FRIOS Augmentation

Medicinal Mixing Beaker

4 Straight and Single-angle Applicators

3 Double-angle Applicators 3 Applicators

FRIOS® SinusSet

Drill Set

Sinus fl oor elevation is now a standard procedure. With its well-designed range of instruments that can be used in any situation, the FRIOS® SinusSet from DENTSPLY Friadent offers the best prerequisites for long-term success.

FRIOS® SinusSet

Sinus fl oor elevation – ergonomic and esthetic. All preparation steps for the open sinus lift can be carried out with this titanium set.

Clearly organized – all instruments are color-coded and arranged in sequence of usePreparing the lateral bone window – all instruments from large, diamond-coated round drills to fi ne fi ssure drills are includedMobilization of the sinus mucous membrane – with different angled elevatorsMixing the augmentation material – in stable surgical containerFilling the sinus – with different surgical applicators

Eicker LA, Tomakidi P, Haessler D, Neugebauer J, Zöller JE:Die Vitalität von gefilterten Knochen spänen zumpräimplantologischen Knochenaufbau – HistochemischeUntersuchungen und klinische Erfahrungen. Z Zahnärztl Implantol 2002; 18(2): 93 – 100

Eicker LA, Neugebauer J, Tomakidi P, Haessler D, Zöller JE:The vital potential of filtered bone particles used for boneaugmentation. Scientific Poster: 17th Annual Academy of OsseointegrationConference, Dallas, Texas, March 14 – 16, 2002

Young MPJ, Korachi M, Carter DH, Worthington H, Drucker DB:Microbial analysis of bone collected during implant surgery –a clinical and laboratory study. Clin Oral Impl Res 2001; 12(2): 95 – 103

Haessler D, Zöller J, Vizethum F:Autogene Knochentransplantation mit Hilfe eines Spankollektors– Eine Methodenbeschreibung. Implantologie 1995; 3(4): 315 – 322

Young MPJ, Worthington H, Lloyd RE, Drucker DB, Sloan P,Carter DH: Bone collected during implant surgery – a clinical and historicalstudy. Clin Oral Impl Res 2002; 13(3): 298 – 303

Khoury F, Happe A, Basner C, Neugebauer J:Utilizing diamond discs for harvesting bone blocks.Scientific Poster: 8th International Congress on Reconstructiveand Preprosthetic Surgery, San Diego, USA, April 15 – 17, 1999

Khoury F, Happe A: Zur Diagnostik und Methodik von intra-oralen Knochen-entnahmen. Z Zahnärztl Implantol 1999; 15(3): 167 – 176

Khoury F: Prognostic factors in implant surgery.Arab Dent J 1999; 4(1): 33 – 42

Khoury F, Hensher R: The bony lid approach for the apical root resection of lowermolars. Int J Oral Maxillofac Surg 1987; 16(2): 166 – 170

Khoury F: Methode und Ergebnisse reponierbarer Knochendeckel beiWurzelspitzenresektion unterer Molaren. Dtsch Z Mund Kiefer Gesichtschir 1986; 10(2): 124 – 129

Weibrich G, Götz H, Gnoth S-H, Trettin R, Duschner H, Wagner W:Charakterisierung der Oberflächenmorphologie von Knochen-ersatzmaterialien mittels REM. Z Zahnärztl Implantol 2000; 16(3): 151 – 159

Schopper C, Moser D, Wanschitz F, Watzinger F, Lagogiannis G,Spassova E, Ewers R: Histomorphologic findings on human bone samples six monthsafter bone augmentation of the maxillary sinus with ALGIPORE®.J Long Term Eff Med Implants 1999; 9(3): 203 – 213

Basner C, Spassova E, Ewers R, Cantzler P, Bergner N: X-Ray diffractometry analysis of hydroxy-apatite bone substitutionmaterials. Scientific Poster: 77th General Session of the IADR and 28th AnnualMeeting of the AADR, Vancouver, Canada 1999

Haessler D: Die Sinusliftoperation. In: Hartmann HJ (Hrsg): Aktueller Stand der zahnärztlichen Implan-tologie Bd 1, Teil 2, Kp 11.10, Spitta-Verlag Balingen 1998

Schopper C, Ewers R, Moser D: Bioresorption of ALGIPORE® at human recipient sites.Abstract: J Craniomaxillofac Surg 1998; 26 (Suppl 1): 172 – 173

Terheyden H, Jepsen S, Vogeler St, Tucker M, Rueger DC:Recombinant human osteo genic protein 1 in the rat mandibularaugmentation model: differences in morphology of the newlyformed bone are dependent on the type of carrier. Mund Kiefer Gesichtschir 1997; 1(5): 272 – 275

Feifel H, Gerner A, Schmidt K.-H, Wimmer F, Schmitz H-J: Die Beeinflussung der Knochenrege neration in phykogener Hydro-xylapatitkeramik durch einen osteo induktiven Proteinkomplex.Histologische und histomorphometrische Untersuchungen amKaninchen. Dtsch Z Mund Kiefer Gesichtschir 1995; 19(1): 25 – 27

Behrens P, Bruns J, Gunstmann R, Mohan S, Doden E:Histomorphologic and biochemical investigations of hydroxyapa-tite in combination with the transfor ming growth factor ß1(TGFß1).Osteologie 1995; 4 (Suppl 1)

Ewers R, Schumann B: Experimental and clinical applications of ALGIPORE®, a phycogenichydroxyapatite. Abstract: J Craniomaxillofac Surg 1994; 22 (Suppl 1): 92

Herr G, Wahl D, Küsswetter W: Osteogenic activity of bone morphogenetic potein and hydro-xyapatite composite implants. Ann Chir Gynaecol 1993; 82 (Suppl 207): 99 – 107

Ewers R, Rasse M, Schumann B: Development and clinical experience with the bone substitutematerial ALGIPORE®.Osteologie 1992; 1(Suppl 1): 18 – 19

Bieniek KW, Küpper H, Spiekermann H: Tierexperimentelle Untersuchungen zur parodontalen Implantationvon kompakten, makroporösen und phykogenen HA-Keramik-granulaten. ZWR 1989; 11: 958 – 960

Kasperk C, Ewers R, Simons B, Kasperk R:Algae-derived (phycogene) hydroxylapatite. A comparative histological study. Int J Oral Maxillofac Surg 1988; 17(5): 319 – 324

Ewers R, Kasperk C, Simons B: Biologisches Knochenimplantat aus Meeresalgen.Zahnärztl Prax 1987; 38(9): 318 – 320

Bhatnagar RS, Qian JJ, Gough CA: The role in cell binding of ß-bend within the triple helical region in collagen a1(l) chain: Structural and biological evidence for conformational tautomerism on fi ber surface. J Biomol Struct Dyn 1997; 14(5): 547 – 560

