way to "perfect" the human condition.?

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Transcript of way to "perfect" the human condition.?

  • 1. Genetics .....the way to perfect the human condition.....??

2. 3. 4. 5. Genetics - the good.and the bad 6. Design-a-Kid Athletic Ability Creativity Intelligence Bravery 7. Height, Strength Cloned human growth hormone 8. Too much..... Nitrate The Fugates of Troublesome Creek(Trost et al, Science 82, 1982). 9. Too Much Growth Hormone Acromegaly 10. Andre the Giant Height:74 Weight:500 lbs 11. At 7 feet 8 inches, De-Fen Yao, is considered the world's tallest woman. Her abnormal growth was due toAcromegaly , a disease resulting from a tumour on the pituitary gland causing it to pump out excess growth hormone, that inflicted her when she was 15 years old 12. Unregulated Production of Growth Hormone 13. Unregulated Production of Growth Hormone 14. Unregulated Production of Growth Hormone 15. Creativity Virginia Woolf Vincent Van Gogh 16. Manic Depression? Individuals recognized for creativity are ~40x more likely to be diagnosed as manic depressive Creativity 17. Bravery 18. Bravery Thrill-seeking? 19. Genetics - Old and New 20. Gregor Mendel the first geneticist Conducted genetic crosses with pea plants 21. 22. Trait Studied Dominant Form Recessive Form SEEDSHAPE SEEDCOLOR PODSHAPE PODCOLOR FLOWERCOLOR FLOWERPOSITION STEMLENGTH tall dwarf long stem short stem purple white yellow green wrinkled inflated yellow green smooth wrinkled Fig. 11.5, p. 178 23. Cross-fertilizing peas carpel stamen 24. Mendel looked at 34 different physical characteristics (traits) of pea plants that varied among plant populations Then he made quantitative calculations of these traits as they appeared in subsequent generations 25. Example Yellow Seeds (Y)X Green Seeds (y) 26. Example All Yellow Yellow Seeds (Y)X Green Seeds (y) Yellow: dominant Green:recessive 27. Example All Yellow Yellow Seeds (Y)X Green Seeds (y) Self-fertilization Yellow: dominant Green:recessive 28. Example All Yellow Yellow Yellow Yellow Green Yellow Seeds (Y)X Green Seeds (y) Self-fertilization Yellow: dominant Green:recessive 29. Example All Yellow Yellow Yellow Yellow Green All Green Yellow Seeds (Y)X Green Seeds (y) Self-fertilization Yellow: dominant Green:recessive 30. Example All Yellow Yellow Yellow Yellow Green All Yellow All Green Yellow Seeds (Y)X Green Seeds (y) Self-fertilization Yellow: dominant Green:recessive 31. Example All Yellow Yellow Yellow Yellow Green YellowYellowYellowGreen All Yellow All Green Yellow Seeds (Y)X Green Seeds (y) Self-fertilization Yellow: dominant Green:recessive 32. Mendel proposed that:

  • Traits segregate as discrete units ( allelesorgenes )
  • Indiploidorganisms, alleles come in pairs (one inherited from each parent)
  • If the two alleles in a pair are heterozygous (i.e, different), one allele will bedominantand the other allele will berecessive
  • A homozygous pair of alleles are the same
  • A heterozygous pair of alleles are different
  • Inheritance of alleles is random

33. Phenotype the appearance of the organism 34. Phenotype the appearance of the organism 35. 3 1 Phenotype the appearance of the organism dominantphenotype 75% recessivephenotype 25% 36. 3 1 Phenotype the appearance of the organism Genotype the genetic composition of the organism dominantphenotype 75% recessivephenotype 25% Yy Yy 37. 3 1 Phenotype the appearance of the organism Genotype the genetic composition of the organism dominantphenotype 75% recessivephenotype 25% Yy Yy Y Y Y y Y y y y 38. 3 1 Phenotype the appearance of the organism Genotype the genetic composition of the organism dominantphenotype 75% recessivephenotype 25% Yy Yy 1 2 1 Y Y Y y Y y y y 39. 3 1 Phenotype the appearance of the organism Genotype the genetic composition of the organism dominantphenotype 75% recessivephenotype 25% Yy Yy 1 2 1 hetero- zygous 50% homozygous dominant 25% homozygous recessive25% Y Y Y y Y y y y 40. The Punnett Square:method to determine genotypes of a genetic cross Y y Yy Yy Y y Y Y Y y Y y y y One parent The other parent 41. Mendel's First Law:Two members of agene pair segregatefrom each other into the gametes, whereby one half of the gametes carries one of the traits, the other half carries the other. ALawis "adescriptive generalizationabout how some aspect of the natural world behaves....under stated circumstances ". Mendel's First Law:Two members of agene pair segregatefrom each other into the gametes, whereby one half of the gametes carries one of the traits, the other half carries the other. 42. Mendels Data Smooth Wrinkled 43. Mendels Data Smooth Wrinkled Predicted 750 250 44. Mendels Data Smooth Wrinkled Predicted 750 250 Observed 751 249 746 254 758 242 45. Mendels Data Smooth Wrinkled Predicted 750 250 Too good to be true? Observed 751 249 746 254 758 242 46. Trait Studied Dominant Form Recessive Form Dominant-to- Recessive Ratio SEEDSHAPE SEEDCOLOR PODSHAPE PODCOLOR FLOWERCOLOR FLOWERPOSITION STEMLENGTH 2.96:1 3.01:1 2.95:1 2.82:1 3.15:1 3.14:1 2.84:1 tall dwarf long stem short stem purple white yellow green wrinkled inflated yellow green smooth wrinkled Fig. 11.5, p. 178 47. Mendel's Second Law:During gamete formation the segregation of one gene pair is independent of all other gene pairs 48.