Gabriel’s Phthalimide Systhesis
-
Upload
abuturab-mohammadi -
Category
Documents
-
view
18 -
download
3
Transcript of Gabriel’s Phthalimide Systhesis
![Page 1: Gabriel’s Phthalimide Systhesis](https://reader036.fdocuments.net/reader036/viewer/2022081821/554072374a795954208b4a3a/html5/thumbnails/1.jpg)
Gabriel’s Phthalimide Synthesis
--Abuturab mohammadi
![Page 2: Gabriel’s Phthalimide Systhesis](https://reader036.fdocuments.net/reader036/viewer/2022081821/554072374a795954208b4a3a/html5/thumbnails/2.jpg)
Gabriel’s phthalimide systhesis converts R-X and NH3 into 1˚amine
![Page 3: Gabriel’s Phthalimide Systhesis](https://reader036.fdocuments.net/reader036/viewer/2022081821/554072374a795954208b4a3a/html5/thumbnails/3.jpg)
First step is the conversion of phthalic anhydride into phthalamide
![Page 4: Gabriel’s Phthalimide Systhesis](https://reader036.fdocuments.net/reader036/viewer/2022081821/554072374a795954208b4a3a/html5/thumbnails/4.jpg)
Phthalic acid is reused as anhydride and thus is the carrier of the reaction[DMF is polar aprotic solvent and is an excellent medium for SN2]
The alkyl halide undergoes nucleophilic displacement by phthalimide anion(sn2)to form N-substituted phthalimide the latter is then hydrolysed either by acid or by alkali
![Page 5: Gabriel’s Phthalimide Systhesis](https://reader036.fdocuments.net/reader036/viewer/2022081821/554072374a795954208b4a3a/html5/thumbnails/5.jpg)
Instead of using acid or base hydrolysis hydrazine can also be used if hydrolysis is difficult
![Page 6: Gabriel’s Phthalimide Systhesis](https://reader036.fdocuments.net/reader036/viewer/2022081821/554072374a795954208b4a3a/html5/thumbnails/6.jpg)
Gabriel’s sysnthesis is useful for the synthesis of complex compund because phthalimide group is fairly unreactive & is easily separated at the end of hydrolysis
It is the best method of preparation of 1˚amines
![Page 7: Gabriel’s Phthalimide Systhesis](https://reader036.fdocuments.net/reader036/viewer/2022081821/554072374a795954208b4a3a/html5/thumbnails/7.jpg)