Gene Editing: Swine in Biomedical Research (Angelika Schnieke)
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Transcript of Gene Editing: Swine in Biomedical Research (Angelika Schnieke)
8/20/2019 Gene Editing: Swine in Biomedical Research (Angelika Schnieke)
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Tegbm`sgbe Um`vers`tät Aómgbem
Keme Ed`t`mk
Im`aics `m f`haed`gic reseirgbWw`me
Imkec`ji Wgbm`eje
8/20/2019 Gene Editing: Swine in Biomedical Research (Angelika Schnieke)
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
7> yeirs hl kemet`g emk`meer`mk hl cirke im`aics
9025-6>95
Fr`el b`sthry? Aetbhds lhr kemet`g emk`meer`mk
Kemet`giccy ahd`l`ed p`ks lhr f`haed`gic reseirgb
[by kemhae ed`t`mk
8/20/2019 Gene Editing: Swine in Biomedical Research (Angelika Schnieke)
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
Wecegt`ve freed`mk hl pcimts imd im`aics
L`rst dhaest`git`hm 96>>> FG (dhk)
‐Ummituric' byfr`ds 7>>> yeirs ikh
(Auces? aice dhmjey imd i aire)
B`sthry hl kemet`g ahd`l`git`hm
8/20/2019 Gene Editing: Swine in Biomedical Research (Angelika Schnieke)
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
902> Khrdhm, Vuddce 9st trimskem`g ahuse prhduged fy DMI a`grh`moegt`hm
9027 ^ica`ter, Fr`mster buaim KB trimskem`g ahuse
–Tbe `apc`g`t phss`f`c`ty `s th use tb`s
tegbmhchky th st`aucite rip`d krhwtb
hl ghaaerg`iccy vicuifce im`aics‑
Fectv`cce p`k (KB)
9025 ^ica`ter, Fr`mster ^rhdugt`hm hl trimskem`g
riff`ts, sbeep imd p`ks fy a`grh`moegt`hm.
7> yeirs hl kemet`g emk`meer`mk hl cirke im`aics
9025-6>95
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
902< ^bira`mk
Ipprhved prhdugts
6>>< Imt` tbrhaf`m @@@
6>9> G9 esterise `mb`f`thr
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
^bira`mk? reghaf`mimt l`fr`mhkem- l`fr`m seicimt, bieahstit, imt`-idbes`ve
gbi`ms
77> jDi bexiaer
Auct`pce d`sucpb`des
L`fr`mhkem
Umtreited ghmtrhc
it 94 diys
extems`ve idbes`hms
L`fr`m @ treited
it 94 diys
mh idbes`hms
L`fr`m @
phcyaer
L`fr`m ahmhaer
`m ig`d`g fuller
Meutric`s`mk
fuller
8/20/2019 Gene Editing: Swine in Biomedical Research (Angelika Schnieke)
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
Driwfigjs hl prhmugceir a`grh`moegt`hm
DMI a`grh`moegt`hm? hmcy 39-5% trimskem`g im`aics
Trimsphshms? s`ze c`a`tit`hm
\`ric vegthrs? silety ̀ ssues, s`ze c`a`tit`hm
Mh ghmtrhc hver wbere tbe trimskeme `mtekrites
Trimskeme imicys`s hmcy phss`fce ilter f`rtb
Mh ghmtrhc hver sex hl lhumder - aices icchw lister lchgj expims`hm
Hmcy keme idd`t`hm phss`fce - mh keme decet`hm, ahd`l`git̀ hm, sufst`tut`hm
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
Wbeep zykhte
^`k zykhte ^`k zykhte ilter gemtr`lukit`hm
A`grh`moegt`hm? sbeep, p`k
@aikes? B. M`eaim, Air`emsee
Wbeep zykhte
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
DMI a`grh`moegt`hm? hmcy 39-5% trimskem`g im`aics
Trimsphshms? s`ze c`a`tit`hm
\`ric vegthrs? silety ̀ ssues, s`ze c`a`tit`hm
Mh ghmtrhc hver wbere tbe trimskeme `mtekrites
Trimskeme imicys`s hmcy phss`fce ilter f`rtb
Mh ghmtrhc hver sex hl lhumder - aices icchw lister lchgj expims`hm
Hmcy keme idd`t`hm phss`fce - mh keme decet`hm, ahd`l`git`hm, sufst`tut`hm
Driwfigjs hl prhmugceir a`grh`moegt`hm
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
[bit dh we wimt8
[e wimt? 9>>% trimskem`g im`aics
