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Foods That Fight Cancer · Cancer is caused by our environment (nearly always) In Australia, we are...
Transcript of Foods That Fight Cancer · Cancer is caused by our environment (nearly always) In Australia, we are...
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Foods That Fight Cancer
Dr David Wilkinson
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• You had cancer treatment and want protection for the future
• You have a risk factor for cancer, such as family history
Is this you?
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• You are interested in a natural approach
• You feel isolated and alone, trying to decide what to do
Or this?
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Try some light reading:
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Peruse a few scientific journals
• American Journal of Clinical Nutrition
• American Journal of Epidemiology
• Anticancer Research
• British Journal of Nutrition
• Cancer Causes Control
• Cancer, Epidemiology, Biomarkers, and Prevention
• Cancer Letters
• Cancer Prevention Research
• Clinical Cancer Research
• Carcinogenesis
• International Journal of Cancer
• Journal of Agriculture and Food Chemistry
• Journal of Clinical Oncology
• Journal of Nutrition
• Nutrition and Cancer
• Nutrition Research
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• You want evidence
• You are becoming from stressed from trying to figure it all out for yourself
Do you end up like this?
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Cancer is caused by our environment (nearly always)
In Australia, we are expecting 50,000 deaths per year from cancer
(about 30% of annual deaths)And a quarter of cancers are preventable
Medical Journal of Australia 2012 : “Estimating the future burden of cancers”
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Cancer facts and figures 2017 American Cancer Societywww.cancer.org/acs
In the USA, in 2017,there were an estimated
1,688,780 new cancer cases and 600,920 cancer deaths…
1/3 are attributable to poor nutrition, physical inactivity and obesity
Cancer is caused by our environment (nearly always)
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Types of Research
Population studies
Laboratory research
Randomized trials
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Rock, C. L. et al. J Clin Oncol; 23:6631-6638 2005
1551 women with a history of breast cancer : Risk of recurrence or a new cancer
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Pub Med : Database of medical journals
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Angiogenesis
Beliveau R, Gingras D: Foods That Fight Cancer
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Angiogenesis
William Li: Can we eat to starve cancer?Filmed February 2010 at TED2010 www.angio.org
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Apoptosis
Leaves “falling off”Programmed cell deathExamples:
Tadpole tailsShaping of the human handRemoving cancer cells
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Inflammation DNA damageDNA repair errors (mutations)Growth factorsPromotes angiogenesisFacilitates invasion
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Study 1:“Dietary Influences On Survival After Ovarian Cancer”Nagle et al, University of QldInternational J of Cancer, 2003
• 609 women followed for 7 years• Pre-diagnosis diet assessed• Vegetables esp crucifers - 25% better survival• Red meat - bad
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Study 2:“Pre-diagnosis diet and survival after a diagnosis of ovarian cancer”Playdon, Nagle et al, (Aus Ov Ca Study Group)British Journal of Cancer, 2017
• 800 women followed over 9 years• High fibre intake – 31% decrease in mortality• Fish, leafy green vegetables - good• Saturated fat, High glycaemic index - bad
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Dr William Li (Angio.org)
To prevent ovarian cancer:EndivesFishTomatoesGingerGreen teaLignans (flaxseeds)
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Review paperKoshiyama (Japan)Healthcare, 2019
“The effects of the dietary and nutrient intake on gynecological cancers”
• Cervix• Endometrium• Ovaries
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Cervical cancer:Prevention of HPV and CIN
• Increase vegetable consumption• Papaya, onions, green tea, tomatoes, broccoli• Radiotherapy and chemotherapy enhanced by
quercetin, apigenin, PUFAs
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Endometrial cancer
• Risk factors are obesity and oestrogen• Oestrogens are formed in adipose tissue
• Also: sugar intake, high insulin levels and diabetes• Insulin stimulates growth of endometrial cells• And increases IGF-1
• Risk is reduced by:• Fish (omega 3 PUFAs)• Kaempferol (green tea, onions, crucifers)
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Ovarian cancer:Stop inflammation
• Pro-inflammatory: • saturated fat, carbohydrates
• Anti-inflammatory: • omega 3 PUFAs (Flaxseeds, fish), vegetables
Also:• Red meat and processed meat increase risk• Poultry is okay
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Inflammation DNA damageDNA repair errors (mutations)Growth factorsPromotes angiogenesisFacilitates invasion
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Other studies
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Prospective randomized trial
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Crucifers• Rocket
• Bok choy
• Broccoli
• Brussels sprouts
• Cabbage
• Cauliflower
• Collard greens
• Horseradish
• Kale
• Mustard
• Radish
• Turnip
• Wasabi
• Watercress
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How does it work?
Sulforaphane• Detoxifies
• Apoptosis• Blocks angiogenesis• Stem cells
• Inhibits cell migration
Indole-3-Carbinol• Detoxifies
• Apoptosis• Synergizes with paclitaxel (in HER2 +)• Blocks oestrogen, reduces 16aOH-E1
• Synergizes with Tamoxifen
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Chemistry : Myrosinase
Glucoraphanin in broccoli is converted by
Myrosinase to become
Sulphorafane
Glucobrassicin in broccoli is converted by
Myrosinaseto become
Indole-3-Carbinol
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The Internet : Partly Right
[health.com]
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The Secret : Don’t boil me!
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Camellia sinensisGreen tea EGCG
Green Tea
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How does it work?• Blocks cell signals• Promotes apoptosis• Stops angiogenesis• Arrests dividing cells• Prevents invasion into tissues• Anti-inflammatory• Binds carcinogens• Antioxidant • Protects against UVB damage • Detoxifies• Improves function of intestinal
flora• Helps reduce body weight
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The Internet : Partly Right
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Preparation:
How long to wait?Tea bags or loose leaves?
Concentration of catechins (mg/g) in green teaBoiling Water:
Steep for 30 secs 435 mins 117
Tea bag (5 mins) 72Tea leaves (5 mins) 117
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Drink Green Tea:With or Without Food?
Green tea catechin mixture
fed to 30 volunteers
Measured blood levels of catechins
Compared intake on
empty stomach vs with food
Clinical Cancer Research 2005
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How many serves do you eat?
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Everyday superfoods every day
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Rock, C. L. et al. J Clin Oncol; 23:6631-6638 2005
1551 women with a history of breast cancer : Risk of recurrence or a new cancer
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www.foodagainstcancer.com
Book: “Can food be medicine against cancer?”
Sign up for:Food Against Cancer Program