for In Vitro Diagnostic Use - Shimadzu

Liquid ChromatographLiquid Chromatograph Mass Spectrometer

CL Seriesfor In Vitro Diagnostic Use

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Consistency. Performance. Reliability.Shimadzu’s CL Series LC, LC-MS, and LC-MS/MS for in vitro diagnostic use

Analytical instrumentation such as LC-MS has become the tool of choice for many specific and sensitive clinical diagnostic tests. Quality manufacturing of medical devices requires strict adherence to procedures intended to ensure the performance and reliability of the finished product.

Shimadzu’s US factory in Canby, Oregon proudly performs its work in accordance with all accreditation guidelines.

CL Series Class I Medical Devices are designed to deliver maximum performance resulting in reproducible and reliable data while reducing analytical run time to improve work efficiency.

www.ssi.shimadzu.com/CLseries

Users demanding speed and reliability from LC-MS analysis have two new choices in HPLC systems, Shimadzu’s Nexera CL Series and Prominence CL Series. Whether your needs are high-throughput elite performance or affordable ruggedness and durability, Shimadzu offers the perfect fit for your in vitro diagnostic LC laboratory. All systems are modular, and can be configured for your exact needs.

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HPLC/UHPLC

Nexera CL

SIL-30ACMP CL System

Ultra-High Performance Liquid Chromatography system for operation up to 19,000 PSI. The SIL-30ACMP CL autosampler holds up to six microtiter plates, offering your laboratory high-capacity and high-speed operation. Open-access design enables the loading of samples, even during analysis. Intelligent design and standard rinse pump virtually eliminate carryover.

Shimadzu’s LC-30AD CL liquid chromatograph pumps deliver precise and rapid gradients for stable retention times and optimized separations.

SIL-20ACXR CL System

High Performance Liquid Chromatography system for operation up to 9500 PSI. The SIL-20ACXR CL autosampler offers rapid and accurate injection and low carryover. Shimadzu’s LC-20ADXR CL liquid chromatograph pumps deliver outstanding gradient performance and exceptional durability for applications requiring higher than standard HPLC operating pressures.

Advanced firmware enables rapid cycle times.

Prominence CL

SIL-20AC CL System

High Performance Liquid Chromatography system for operation up to 6000 PSI. The SIL-20AC CL autosampler in combination with the LC-20AD CL liquid chromatography pumps represent an outstanding value in HPLC hardware.

Durable and robust, these components offer low carryover and excellent gradient performance for applications requiring standard HPLC operating pressures.


LC-MS, LC-MS/MSCL Series Liquid Chromatograph Mass Spectrometers (LC-MS, LC-MS/MS) provide high performance and excellence in data quality, enabling dramatic improvements in laboratory throughput. Simultaneous multicomponent analysis using high-performance mass spectrometry enables the clinical laboratory to report quantitative data with efficiency and confidence.

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Single Quad

LCMS-2020 CL

An ultra-fast single-quadrupole mass spectrometer (MS) designed for ease of use with an HPLC or UHPLC system. The LCMS-2020 CL offers high performance at low cost for your routine laboratory analyses.

Triple Quad

LCMS-8040 CL

An ultra-fast triple quadrupole mass spectrometer (MS/MS), incorporating improved ion optics systems for increased sensitivity. The LCMS-8040 CL is appropriate for laboratories requiring lower detection limits in specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analyses.

LCMS-8050 CL

This high-sensitivity triple quadrupole mass spectrometer (MS/MS) offers outstanding measurement speeds and quantitative performance. Specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analysis is improved with a heated electrospray source and ultra-efficient collision cell.

LCMS-8060 CL

With new ion focusing technology, and incorporating Shimadzu’s proprietary ultrafast technologies, the LCMS-8060 CL creates a meaningful impact on trace quantitative detection. Combined with a robust design and easy maintenance, the LCMS-8060 CL is the ideal solution for better data quality and higher throughput.

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Designed for Outstanding PerformanceShimadzu’s CL Series devices are registered with the United States Food and Drug Administration as Class I medical devices. Our CL Series products deliver reliable results, meeting the demands of today’s clinical laboratories. Ultra-fast acquisition data speeds enable optimum throughput, allowing sensitive quantitative analyses with exceptional robustness and ease of use.

Exceptional Durability

Shimadzu CL Series instruments, proudly manufactured in the United States of America, are engineered for long lifetimes and easy maintenance. Clinical laboratories benefit from minimal downtime and low total cost of ownership. These compact platforms are designed to be clinical workhorses consistently delivering precise and reliable data.