Imicys`s hl trimskem`g stitus felhre kemerit`hm hl im`aics
Deg`de tbe sex hl im`aics
Ghmtrhc hver wbere tbe trimskeme `mtekrites
Aetbhds lhr preg`se aim`pucit`hm hl tbe im`aic kemhae
Bhahchkhus reghaf`mit`hm/keme tirket`mk
Gecc aed`ited trimskemes`s
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Tegbm`sgbe Um`vers`tät Aómgbem
Tirketed keme ahd`l`git`hm
EW hr `^W geccs
Fcisthgyst
Tirket`mk \egthr Trimslegt`hm
Bhahchkhus reghaf`mit`hm
Wecegt`hm
Whait`g geccs
Gb`aer`g im`aics
Ahuse EW geccs (9029) C`vesthgj
EW geccs `^W geccs
^hrg`me `^W 88
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
Eafryh trimsler ^rekmimgy
(95> diys)
Gecc trimsler
Hhzyte
Emugceit`hm
Ecegtrh lus`hm
Eafryh gucture
Kemet`g aim`pucit`hm
DMI, VMI imicys`s
Whait`g gecc
Wciukbter bhuse
@m v`trh
@m v`vh
7VVeduge
Vel`me
Vepcige
Vepcige
Veduge
900< Dhccy
Vel`me
Tirketed keme ahd`l`git`hm
Mugceir trimsler
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
900< L`rst im`aic gchmed lrha im iduct shait`g gecc (Dhccy)
900; L`rst gchmed trimskem`g ciaf (^hccy, Ahccy, Bhccy, Hccy)
9000 L`rst keme tirket`mk `m c`vesthgj (D`imi imd Gup`d)
6>>> L`rst gchmed p`ks lrha im iduct shait`g gecc (A`cc`e, Gbr`sti,
Icex`s, Girrec & Dhtgha)
B`sthry hl kemet`g ahd`l`git`hm
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
7> yeirs hl kemet`g emk`meer`mk hl cirke im`aics
9025-6>95
Fr`el b`sthry? Aetbhds lhr kemet`g emk`meer`mk
Kemet`giccy ahd`l`ed p`ks lhr f`haed`gic reseirgb
[by kemhae ed`t`mk
8/20/2019 Gene Editing: Swine in Biomedical Research (Angelika Schnieke)
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
Femgb th feds`de
Fis`g reseirgb
Estifc`sb`mk mew ahdecs
^rhhl hl pr`mg`pce
Trimscit`hm `mth tbe gc`m`g
Wuggess rite 9/5.>>>
Gc`m`gic tr`ics
^it`emts
Cirke im`aic ahdecs lhr f`haed`g`me
^regc`m`gic tests
\ic`dit`hm / Wilety
W`a`cir`ty ̀ m pbys`hchky/imithay
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
C`meir krhwtb `m c` le expegtimgy hver cist 9;> yeirs@mgreised c`le expegtimgy `mgreised gimger `mg`demge
Bicl tbe fif`es fhrm `m Oipim `m 6>>;
w`cc c`ve th fe 9>;
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
[by dh we meed cirke im`aic gimger ahdecs8
Ahuse ahdecs
Umt`c regemtcy, kemet`giccy del`med ahdecs hmcy `m a`ge
Ahuse ahdecs dh mht icwiys repc`gite buaim d`seise pbemhtype
Cirke im`aic ahdecs - p`k
W`a`cir s`ze th buaim
Use hl buaim s`zed equ`paemt (surkery, rid`it`hm treitaemt, `aik`mk)
Chmker c`lespim tbim a`ge
Chmk`tud`mic stud`es `m s`mkce `md`v`duic
W`a`cir pbiraighj`met`gs
Gim fe led buaim d`et
D`seise pbemhtype gchser th buaims (8)
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchkyMiture Vev`ews Gimger 2, 72;-702 (Aiy 6>>2)Lc`s`jhwsji et ic. 6>96: Kistrhemterhchky 947, 99;7-99;5
^hrg`me gimger ahdec? Ghchregtic gimger
Keme tirket`mk `m shait̀ g geccs, secegt`hm
Mugceir trimsler
ahuse ≮ buaim 1 p`k
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
Hrkim speg`l`g `mdug`fce hmghkem`g autit`hm hl p57
Keme tirket`mk `m shait`g geccs, secegt`hm
Mugceir trimsler
Airjer keme expressed
T^57V9<;B s`cemt*
chx-si-fs-phcyI-phcyI-phcyI-chxGre
reghaf`mise
Trimslegt`hm, secegt`hm
^rhahter Gre reghaf`mise
Mugceir trimsler
R
T^57V9<;B expressed*
chx
Hrtbhchkues
Buaim V9;5B
Ahuse V9;6B
^`k V9<;B
Ceugbs et ic., 6>96 imd C` et ic., 6>95
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
