GC-MSD Introducing the new 7890B/5977A

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GC-MSD Introducing the new 7890B/5977A. Badr Astiphan GCMS Product Sales Specialist 1-866-524-7936 302-290-5631 cell [email protected]. We are First in GC Continuously innovating. Units Installed >250,000 GC >60,000 MS. 7000 GC Triple Quad. 7200 GC QTOF. Low Thermal Mass - PowerPoint PPT Presentation

Transcript of GC-MSD Introducing the new 7890B/5977A

Houston 5977A GCMS Intro

1GC-MSDIntroducing the new 7890B/5977AJanuary 8, 2013Agilent ConfidentialBadr AstiphanGCMS Product Sales Specialist1-866-524-7936302-290-5631 [email protected]

1January 8, 2013Agilent Confidential2We are First in GCContinuously innovating5970 MSD

Fused SilicaCapillary ColumnMicroprocessor Control

5840 GC

5880 GC

5890 GC

HyperbolicGold Quad

Inert MS Ion Source

6890 GC

7200 GC QTOF

7000 GC Triple Quad

Capillary FlowTechnologyAutoInjection

Electronic PneumaticControlRetention TimeLocking

2nd Gen LinearElectron CaptureDetector

Low Thermal MassTechnologyUnits Installed>250,000 GC>60,000 MSMulti-ModeInlet

1970s1980s1990s2000s2010sJanuary 8, 2013Agilent Confidential37890A/5975C GC/MSD:The Most Popular GC/MS in the World

Over 20,000 5975 systems since 2005The industry standard GCMS

Agilent 5977 MSD

January 8, 2013Agilent Confidential4

4Proven TechnologiesImproving the Industry Standards for GC/SQGold Quartz QuadTriple Axis DetectorHigh Temperature Inert Source

Unique Entrance Lens Design

All of 5975s features also built in 5977, such as Gold Quad, SIM/Scan, Gain tuning, Triple-Axis Detector, Trace Ion Detection, Auto CI, etc..

January 8, 2013Agilent Confidential5

January 8, 2013Agilent Confidential6High Temperature Ion Source

Solid inert material not a coatingNot damaged by multiple cleanings Programmable to 350C Improved response for many compoundsMore robust operation for dirty samples Better response for sticky compoundsSharper peaks for high boilers (late eluters) more performance for a wide range of applications Polyaromatic Hydrocarbon (PAH) January 8, 2013Agilent Confidential7Unique Entrance Lens Eliminates Pre-filter

New, improved lensJanuary 8, 2013Agilent Confidential8Fringe fields

Unique Entrance Lens Eliminates Pre-filterJanuary 8, 2013Agilent Confidential9

Quartz Gold Hyperbolic and Beautiful! Why quartz?Low coefficient of linear expansion (expansivity; ) dL = L0 dt [t = C; dL = change in length (m); L0 = length at 0 C] Why gold? Inert material with excellent electrical properties for high voltage Why hyperbolic? Ideal electrical field is generated by hyperbolic surfaces (NOT ROUND)Much more than just a beautiful piece of glass

Round QuadJanuary 8, 2013Agilent Confidential10Triple-Axis Detector

ion beamXYOffsetZWith a combination of three axes and appropriate shielding, noise from secondary particles can be reduced to a minimumJanuary 8, 2013Agilent Confidential11Triple Channel EMTriple channels improve signal amplificationLower initial EM voltage requiredTriple channels increase lifeLower cost of operation

Exit of the triple channelsCollector removed to show exit passagesCollectorExpanded Capabilities: 7890B/5977AImproving the Industry Standards for GC/SQHigher Ion Count Extractor EI source Increased ion count S/N > 1500:1 IDL < 10 fg (industry first) Improved thermal profileSave Time & Energy Sequence Scheduler Standby post run Ready to run from standby Bake Mode as needed Factory backflush option Fast Vent capability DS42i rough pumpstandby power reductionSafety/Protection Vacuum failure Shut off gas (He or H2)Better Vacuum by Agilent Pump New Agilent V304 Turbo TwisTorr Molecular Drag technology Improved pumping light gases H2 (220 L/s); He (255 L/s) Agilent Floating Suspension Longer life Quiet operationFaster Scanning 20,000 u/s But never equal to the 7200 Q-TOF speed or scan sensitivity

7890B GC Direct Communications Features EMF, calculator, etc.

January 8, 2013Agilent Confidential12New Extractor Ion Source for 5977Agilent ConfidentialPage 13Why the Extractor EI Source?

Increase in ion countTrue increase in sensitivity

Better trace level precisionLower IDL and MDL

Proven sensitivity increase demonstrated with over 1500 7000 Series GC/TQ!January 8, 2013Comparison of Inert and Extractor Ion SourceAgilent ConfidentialPage 14Repeller(Push)Drawout PlateIon Focus LensEntrance LensIonization areaIonsInert Ion SourceExtractor Lens(Pull)Extractor SourceMore ions to Mass FilterMass FilterJanuary 8, 2013Extractor Source Etune Sensitivity IncreaseJanuary 6, 2013Agilent Confidential15

Blue Extractor 40ppb solution (SVOC)Red Standard 40ppb solution (SVOC)

More improvements on 5977s Extractor Ion Source: Improved Thermal Profile

Page 16Why is this important?Better performance of high boilers i.e. PAH even at lower concentration!

