Under the patronage of:

P 2728C

P 7413C

P 7444C

Frontiers ofRadiosurgeryOCTOBER 24 & 25, 2019MILANO, ITALY

Centro Diagnostico ItalianoVia Simone Saint Bon 20, 20147 Milano - Italy

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PROGRAM

THURSDAY, OCTOBER 24 2019

08:30 - 09:00 INTRODUCTIONSPantaleo RomanelliScientific Director for Brain Radiosurgery,Cyberknife Center, Centro Diagnostico Italiano(CDI), Milan, ItalyVisiting Scientist,European Synchrotron Radiation Facility(ESRF),Grenoble,France

Shalom KalnickiProfessor and Chairman, Department of Radiation Oncology, Montefiore Hospital-Albert Einstein Medical Center,Bronx,NY,USAChairman of the Board of Directors, Radiosurgery Society (RSS)

Joanne DavisExecutive Director, Radiosurgery Society San Mateo, California, USA

Diana Bracco President and CEO of Bracco Group and CDI, Milan, Italy

Roberto Carlo RossiOrdine Provinciale dei Medici Chirurghi e degli Odontoiatri di Milano

09:00 - 11:30 STEREOTACTIC RADIOSURGERY (SRS) FOR INTRACRANIAL LESIONS Moderated by: Michael Schulder (New York, USA), Antonino Germanò (Messina, Italy)

09:00 - 09:20 SRS for Trigeminal Neuralgia and Epilepsy Pantaleo Romanelli (Milan, Italy)

09:20 - 09:40 SRS for Optic Pathways and Skull BaseAlfredo Conti (Messina, Italy)

09:40 - 10:00 SRS for Acoustic SchwannomasAlexander Muacevic (Munich, Germany)

10:00 - 10:20 SRS for Gliomas Scott Soltys (Stanford, California, USA)

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10:20 - 10:40 Brain MetastasesMaximilian Ruge (Cologne, Germany)

10:40 - 11:00 Question & Answer Session

11:00 - 11:15 Coffee break

11:15 - 13:00 BRAIN AND SPINE SRS ORAL ABSTRACT PRESENTATIONSModerated by: Pantaleo Romanelli (Milan, Italy), Yusuf Sukru Caglar (Ankara, Turkey)

11:15 - 11:25 Factors affecting Outcome in Frameless Non-Isocentric Stereotactic Radiosurgery for Trigeminal Neuralgia: A Multicentric Cohort StudyAlfredo Conti, MD, PhD, University Of Messina, Italy

11:25 - 11:35 CyberKnife Radiosurgery Provides Acceptable Long Term Control with Low Risk of Re-bleeding in Arteriovenous Malformations Not Suitable for SurgeryFranziska Loebel, MD, Charité University Hospital Berlin, Germany

11:35 - 11:45 Gamma Knife Radiosurgery for Arteriovenous Malformations: A Clinical Series of 199 PatientsSelcuk Peker, MD, Koc University School of Medicine, Istanbul, Turkey

11:45 - 11:55 Safety of Cyberknife Radiosurgery in Optic Nerve Sheath MeningiomaCarolin Senger, MD, Charité University Hospital Berlin, Germany

11:55 - 12:05 Frame-based and Masked Stereotactic Radiosurgery: A Patient Experience Comparison with the Gamma Knife IconMichael Schulder, MD, Northwell Health, NY, USA

BRAIN AND SPINE SRS ORAL ABSTRACT PRESENTATIONS

12:05 - 12:10 Preliminary Results of Fractionated Cyberknife Radiosurgery for Uveal MelanomaIsa Bossi Zanetti, MD, Centro Diagnostico Italiano, Italy

12:10 -12:15 Longitudinal Radiographic Outcomes of Vestibular Schwannoma in Single and Fractionated Stereotactic RadiosurgeryMohamed Khattab, MD, Vanderbilt University Medical Center, TN, USA

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12:15 - 12:20 A Retrospective Cohort Study of Longitudinal Audiologic Assessment in Single and Fractionated Stereotactic Radiosurgery for Vestibular SchwannomaMohamed Khattab, MD, Vanderbilt University Medical Center, TN, USA