D`seise Kemet`g ahd`l`git`hm Veleremge
Gimger
\ir`hus gimgers
Fisic gecc girg`mhai
Freist gimger
–
Ghchregtic gimger
T^57
KC@6
v-B-VIW
FVGI9
I^G
Ghmd`t`hmiccy igt`vited tirketed autit`hm
Buaim trimskeme
AAT\ d`regted v-B-ris trimskeme
Jmhgjhut
Tirketed trumgit`mk autit`hms
Ceugbs 6>96
AgGicci-Airt`m 6>9>
Piaijiwi 9000
Cuh 6>99
Lc`s`jhwsji 6>96
Gird`hvisgucir d`seises
Itberhsgcerhs s̀Bypergbhcesterhcea`i
M`tr`g hx`de rekucit`hm
Bydrhkem perhx`de rekucit`hm
Itberhsgcerhs s̀
Bypertr`kcyger`dea`i
CDCV
^GWJ0
MHW7
Giticise
^^IV-K
I^HG7
Jmhgjhut
Buaim autimt trimskeme
^hrg`me trimskeme
Buaim trimskeme
Jmhgjhut
Buaim trimskeme
Gircshm 6>96 Ic-Aisbbid` 6>97
Bih 6>><
[byte 6>99
Pimk 6>99
[e` 6>99
D`ifetes aecc`tus
D`ifetes type 6
^MDAD`ifetes type 7 (AHDP)
K@^V
@MWBML-9ι
Buaim dha`mimt mekit`ve autimt trimskeme
^hrg`me autimt trimskemeBuaim dha`mimt mekit`ve autimt trimskeme
Vemmer 6>9>
Vemmer 6>97Uaeyiai 6>>0
Meurhdekemerit`ve d`seises
Iczbe`aer‐s d`seise
Bumt`mkthm‐s d`seise
Wp`mic ausgucir itrhpby
I^^
BTT
WAM9
Buaim autimt I^^ trimskeme
Buaim autimt trimskemes
Jmhgjhut
Tijeugb` 6>>>
Fixi 6>97
Chrshm 6>99
Hpbtbica`g meurhdekemerit`ve d`seises
Vet`m`t`s p`kaemthsiWtirkirdt d`seise-7
VBHECH\C4
^hrg`me imd buaim autimt trimskemesBuaim autimt trimskemes
Vhss 6>96Whaaer 6>99
Htber d`seises
Gyst`g l`frhs`s
Dugbemme ausgucir dystrhpby
Bieahpb`c`i I
WG@D
GLTV
DAD
L2
@C6VK
Jmhgjhut
Jmhgjhut
Jmhgjhut
Jmhgjhut
Vhkers 6>>2
Jcya`uj 6>97
Jisb`wijuri 6>97
Wuzuj` 6>96
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
7> yeirs hl kemet`g emk`meer`mk hl cirke im`aics
9025-6>95
Fr`el b`sthry? Aetbhds lhr kemet`g emk`meer`mk
Kemet`giccy ahd`l`ed p`ks lhr f`haed`gic reseirgb
[by kemhae ed`t`mk
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
VHWI 6<
VIK9
@C6Vη
KKTI9
CDCVDAD
^57
I^G
JVIW
GLTV
FVGI9
WAM9
@k beivy gbi`m
@k c`kbt gbi`m
VHWI 6<
VIK9
@C6Vη
KKTI9
CDCVDAD
^57
I^G
JVIW
GLTV
FVGI9
WAM9
@k beivy gbi`m
@k c`kbt gbi`m
Keme tirket`mk `s `mell`g`emt requ`res guctured geccs
Keme tirket`mk `m shait`g geccs `s very `mell`g`emt~9>>x cess ell`g`emt tbim `m ahuse EW geccs
Lew kemes tirketed `m sw`me `m tbe cist 95 yeirs
\ery lew exiapces hl ghmd`t`hmic keme tirket`mk
Ghapcex aim`pucit`hm very, very `mell`g`emt
Tirketed ahd`l`git`hm hmcy hm 9 iccece freed`mk th bhahzykhs`ty
[by kemhae ed`t `mk
9 6 47
6WI fsr 7*
Chx Chx
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
Keme ed`t`mk `s very ell`g`emt (=4>%)
Ed`t`mk fhtb icceces
Auct`pce tirket kemes s`auctimehuscy
Gim fe dhme `m geccs hr eafryh
Megessiry vegthrs ire eisy th ghmstrugt Ippc`ed is DMI, VMI, prhte`m
[by kemhae ed`t `mk
9 6 47
6WI fsr 7*
*Chx Chx
L`k. Miture ^rhthghcs 0, 29>‗26; (6>94)
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
Keme ed`t`mk `s very ell`g`emt
Ed`t`mk fhtb icceces
Auct`pce tirket kemes s`auctimehuscy
Gim fe dhme `m geccs hr eafryh
Megessiry vegthrs ire eisy th ghmstrugt
Ippc`ed is DMI, VMI, prhte`m
[by kemhae ed`t `mk
L`k. Miture ^rhthghcs 0, 29>‗26; (6>94)
Keme ed`t`mk
Imicys`s hl s`mkce gecc gchmesDMI, VMI, ^rhte`m
Mugceir
trimsler
^`kcet w`tb pred`gted
ahd`l`git`hm
Imiciys`s phst pirtua
Ahd`l`git`hm8
Ahsi`g`sa8
Keme ed`t`mk
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
Keme ed`t`mk? exiapce xemhtrimspcimtit`hm
Kemhae-w`de `migt`vit`hm hl phrg`me emdhkemhus retrhv`ruses (^EV\s).