Qian JJ, Bhatnagar RS: Enhanced cell attachment to anorganic bone mineral in the presence of a synthetic peptide related to collagen. J Biomed Mater Res 1996; 31(4): 545 – 554

Bhatnagar RS, Qian JJ, Wedrychowska A, Sadeghi M, Wu YM, Smith N: Design of biomimetic habitats for tissue engineering with P-15, a synthetic peptide analogue of collagen. Tissue Eng 1999; 5(1): 53 – 65

Bhatnagar RS, Qian JJ, Wedrychowska A, Smith N: Construction of biomimetic environments with a synthetic peptide analogue of collagen. Materials Research Society Symposium Proceedings 1998; 530: 43 – 54

Yukna RA, Callan DP, Krauser JT, Evans GH, Aichelmann-Reidy E, Moore K, Cruz R, Scott JB: Multi-center clinical evaluation of combination anorganic bovine-derived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) as a bone replacement graft material in human periodontal osseous defects: 6-month results. J Periodontol 1998; 69(6): 655 – 663

Sogal A, Tofe AJ: Risk assessment of bovine spongiform encephalopathy trans-mission through bone graft material derived from bovine bone used for dental applications. J Periodontol 1999; 70(9): 1053 – 1063

Bhatnagar RS, Qian JJ, Wedrychowska A, Dixon E, Smith N: Biomimetic habitats for cells: Ordered matrix deposition and differentiation in gingival fi broblasts cultured on hydroxyapatite coated with a collagen analogue. Cells and Materials 1999; 9(2): 93 – 104

Krauser JT, Rohrer MD, Wallace SS: Human histologic and histomorphometric analysis comparing OSTEOGRAF®/N with PepGen® P-15 in the maxillary sinus elevation procedure: A case report. Impl Dent 2000; 9(4): 298 – 302

Basner C, Salaske I: Laserperforierte Titanfolien in der Implantologie. Implantologie Journal 2002; 6(4): 38 – 41

Basner C, Salaske I, Khoury F, Arpak N: Knochenregeneration mit Titanfolien. Nichtresorbierbare Membranen in der Implantologie. Implantologie Journal 2001; 5(4): 36 – 42

Khoury F, Ponte A, Nakib S: Preliminary report of a prospective study using atitanium membrane (BoneShield) in implant surgery. Scientifi c Poster: EAO 9th Annual Congress European Association for Osseointegration, Amsterdam, NL, September 14 – 16, 2000

Arpak MN, Alkan A, Nergiz I: A case of localized ridge augmentation from using a titanium membrane: A pilot study. J Oral Sci 2000; 42(3): 133 – 138

Watzinger F, Luksch J, Millesi W, Schopper C, Neugebauer J, Moser D, Ewers R: Guided bone regeneration with titanium membranes: A clinical study. Br J Oral Maxillofac Surg 2000; 38(4): 312 – 315

Ewers R, Neugebauer J, Schopper C, Watzinger F: Bone reconstruction through graft fi xation with the titanium barrier FRIOS® BoneShield. Scientifi c Poster: 8th International Congress on Reconstructive and Preprosthetic Surgery, San Diego, USA, April 15 – 17, 1999

Khoury F: Prognostic factors in implant surgery. Arab Dent J 1999; 4(1): 33 – 42

Ewers R, Neugebauer J, Rode M, Gehrke P: Fixation of augmentation material with a titanium mesh barrier. Scientifi c Poster: XVI Congresso Internazionale Accademia Italiana di Odontoiatria Protesica, Bologna, Novembre 7 – 8, 1997

Ewers R, Neugebauer J, Schopper C: Guided bone regeneration of the alveolar process with the FRIOS® BoneShield by sinus fl oor augmentation. Scientifi c Poster: 7th International FRIATEC Symposium, April 4 – 5, 1997

Ackermann KL, Kirsch A, Wittal CG: Le système d’augmentation FRIOS®. Un nouveau système pour la stabilisation de la membrane. Implant 1994; Octobre: 69 – 73

Βιβλιογραφία

FRIOS® MicroSaw

FRIOS® BoneCollector FRIOS® ALGIPORE® PepGen P-15® · OSTEOGRAF®/N FRIOS® BoneShield

FRIOS® FixationSet

FRIOS® Membrane Tacks

Form-fi t laser-perforated titanium: the perforation allows for diffusion of oxygen and migration of cells.

Mechanical stability without membrane support: ultra-thin, radiopaqueBiocompatible – medical grade titanium, laser-perforated for diffusion of oxygen and migration of defense cellsVersatile – available in various shapes and sizes. Cutting and shaping with the FRIOS® Bone-Shield FormSet adapts them to every situation.Easy to secure – with FRIOS® Membrane Tacks made of medical grade titanium

Worldwide number one for securing membranes

Perfect hold – well secured mem-branes prevent material displace-ment and promote bone formationBiocompatible – manufactured from titanium alloy and gamma-sterilized – the perfect supplement to FRIOS® BoneShieldsUniversal – can be used with all resorbable and non-resorbable membranesEconomical – FRIOS® Membrane Tacks not used can be stored in the tray

Fixation and Instruments

FRIOS® BoneShields

oval20/15 mm

oval24/20 mm

triangular16/14 mm

triangular21/17 mm

implant-fi xed rectangular 33/25 mm

FRIOS® BoneShield FormSet: Titanium plunger and silicone mold. Sterilizable, hygienic, practical. Simplifi es anatomical shaping of the membrane and prevents sharp edges

FRIOS® BoneShields

FRIOS® BoneShields – lasting stability that protects and shapes

The perforation allows for diffusion of oxygen and migration of defense cells

The result: new bone

Clinical pictures: Prof. Dr. Fouad Khoury, Olsberg, Germany

FRIOS® FixationSet

Implant Mallet

FRIOS® Drilling and Positioning Tool for Membrane Tacks

FRIOS®

Membrane Tacks

FRIOS® Straight Seating Instrument for Membrane Tacks

FRIOS® FixationSet

FRIOS® Angled Seating Instrument for Membrane Tacks

Holder for FRIOS® Membrane Tacks

Disposable Drill for FRIOS® Membrane Tacks

Clinical application of FRIOS® BoneShieldsHigh mechanical stability and the ability to retain a three-dimensional shape make FRIOS® BoneShields superior over many other membranes. FRIOS® BoneShield is selected to fi t the defect and can easily be shaped according to anatomical situations. Sharp edges can be eliminated with the FRIOS® BoneShield FormSet. FRIOS® Membrane Tacks can easily secure the fi ne foil. All FRIOS® BoneShields are anodized yellow to prevent compromised esthet-ics in case of very thin, transparent mucosa.