12:20 -12:25 Analysis of the Efficacy of Gamma Knife in Treating Primary Trigeminal NeuralgiaZhoushuang Sun, MD, Friendship Hospital, People’s Republic of China

12:25 -12:30 Efficacy and Safety of Cyberknife Radiosurgery in Elderly with Brain MetastasesGüliz Acker, Charité University Hospital, Germany

12:30 - 12:35 Hypofractionated Stereotactic Radiosurgery (hSRS) as Salvage Treatment of Brain MetastasesDaniel Rueß, MD, University Hospital of Cologne, Germany

12:35-12:40 First Report On Frameless Mask Optimization Using the Elekta Leksell Gamma Knife IconMichael Schulder, MD, Northwell Health, NY, USA

12:40 - 12:45 The Combined Stereotactic Radiosurgery and Endovascular Approach for Large Arteriovenous MalformationsVladyslav Buryk, MD, PhD, Sigulda Hospital, Latvia

12:45 - 12:50 Gamma Knife Anterior Capsulotomy for Treatment Resistant Obsessive Compulsive DiseaseSelcuk Peker, MD, Koc University School of Medicine, Istanbul, Turkey

12:50 - 13:00 Question & Answer Session

13:00 - 14:00 Lunch

14:00 - 16:30 STEREOTACTIC BODY RADIOTHERAPY (SBRT) FOR EXTRACRANIAL LESIONS Moderated by: Chandan Guha (New York, USA), Giancarlo Beltramo (Milan, Italy)

14:00 - 14:20 SBRT for Oligometastatic DiseaseShalom Kalnicki (New York, USA)

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14:20 - 14:40Stereotactic Radiosurgery for Spinal Lesions Madhur K. Garg (New York, USA)

14:40 - 15:00 SBRT for Lung CancerHale Basak Caglar (Anadolu, Turkey)

15:00 - 15:20 SBRT fro Hepatobilliary TumorsAndrew Gaya (London, UK)

15:20 - 15:40 SBRT for Primary Renal Cell CarcinomaAlexander Muacevic (Munich, Germany)

15:40 - 16:00 SBRT for Prostate Cancer Giancarlo Beltramo (Milan, Italy)

16:00 - 16:20NRG/SWOG Clinical Trials for Prostate Stereotactic Radiation Therapy: Issues and QuestionsRichard K. Valicenti, (California, USA)

16:20 - 16:30 Question & Answer Session

16:30 - 18:00 SBRT FOR EXTRACRANIAL LESIONS ORAL ABSTRACTS Moderated by: Giancarlo Beltramo (Milan, Italy), Madhur K. Garg (New York, USA), Hale Basak Caglar (Anadolu, Turkey)

16:30 - 16:40 Cost-Effectiveness Analysis of Upfront SBRT for Oligometastatic Stage IV Non-Small Cell Lung Cancer Based on Mutational Status Diane Ling, MD, University of Pittsburgh Medical Center Hillman Cancer Center, PA, USA

16:40 - 16:50 Stereotactic Body Radiotherapy (SBRT) for Metastasic Abdomino-Pelvic Lymph Nodes Paula Antonini, MD, Hospital Virgen del Consuelo, Spain

16:50 - 17:00 Plan Quality and Treatment Time of Patients Receiving Pancreatic SBRT with Volumetric Modulated Arc TherapyRojymon Jacob, MD, University of Alabama at Birmingham, AL, USA

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17:00 - 17:10 Evaluation of Outcomes after Stereotactic Hypofractionated Radiotherapy for Prostate CancerGiancarlo Beltramo, MD, Centro Diagnostico Italiano, Milan, Italy

EXTRACRANIAL SBRT ORAL ABSTRACT PRESENTATIONS

17:10 - 17:15 Stereotactic Robotic Body Radiotherapy for Carcinoma ProstateTejinder Kataria nee Sethi, MD, Medanta Cancer Institute, The Medicity, India

17:15 - 17:20 Evaluation of SABR (Stereotactic Ablative Body Radiotherapy) in the Management of Oligometastatic Prostate Cancer: A Case Report of Single CenterMaris Mezeckis, MD, Sigulda Hospital, LatviaVladyslav Buryk, MD, PhD, Sigulda Hospital, Latvia

