Friends and Colleagues,

Welcome to the Fourth Annual Roseman University of Health Sciences Research Symposium. We are pleased and grateful to continue the momentum that has been building since our first Symposium three years ago. This year, we received 118 abstracts to date across both campuses in South Jordan and Henderson as well as from a growing contingent from our colleagues outside of Roseman. We look forward to featuring the discoveries and scholarly work of our faculty members, staff, post-doctoral researchers, residents, and students from all of Roseman’s health disciplines. Many of the presenting authors both inside and outside of Roseman carry affiliations with other great universities and entities worldwide like Virginia Commonwealth University, University of Michigan, University of Southern California, NYU, UNC Chapel Hill, Touro University Nevada, University of Chicago, University of Dresden, Germany, Mekelle University in Ethiopia and pharmaceutical manufacturer Merck & Co. Our presenters are immensely talented and in demand, working across borders to create solutions, collaborating with other great minds, and bridging our communities.

This year’s abstracts cover a wide range of topics in various areas including bench-top science, clinical research, and educational research. These works independently and collectively represent prodigious planning, methodical execution, and deeply insightful findings. These works, with a wide breadth and depth of scientific subject matter, are steps towards solutions, solutions that advance not only our work and our national and international reputation, but advance the human race. Some interesting presentations to note include research on healthcare policy and which social determinants of health are most likely to acted upon in US policymaking, a retrospective cross-sectional study on an antiretroviral therapy among HIV patients in Northern Ethiopia, and research on how Roseman faculty use and understand the Six-Point Mastery Learning Model, Roseman’s innovative learning model which has challenged the way healthcare education is taught. As you can see, the work being conducted is truly transformational and holds great possibility in evolving our understanding of critically important issues.

We believe that this thinking, input and collaboration not only showcases current thinking, but sparks new ideas, new modes of thinking, and imagination. We are proud of the minds and hearts of those in this room today.

Thank you to all those responsible for making this important event happen, as well as to all those attending the symposium and supporting the work of colleagues, students and friends. We believe this symposium will continue to grow and serve as a platform for the best thinking and research and a home for sparking imagination, solutions, discovery and learning.

Sincerely,

Renee Coffman, President

Agenda 1:30 – 3:00 PM Check In – All Poster Presenters

Front Lobby

3:00 – 4:00 PM Chancellor’s Welcome & Keynote Address Dr. Randall T. Peterson L.S. Skaggs Presidential Endowed Professor,

Dean, University of Utah College of Pharmacy D3 Classroom

4:00 – 4:50 PM Meet the Researchers – Poster Presentations Hallways outside Library and D3 Classroom 5:00 – 6:00 PM Podium Presentations D3 Classroom

Attendees are welcome to a meal provided in the adjacent breakout room

6:00 – 6:15 PM Awards & Wrap-up D3 Classroom

Keynote Speaker: Dr. Randall T. Peterson D3 Classroom 3:00 – 4:00 PM Sex, Drugs, and Disco: Tales of Zebrafish Chemical Biology Dr. Randall T. Peterson L.S. Skaggs Presidential Endowed Professor, Dean, University of Utah College of Pharmacy Randall T. Peterson, PhD is a chemical biologist whose research utilizes high-throughput screening technologies to discover new drug candidates for cardiovascular and nervous system disorders. Unlike conventional drug discovery programs that utilize simplified, in vitro assays, the Peterson lab screens using living zebrafish, ensuring that the drug candidates discovered are active in vivo. Several of the compounds discovered by the Peterson laboratory have become widely used research tools or are in clinical development.

Dr. Peterson received his PhD from Harvard University where he studied as a Howard Hughes Medical Institute predoctoral fellow in the laboratory of Stuart Schreiber. He completed a postdoctoral fellowship with Mark Fishman at Massachusetts General Hospital. Dr. Peterson spent 14 years as a faculty member at Harvard University where he was the Charles Addison and Elizabeth Ann Sanders Chair in Basic Science at Harvard Medical School, Scientific Director of the MGH Cardiovascular Research Center, and Senior Associate Member of the Broad Institute of Harvard and MIT. In 2017 he moved to the University of Utah as L.S. Skaggs Presidential Endowed Professor and Dean of the College of Pharmacy.