Confidence in Clinical Measurements

A critical parameter of instrument performance is carryover of patient samples. Ultra-low carryover is required in highly sensitive LC-MS/MS assays. The SIL-30ACMP CL autosampler standard injection cycle demonstrates exceptional carryover performance even on compounds that are very prone to adsorption. Additionally, the SIL-30ACMP CL can employ an additional rinsing mechanism to mitigate carryover. These features ensure that accurate quantitation is possible even for the most complex biological matrices.

A Continuing Commitment to Improving Human Health

For the past 140 years, Shimadzu Corporation has maintained the pioneering spirit of our founders. Shimadzu has more than 100 years’ experience in the medical field, providing a broad range of X-ray systems, including:

• Cardiovascular • Angiography • Fluoroscopy • Surgical mobile C-arm • General Radiography • Mobile X-ray systems.

We continue this tradition with our CL Series products, delivering outstanding performance and quality to clinical laboratories for accurate and reliable quantitative analysis of clinical biospecimens.


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Powerful Software for Quantitative Analyses with Ease and EfficiencyShimadzu’s family of software allows easy operation of analytical instrumentation including auto-tuning, acquisition parameters, data review, and report generation. The software also allows the creation of quantitation methods for multi-component analysis, enabling laboratories to perform quantitative analyses with easily and efficiently.

Real-Time Analysis Window with Instrument Status

The data acquisition window displays chromatograms in real time, as well as instrument status information such as pressure, temperature, and analytical run time. Instrument status logs are permanently stored in each data file, making audit retrieval and troubleshooting secure and intuitive.

Analysis Window (Quantitation Browser) for Multiple Data File Review

The Quantitation Browser allows users to analyze and compare entire data sets in a single window. Rapid review and simultaneous calculation of multiple compound results from multiple sample injections is possible. In addition to calculating a complete batch of analytical data, it enables quick, easy confirmation of data quality. The browser provides efficient quantitative processing of multiple analytes.

Progress of analysis queue displayed

Current instrument status displayed

Chromatograms and MS spectra displayed in real time

Statistical results for multiple data files can be displayed

Quantitative parameters can be displayed and/or changed

Calibration curve information can be verified

Chromatogram for selected component data is displayed

CL Series

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This brochure may contain references to products that are not available in your country. Please contact us to check the availability of these products in your country.

Company names, product/service names and logos used in this publication are trademarks and trade names of Shimadzu Corporation or its affiliates, whether or not they are used with trademark symbol “TM” or “®”.Third-party trademarks and trade names may be used in this publication to refer to either the entities or their products/services. Shimadzu disclaims any proprietary interest in trademarks and trade names other than its own.

The contents of this publication are provided to you “as is” without warranty of any kind, and are subject to change without notice. Shimadzu does not assume any responsibility or liability for any damage, whether direct or indirect, relating to the use of this publication.

Shimadzu Corporationwww.shimadzu.com/an/

Shimadzu Scientific Instruments7102 Riverwood Drive, Columbia, Maryland 21046, U.S.A.Phone: 800-477-1227/410-381-1227, Fax: 410-381-1222

www.ssi.shimadzu.com

CL Series Liquid Chromatograph and Mass Spectrometry Listed Devices:

Single Quad LC-MS LCMS-2020 CL

Triple Quad LC-MS/MS LCMS-8040 CL



Column Oven CTO-20AC CL

Communications CBM-20A CL

Communications CBM-20Alite CL

Degassing Unit DGU-20A5R CL

Diode Array Detector SPD-M20A CL

Low Volume LPGE LC-30AD CL

Nexera CL Autosampler SIL-20ACXR CL

Nexera CL Autosampler SIL-30AC CL

Nexera CL Autosampler SIL-30ACMP CL

Nexera CL Column Oven CTO-30A CL

Nexera CL Diode Array Detector SPD-M30A CL

Nexera CL Liquid Chromatograph LC-20ADXR CL

Nexera CL Liquid Chromatograph LC-30AD CL

Prominence CL Autosampler SIL-20AC CL

Prominence CL Autosampler SIL-20ACHT CL

Prominence CL Autosampler SIL-20AHT CL

Prominence CL Liquid Chromatograph LC-20AD CL

Reservoir Switching Valve for LC-30AD CL

UV-VIS Detector SPD-20A CL

UV-VIS Detector SPD-20AV CL

Valve Unit FCV-20AH2 CL

Valve Unit FCV-32AH CL


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for In Vitro Diagnostic Use - Shimadzu

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