17:20 - 17:25 Hypofractionated Robotic Radiosurgery for Relapsed and OligometastaticProstate CancerBora Uysal, MD, University of Health Sciences, Gulhane Training and ResearchHospital, Ankara, TurkeyAzamat Dauletkazin MD, University of Health Sciences, Kutahya Training and Research Hospital, Kutahya, TurkeyHakan Gamsiz, MD, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, TurkeyOmer Sager, MD, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, TurkeyFerrat Dincoglan, MD, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, TurkeySelcuk Demiral, MD, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, TurkeyMurat Beyzadeoglu, MD, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey

17:25 - 17:30 SBRT to Portal Vein Tumor Thrombus: Paving the Way for Liver TransplantShyam Singh Bisht, MD, Medanta-The Medicity, India

17:30 - 17:45 Question & Answer Session

17:45 - 18:00Day 1 Closing Remarks Pantaleo Romanelli (Milan, Italy), Shalom Kalnicki (New York, USA)

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FRIDAY, OCTOBER 25, 2019

08:30 - 10:45IMMUNOTHERAPY, SRS AND ABLATIVE THERAPIES FOR THE TREATMENT OF CNS LESIONSModerated by: Mansoor Ahmed (Bethesda, USA)

08:30 - 09:00 Pre-clinical models of immunotherapy and SRS for brain lesionsSandeep Burma (Dallas, TX, USA)

09:00 - 09:30 Combination Immunotherapy and SRS for the Treatment of Brain MetastasesSilvia Chiara Formenti (New York, USA)

09:30 - 10:00 Advancements in GRID/Lattice/FLASH/Microbeam TherapyMansoor Ahmed (Bethesda, USA)

10:00 - 10:30High-Focused Ultrasound and Ablative Therapies for the Treatment of CNS LesionsChandan Guha (New York, USA)

10:30 - 10:45 Question & Answer Session

10:45 - 11:15 Keynote lecture - introduced by Dr Shalom Kalnicki: Synchrotron-generated Microbeams: an emerging frontier for SRS and Brain MicroImaging Pantaleo Romanelli (Milan, Italy)

11:15 -11:30 Coffee Break

11:30 - 13:00STATE - OF - THE - ART AND EMERGING TECHNOLOGIES IN RADIOSURGERYModerated by: Irene Redaelli (Milan, Italy), Christos Antypas (Athens, Greece)

11:30 - 11:50Emerging Technologies of SRS/SBRTStanley Benedict (Sacramento, California, USA)

11:50 - 12:10Launching a New SRS Device: ZapIgor Barani (Phoenix, Arizona, USA)Lecture sponsored by ZAPNo CME session

12:10 - 12:30 Frontiers of Focused Ultrasounds in the treatment of Brain DisordersJin Woo Chang (Seoul, Korea)

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12:30 - 12:40 Microbeam radiation therapy against cancer – possible underlying biological mechanismsValentin Djonov (Berne, Switzerland) 12:40 - 13:00 Question & Answer Session

13:00 - 14:00 Lunch Break

14:00 - 15:20MEDICAL PHYSICS AND EMERGING TECHNOLOGIES ORAL ABSTRACT PRESENTATIONSModerated by: Stanley Benedict (Sacramento, California, USA), Christos Antypas (Athens, Greece)

14:00 - 14:10 Radiomic: Prediction of Acoustic Neuroma Response to the Cyberknife TreatmentIsa Bossi Zanetti, MD, Centro Diagnostico Italiano, Milan, Italy

14:10 - 14:20 Implementation of Quality Assurance Program for CyberKnife Treatment Planning SystemTatsiana Reynolds, PhD, Minnesota Oncology, MN, USA

14:20 - 14:30 An Evaluation of a High Resolution Film-Less Patient Specific Quality Assurance Solution for Mono-Isocentric Multiple Metastasis Radiosurgery Plans with Non-Coplanar FieldsRoland Teboh, PhD, Hackensack University Medical Center, USA

14:30 - 14:40Question & Answer Session

MEDICAL PHYSICS AND EMERGING TECHNOLOGIES ORAL ABSTRACT PRESENTATIONS

14:40 - 14:45 Use of Electromagnetic Transmitter to Monitor Intrafraction Motion in Prostate Cancer Radiotherapy: Application, Stability, Treatment TimeTulay Ercan, PhD, Gayrettepe Florence Nightingale Hospital, Turkey

