (Saale)

Getting to the Leopoldina Halle

From Leipzig/Halle airportby taxi in 30 to 40 minutes (around 40 €) or with Deutsche Bahn in 15 minutes (trains run hourly)

From Halle´s main train stationby taxi in 5 to 10 minutes or by tram route 7 (to Kröllwitz) alighting at Moritzburg-ring

12

Notes

ConatctDeutsche Akademie der Naturforscher Leopoldina e. V.Nationale Akademie der Wissenschaften

Telefon: +49 (0)30 472 39 – 600E-Mail: jahresversammlung2017@leopoldina.orgwww.leopoldina.org

Cover: fotolia.com | ibreakstock

RegistrationThe Annual Assembly is open to the general public. No conference fee is required. Participants have to registerbefore 31 August 2017. Please register here:www.leopoldina.org/de/jv-2017 or use our registration card.