Friuli Innovazione and FVG biotech enterprise network

Lodi, 6th September 2016

CASE

STUDY

Prof. Stefano Marchetti

CEO Transactiva srl

© Friuli Innovazione 2 2

Science and Technology Park Luigi Danieli

Udine

• www.friulinnovazione.it

© Friuli Innovazione 3

3 main buildings

6.400 m2 offices and laboratories

80.000 m2 total area

> 30 enterprises and laboratories hosted

Friuli Innovazione at a glance Infrastructures

© Friuli Innovazione 4

Friuli Innovazione at a glance Activities

• Laboratory of Metallurgy, Surface Technologies and Advanced Materials

• Applied Genomics Institute

Laboratories

• Biotechnologies

• Metallurgy, Surface Technologies and Advanced Materials

• Extended ICT

• Energy and Environment

Main Sectors

Enterprise

Development

Technology

Transfer

Enterprise

Funding

Friuli Innovazione

Spazio Impresa

Hosting

© Friuli Innovazione 5

Research

Entrapreneurs

Public

Banking

Friuli Innovazione at a glance Approach

© Friuli Innovazione 6

Technology

Transfer

Enterprise

Funding

Friuli Innovazione

Spazio Impresa

Friuli Innovazione integrated offering for enterprises and business ideas

Enterprise

Development Hosting

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© Friuli Innovazione 7

Enterprise Development

• To support and assist the creation of high-technology

enterprises, the Techno Seed incubator undertakes:

• guidance and training

• business plan development

• technological feasibility studies

• assistance with enterprise creation formalities

• assistance with fund raising and access to innovative forms of

finance

• networking, searching for partners and alliances

• mentoring

Promotes ICT and Hi-Tech start-ups

based on innovative ideas

Certified incubator in Italy

Enterprise Development

Techno Seed incubator

© Friuli Innovazione

• 2005 business incubator Techno Seed

begun

• 2011 Techno Seed went international

• 2013 Techno Seed was the second

incubator certified at national level and

the first at regional level

2005 - 2015

© Friuli Innovazione

• 560 business ideas

• 180 business plans

• 1900 young entrepreneurs educated

• 2500 consultancy hours delivered

• 47 new enterprises started

• 12 groups (business ideas) running

• 1,5 millions Euro of own

resources delivered to groups and

enterprises (financing with European

national and regional projects)

2005 – 2015 (some figures)

© Friuli Innovazione

• > 190 new jobs

• > 5 millions Euro revenues

• 30 young entrepreneurs moved in

Europe through Erasmus for Young

Entrepreneurs

• 11 regional entrepreneurs who

hosted foreign young entrepreneurs

• 16 patents

2005 – 2015 (some figures)

© Friuli Innovazione 12

LR 26/2005 art. 21, comma 1, lettera a

Unione Europea

Programma Erasmus per

Giovani Imprenditori Programmi di scambio a livello europeo

Fondo speciale per start

up innovative Finanziamenti senza garanzie e

basso tasso di interesse

Formazione, consulenza

Enterprise

Academy

Incubator Pipeline

© Friuli Innovazione

Trilateral Start up ecosystem

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© Friuli Innovazione

Trilateral Start up ecosystem

• “The Landing Point for Start-ups entering the European

Market”

• Joint trilateral acceleration program for best trilateral start-ups

• Joint trilateral events

• Joint communication platform including event calendar

• Building trilateral start-up community and branding

• Joint coordinated infrastructure (like co-working spaces)

• ….

14

© Friuli Innovazione 15

References

Fabio Feruglio

Managing Director

Mobile +39 335 6988766

Email fabio.feruglio@friulinnovazione.it

Direct +39 0432 629933

www.friulinnovazione.it

Friuli Innovazione

Parco Scientifico e Tecnologico Luigi Danieli

Via J. Linussio, 51

33100 Udine

Italia

Elisa Micelli

Techno Seed Responsible

Mobile +39 345 9646875

Email elisa.micelli@friulinnovazione.it

Direct +39 0432 629941

Friuli

Innovazione

and

Biotech 16

© Friuli Innovazione

Friuli Innovazione and Biotech

• Associazione Istituto di Genomica Applicata

www.appliedgenomics.org

• IGA Technology Services www.igatechnology.com

• Transactiva www.transactiva.it

• Laboratori Turval Italia www.turval.com

• Gadamed www.gadagroup.it

• Biofarma www.biofarma.it

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Biotech SME

Academic spin-off of the University of Udine Year of establishment Capital stock Registered office Employees Active members Facilities Molecular biology laboratory Biochemistry laboratory In vitro laboratory Growth chambers Greenhouses

2001 105 € PST Udine

7 3 150 sq. mt. 100 sq. mt 60 sq. mt. 50 sq. mt. 2750 sq. mt.

Parco Scientifico e Tecnologico "Luigi Danieli“ Via J. Linussio 51 33100 Udine T + 39 0432 629.745/753 F + 39 0432 603.887 info@transactiva.it www.transactiva.it

The use of plant-based innovative expression systems for the production of non-food, non-feed, non-fibre commodities like therapeutic molecules, fuels, biodegradable plastics, industrial and commercial proteins.