14:45 - 14:50Cyberknife Patient Specific Quality Assurance using 2D Mapcheck Diode ArrayTatsiana Reynolds, PhD, Minnesota Oncology, MN, USA

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14:50 - 14:55 The Determination of the Impact of Inverse Planning Technique with Dynamic Multi Leaf Colimator (dMLC) and Volumetric Arc Therapy (VMAT) with FFF on Peripheral Organ DosesEsil Kara, Koru Ankara Hospital, Turkey

14:55 - 15:00 Single vs Multiple VMAT Arcs for Brain TumorsAsad Zameer, Karachi, Pakistan

15:00 - 15:05 Cyberknife Treatment of a Rectal Carcinoma Recurrence: Influence on the Dosimetry of a Rectal ProsthesisMaria Cristina Frassanito, PhD, Mater Dei Hospital, Bari, ItalyPalma Rita Altieri, PhD, Italian National Institute of Nuclear Physics (INFN), Bari, ItalyPasquale Tarantino, PhD, Mater Dei Hospital, Bari, ItalyAnna Maria Grazia Pastore, PhD, Mater Dei Hospital, Bari, Italy

15:05 - 15:10 Feasibility Study of Tantalum Markers for the Treatment of Ocular Melanoma with CyberKnife Stereotactic RadiotherapyAnna Stefania Martinotti, Cyberknife Center, Centro Diagnostico Italiano, Milan, Italy

15:10 - 15:30 Question & Answer Session

15:30 - 16:15IMAGING FOR INTRACRANIAL AND EXTRACRANIAL STEREOTACTIC RADIOTHERAPY Moderated by: Sergio Papa (Milan, Italy), Fulvio Uggeri (Milan, Italy)

15:30 - 15:50Imaging for intracranial and spinal SRS Alfredo Conti (Messina, Italy)

15:50 - 16:10Imaging for extracranial SBRTGianpaolo Carrafiello (Milan, Italy)

16:10 - 16:15 Question & Answer Session

16:15 - 17:15Round Table/ Take Home Messages: Moderators: Pantaleo Romanelli (Milan, Italy), Shalom Kalnicki (New York, USA)Panelists: Mansoor Ahmed (Bethesda, USA), Chandan Guha (New York, USA), Hale Basak Caglar (Anadolu, Turkey), Madhur K. Garg (New York, USA), Stanley Benedict (California, USA), Christos Antypas (Athens, Greece)

Final remarksPantaleo Romanelli (Milan, Italy), Shalom Kalnicki (New York, USA)

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FACULTIES

Mansoor Ahmed, PhDDirector of Radiation Research Program,National Cancer Institute, National Institute of Health(NIH), Bethesda, MD, USA

Christos Antypas, PhDMedical Physicist, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece

Igor Barani, MD Associate Professor and Chairman, Department of Radiation Oncology, Barrow Neurological Institute, Phoenix, AZ, USA

Giancarlo Beltramo, MD Director, Cyberknife Center, Centro Diagnostico Italiano (CDI), Milan, Italy

Stanley H. Benedict, PhD Professor and Vice Chairman of Clinical Physics, University of California, Davis, CA, USA

Sandeep Burma, PhDAssociate Professor, Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Inwood Road, Dallas, TX, USA

Hale Basak Caglar, MDProfessor of Radiation Oncology, Anadolu Medical Center, Istanbul Medipol University, Turkey

Yusuf Sukru Caglar, MDProfessor and Chairman, Department of Neurosurgery, University of Ankara,TurkeyPast President, Turkish Neurosurgical Society

Gianpaolo Carrafiello, MDProfessor of Radiology, University of Milan, Italy

Jin Woo Chang, MD, PhD Professor of Neurosurgery, Director of the Brain Research Institute,Yonsei University College of Medicine, Seoul, KoreaPresident of the World Federation for Stereotactic and Functional Neurosurgery(WSSFN)

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Alfredo Conti, MD, PhD Associate Professor of Neurosurgery, University of Bologna, Italy