Pilot drilling – for membrane tacks: facilitates placement in very dense bone Complete – the FRIOS® Drilling and Positioning Tool for Membrane Tacks is included in the tray. The set also includes very fi ne dispos-able drills.

A complete instrument set for precise positioning of FRIOS® Membrane Tacks

Quick and precise – precisely designed set of instruments for po-sitioning FRIOS® Membrane Tacks

Augmentation with DENTSPLY Friadent

A stable foundation is the basis of a successful implant-supported restoration. In many cases, bone must be reconstructed before implant placement. Missing bone not only makes implant placement diffi cult or even impossible, but also endangers the long-term success.

DENTSPLY Friadent makes augmentation easy with the wide range of proven products in the FRIOS® augmentation system (FRIADENT Osseous Reconstruction System) and the bone grafting materials FRIOS® ALGIPORE®, PepGen P-15® and OSTEOGRAF®/N.

Innovation and experience

All instruments and materials were developed in close consultation with experi-enced implant specialists. FRIADENT uses medical grade titanium or titanium alloy for these instruments wherever technically possible. Whether you need autogenous bone, prefer GBR or are using a bone grafting material – DENTSPLY Friadent can supply everything you need for successful implant treatment.

Το αυτογενές οστό είναι η πρώτη επιλογή πολλών κλινικών. Η FRIOS® έχει τα σωστά εργαλεία για την εύκολη συλλογή οστού. Ανεξάρτητα από το αν θέλετε μπλοκ οστού ή λεπτές φλύδες οστού είστε έτοιμοι να ανταπεξέλθετε σε κάθε κλινική περίπτωση.

Vital bone cells (osteoblasts)in cell culture

Συλλογή Αυτογενούς Οστού

Picture: L.A. Eicker,Cologne/Germany

Αναλώσιμος απορροφητήρας

Αντάπτορας απορρόφησης Αναλώσιμο φίλτρο τιτανίου,

κατασκευασμένο από ιατρικό τιτάνιο

FRIOS® BoneCollectorΑποστειρώσιμη θήκη τιτανίου

FRIOS® BoneCollector

Προφύλαξη για τις μολύνσεις

FRIOS® BoneCollector: συλλογή μεγάλων τεμαχίων ζωντανού οστού με το φίλτρο τιτανίου

Συλλογή Αυτογενούς Οστού

Preparation of bone blocks and access windows – fast and atraumatic

Precise – 0.25 mm thick blade enables minimum bone lossFast – work effi ciently, even in the most diffi cult anatomical conditions, with the specially modifi ed FRIOS® Handpieces and Contra-angle Handpieces

Easy – the FRIOS® Angled Handpiece enables precise preparation even in hard to reach areas such as the retromolar regionAtraumatic – the adjustable soft-tissue protector is easy to install and easy to remove. The direct irrigation of the saw-blade prevents over-heating during the procedure

Bone preparation without bone loss – the 0.25 mm thick diamond disc of the FRIOS® MicroSaw

FRIOS® MicroSaw according to Prof. Dr. F. Khoury

Powerful – particularly quiet, smooth running and high turbine torque when combined with the FRIOS® Handpieces and Contra-angle Handpieces Proven – in clinical use since 1986

The FRIOS® MicroSaw Handpiece – for vertical osteotomies

The FRIOS® MicroSaw Contra-angle Handpiece is designed for all horizontal sections


FRIOS® Handpiece Angled

FRIOS® Contra-angle Handpiece

FRIOS® Handpiece Straight

FRIOS® MicroSaw Straight Chisel (D4 and D6)

FRIOS® MicroSaw Angled Chisel (D4 and D6)

FRIOS® MicroSaw Protector for FRIOS® Contra-angle Handpiece

FRIOS® MicroSaw Protector for FRIOS® Handpieces

FRIOS® MicroSaw Diamond Discs

FRIOS® MicroSaw Drills

FRIOS® MicroSaw ExpertSet

Product Forms

PepGen P-15® – OSTEOGRAF®/N Available in 1-gram vialsSimple application with the OSTEOGRAF® application syringePepGen P-15® can be mixed with OSTEOGRAF®/N and FRIOS® ALGIPORE®

PepGen P-15® FlowPepGen P-15® in gel matrix for simple application in diffi cult to access placesAvailable ready fi lled in 0.5 cm3 syringesThe application is similar to the bone regeneration procedure with particulate materialsExpands to the size of the defect when it comes in contact with biological fl uid

PepGen P-15® and OSTEOGRAF®/Nvials with patented connecting piece(Cannula vial)

Application syringe for precise dispensing of PepGen P-15® andOSTEOGRAF®/N

For single use: PepGen P-15® in gel matrix, ready for use in the disposable syringe


Membranes are used for guided bone regeneration (GBR) and for containment of bone chips and bone grafting material. Various resorbable and non-resorbable materials are used for these applications today. Their high mechanical stability and ability to retain a three-dimensional shape make FRIOS® BoneShields superior over many other membranes. Therefore, we also use the best material: medical grade titanium

Μόνο μία χειρουργική διαδικασία

Συλλογή τεμαχίων ζωντανού οστού κατά την παρασκευή του εμφυτευματικού φρεατίου

Λιγότερο τραύμα για τον ασθενή

Μέγιστη βιοσυμβατότητα

Μέγιστη αποστείρωση

Disposable suction tube

Suction unit adapter Disposable titanium

fi lter manufactured from medical grade titanium

FRIOS® BoneCollectorSterilizable titanium case

Harvest vital bone chips while preparing the implant site

Only one surgical procedure – harvest valuable, vital bone during implant placementLess trauma for the patient – no second surgical site requiredMaximum biocompatibility – housing and fi lter are manufac-tured from medical grade titanium


Prevents contamination – second suction tube used during the procedureMaximum sterility – the FRIOS® BoneCollector can be sterilized, the suction tip and titanium fi lter are disposable

FRIOS® BoneCollector: harvest large vital bone chips with the titanium fi lter

Harvesting Autogenous Bone

Παρασκευή μπλοκ οστού καιπαραθύρων πρόσβασης – γρήγορακαι ατραυματικά

Με ακρίβεια – λεπίδα πάχους 0.25mm επιτρέπει την ελάχιστηαπώλεια οστού Γρήγορα– αποδοτική εργασίαακόμα και στις πιο δύσκολεςανατομικά συνθήκες, με τις ειδικάσχεδιασμένες ευθείες και γωνιακέςχειρολαβές FRIOS

Εύκολα – η γωνιακή χειρολαβή FRI-OS® καθιστά δυνατή την με ακρίβειαπαρασκευή ακόμ ακαι σε δύσκολαπροσβάσιμες περιοχές Ατραυματικά– το προστατευτικότων μαλακών ιστών μπορεί εύκολανα εγκατασταθεί και να αφαιρεθεί. Οάμεσος κατιονισμός της λεπίδαςεμποδίζει την υπερθέρμανση τουοστού

