Food Sources of Saturated Fat and Risk of Heart Disease
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Food Sources of Saturated Fat and Risk of Heart Disease Dariush Mozaffarian, MD DrPH Division of Cardiovascular Medicine, BWH/HMS Department of Epidemiology, HSPH Saturated or Not: Does Type of Fat Matter? Harvard School of Public Health April 25, 2014
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Food Sources of Saturated Fat and Risk of Heart Disease. Dariush Mozaffarian, MD DrPH Division of Cardiovascular Medicine, BWH/HMS Department of Epidemiology, HSPH Saturated or Not: Does Type of Fat Matter? Harvard School of Public Health April 25, 2014. Dietary Fats & Blood Lipids. SFA. - PowerPoint PPT Presentation
Transcript of Food Sources of Saturated Fat and Risk of Heart Disease
Food Sources of Saturated Fat and Risk of Heart Disease
Dariush Mozaffarian, MD DrPH
Division of Cardiovascular Medicine, BWH/HMSDepartment of Epidemiology, HSPH
Saturated or Not: Does Type of Fat Matter?Harvard School of Public Health
April 25, 2014
Meta-analysis of 60 feeding RCTs. Mensink & Katan, AJCN 2003
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Dietary Fats & Blood Lipids
PUFA
MUFA
SFA
PUFA
MUFASFA
PUFA
MUFA
SFA
PUFA
MUFA
SFA
No Δ ApoB
Chowdury et al, Annals Intern Med 2014
Dietary Fats & CHD Events
Saturated Fat & CHD Events
Siri-Tarino et al, AJCN 2010
No Significant Association
16 prospectivecohort studies from
around the world
RR comparing extreme categories (highest vs. lowest)
of saturated fat intake
Food Sources of Saturated Fat in the US
Based on NHANES 2005-06. From USDA Dietary Guidelines 2010
Micha et al., Circulation 2010
Food Sources: Meats & CHD
Unprocessed Red Meat (100 g/d)
RR = 1.00(0.81, 1.23)
Processed Meat (50 g/d)
RR = 1.42(1.07, 1.89)
Food Sources: Meats & CVD Mortality
Total Red Meat
RR = 1.09(0.93, 1.27)
Processed Meat
RR = 1.17(1.02, 1.33)
O’Sullivan et al., Am J Public Health 2013
Food Sources: Meats & CVD Mortality
Total Red Meat (100 g/d)
RR = 1.09(1.00, 1.18)
Processed Meat (100 g/d)
RR = 1.69(1.37, 2.10)
Rohrmann et al., BMC Medicine 2013
Among 448,568 European men and women (EPIC),
including 5,556 CVD deaths
Food Sources: Dairy & CVD Mortality
MilkRR = 0.96(0.81, 1.13)
CheeseRR = 1.00(0.81, 1.24)
O’Sullivan et al., Am J Public Health 2013
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Milk Yogurt Cheese
P-trend=0.50
Adjusted for age, sex, center, education, smoking, physical activity, alcohol intake, and consumption offruits, vegetables, red meat, processed meat, sugar sweetened beverages, coffee, cereals, and cerearl products.
Quintiles of Consumption
Dairy Foods & Diabetes
Sluijis et al., AJCN 2012
Among 340,234 Europeans from 8 countries, with 12,403 cases of incident diabetes
P-trend=0.06 P-trend=0.01RR of
Diabetes
Estruch et al. NEJM 2013
Healthy Diet Patterns & CVD Events
HR = 0.70 (0.55, 0.89)
Randomized controlled trial among 7447 Spanish adults at higher risk
No change in saturated fat.
Global Disease Burdens Due to Major Risk Factors in 2010
Lim et al, Lancet 2012
Diet high in SFA & low in PUFA0.47
Healthy Food Replacements
Healthy Food Replacements
Healthy Food Replacements
Prioritizing Fat or Saturated Fat: Useful ?
Preventing Chronic Diseases: Food Patterns
EAT:
• Seafood
• Fruits
• Nuts
• Vegetables
• Vegetable Oils
• Whole grains
• Yogurt
Essential Dietary Habits for Health
LIMIT:
• Starches, refined grains, sugars
• Processed Meats
• Sweetened Drinks
• Industrial Trans Fat *
• Salt *
Mozaffarian, Appel, & Van Horn. Circulation 2011
Also: Don’t smoke, turn off the TV, get enough sleep, and be physically active.
