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Inorganic Nanomaterials for Antimicrobial Protection

Dr. Selvaraj Subbiah

Materials Innovations for Infection Prevention9 November 2009

Institute of Materials, Minerals and Mining, London

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Intrinsiq Materials Ltd

• Leading Nanotechnology Company with a broad set of international customers and partners.

• Powerful Platform Technologies • Novel tool for development and manufacture of novel

nanomaterials• Controlled release of high value actives • Novel antimicrobial and antiviral materials

• Considered by HSE/HSL as leaders in safe inorganic nanomaterial production, handling, packing and shipping.

• Substantial IP portfolio of 34 patent families

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IML’s Patented Development Tool & Production Process

Feedstock

Vaporised

Cooled &Cooled &Modified

Nanoproduct

NanoProduct

IML is one of the few companies that has both a powerful development tool and scalable production process

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Intrinsiq Materials – Made to Order

MetalsMetals OxidesOxides CarbidesCarbides andand NitridesNitrides

MixedMixedMaterialsMaterials

Aluminium, Copper

Silver, Nickel

Cobalt, Titanium

Stainless Steel

Tungsten, Silicon

Tantalum

Molybdenum

Zinc Oxide, Copper Oxide

Cerium Oxide, Tin Oxide

Cuprous Oxide, Titanium Dioxide

Nickel Oxide, Zirconium Oxide

Tungsten Carbide

Aluminium Nitride

Aluminium Oxy Nitride

Silicon Nitride

Boron Nitride

Blends

Alloys

Doped

Structured

Stoichiometry

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TEM images of nano dispersion (in house technique, water based dispersion )

Extremely small particle distribution – easy to disperse

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Positive Control (citric acid)

IML Materials

Actives Screening vs Controls

Negative Control

Antiviral Actives vs Influenza Virus – H5N1 (bird flu)

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Antibacterial efficacy – E.coli

PQN 842; effective for both organism ( 6-6.5 log reduction in 15 minutes)

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Antibacterial efficacy – Staph.aureus

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Application Flexibility

Coated paper

Filter media coated with active material

Melt blown nonwoven

Spun bond polyester

HEPA glass fiber

Nano coatedUncoated

Nano-latex glove

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Nanoparticles incorporated glove (different magnification)After washing with water

5K 50K NP- Glove

80K

Washing did not leach out antimicrobial active nanoparticlesWashing did not leach out antimicrobial active nanoparticles

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Face mask with antimicrobial actives

A B C

A. Blank polypropylene material - uncoatedB. Coated with Antimicrobial active-AC. Coated with Antimicrobial active-B

Nanoparticle leaching: After incorporation, filter media was washed with water few times and SEM image was taken to confirm the presence of nanoparticles on the fiber

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SEM image of nanoparticles incorporated facemask materials – after washing

4K

25K50K

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Nylon with nano particle- uniform fibers

Nanoparticle incorporated nylon fibers made via NanospiderPotential for large scale productionFurther optimization needed

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Intrinsiq Materials’ Solution

• Broad Spectrum Biocide• antibacterial / antiviral / antifungal

• Performance • Inorganic material and not organic material• Durable

• Processing Flexibility • Technology to incorporate nanoparticles into fibers /

coatings etc• Safety

• Components are well known and generally considered as safe

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Summary

• Technology developed (for materials) and commercialised by globally recognised leaders in their fields

• Novel, multi-functional particles produced using plasma processing

• Demonstrated broad spectrum of activity• Active against Gram +, Gram -, yeast, and pathogenic

viruses

• Proven efficacy when coated on multiple substrates• Strong IP position – ample “white space”

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Thank you

Business Development Enquiries: Dr. Ian Clark - Sales & Marketing Director (

ianclark@intrinsiqmaterials.com)