Genetics Spring 2015 Chromosomes and Sex-Chromosomes Inheritance I.
Folding: chromosomes, chromatine and cell cycle
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Transcript of Folding: chromosomes, chromatine and cell cycle
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•
Chromosomes, chromatin and cell
cycle
Catalina Urango GiraldoMedicine Student
3rd Semester
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CELL CYCLE Cell division
2 daughter
cells
Has control points
guara
nte
e
Normal cells and growth
Depending on its length
Ending sequence
s
determine
alterations
Cancer!!
DNA is packaged in the form of
chromosomes
telomeres
Life expectancyReproductive capacity of cells
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Scientists find “brake-override” proteins that enable development of some cancers
Biology & Nature
July 7/2011
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• CKs 1 and CKs 2 are two proteins known for being overexpressed in cancer.
•In the present study, the search team found that a CKs overexpression allows cancer cells to keep dividing.
Cancer CKs overexpression
cancer cells uncontrolled growth
by
a checkpoint nullifying effect RESEARCH DISCOVERY
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When a mutation induces an uncontrolled and fast cell growth, the cell sends a break signal.
• The break signal, produced as a checkpoint response, stops cell cycle, and DNA’s replication won’t goes on.
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BUT…!!
When it comes to cancer, it was found that:
Thanks to a CKs overexpression, the cancer cells will ignore the S-phase checkpoint response, pass over it and keep dividing.
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OBSERVATION
In my opinion, every research that leads medicine to a better understanding of how cancer “operates” in the body, represents one more step to find a treatment.
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Research links telomere length to emphysema risk.
Health & Medicine
July 15/2011
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The telomeres are the body’s own celullar clocks.
In this study, it was found a close relationship between telomere length and a increase susceptibility to develop emphysema.
Its length is determine :• Genetically• by Cell division (makes them shorter)
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GETTING RESULTS
↖
→ short telomere
↖
→ long telomere
Developed emphysema
Did NOT develop lung disease
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the results obtained in this research indicates that short telomeres plus cigarette smoke might
accelerates aging in the lung in some individuals.
Short telomere
lung damage
Cells can not longer divide
Increases risk to develop emphysema
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OBSERVATION
in my opinion, it is important to keep searching about diseases that can be related to the telomere length, so it can be determine how the susceptibility to a disease can be affected and what can be done to improve health with age.
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Medical Utility
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MEDICAL UTILITY Thanks to this researches, medicine can advance, and
now with the discover of CKs role in cancer, there is a new target for cancer treatment.
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MEDICAL UTILITY With the discovering of the link between short
telomere and emphysema, new research can establish methods to preserve some organs function with age.
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MEDICAL UTILITY With all this research, medicine is getting close to
guarantee more efficient methods for curing cancer and preserve life with the age.
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BIBLIOGRAPHY
- Scientists find “brake-override” proteins that enable development of some cancers. URL: http://esciencenews.com/articles/2011/07/07/scientists.find.brake.override.proteins.enable.development.some.cancers
(Biology & Nature)
- Research links telomere length to emphysema risk. URL: http://esciencenews.com/articles/2011/07/15/research.links.telomere.length.emphysema.risk
(Health & Medicine) - MARTINEZ S., Lina Maria. Biologia Molecular.
6.ed.Medellin:UPB.Fac.de Medicina,2011.52 p.
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