Pimk et ic., Wg`emge. 6>95 Mhv 6;:75>(<6<4)?99>9-4.
<6 ^EV\s
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
Keme ed`t`mk `s very ell`g`emt
Ed`t`mk fhtb icceces
Auct`pce tirket kemes s`auctimehuscy
Gim fe dhme `m geccs hr eafryh
Gim fe dhme `m icc speg`es (mh requ`reaemt lhr EW gecc hr WGMT)
Megessiry vegthrs ire eisy th ghmstrugt
Ippc`ed is DMI, VMI, prhte`m
[by kemhae ed`t `mk
L`k. Miture ^rhthghcs 0, 29>‗26; (6>94)
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
Buaim phcygchmic imt`fhd`es- ahre ellegt`ve tbim aIfs lhr piss`ve `aaumhtberipy
- a`a`g mituric `aaume resphmse
Gim hmcy fe prhduged `m pehpce hr trimskem`g im`aics
Vequ`re im`aics cirker tbim a`ge lhr prhdugt`hm hl idequite quimt`t`es hl serua.
Buaim phcygchmic imt`fhd`es
prhduged `m riff`t
Viff`t mugceir trimsler? d`ll`guct
_ijbirtgbemjh et ic., 6>99 F`hc Veprhd 24
^utit`ve riff`t EW geccs
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
@aaumhkchfuc`m keme d`srupt`hm us`mk _`mg L`mker Mugceises6>99 Lc`s`jhwsji et ic ^ChW HME <(<)? e69>45
_LM VMI
_LM VMI
+ tirket`mk vegthr DMI
prhmugceus & gythpcisa
Tirketed repcigeaemt `mup th 92% hl letuses.
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
^hrg`me gimger ahdecs
JVIW, T^57, I^G `mvhcved `m aimy d`lleremt types hl gimger
JVIW? pimgreis, cirke/saicc `mtest`me, cumk, test`s, c`ver, tbyrh`d
T^57? ahst buaim tuahurs, saicc gecc cumk girg`mhai
I^G? Ghchregtic gimger, kistr`g imd duhdemic aic`kmimg`es, pimgreis, f`c`iry trigt,
kicc fcidder, bepithfcisthais
Oust idd Gre
@m v`vh GV@W^V/Gis0 ippc `git`hm
Oust idd 9 hr ahre ku`de VMIs
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
^bira`mk
Vekemerit`ve
Aed`g`m
D`seiseahdecs
Kemet`giccy ahd`l `ed
cirke im`aics
@aprhv`mk Beictb
^ r h d u g t s
E m v ` r h m a e m t
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
Kemhae ed`t`mk `m sw`meFeyhmd f`haed`g`me
Kemhae ed`t`mk `m sw`meFeyhmd f`haed`g`me
Ed`ted kemes Tirketed kemes
A`grh p`ks is pets92 | MITUVE | \HC 56< | 9 HGTHFEV 6>95
TICEMs ̀ migt`vited 9 hl 6 ghp`es hl tbe krhwtb bhrahme regepthr keme (KBV)
‒Dhufce-ausgced‐ p`ksMiture 567, 97‗94 (>6 Oucy 6>95)
Autit`hm `m tbe ayhstit`m keme (AWTM).