Παρασκευή οστού χωρίς οστική απώλεια –διαμαντόδισκος πάχους 0.25 mm FRIOS®

MicroSaw

FRIOS® MicroSaw σύμφωνα με τον Prof. Dr. F. Khoury

Δυνατό

Αποδεδειγμένο – σε κλινική χρήσηαπό το 1986

FRIOS® MicroSaw χειρολαβή– για κάθετεςοστεοτομές

FRIOS® MicroSaw γωνιακή χειρολαβή:σχεδιαμένη για όλες τις οριζόντιες τομές

Κλινικές φωτογραφίες: Prof. Dr. Fouad Khoury,Olsberg, Germany




FRIOS® MicroSaw StraightChisel (D4 and D6)

FRIOS® MicroSaw AngledChisel (D4 and D6)

FRIOS® MicroSawProtector for FRIOS®

Contra-angle Handpiece

FRIOS® MicroSawProtector for FRI-OS® Handpieces

FRIOS® MicroSawDiamond Discs



Product Forms







Membranes are used for guided bone regeneration (GBR) and for containment of bone chips and bone grafting material. Various resorbable and non-resorbable materials are used for these applications today. Their high mechanical stability and ability to retain a three-dimensional shape make FRIOS® BoneShields superior over many other membranes. Therefore, we also use the best material: medical grade titanium

Bone Regeneration

OSTEOGRAF®/N

The safe foundation: natural hydro-xyapatite for fi lling bone defects

Volume and structure – OSTEOGRAF®/N supplies the calcium phosphate mineral needed for the formation of new bone100% pure – natural hydroxy-apatite. All organic elements are removed through high temperature processing at 1100°C100% protein-free – this process is monitored by the FDA and EC Notifi ed BodySimple – hydrophile, easily mixed with autogenous bone

The proven particulate in a gel matrix

The proven solution made even simpler – PepGen P-15® particulate, now in an inert biocompatible gel matrix for easy deliveryReady for application – in a sterile,disposable syringe Easy to apply – even in places that are diffi cult to accessEasy to use – no mixing, does not require refrigerationReliable results – hydrogel acts as a biocompatible place holder and allows unhindered vascularization

PepGen P-15® PepGen P-15® Flow

The missing link in bone regeneration

Unrivaled – PepGen P-15® is the only tissue-engineered material on the market that has been proven to enhance vital bone formationDocumented – multicenter, long-term clinical trialsPredictable results – cellular attach-ment is promoted by an increased number of receptor sitesEnhanced bone regeneration – increased cellular activity resulting in faster healing and bone formationNo immunological reactions – no risk of disease transmissionClinically tested – in clinical use since 1995Flexible application – mixes well with other bone grafting materials (such as FRIOS® ALGIPORE®, OSTEOGRAF®/N).

OSTEOGRAF®/N PepGen P-15®

(8 month) (4 month)

Vital bone 16 % 14 %

Non-resorbed bone 22 % 28 %grafting material

Bone marrow/ 62 % 58 %connective tissue

Dr. J.T. Krauser, Boca Raton/USA

Histomorphometric analysis:Comparison of OSTEOGRAF®/N and autogenous bone with PepGen P-15® alone after 8 and 4 months

8 months: OSTEOGRAF®/N and autogenous bone (2.5x magnifi cation), 80 : 20

4 months: PepGen P-15® alone (2.5x magnifi cation)

Proven in practicePepGen P-15® has been shown to produce the same amount of bone in half the time as ABM/autogenous bone. The time required before implant placement in an augmented sinus can be reduced by using PepGen P-15®.Sinus augmentation results demonstrate that PepGen P-15® effectively produces vital bone.

PepGen P-15® – unique and patentedConventional materials only provide guidance structures for bone forma-tion (fi ller material).

The following illustrations compare a cell binding to P-15 – as part of natural Type-I collagen coated structure – to a cell binding with a carrier with synthetic P-15. In the body, cells bind to a PepGen P-15® particle the same way they would bind to a graft or autogenous bone. PepGen P-15® is a biomimetic of auto-genous bone.

PepGen P-15® provides active receptors for cellular attachmentPepGen P-15® is the only material that accelerates natural bone re-generation. The organic component is manufactured synthetically. With an increased number of receptor sites PepGen P-15® offers increased security for bone regeneration and leads to improved bone quality.Only PepGen P-15® initiates the cascade of events that results in the formation of new bone. This cascade leads to cell proliferation and cell differentiation and thus triggers the formation of new bone.

Autogenous bone PepGen P-15®

FRIOS® MicroSaw –full function set

Όλες οι διαδικασίες οστικήςπαρασκευής μπορούν ναδιεξαχθούν με τις ευθείες καιγωνιακές χειρολαβές πουεμπεριέχονται στο expert set. Οιχειρολαβές μπορούν ναχρησιμοποιηθούν και σε άλλουςτομείς της χειρουργικής και τηςπροσθετικής πράξης.

Χειρουργική μονάδα που μπορείνα προγραμματιστεί και γιατοποθέτηση εμφυτευμάτων καιγια μοσχεύματα.

FRIOS® Unit S/i

πρόγραμμα για τοποθέτησηεμφυτευμάτων και για μοσχεύματαλειτουργία tapping με το πάτημα ενόςκουμπιού τρεις ρυθμίσεις ροής ορού φως και επαρκές χειρουργικό μοτέρμέχρι και 40,000 στροφές μέχρι και50 Ncm ροπή συμβατή με 1 : 1 και 20 : 1 σε αναλογίαευθείες και γωνιακές χειρολαβές

Οι χειρολαβές FRIOS® και τα χειρουργικά μοτέρFRIOS® είναι σχεδιασμένανα συνεργάζονται άψογαμεταξύ τους

Bone graft materials have been an integral part of augmentation procedures for years. DENTSPLY Friadent offers FRIOS® ALGIPORE®, a classic biological bone grafting material composed of natural calcium phosphate.