Valentin Djonov, MD Professor and Chairman, Institute of Anatomy, University of Berne, Switzerland

Silvia Formenti, MDProfessor and Chairman, Department of Radiation Oncology at Weill Cornell, Radiation Oncologist in Chief at NewYork-Presbyterian Hospital

Madhur K. Garg, MD, MBA Professor and Clinical Director, Department of Radiation Oncology, Montefiore Hospital-Albert Einstein Medical College, Bronx, NY, USA

Andrew Gaya, MD, FRCP, FRCR Consultant Clinical Oncologist, London, UK

Antonino Germanò, MD Professor and Chairman, Department of Neurosurgery, University of Messina, Italy

Chandan Guha, MD, PhDProfessor and Vice-Chairman, Director of Translational Oncology, Department of Radiation Oncology, Montefiore Hospital-Albert Einstein Medical Center, Bronx, NY, USA

Shalom Kalnicki, MDProfessor and Chairman, Department of Radiation Oncology,Montefiore Hospital-Albert Einstein Medical Center, Bronx, NY, USAChairman of the Board of Directors, Radiosurgery Society (RSS)

Alexander Muacevic, MD Medical Director, European Cyberknife Center; Professor of Neurosurgery, Ludwig-Maximilian University, Munich, Germany

Sergio Papa, MD Director of Radiology and Stereotactic Radiosurgery, Centro Diagnostico Italiano (CDI), Milan, Italy

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Irene Redaelli, PhD Cyberknife Center, Centro Diagnostico Italiano (CDI), Milan, Italy

Pantaleo Romanelli, MDScientific Director for Brain Radiosurgery, Cyberknife Center, Centro Diagnostico Italiano (CDI), Milan, ItalyVisiting Scientist, European Synchrotron Radiation Facility (ESRF), Grenoble, France

Maximilian Ruge, MD Professor and Chairman, Department of Stereotactic and Functional Neurosurgery, University Hopital of Cologne, Germany

Scott Soltys, MDAssociate Professor of Radiation Oncology, Stanford University Medical Center, Stanford, CA, USA

Michael Schulder, MDProfessor and Vice-Chairman, Department of Neurosurgery; Directorof Brain Tumor Institute, North Shore University Hospital Manhasset, NY, USAPast President, World Federation of Stereotactic and Functional Neurosurgery (WSSFN)

Fulvio Uggeri, PhD Head of Global Innovation & Technical Operations, Global Business Unit Imaging, Bracco Imaging SpA, Milan, Italy

Richard K. Valicenti, MD, MA, FASTRO Professor and Chairman, Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, CA, USA

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GENERAL INFORMATION

MEETING VENUECentro Diagnostico ItalianoVia Simone Saint Bon 20, 20147 Milano - Italy

HOW TO REACH THE VENUEClosest subway stop: Inganni - approx. 180 mt / 3 minutes walking distance. Line M1.From Malpensa Airport: Malpensa Shuttle until Milano Cadorna train station.From Cadorna take the subway Line M1 until Inganni (8 stops).

ORGANIZING CO-CHAIRS

Shalom KalnickiMD, Chairman Department of Radiation Oncology, Montefiore University, Chairman of Radiosurgery Society Board of DirectorsBronx, New York (US)

Pantaleo Romanelli, MDMD, Scientific Director, Brain Radiosurgery, Centro Diagnostico Italiano, Milan, Italy

CONGRESS ATTENDANCE INCLUDES• Admission to the scientific sessions• Congress bag with complete meeting materials• Certificate of attendance• Access to the exhibition area• Lunch and coffee breaks

ABSTRACTSThe Abstracts are now available at the link below:https://www.cureus.com/channels/therss

CME 15 CME for italian participants have been confirmed for the below categories:Neurosurgeons; radiation oncologists; surgeons; medical oncologists; medical physicists; dosimetrists and healthcare professionals; radiation therapists.

SOCIAL DINNERA social dinner will be held at Granaio - Duomo on Thursday, 24th October 2019.Address: Via Giuseppe Mengoni, 2.Subway stop “Duomo” approx. 150 mt from the restaurant.Dinner will start at 8:30 pm.Contribution for the dinner is EUR 65,00. Booking can be made until Monday 21st October and can be paid onsite only by cash.

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