A recipient of numerous grants from the National Institutes of Health, charitable foundations, and private industry, Dr. Peterson is currently co-leader of a $12 million National Institute of Neurological Disorders and Stroke Center of Excellence grant seeking to develop novel pharmaceutical countermeasures for cyanide exposure. He was the PI on a prestigious National Institute of Mental Health EUREKA grant and a grant from the Bill and Melinda Gates Foundation. He has published more than 100 high-impact papers and delivered hundreds of lectures on the subject of drug discovery across the US and internationally.

An inventor on numerous patents, Dr. Peterson has developed methods and compositions that can be used in the treatment of conditions ranging from heart failure to epilepsy. He has founded or served as a scientific advisor to several companies including Utah companies Montigen Pharmaceuticals Inc. and Tolero Pharmaceuticals, Inc.

Meet the Researchers – Poster Presentations 4:00 – 4:50 PM

Poster Number Title Presenter

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1 Exploring the Effect of Mercury on Epigenetic Gene Expression in C. Elegans

Nancy Wilson Brigham Young University

2

Synthesis and Antileishmanial Activity Evaluation of some 2,3-Disubstituted Quinazoline-4(3H)-Ones Bearing Quinoline and Pyrazole Moieties

Roza G Tesfahunegn Roseman University College of Pharmacy

3 Histone Post-Translational Modifications and Nucleosome Positioning: A New Layer in the Histone Code Hypothesis?

Andrew Earl Brigham Young University

4

Locus-Specific Nucleosome Positioning Method Used to Evaluate Engineered Nucleosome Positioning in Caenorhabditis Elegans

John Carter Brigham Young University

5 Synthesis of Jaspine B C-2 Alkyl Amine Analogs Targeting Sphingomyelin Synthase

Farjana Afrin Idaho State University

6

Understanding Key Epigenetic Changes During Differentiation and Polarization of Human Macrophages from Peripheral Blood Monocytes

Kevin D. Adams Brigham Young University

7 A Novel Perspective on the Evolutionary Dynamics of Non-Stem Cancer Cells

Jake Hogan Brigham Young University

8 Identification of MMP-8 Inhibitors from Natural Sources

Jennifer Campbell Roseman University College of Pharmacy

9 Single Nucleotide Polymorphisms and Their Influence in Nucleosome Positioning Variance Among Caenorhabditis Elegans

Davis Garner Brigham Young University

10

Metformin and Exercise Treatments Not Effective in Ameliorating Doxorubicin-Induced Iron Dysregulation and Cardiotoxicity in Mice

Erik Marchant Brigham Young University

11 Potency and Stability Testing in Various DHEA Products Using HPLC

Khoa Nguyen Roseman University College of Pharmacy

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12 Next-Gen Sequencing for Next-Gen Biomonitoring

Benjamin Wright Brigham Young University

13 Reduction of CSE-Induced Ca9-22 Cell Invasion by SAGEs

Daniel Dalanhese Roseman University College of Dental Medicine

14 Multiple NGF Treatments Enhance Regeneration in Peripheral Nerves

Caleb Dixon Brigham Young University

15

Curcumin Alters Iron Regulation in C2C12 Skeletal Muscle Cells and Prevents Iron Accumulation in a Model of Elevated Oxidative Stress

Dylan Simkins Brigham Young University

16 The Microbiota Influences Life History Variation in Drosophila Melanogaster

Amber Walters Brigham Young University

17 Silencing Gene Silencing Hailey Hein Brigham Young University

18 Decreased Inflammatory Cytokines During Gas6-Mediated Invasion of Gingival Cells

Siri Sarva Roseman University College of Dental Medicine

19 Microbiome Influence on Drosophila Melanogaster Life-History Evolution

Rachel Hughes Brigham Young University

20 Long-Term PP2A Inhibition in Mice Does Not Dysregulate Peripheral Glucose Homeostasis and Insulin Mediated Signal Transduction