Bone Regeneration with FRIOS® ALGIPORE®

Magnifi cation: 2000x


FRIOS® ALGIPORE®:Resembles natural bone

Bone Regeneration

OSTEOGRAF®/N

The safe foundation: natural hydro-xyapatite for fi lling bone defects

Volume and structure – OSTEOGRAF®/N supplies the calcium phosphate mineral needed for the formation of new bone100% pure – natural hydroxy-apatite. All organic elements are removed through high temperature processing at 1100°C100% protein-free – this process is monitored by the FDA and EC Notifi ed BodySimple – hydrophile, easily mixed with autogenous bone

The proven particulate in a gel matrix

The proven solution made even simpler – PepGen P-15® particulate, now in an inert biocompatible gel matrix for easy deliveryReady for application – in a sterile,disposable syringe Easy to apply – even in places that are diffi cult to accessEasy to use – no mixing, does not require refrigerationReliable results – hydrogel acts as a biocompatible place holder and allows unhindered vascularization

PepGen P-15® PepGen P-15® Flow

The missing link in bone regeneration

Unrivaled – PepGen P-15® is the only tissue-engineered material on the market that has been proven to enhance vital bone formationDocumented – multicenter, long-term clinical trialsPredictable results – cellular attach-ment is promoted by an increased number of receptor sitesEnhanced bone regeneration – increased cellular activity resulting in faster healing and bone formationNo immunological reactions – no risk of disease transmissionClinically tested – in clinical use since 1995Flexible application – mixes well with other bone grafting materials (such as FRIOS® ALGIPORE®, OSTEOGRAF®/N).

OSTEOGRAF®/N PepGen P-15®

(8 month) (4 month)

Vital bone 16 % 14 %

Non-resorbed bone 22 % 28 %grafting material

Bone marrow/ 62 % 58 %connective tissue

Dr. J.T. Krauser, Boca Raton/USA

Histomorphometric analysis:Comparison of OSTEOGRAF®/N and autogenous bone with PepGen P-15® alone after 8 and 4 months

8 months: OSTEOGRAF®/N and autogenous bone (2.5x magnifi cation), 80 : 20

4 months: PepGen P-15® alone (2.5x magnifi cation)

Proven in practicePepGen P-15® has been shown to produce the same amount of bone in half the time as ABM/autogenous bone. The time required before implant placement in an augmented sinus can be reduced by using PepGen P-15®.Sinus augmentation results demonstrate that PepGen P-15® effectively produces vital bone.

PepGen P-15® – unique and patentedConventional materials only provide guidance structures for bone forma-tion (fi ller material).

The following illustrations compare a cell binding to P-15 – as part of natural Type-I collagen coated structure – to a cell binding with a carrier with synthetic P-15. In the body, cells bind to a PepGen P-15® particle the same way they would bind to a graft or autogenous bone. PepGen P-15® is a biomimetic of auto-genous bone.

PepGen P-15® provides active receptors for cellular attachmentPepGen P-15® is the only material that accelerates natural bone re-generation. The organic component is manufactured synthetically. With an increased number of receptor sites PepGen P-15® offers increased security for bone regeneration and leads to improved bone quality.Only PepGen P-15® initiates the cascade of events that results in the formation of new bone. This cascade leads to cell proliferation and cell differentiation and thus triggers the formation of new bone.

Autogenous bone PepGen P-15®

Every step of the procedure has a matching FRIOS® Handpiece and Contra-angle Handpiece

FRIOS® MicroSaw – full function set

All bone preparation procedures can be carried out accurately and quickly with the two different FRIOS® Handpieces and a Contra-angle Handpiece included in the FRIOS® MicroSaw ExpertSet. You can con-duct horizontal osteotomies with the FRIOS® Contra-angle Handpiece and the FRIOS® MicroSaw, and vertical osteotomies with the FRIOS® Handpiece. All FRIOS® Handpieces and Contra-angle Handpieces can also be used for other procedures in surgery, implant dentistry and prosthetics.

Induction-driven surgical unit with preset programming for grafting and implant placement

We will be pleased to send you detailed information on the FRIOS® Unit S/i on request.

FRIOS® Unit S/i

implant placement and grafting programtapping function at the press of a buttonthree settings for irrigation fl ow light and effi cient surgical motorup to 40,000 revolutionsup to 50 Ncm torquecompatible with 1 : 1 and 20 : 1 ratiosergonomically designed contra-angle handpiece available – single-piece or demountable

FRIOS® Handpieces and FRIOS® drive units are designed for optimum operation together.

Τα οστικά μοσχεύματα αποτελούν ένα αναπόσπαστο κομμάτι των αυξητικών τεχνικών για χρόνια. Η DENTSPLY Friadentπροσφέρει το FRIOS® ALGIPORE®, ένα κλασσικό οστικό μόσχευμα από υδροξυαπατίτη.

Οστική Αναγέννηση με FRIOS® ALGIPORE®

Magnification: 2000x

Magnification: 2500x

FRIOS® ALGIPORE®:Ομοιάζει του φυσικού οστού

Το FRIOS® ALGIPORE® είναι εντελώς φυσικό: Συλλέγεται από ένα εξαιρετικά πορώδεςκοράλλι του ωκεανού. Η βιομηχανική διαδικασία διατηρεί το καθαρόμεταλλικό (mineral) πλαίσιο του φυτού.

Οστική Αναγέννηση με FRIOS® ALGIPORE®

Ανάλογα με τον όγκο και τον τύπο του οστικού ελλείμματοςμπορεί να επιλεχθεί διαφορετικό μέγεθος κόκκου

FRIOS® ALGIPORE®

Το σωστό μέγεθος κόκκου για κάθε περίπτωση

0.3 – 0.5 mm :για ελλείμματα οστού μέχρι 0.5 cm3

0.5 – 1.0 mm : για αύξηση σε ελλείμματα οστού μέχρι 1.0 cm3

1.0 – 2.0 mm : για αύξηση μετά από ανύψωση ιγμορείου από1.0 cm3

Διατηρεί τον όγκο– αργήαπορρόφηση του υλικού Διαθέσιμο σε διάφορα μεγέθη κόκκουΕύκολο στην εφαρμογή–αναμειγμένο με το αίμα του ασθενούς και με την προσθήκηαυτογενούς οστού βελτιώνει την επούλωση15 χρόνια κλινικής εμπειρίας – Το FRIOS® ALGIPORE® χρησιμοποιείται επιτυχώς στις κλινικές από το 1988. Έλαβε το CE χαρακτηριστικό το 1998 και την έγκριση FDA το 2003.

Το βιολογικό πλαίσιο για αξιόπιστοσχηματισμό οστού

Έντονα πορώδες φωσφορικόασβέστιο – εντελώς φυσικό.Μοιάζει πολύ με το φωσφορικόασβέστιο του ανθρωπίνου οστού.Ευνοεί τον σχηματισμό οστού –λόγω της εσωτερικής σύνδεσηςτων πόρων και της αδρήςεπιφάνειας

FRIOS® ALGIPORE®, blood and autogenous bone chips – the ideal combination

FRIOS® ALGIPORE®, Sinus fl oor elevation using FRIOS® ALGIPORE® and FRIALIT®-2 Stepped Cylinder Implant. Covering the lateral access window with FRIOS® BoneShield secured by FRIOS®

Membrane Tacks

FRIOS® ALGIPORE® – clinical applicationThe material is mixed with the patient’s blood prior to application. It demonstrates good coagulation characteristics and, in this state, can be easily applied. Blood is the best material for closing a wound and promoting bone healing. The addition of autogenous bone chips can further improve bone regeneration.

