GAS GANGRENE

Gas GangreneWhat is GAS GANGRENE?? - A deep wound infection,destructive of tissue, often caused by combination of two or more species.

Symptoms

• High fever• Shock• Massive tissue destruction• Blackening of skin• Severe pain around a skin of wound• Blisters with gas bubbles form near the

infected area, • the heartbeat and breathing become rapid.

Causative agent

• Clostribium species

c. Perfringens

(mostly)

c.novyi

c.septicum

Pathogenesis- Bacteria enters the

broken skin or wound

- Spores are produced

- The bacteria

present in circulation

system

- the anaerobic

tissue present

- The bacteria are

grow and ferment the

muscle carbohydrate

- The toxins and enzyme

are produced

Examples of enzyme:

colagenases, proteases

and lipases

- These enzymes will

kill other host cell and extend the anaerobic

environment

- Produce gases

(Hydrogen gas and gas

bubble)- Crepitant

tissue ( destroyed

tissue)

Epidemiology

– The persons at risk those with Diabetes Mellitus, blood vessel disease and colon cancer

– Contact with contaminated cloth and other foreign material

– Trauma or recent surgical wound

Treatment

• High doses of antibiotic : Penicillin

• The dead tissue is removed or limbs are amputated

• No vaccine

Prevention

• Cleaning the wound• Avoid the contaminated material• impaired circulation in patients with poor

circulation• Treatment with hyperbaric oxygen- to treat

the gas gangrene• antitoxin