Fructose. 2 FRUKTOSE (LEVULOSE) Blood Blood – Glucose – Galactose – Fructose Food Food –...

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Fructose

Transcript of Fructose. 2 FRUKTOSE (LEVULOSE) Blood Blood – Glucose – Galactose – Fructose Food Food –...

Page 1: Fructose. 2 FRUKTOSE (LEVULOSE) Blood Blood – Glucose – Galactose – Fructose Food Food – Honey – Fruits – Potato – Onion + glucose + glucose + sucrose.

Fructose

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FRUKTOSE (LEVULOSE)FRUKTOSE (LEVULOSE)

• BloodBlood– GlucoseGlucose– GalactoseGalactose– FructoseFructose

• FoodFood– HoneyHoney– FruitsFruits– PotatoPotato– OnionOnion

• + glucose+ glucose• + sucrose+ sucrose

• Degradation of Degradation of sucrosesucrose

• Diabetes mellitusDiabetes mellitus• Influence on lipid Influence on lipid

metabolismmetabolism

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Effect of fructoseEffect of fructose

• Ingestion results Ingestion results inin– ObesityObesity– [LDL] [LDL] – [TRIGLYCERID] [TRIGLYCERID] – Metabolic Metabolic

syndromssyndroms

• Chelating effectChelating effect– CuCu– ZnZn– CrCr

• Insulin resistence Insulin resistence (DM Type II. típus)(DM Type II. típus)

• Glycation of Glycation of proteinsproteins

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FRUCTOSEFRUCTOSE

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Absorption of monosaccharides

• Transporters:– GLUT-5– GLUT-2– Glucose

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Absorption of carbohydratesAbsorption of carbohydrates

Gal

Glu

Fru

Extracellular spaceEntherocytesIntestinalis lumen

LactoseLactose

StarchStarch

SucroseSucrose

2Na+

K+

SGLT1

GluGluTT55 GluT2

K+Na+ATP-ase

LactaseLactase

AmylaseAmylase-glucosidase-glucosidase

ATP

ADP

Sucrase

Na+

K+

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0

FRUCTOSE

GLUCOSE

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C

O

H

C

C

OH

OH

C OH

C

CH2

H

H

H OH

OH

H

CH2

C

C

OH

OH

C OH

C

CH2

H

H

H OH

OH

H

OH CH2

C

C

O

OH

C OH

C

CH2

H

H

H OH

OH

OH

D-glukóz D-glucitolsorbitol

D-fruktóz

NADPH + H+ NAD+NADP+ NADH + H+

aldóz-reduktáz szorbitoldehidrogenáz

(nincs a májban)

D-fructose in liquor and in seminal plasmaD-fructose in liquor and in seminal plasma

Peripherial neurons. Diabetic hyperglycaemiaPeripherial neurons. Diabetic hyperglycaemia

Accumulation of Sorbitol Accumulation of Sorbitol periferial neuropathyperiferial neuropathy

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Degradation of Degradation of fructose infructose in

musclemuscleliverliver

0

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Deficiency of liver fructokinase

• Benign diseaseBenign disease• FructoseuriaFructoseuria

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FRUCTOSE

0

FRUCTOSE

GLUCOSE

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Deficiency of Fructose-1-Deficiency of Fructose-1-phosphate aldolase (Fructose phosphate aldolase (Fructose

intolerance)intolerance)• Hereditery Hereditery

fructose fructose intolerance (HFI)intolerance (HFI)

• fruktosemyfruktosemy• Deficiency of Deficiency of

fructose 1,6-fructose 1,6-bisphosphate bisphosphate aldolase Baldolase B

• Def, of aldolase Def, of aldolase B B

• vomiting• hypoglycaemia• Cachexy• hepatomegaly• jaundice• coagulopathy• Metabolic acidosis • Coma• renal Fanconi

syndrome

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0

FRUCTOSE

GLUCOSE

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Nakagawa T et al. (2005) Hypothesis: fructose-induced hyperuricemia as a causal mechanism for theepidemic of the metabolic syndrome Nat Clin Pract Neprol 1: 80–86 doi:10.1038/ncpneph0019

Figure 1 Fructose-induced production of uric acid in the hepatocyte

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0

FRUKTÓZ

GLUKÓZ

[Fruktóz-1-P] [Fruktóz-1-P] Foszfát-hiányFoszfát-hiány

A hipoglikémia kialakulásának valószínű okaA hipoglikémia kialakulásának valószínű oka

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0

FRUKTÓZ

GLUKÓZ