From stem cells to plateletsregulation, environment and pathology

Alessandra Balduini, MDDepartment of Biochemistry

University of Pavia

Progetto Regione 7 Marzo 2008

Megakaryocyte Differentiation

Kaushansky K, Blood 1995, 86: 419

Mattia G et al, Blood 2002, 99: 888

Ploidy

Proplatelet extension

Patel S et al, JCI 2005,115: 3348

Proplatelets

Italiano J et al, J Thromb Haemost 2003, 1: 1174

Proplatelet branching

Patel S et al, JCI 2005,115: 3348

Proplatelet cytoskeleton

Hartwig J et al, J Thromb Haemost 2003, 1: 1580

Platelet release

Hartwig J et al, J Thromb Haemost 2003, 1: 1580

Bone marrow niches

Experimental model ofthrombopoiesis

Avecilla St et al, Nature Medicine 2004,10: 64

α2β1

PPF regulation model

Chen Z, Balduini A et al, Blood 2007

Acknowledgments

Harvard Medical SchoolZhao Chen

Ramesh Shivdasani

University of PaviaCristian Gruppi

Enrica TiraMauro Torti

Cesare Balduini

Fondazione San MatteoAlessandro Pecci

Valeria BozziCarlo Balduini

Tufts UniversityChris CanizzaroMichael LovettDavid Kaplan

Isabella PallottaAlessandro MalaraStefania Badalucco