Breaking up the particles during mixing allows the internal pore structure to become more access-ible to bone rege nerating cells. FRIOS® ALGIPORE® is ideal for recon structing multiple wall bone defects. The FRIOS® BoneShield prevents the ingrowth of connective tissue and secures the bone grafting material.

From left: Corallina offi cinalis from the Atlantic off Scotland and France, Amphiroa ephedra from the Atlantic off South Africa.

Enlarged section 1: Trabecula of newly formed bone with medullary tissue. Interconnection of FRIOS® ALGIPORE® particles. Magnifi cation 4x

Enlarged section 2: In addition to the trabecula formation, the growth of bone into the particulate pore structure and the start of resorption can be detected. The bone is partially reticulated, and partially has a functional lamellar structure. Magnifi cation 10x Enlarged section 3:

Detail view of the mineralization zone with newly formed bone and matured osteocytes. There is still young, non-mineralized bone tissue (osteoid tissue) within the pore structure of FRIOS® ALGIPORE®. Magnifi cation 40x

Histologies: Prof. Dr. Dr. R. Ewers, Vienna

Human biopsy after sinus fl oor elevation with FRIOS® ALGIPORE®.

General picture of a non-decalcifi ed trans-parent bone section. (Survival rate 11.5 months, thionine stain.) Magnifi cation 1x



The quick and safe method for new bone formation! PepGen P-15® has been proven to enhance vital bone regeneration. This has been confi rmed through multicenter clinical trials.

Cellular colonization on natural hydroxyapatite (picture above) and on PepGen P-15® (picture below)

Bone Regeneration

Disposable suction tube

Suction unit adapter Disposable titanium

fi lter manufactured from medical grade titanium

FRIOS® BoneCollectorSterilizable titanium case

Harvest vital bone chips while preparing the implant site

Only one surgical procedure – harvest valuable, vital bone during implant placementLess trauma for the patient – no second surgical site requiredMaximum biocompatibility – housing and fi lter are manufac-tured from medical grade titanium


Prevents contamination – second suction tube used during the procedureMaximum sterility – the FRIOS® BoneCollector can be sterilized, the suction tip and titanium fi lter are disposable

FRIOS® BoneCollector: harvest large vital bone chips with the titanium fi lter


Preparation of bone blocks and access windows – fast and atraumatic

Precise – 0.25 mm thick blade enables minimum bone lossFast – work effi ciently, even in the most diffi cult anatomical conditions, with the specially modifi ed FRIOS® Handpieces and Contra-angle Handpieces

Easy – the FRIOS® Angled Handpiece enables precise preparation even in hard to reach areas such as the retromolar regionAtraumatic – the adjustable soft-tissue protector is easy to install and easy to remove. The direct irrigation of the saw-blade prevents over-heating during the procedure

Bone preparation without bone loss – the 0.25 mm thick diamond disc of the FRIOS® MicroSaw

FRIOS® MicroSaw according to Prof. Dr. F. Khoury

Powerful – particularly quiet, smooth running and high turbine torque when combined with the FRIOS® Handpieces and Contra-angle Handpieces Proven – in clinical use since 1986

The FRIOS® MicroSaw Handpiece – for vertical osteotomies

The FRIOS® MicroSaw Contra-angle Handpiece is designed for all horizontal sections





FRIOS® MicroSaw Straight Chisel (D4 and D6)

FRIOS® MicroSaw Angled Chisel (D4 and D6)

FRIOS® MicroSaw Protector for FRIOS® Contra-angle Handpiece

FRIOS® MicroSaw Protector for FRIOS® Handpieces

FRIOS® MicroSaw Diamond Discs



Product Forms






Συγκράτηση και ΕργαλείαΟι μεμβράνες χρησιμοποιούνται για καθοδηγούμενη οστική αναγέννηση(GBR) και για την συγκράτηση των οστικών μοσχευμάτων.Διάφορα απορροφήσιμα και μη-απορροφήσιμα υλικά χρησιμοποιούνται σήμερα για αυτές τις εφαρμογές.Η υψηλή μηχανική τους σταθερότητα και ικανότητα να διατηρούν τρισδιάστατο σχήμα καθιστούν τις μεμβράνες FRIOS® BoneShields ανώτερες έναντι πολλών άλλων μεμβρανών. Εκτός αυτού χρησιμοποιείται για την κατασκευή τους το καλύτερο υλικό: τιτάνιο ιατρικού βαθμού.


Διάτρητο τιτάνιο-διαμορφωμένο με laser: η διάτρηση της μεμβράνης επιτρέπει την διάχυση του οξυγόνου και την μετανάστευση των κυττάρων

Μηχανική σταθερότητα Βιοσυμβατό Ευέλικτο

Εύκολη σταθεροποίηση

Παγκοσμίως νούμερο ένα στην σταθεροποίηση μεμβρανών

Τέλεια συγκράτησηΒιοσυμβατέςΜπορούν να χρησιμοποιηθούν για όλες τις μεμβράνες Οικονομικές

Συγκράτηση και Εργαλεία

FRIOS® BoneShields

oval20/15 mm

oval24/20 mm

triangular16/14 mm

triangular21/17 mm

implant-fixed rectangular 33/25 mm

FRIOS® BoneShield FormSet

FRIOS® BoneShields

FRIOS® BoneShields – lasting stability that protects and shapes

The perforation allows for diffusion of oxygen and migration of defense cells

The result: new bone


FRIOS® FixationSet

Implant Mallet

FRIOS® Drilling and Positioning Tool for Membrane Tacks

FRIOS®

Membrane Tacks

FRIOS® Straight Seating Instrument for Membrane Tacks

FRIOS® FixationSet

FRIOS® Angled Seating Instrument for Membrane Tacks

Holder for FRIOS® Membrane Tacks

Disposable Drill for FRIOS® Membrane Tacks

Clinical application of FRIOS® BoneShieldsHigh mechanical stability and the ability to retain a three-dimensional shape make FRIOS® BoneShields superior over many other membranes. FRIOS® BoneShield is selected to fi t the defect and can easily be shaped according to anatomical situations. Sharp edges can be eliminated with the FRIOS® BoneShield FormSet. FRIOS® Membrane Tacks can easily secure the fi ne foil. All FRIOS® BoneShields are anodized yellow to prevent compromised esthet-ics in case of very thin, transparent mucosa.

Pilot drilling – for membrane tacks: facilitates placement in very dense bone Complete – the FRIOS® Drilling and Positioning Tool for Membrane Tacks is included in the tray. The set also includes very fi ne dispos-able drills.

