Genetics Conference Presentation Carl Arnold · 2016-05-10 · Genetics Conference Presentation...
Transcript of Genetics Conference Presentation Carl Arnold · 2016-05-10 · Genetics Conference Presentation...
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Outline
• Headline findings from the Infant Death Audit
• Schools work
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Background
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Features of Local Deaths: MothersNorth Kirklees South
Age < 18 yrs 4% 3%
> 35 yrs 13% 21%
SC 4-6 54% 54%
Ethnicity White 45% 50%
Pakistani 42% 31%
Previous Pregnancy – not A+W White 57% 55%
Pakistani 76% 46%
Screening Genetic White 70% 48%
Pakistani 87% 100%
Non Genetic White 85% 100%
Pakistani 100% 86%
Consanguinity Pakistani 74% 67%
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Features of Local Deaths: Mothers 2
North Kirklees South
Smoking at Booking White 55% 36%
Baby born prem 34% -
Baby born at term 15% -
Alcohol at Booking White 21% 24%
BMI Obese White 17% *
Pakistani 32% *
At least Overweight White 50% 26%
Pakistani 53% 69%
Diabetes 10% 7%
Delivery by emergency section 37% 30%
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Features of Local Deaths: Infants
North Kirklees South
Boys 62% 51%
Premature Birth (<37/40) White 65% 58%
Pakistani 42% 53%
Multiple Births White 16% 18%
Pakistani 6% 3%
Cause of death
Prematurity White 43%
Pakistani 25%
Congenital abnormality White 25%
Pakistani 52%
FH cong abn + cong abn cause of death 76% 52%
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Deaths due to congenital abnormality
• Family history of congenital abnormality
– Assoc with cong abn as cause of infant deaths
– + consanguinity often linked, esp.
intergenerational
• Consanguinity 3 in 4 Pakistanis
– Congenital abnormality - cause of death in 59%
• In Pakistanis, even when consanguinity
absent, congenital abnormalities greater %
cause of death than White
All Kirk
lees
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Work so far
• ESOL Classes
• Training for Professionals/community leaders
• Outreach work with local community leaders
• Awareness raising with
public/community/voluntary groups
• Auntie Pam’s signposting service
• Work with local schools
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The commissioning cycle
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Year 9-10
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You and Your Genes
• Lesson 6: Predicting inheritance
• Lesson 7: Decision making – genetic testing
of fetuses
• Lesson 8: Decision making – more genetic
testing
• Lesson 9: Using genetic testing
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What are dominant and recessive
genes?
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Recessive Inheritance
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Moving the Lesson away from the
local area
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Giving the Lesson a local context
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Outcomes
• Group discussion to talk about who should
talk about this issue and the role of genetic
counselling/testing
• Prematurity main cause for white babies
• Genetic abnormality main cause in Pakistani
babies
• Most genetic disorders are often rare
• To promote awareness of genetic
screening/counselling
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What Next?
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Thank you