Molecular Farming

R&D activities in Transactiva are primarily aimed at devising novel industrial platforms for the production of pharmaceuticals in plants.

Comparison of the available hosts for the production of therapeutical recombinant proteins

Transgenic plants as an industrial system for pharma production

Depending on the requested amounts and considering other specific needs, target molecules are synthesised in tobacco leaves or rice seeds

Both system are suitable for the production of active proteins with a high level of bioequivalence as compared to their native counterparts.

whose manufacturing cannot be achieved by chemical synthesis available in limited amounts or completely excluded from clinical practice due to the inadequacy of their production systems

Attention is given to therapeutic molecules:

Pharmaceuticals in the pipeline

Transactiva is currently working on two main research areas: Production of recombinant human enzymes to be used in the enzyme replacement therapy (ERT) of rare metabolic diseases Acid Beta Glucosidase (rhGCase) Acid Alpha Glucosidase (rhGAA)

Expression of immunoglobulin-like molecules, with particular focus on personalized NHL vaccines and monoclonal antibodies

Anti-idiotype NHL vaccines Monoclonal antibodies

TOBACCO

RICE

RICE

Pharmaceuticals in the pipeline

Institute of Applied Genomics

• No-profit Research Institute funded on April 13th, 2006 • Legally recognised by FVG Regional Adiministration on August 4th,

2008

To explore and exploit the genetic variation underlying the

phenotypic diversity occurring in nature, and to make

achievements available to the scientific community and to

society.

Mission

IGA sequencing projects

IGA ‘genomes’ papers: Citrus (2014)

• Start-up company founded by Institute of Applied Genomics (IGA) in

September 2009

• 100% ownership of IGA

• Provides ‘classical’ and next generation sequencing services as well as

bioinformatics analyses

• Works exclusively on Illumina NGS platform

• Illumina Certified Service Provider for sequencing

since 2009

www.igatechnology.com

Computer infrastructures

• 1104 GB of RAM for data analysis • 140 TB for storage for big data

conservation • Currently expanding

Transcriptome Epigenome

• Gene expression profiling

• ncRNA analysis

• Whole transcriptome analysis

• RNA immunoprecipitation sequencing (RIP-seq)

• Chromatin immunoprecipitation sequencing (ChIP-seq)

• Methylation analysis (BS-seq)

NGS applications

• Targeted resequencing

• Metagenomic & microbial diversity

• Whole genome resequencing

• De novo sequencing

Genome

Developing the scientific knowledge on probiotics and the Probiotic Lactic Yeast®

Kluyveromyces marxianus fragilis B0399 (TURVAL® B0399®)

• to produce the active ingredient

• to supply users and distributors

• to provide scientific information and updates

• Food, Yogurt, Snacks and Probiotics

• Nutraceutical and clinic field for human use

• Zootechnical field such as cattle, swine and piglets

Specific formulations for: Horses, Pets, Poultry, Ostriches, Pigeons, Camels and camelids

MARKET

Laboratori TURVAL Italia srl MISSION

PROBIOTIC BRANDS BASED ON TURVAL® B0399®

Zootechnical Products:

Human Products:

Probiotic Lactic Yeast® TURVAL® B0399® brought multiple AWARDS to yogurts producers for the

most innovative product:

EUFYR: recognizing innovation in Private Label

(Amsterdam, 2014)

JOGOFIR: innovative probiotic fermented milk

beverage (NoviSad, 2015)

GADA® Group

Company Profile

37 GADA® Group

Operative Companies & Business Units

Divisions

Strategic Areas

Integrated Services

Logistic & Maintenance

Labo & Transfusion Cardiac

Surgery

Int. Radio

Int. Cardio Dialysis

Blood Management Business Unit

Cardiovascular

Business Unit

SALES & DISTRIBUTION SERVICES

GENERAL Hospital

© Friuli Innovazione

Friuli Innovazione and Biotech

Biofarma

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40

FVG: regional

research system

• 2 Universities

• 2 Academic hospitals

• 4 Science and Technology Parks

(Open Innovation System)

• BioHighTech NET

• 2 Startups incubators

• SISSA

• 2 ITS

• Elettra Sincrotrone

• 2 CNR institutes

• ICGEB

• Italian Liver Foundation

• LNCIB

• 2 research and therapy institutes

(CRO, Burlo Garofolo)

• ITIS Trieste

• …

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FVG: Biotech

Enterprise Network

• Formalized in 2016

• 32 enterprises (…and

counting!)

• Promoter of the SMART

HEALTH S3

42

FVG: Biotech

Enterprise Network

Smart Health cluster

Biomedical, in vitro and in vivo

Diagnostics

Medical informatics and Bioinformatics

Innovative Therapy

Ambient Assisted Living

• More than 150

regional

enterprises

• 4 technological

development

trajectories

FVG: Biotech

Enterprise Network