A complete instrument set for precise positioning of FRIOS® Membrane Tacks

Quick and precise – precisely designed set of instruments for po-sitioning FRIOS® Membrane Tacks






Autogenous bone is the fi rst choice for many clinicians. FRIOS® has the right instruments for easy bone harvesting. Whether you want bone blocks or fi ne bone chips you will be well prepared for every clinical situation.

Vital bone cells (osteoblasts) in cell culture


Picture: L.A. Eicker, Cologne/Germany


Form-fi t laser-perforated titanium: the perforation allows for diffusion of oxygen and migration of cells.

Mechanical stability without membrane support: ultra-thin, radiopaqueBiocompatible – medical grade titanium, laser-perforated for diffusion of oxygen and migration of defense cellsVersatile – available in various shapes and sizes. Cutting and shaping with the FRIOS® Bone-Shield FormSet adapts them to every situation.Easy to secure – with FRIOS® Membrane Tacks made of medical grade titanium

Worldwide number one for securing membranes

Perfect hold – well secured mem-branes prevent material displace-ment and promote bone formationBiocompatible – manufactured from titanium alloy and gamma-sterilized – the perfect supplement to FRIOS® BoneShieldsUniversal – can be used with all resorbable and non-resorbable membranesEconomical – FRIOS® Membrane Tacks not used can be stored in the tray


FRIOS® BoneShields

oval20/15 mm

oval24/20 mm

triangular16/14 mm

triangular21/17 mm

implant-fi xed rectangular 33/25 mm

FRIOS® BoneShield FormSet: Titanium plunger and silicone mold. Sterilizable, hygienic, practical. Simplifi es anatomical shaping of the membrane and prevents sharp edges

FRIOS® BoneShields

FRIOS® BoneShields –σταθερότητα με διάρκεια

Η διάτρηση επιτρέπει την διάχυση του οξυγόνου και την μετανάστευση των κυττάρων

Το αποτέλεσμα: νέο οστό

Κλινικές φωτογραφίες: Prof. Dr. FouadKhoury, Olsberg, Germany

FRIOS® FixationSet

Εμφυτευματικό σφυρί

FRIOS® εργαλείο τοποθέτησης καρφίδων

FRIOS®

Καρφίδες

Ευθύ εργαλείο τοποθέτησης FRIOS®

FRIOS®

FixationSet

Κεκλιμένο εργαλείο τοποθέτησης FRIOS®

Θέση για τις καρφίδες FRIOS®

Αναλώσιμη φρέζα για τις καρφίδες FRIOS®

Ένα πλήρες σετ εργαλείων για την σταθεροποίηση των καρφίδων FRIOS®

Membrane Tacks






Autogenous bone is the fi rst choice for many clinicians. FRIOS® has the right instruments for easy bone harvesting. Whether you want bone blocks or fi ne bone chips you will be well prepared for every clinical situation.

Vital bone cells (osteoblasts) in cell culture


Picture: L.A. Eicker, Cologne/Germany

MedicinalMixing Beaker

4 Straight and Single-angleApplicators

3 Double-angleApplicators 3 Applicators

FRIOS® SinusSet

Drill Set

Η ανύψωση ιγμορείου είναι πια μία συνηθισμένη διαδικασία. Με την καλοσχεδιασμένη γκάμα εργαλείων, που μπορούν να χρησιμοποιηθούν σε κάθε περίπτωση, το FRIOS® SinusSet από την DENTSPLY Friadentπροσφέρει τις καλύτερες προϋποθέσεις για μακροπρόθεσμη επιτυχία.

FRIOS® SinusSet

Eicker LA, Tomakidi P, Haessler D, Neugebauer J, Zöller JE: Die Vitalität von gefi lterten Knochen spänen zum präimplantologischen Knochenaufbau – Histochemische Untersuchungen und klinische Erfahrungen. Z Zahnärztl Implantol 2002; 18(2): 93 – 100

Eicker LA, Neugebauer J, Tomakidi P, Haessler D, Zöller JE: The vital potential of fi ltered bone particles used for bone augmentation. Scientifi c Poster: 17th Annual Academy of Osseointegration Conference, Dallas, Texas, March 14 – 16, 2002

Young MPJ, Korachi M, Carter DH, Worthington H, Drucker DB: Microbial analysis of bone collected during implant surgery – a clinical and laboratory study. Clin Oral Impl Res 2001; 12(2): 95 – 103

Haessler D, Zöller J, Vizethum F:Autogene Knochentransplantation mit Hilfe eines Spankollektors– Eine Methodenbeschreibung. Implantologie 1995; 3(4): 315 – 322

Young MPJ, Worthington H, Lloyd RE, Drucker DB, Sloan P, Carter DH: Bone collected during implant surgery – a clinical and historical study. Clin Oral Impl Res 2002; 13(3): 298 – 303

Khoury F, Happe A, Basner C, Neugebauer J:Utilizing diamond discs for harvesting bone blocks.Scientifi c Poster: 8th International Congress on Reconstructive and Preprosthetic Surgery, San Diego, USA, April 15 – 17, 1999

Khoury F, Happe A: Zur Diagnostik und Methodik von intra-oralen Knochen-entnahmen. Z Zahnärztl Implantol 1999; 15(3): 167 – 176


Khoury F, Hensher R: The bony lid approach for the apical root resection of lower molars. Int J Oral Maxillofac Surg 1987; 16(2): 166 – 170

Khoury F: Methode und Ergebnisse reponierbarer Knochendeckel bei Wurzelspitzenresektion unterer Molaren. Dtsch Z Mund Kiefer Gesichtschir 1986; 10(2): 124 – 129

Weibrich G, Götz H, Gnoth S-H, Trettin R, Duschner H, Wagner W: Charakterisierung der Oberfl ächenmorphologie von Knochen-ersatzmaterialien mittels REM. Z Zahnärztl Implantol 2000; 16(3): 151 – 159

Schopper C, Moser D, Wanschitz F, Watzinger F, Lagogiannis G, Spassova E, Ewers R: Histomorphologic fi ndings on human bone samples six months after bone augmentation of the maxillary sinus with ALGIPORE®. J Long Term Eff Med Implants 1999; 9(3): 203 – 213

Basner C, Spassova E, Ewers R, Cantzler P, Bergner N: X-Ray diffractometry analysis of hydroxy-apatite bone substitution materials. Scientifi c Poster: 77th General Session of the IADR and 28th Annual Meeting of the AADR, Vancouver, Canada 1999

Haessler D: Die Sinusliftoperation. In: Hartmann HJ (Hrsg): Aktueller Stand der zahnärztlichen Implan-tologie Bd 1, Teil 2, Kp 11.10, Spitta-Verlag Balingen 1998