10 Injections80 min analysisGood repeatability of PAH even at the trace level (5ppb)!!Improvement for better Mass Spectrometer of Gas ChromatographJanuary 15, 2013Comparing repeatability of 80min MethodPhthalates analysis with 5977 GC/MSD Oct 2012Page 17

5977 result 5975 resultTwo years ago

5977 result200ppb PAH5ppb PAHKey features of Direct Communication between 7890B and 5977AAgilent ConfidentialPage 18Sleep/Wake modeSleep mode saves power (320W 190W)Lower lab operating costSafety ControlIf 5977A MSD pump fail, 7890B will shut off the gas supplyCool Down MSD Faster (FastVent)When MSD Vent Cycle started, GC will cool down MSD analyzer at the optimum gas flow to MSD.Helium carrier gas : gas waste is eliminatedHydrogen carrier gas: risk of explosion is reduced 40% faster when cooling down from 280C to 100C (< 25 min)

January 8, 2013Saving Energy and Time19VentFastVentPower savedTime savedPower( VA)Source TempTime(min)Time saved using Fast VentBetter HW Features: Agilent Turbo Pump (V304)Agilent ConfidentialPage 20Agilent Quality Standard

TwisTorr 304 FSInnovation for: Higher pumping performance especially for He and H2High reliability lower cost of operationJanuary 8, 2013Press release : http://www.agilent.com/about/newsroom/presrel/2012/19dec-ca12077.html2021TwisTorr 304 FS: Vacuum Design

8 EDM turbo stages (rotor) designed to optimize pumping speed for light gases8 Turbo stators made by pressed SST sheet technology3 TwisTorr drag stages (spiral channels) designed for high compression ratio performances

Agilents new patent-pending Floating Suspension for robust, low noise operation21Better HW Features: Agilent Rough PumpsAgilent ConfidentialPage 22New DS42iNew IDP-3cHigh performanceEnergy saving designInverter not compatible with diff pumpHigh performanceOil-free scroll pumpNH3 CI compatible

with Agilent Quality StandardsJanuary 8, 2013January 8, 2013Agilent Confidential23

Agilent Inert Flow Path From Injection to Detection

Ultimetal TCD, FPD, NPD/FID JetsUltimetal Capillary Flow TechnologyDevices, Ultimate UnionUltimetal Inlet Weldment, Shell and Transfer LinesUltra Inert GC ColumnUltra Inert Gold Seal

Ultra Inert Inlet Liner

Newnow from a single supplierProgrammable Helium Conservation ModuleWorks with Gas Saver function of 7890 based GC

Standby Method can be programmed after the sequence ends

Analytical methods are unchanged since Helium is still the carrier during the run

5977A GC/MSD IDL SpecificationIDL is a statistically derived value from the precision (%RSD) of 8 consecutive, splitless injections of 100fg OFN at 99 % confidence level. The more precise instruments (lower %RSD) will generate lower IDLs.

The Agilent 7890B/5977A with an ALS or CTC autosampler has the following specifications:January 15, 201325Ion Source typeHigh Vacuum pump typeIDL of OFN by 8 replicates of ALS*Extractor SourceTurbo Pump10fg Inert SourceTurbo Pump24fgDiffusion Pump30fg*Systems without an Autosampler will have only S/N specification.These are installation specification, performed on customer site, immediately after installation and carry a lot more value than a reference specs. 25Why IDL specification is useful for the 5977 in SIM?Influence of Noise in S/N specs

In SIM (or MS/MS) when the Noise is too low, such as during acquisition of an OFN standard, S/N results may not give the best characterization

If the noise level is insignificant - varies a lot and too low- the derived value from it (S/N) also becomes insignificant

Value of IDL

IDL is derived from reproducibility/precision results, the same metrics most users utilize every day in their work. The IDL statistical process is the same used for Method Detection Limit calculations, and the %RSD values are tools to monitor analytical performance

IDL characterizes the whole system AS, GC, MS- giving confidence in overall reliability. It is the results of 8 consecutive injections, unlike S/N in a single shut, which can be influenced by many parameters/conditions

January 15, 201326The Influence of the low Noise on S/N valuesSame Data File, RMS, 5 Second Noise Region

Noise region: 5.66min - 5.74 minS/N: 3335Noise region: 5.65min - 5.73 min S/N: 10785A 0.01 min. shift in the noise region resulted a 6000 higher S/N value. When the noise is insignificant (low), the derived S/N value is also insignificant!Noise region: 5.65min-5.73 minNoise region:5.66min-5.74 minS/NS/NJanuary 15, 201327Confidential, November 14, 2012January 8, 2013Agilent Confidential28Market Leading PerformancePremium Value: The Best Just Got BetterDetectorPerformanceMSDScan 1500:1 S/N; SIM 10 fg IDL Best in Class with IDL tested at installation when ALS or Combi available (with Extractor Source)FID