Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)
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Transcript of Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)
Gaucher Disease: Bone Imaging
DXA (Dual-Energy X-ray Absorptiometry)
DXA Spine Image and Test Results
DXA Hip Image and Test Results
Absorptiometry
BMD ↓
BMD ↓
BMD ↓
DXA: Trabecular Bone Change
BMD ↓
BMD ↓
BMD ↓
DXA: Cortical Bone Change
1
2
MeasurementSlice
Computed Tomography
Whole-body CT Scan With Vertebra
Close-up of Vertebra
Forearm CT Scan
Image of Radius and Ulna
TBD ↓
TBD ↓
TBD ↔
Quantitative Computed Tomography (QCT): Trabecular Bone Change
CBD ↓
CBD ↔
CBD ↔
QCT: Cortical Bone Change
Possible Conditions for Bone Loss
Resorption ↑ Formation ↔
Resorption ↔
Formation ↓
Resorption ↑
Formation ↓
Negative Balance
Follow-up Measurements
1 2 3
Measurement
0.5
0.6
0.7
0.8
BM
D [
g/c
m2 ]
Significant Differences
1 2
Measurement Point
0.60
0.65
0.70
0.75
0.80
0.85
BM
D [
g/c
m2]
2.8 sd(p>95%)
sd
