Functional anatomy of liver and biliary tree
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Transcript of Functional anatomy of liver and biliary tree
FUNCTIONAL ANATOMY OF
LIVER AND BILIARY TREE
16/01/2013
Dr SIVARAJ S
DEPT OF PHYSIOLOGY
ALL INDIA INSTITUTE OF MEDICAL SCIENCES
NEW DELHI
Hepatocytes secretory epithelial cells that separate the lumen of the bile canliculi from the endothelium of vascular sinusoids.
Bile Flow Hepatocytes Bile canaliculi
Terminal bile ducts
Hepatic duct
Common bile duct
HEPATOCYTES,SINUSOIDS, AND THE INTRAHEPATIC BILE SYSTEM
STRUCTURE OF BILIARY TREE
Liver has a dual blood supply, but a Single Venous Drainage system
Portal vein ~75% hepatic artery ~25% Portal venules+Hepatic arterioles
Hepatic sinusoids
Terminal hepatic venules(Cen.vein)
Hepatic veins Bile ducts mainly supplied by Rt.hepatic
artery
BLOOD SUPPLY TO THE LIVER
Classic hepatic lobule All hepatocytes drained by a
single central vein as the core which is bounded by 2 or more portal triads
Portal lobule All hepatocytes drained by a
single bile ductule and is bounded by 2 or
more central veins Portal acinus Small 3-Dimensional mass of
hepatocytes with one axis formed by line btw two triads(high Po2)and another axis formed by line btw two central veins(low Po2).
Zone I periportal hepatocytes most oxygenated most resistant to circulatory compromise or nutritional deficiency and first to regenarate
Zone II and Zone III exposed to lower conc. of nutrients and oxygen. Vulnerable to injury.
ZONES TO THE ACINUS
Thank you