Juyeon Lee Roseman University College of Pharmacy

21 Microbiota Influences of Ethanol Tolerance in Drosophila Melanogaster

Rebekah Rushforth Brigham Young University

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22 Functional Electrical Stimulation Effects on Lower Extremity Function in Charcot Marie Tooth Disease: Case Report

Christa Young Rocky Mountain University of Health Professions

23 Muscle Thickness with Positioning: Reaching Muscles of the Scapula

Robert Larson Brigham Young University

24 Povidone-Iodine Vapor Kills MRSA Benjamin Ogilvie Brigham Young University

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25 Compliance in Personal Protective Equipment

in the Roseman Student Dental Clinic

Carol Chavez Roseman University College of Dental Medicine

26

Intensive Physical Therapy for a Young Pediatric Patient with Cerebral Palsy: A Retrospective Look at Progress in Standing/Walking Skills with Limited Medical Interventions

Ann Hoffman Rocky Mountain University of Health Professions

27 Assess Dexamethasone Use in Adult Patients Hospitalized with Suspected Bacterial Meningitis

Ernest Mofor Roseman University College of Pharmacy

28 A New Mouthguard: Assessment of Compliance and Quality of Use Among Women’s College Field Hockey Players

Mohan Ellamaraju Drs. Oley, Shaia & Associates, Richmond, VA

29

CD4 Cell Count Trends After Commencement of Antiretroviral Therapy Among HIV-Infected Patients in Tigray, Northern Ethiopia: A Retrospective Cross-Sectional Study

Addisu Azene Roseman University College of Pharmacy

30 Assessing the Effects of a First Cardiovascular Event on Adherence to Statins Prescribed for Primary Prevention: A Claims-Based Analysis

Trenna Weathers Roseman University College of Pharmacy

31 Secret Shopper Patients (SSPS): A Method to Comprehensively Evaluate Quality Assurance and Clinic Operations

Burke Soffe Roseman University College of Dental Medicine

32

Quality Assurance (QA) Score – Using Objective Observation Data to Drive QA Standards and Infection Control Compliance in Dental School Clinic

Burke Soffe Roseman University College of Dental Medicine

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33

Comparison of an Entry-Level Doctor of Physical Therapy EBP Curriculum with National Guidelines: Initial Performance Outcomes

Jeff Lau Rocky Mountain University of Health Professions

34 Continuing Professional Development (CPD) Course Assessing Development of Self-Awareness

Catherine Cone Roseman University College of Pharmacy

35 Developing Clinical Reasoning Skills in Entry-Level PT Students Using a Biopsychosocial Practice Model

Kevin Helgeson Rocky Mountain University of Health Professions

36 Authentic Pre-Clinic Learning for Improved Clinic Outcomes

Clark Dana Roseman University College of Dental Medicine

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37

Meeting the Community Need for More Advanced Practice Health Care Providers: Decreasing Student Attrition due to Major Life Events in Graduate Nursing Programs

Anmy Mayfield Rocky Mountain University of Health Professions

38 Implementation of Intensive Primary Care in an Outpatient Free Medical Clinic

Anmy Mayfield Rocky Mountain University of Health Professions

39 Influences of Peer-Created Media on Classroom Engagement and Assessment Outcomes

Ellen Justus Roseman University College of Dental Medicine

40 Publication Rates of Pharmacy Residents Across the United States

Trenna Weathers Roseman University College of Pharmacy

41 A Comprehensive Summary of Services and Resources Provided by Librarians in Support of Dental Schools in the U.S. and Canada

Nena Schvaneveldt Roseman University

42 A Longitudinal APPE at the Cleveland Clinic – Pilot Year One Design and Implementation

Phillip Lawrence Roseman University College of Pharmacy

43 Promoting Cultural Competency Education in Physical Therapy Curriculum

Hina Garg Rocky Mountain University of Health Professions

44

Internal Consistency and Construct Validity of an Adapted Clinical Cultural Competency Questionnaire (CCCQ-PRE) Instrument in Entry-Level Physical Therapy Students