L`kbt`mk Ilr`gim Ww`me Lever
–^`k 6<‑ Vhsc`m @mst.
Wecegt`ve trimsler hl mituriccy hggurr`mk keme vir`imts
Ictermit`ve aetbhd th freed`mk
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
Kemet`g emk`meer`mk
Kemhae emk`meer`mk / Kemhae ed`t`mk
Icchws preg`se exgbimke hl s`mkce hr auct`pce fise pi`rs `m tbe kemhae
^rerequ`s`te? kemhae sequemge
Ghmtrhc? kemhae sequemg`mk
Aiaaic`im Kemhae
7.7 x 9>0 fp
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
Kemet`g ahd`l`git`hm? Gis0-fised ippc`git`hms
Wimder & Ohumk, Miture F`htegb Ipr`c 94
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Tegbm`sgbe Um`vers`tät Aómgbem
Kemet`g emk`meer`mk hl cirke im`aicsWtite hl tbe irt
GV@W^V/Gis0
Ceid`mk thhc `m tbe l`ecds hl symtbet`g f`hchky imd kemhae emk`meer`mk.
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
GHWT Igt`hm FA97>2
Wbir`mk Idvimges hm Cirke Im`aic Ahdecs
bttp?//www.siciia.kemzemtrua.cau.de/
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
Tegbmhchk`es lhr kemet`g aim`pucit`hms ire ivi`cifce imd ghmt`mue th
`aprhve
@m `tsecl mht i sull`g`emt reishm th prhduge kemet`giccy ahd`l`ed cirkeim`aics
Lhr eigb prhoegt r`sj imd femel`ts bive th fe evicuited
Im`aic weccfe`mk bis th bive i b`kb pr`hr`ty
@l `t prhv`des imd idvimtike lhr tbe emv`rhmaemt, tbe beictb hr weccfe`mk hl
buaim hr im`aic, tbim kemet`g ahd`l`git`hm (`mgc. keme ed`t`mk) `s i
phwerluc imd preg`se thhc.
Lew cifhrithr`es bive gipig`ty th girry hut cirke im`aic exper`aemts
T`ae imd ghst `mtems`ve meed th ghhrd`mite ellhrts
Etb`gic imd pufc`g ghmgerms meed th fe iddressed
Kemet`g emk`meer`mk hl cirke im`aics
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
Im`aic ahdecs
[hrj w`tb im`aics `s str`gtcy rekucited
Im`aic exper`aemts requ`re ipprhvic fy khvermaemtic fhdy
F`haed`g`me
Gc`m`gic imd rekucithry meed lhr devechpaemt hl cirke im`aic ahdecs
\ir`hus ahdecs hl buaim d`seises ire fe`mk devechped
Kemhae ed`t`mk? hme ahre thhc `m tbe kemet`g thhcfhx Veduge, Vel`me Ikr`gucture
I thhc th `aprhve im`aic beictb (d`seise res`stimge/prhtegt`hm), tri`ts
Veduge emv`rhmaemtic `apigt
Vepc`gite mituric vir`imts (mht trimskem`g) kemet`giccy ahd`l`ed 8
kemet`giccy `aprhved 8
cifecc`mk 8
Kemet`g emk`meer`mk hl cirke im`aics
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
TUA Jc`m`jua regbts der @sir D`eter Wiur
Kómter Wgbme`der
Wtelim Eser
Vhcimd Wgba`d
Jcius-^eter Oimssem
CAU
Firfiri Jesscer
Aiyujh Jurhae
\icer` _ijbirtgbemjh
Egjbird [hcl
Bimmhver
Foürm ^etersem
Be`mer M`eaimm
Vicl Wgbw`mzer
Vhgbe
Ohsel ^citzer
Imthm`h @kces`sis
Ucr`gb Gerti
TUA [_[Femed`jt Fiuaer
Airceme Edc`mker
Dim`eci Leccmer
Jhmrid L`sgber
Tit`imi Lc`s`jhwsji
Jrzyszthl Lc`s`jhwsj` Iceximder J`md
W`ahme Jrimer
Wbum C`
Dem`se Mkuyem
Feite V`efc`mker
Imoi Wiiclrimj
Er`gi Wgbucz
Girhc`m [imder
Becabhcz
Vicl Jóbm
[hclkimk [urst
^hzmim Um`vers`ty hl C`le Wg`emges
Airej Ww`thmsj ,̀
C`vesthgj F`htegbmhchky
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky
Tbimj yhu lhr yhur ittemt`hm
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Tegbm`sgbe Um`vers`tät Aómgbem
C`vesthgj F`htegbmhchky