Gas Exchange Regulation of Respiration Dr.Khaled Helmy.
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Transcript of Gas Exchange Regulation of Respiration Dr.Khaled Helmy.
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Gas ExchangeGas Exchange Regulation of RespirationRegulation of Respiration
Dr.Khaled Helmy
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Gas ExchangeGas Exchange
Gas crosses the respiratory membrane by Oxygen enters the blood Carbon dioxide enters the alveoli
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Conducting ZoneConducting Zone
Slide 13.16Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Structures Primary bronchi Secondary bronchi Tertiary bronchi
Conduits to and from respiratory zone, no gas exchange occurs
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Respiratory ZoneRespiratory Zone
Structures Respiratory bronchioles Alveolar duct Alveoli
Site of gas exchange
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Respiratory Membrane Respiratory Membrane
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• Gas Exchange Gas Exchange
Pulmonary gas exchange - in lungsPulmonary gas exchange - in lungs • Oxygen (O2) moves into blood Oxygen (O2) moves into blood blood PO2 < alveolar PO2blood PO2 < alveolar PO2 • Carbon dioxide (CO2) moves out of blood Carbon dioxide (CO2) moves out of blood blood Pco2 > alveolar Pco2blood Pco2 > alveolar Pco2 • Ventilation/perfusion matching (V/Q) Ventilation/perfusion matching (V/Q) Perfusion (blood flow) is matched to ventilation (air Perfusion (blood flow) is matched to ventilation (air
flow) in each group of alveoliflow) in each group of alveoli
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External RespirationExternal Respiration
The alveoli always has more oxygen than the blood Oxygen moves by diffusion towards the area of lower
concentration Pulmonary capillary blood gains oxygen (moves from
lung/alveoli to blood)
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External Respiration (cont’d)External Respiration (cont’d)
Blood returning from tissues has higher concentrations of carbon dioxide than air in the alveoli
Pulmonary capillary blood gives up carbon dioxide Blood leaving the lungs (pulmonary vein) is oxygen-
rich and carbon dioxide-poor (coming in via pulmonary artery is opposite)
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Oxygen Transport in the BloodOxygen Transport in the Blood
Inside red blood cells attached to hemoglobin (oxyhemoglobin [HbO2])
A small amount is carried dissolved in the plasma
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Internal RespirationInternal Respiration
Slide 13.34a
An opposite reaction to what occurs in the lungs Carbon dioxide diffuses out of tissue to blood
(concentration gradient) In RBC’s quickly forms carbonic acid by
combining with water Carbonic acid breaks down via carbonic
anhydrase creating bicarbonate ions Oxygen diffuses from blood into tissue
(concentration gradient)
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External and Internal RespirationExternal and Internal Respiration
Slide 13.34bCopyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Figure 13.11
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External Respiration, External Respiration, Gas Transport, and Gas Transport, and Internal Respiration Internal Respiration SummarySummary
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Figure 13.10
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Neural Regulation of RespirationNeural Regulation of Respiration
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Respiratory Disorders: Respiratory Disorders:
Slide 13.40a
Bronchial asthma
Chronic bronchitis and emphysema
Lung fibrosis
Lung Cancer
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Aging EffectsAging Effects
Slide 13.48Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Elasticity of lungs decreases Vital capacity decreases (decreased
ability to inflate the lungs) Blood oxygen levels decrease Stimulating effects of carbon dioxide
decreases (sleep apnea d/t hypoxia) More risks of respiratory tract infection
(decreased cilia and dust cell function)
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Respiratory Rate Changes Respiratory Rate Changes Throughout LifeThroughout Life
Slide 13.49Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Newborns – 40 to 80 respirations per minute
Infants – 30 respirations per minute Age 5 – 25 respirations per minute Adults – 12 to 18 respirations per
minute Rate often increases somewhat with old
age