Hina Garg Rocky Mountain University of Health Professions

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45 Knowledge, Attitude & Perception of Hookah Smoking Among Dental Students

Hana Lim Roseman University College of Dental Medicine

46 Point of Care Testing – Using Pharmacists to Meet Public Health Needs

Anthony Nowling Roseman University College of Pharmacy

47 The Pharmacist Will See You Now – Point of Care Testing in the United States

Alyssa Meyers Roseman University College of Pharmacy

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48 Time is Money - Reimbursement for

Pharmacist Provision of Point of Care Testing

Ian Anderson Roseman University College of Pharmacy

49 E-Cigarette Use Among Professional Baseball Players

Zachary Hansen Roseman University College of Dental Medicine

50 HCAHPS and the Truth of a Pharmacist’s Impact

Michael Bair Roseman University College of Pharmacy

51 Monoclonal Antibody Dose-Rounding (MAD) Cost Savings Analysis

Mike Rowlett Intermountain Healthcare

52 Perceived Job Satisfaction and Work-Life Balance Among Clinical Pharmacists in Utah

Bryanna Monkurai Roseman University College of Pharmacy

53 Age- and Occupation-Based Public Health Considerations Related to Osteoarthritis of the Knee Joint: A Cadaveric Study

Jessica Immonen Rocky Mountain University of Health Professions

54

Development of an Assessment Tool to Evaluate Pharmacy Technician Engagement and Proficiency in Clinical Services Delivery in the Community Pharmacy Setting

Anthony Moya Roseman University College of Pharmacy

55 How Much Do You Know? An Analysis of Pharmacy Personnel’s Knowledge of Naloxone

Nakisa Mirrafie Roseman University College of Pharmacy

56 Implementation of Pharmacy Services in a Community Oncology Clinic Using APPE Students

Brooke Miller Roseman University College of Pharmacy

Podium Presentations 5:00 – 6:00 PM D3 Classroom Public Health Navigating the Politics of Health: A Systematic Review of U.S. Policymakers’ Views on the Social Determinants of Health, Health Disparities, Health Equity, and Health in all Policies Len B. Novilla, MD, MPH Brigham Young University, Dept. of Health Science, College of Life Sciences Clinical Research Assessing the Effects of a First Cardiovascular Event on Adherence to Statins Prescribed for Primary Prevention: A Claims-Based Analysis Trenna Weathers, PharmD Candidate 2018 Roseman University of Health Sciences, College of Pharmacy A New Mouthguard: Assessment of Quality and Compliance of Use Among College Basketball Players John F. Wisniewski, DMD, MS Roseman University of Health Sciences, College of Dental Medicine Basic Science Research Autophagy in Alveolar Soft Part Sarcoma Confers Mechanisms of Resistance to Chemotherapy Jared Barrott, PhD Idaho State University, College of Pharmacy

2018 Research Symposium Sponsors Thank you to our sponsors!

Presenting Sponsor Zions Bank & Practice Pathways

Hospitality Sponsor NuSkin

Keynote Speaker Sponsor MedQuest

Book of Abstracts Sponsor RBM Building Services

Award Sponsor Dr. Phung Matthews & Anonymous Donor

Roseman University

Research Symposium Organizing Committee

Eric Hanson, PhD – Chair

Associate Professor, College of Pharmacy

Lana Crichton, BA

Chancellor’s Administrative Assistant

Nena Schvaneveldt, MSLIS, AHIP

Head Librarian

Phillip Lawrence, PharmD

Assistant Professor, College of Pharmacy

Rachael Wadley, MBA Marketing Director

We are glad you were able to attend our 4th Annual Research Symposium. Thank you to our presenters, faculty, students, staff, administrators, judges, sponsors, and volunteers who made this event possible.