Schopper C, Ewers R, Moser D: Bioresorption of ALGIPORE® at human recipient sites. Abstract: J Craniomaxillofac Surg 1998; 26 (Suppl 1): 172 – 173

Terheyden H, Jepsen S, Vogeler St, Tucker M, Rueger DC: Recombinant human osteo genic protein 1 in the rat mandibular augmentation model: differences in morphology of the newly formed bone are dependent on the type of carrier. Mund Kiefer Gesichtschir 1997; 1(5): 272 – 275

Feifel H, Gerner A, Schmidt K.-H, Wimmer F, Schmitz H-J: Die Beeinfl ussung der Knochenrege neration in phykogener Hydro-xylapatitkeramik durch einen osteo induktiven Proteinkomplex. Histologische und histomorphometrische Untersuchungen am Kaninchen. Dtsch Z Mund Kiefer Gesichtschir 1995; 19(1): 25 – 27

Behrens P, Bruns J, Gunstmann R, Mohan S, Doden E: Histomorphologic and biochemical investigations of hydroxyapa-tite in combination with the transfor ming growth factor ß1(TGFß1).Osteologie 1995; 4 (Suppl 1)

Ewers R, Schumann B: Experimental and clinical applications of ALGIPORE®, a phycogenic hydroxyapatite. Abstract: J Craniomaxillofac Surg 1994; 22 (Suppl 1): 92

Herr G, Wahl D, Küsswetter W: Osteogenic activity of bone morphogenetic potein and hydro-xyapatite composite implants. Ann Chir Gynaecol 1993; 82 (Suppl 207): 99 – 107

Ewers R, Rasse M, Schumann B: Development and clinical experience with the bone substitute material ALGIPORE®.Osteologie 1992; 1(Suppl 1): 18 – 19

Bieniek KW, Küpper H, Spiekermann H: Tierexperimentelle Untersuchungen zur parodontalen Implantation von kompakten, makroporösen und phykogenen HA-Keramik-granulaten. ZWR 1989; 11: 958 – 960

Kasperk C, Ewers R, Simons B, Kasperk R: Algae-derived (phycogene) hydroxylapatite. A comparative histological study. Int J Oral Maxillofac Surg 1988; 17(5): 319 – 324

Ewers R, Kasperk C, Simons B: Biologisches Knochenimplantat aus Meeresalgen. Zahnärztl Prax 1987; 38(9): 318 – 320

Bhatnagar RS, Qian JJ, Gough CA: The role in cell binding of ß-bend within the triple helical region in collagen a1(l) chain: Structural and biological evidence for conformational tautomerism on fi ber surface. J Biomol Struct Dyn 1997; 14(5): 547 – 560

Qian JJ, Bhatnagar RS: Enhanced cell attachment to anorganic bone mineral in the presence of a synthetic peptide related to collagen. J Biomed Mater Res 1996; 31(4): 545 – 554

Bhatnagar RS, Qian JJ, Wedrychowska A, Sadeghi M, Wu YM, Smith N: Design of biomimetic habitats for tissue engineering with P-15, a synthetic peptide analogue of collagen. Tissue Eng 1999; 5(1): 53 – 65

Bhatnagar RS, Qian JJ, Wedrychowska A, Smith N: Construction of biomimetic environments with a synthetic peptide analogue of collagen. Materials Research Society Symposium Proceedings 1998; 530: 43 – 54

Yukna RA, Callan DP, Krauser JT, Evans GH, Aichelmann-Reidy E, Moore K, Cruz R, Scott JB: Multi-center clinical evaluation of combination anorganic bovine-derived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) as a bone replacement graft material in human periodontal osseous defects: 6-month results. J Periodontol 1998; 69(6): 655 – 663

Sogal A, Tofe AJ: Risk assessment of bovine spongiform encephalopathy trans-mission through bone graft material derived from bovine bone used for dental applications. J Periodontol 1999; 70(9): 1053 – 1063

Bhatnagar RS, Qian JJ, Wedrychowska A, Dixon E, Smith N: Biomimetic habitats for cells: Ordered matrix deposition and differentiation in gingival fi broblasts cultured on hydroxyapatite coated with a collagen analogue. Cells and Materials 1999; 9(2): 93 – 104

Krauser JT, Rohrer MD, Wallace SS: Human histologic and histomorphometric analysis comparing OSTEOGRAF®/N with PepGen® P-15 in the maxillary sinus elevation procedure: A case report. Impl Dent 2000; 9(4): 298 – 302

Basner C, Salaske I: Laserperforierte Titanfolien in der Implantologie. Implantologie Journal 2002; 6(4): 38 – 41

Basner C, Salaske I, Khoury F, Arpak N: Knochenregeneration mit Titanfolien. Nichtresorbierbare Membranen in der Implantologie. Implantologie Journal 2001; 5(4): 36 – 42

Khoury F, Ponte A, Nakib S: Preliminary report of a prospective study using atitanium membrane (BoneShield) in implant surgery. Scientifi c Poster: EAO 9th Annual Congress European Association for Osseointegration, Amsterdam, NL, September 14 – 16, 2000

Arpak MN, Alkan A, Nergiz I: A case of localized ridge augmentation from using a titanium membrane: A pilot study. J Oral Sci 2000; 42(3): 133 – 138

Watzinger F, Luksch J, Millesi W, Schopper C, Neugebauer J, Moser D, Ewers R: Guided bone regeneration with titanium membranes: A clinical study. Br J Oral Maxillofac Surg 2000; 38(4): 312 – 315

Ewers R, Neugebauer J, Schopper C, Watzinger F: Bone reconstruction through graft fi xation with the titanium barrier FRIOS® BoneShield. Scientifi c Poster: 8th International Congress on Reconstructive and Preprosthetic Surgery, San Diego, USA, April 15 – 17, 1999


Ewers R, Neugebauer J, Rode M, Gehrke P: Fixation of augmentation material with a titanium mesh barrier. Scientifi c Poster: XVI Congresso Internazionale Accademia Italiana di Odontoiatria Protesica, Bologna, Novembre 7 – 8, 1997

Ewers R, Neugebauer J, Schopper C: Guided bone regeneration of the alveolar process with the FRIOS® BoneShield by sinus fl oor augmentation. Scientifi c Poster: 7th International FRIATEC Symposium, April 4 – 5, 1997

Ackermann KL, Kirsch A, Wittal CG: Le système d’augmentation FRIOS®. Un nouveau système pour la stabilisation de la membrane. Implant 1994; Octobre: 69 – 73

CONTENTAND BIBLIOGRAPHY

FRIOS® MicroSaw

FRIOS® BoneCollector FRIOS® ALGIPORE® PepGen P-15® · OSTEOGRAF®/N FRIOS® BoneShield

FRIOS® FixationSet

FRIOS Augmentation

Documents

Transcript of FRIOS Augmentation