Flucoral ® Pharmacological Composition Each capsule containing 150mg Fluconazole. Fluconazole is a...
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Transcript of Flucoral ® Pharmacological Composition Each capsule containing 150mg Fluconazole. Fluconazole is a...
Pharmacological Composition
Each capsule containing 150mg Fluconazole.
Fluconazole is a broad spectrum Systemic Antifungal
Mechanism of actionInhibition of cytochrome P-
450→Impairment of Ergosterol synthesis in the fungal cell membrane→Interfers with fungal cell membrane function &growth→stop the fungal growth
N.B:Fluconazole is highly selective
inhibitor to fungal cytochrome P-450 and doesn't affect on liver cytochrome P-450
Pharmacokinetics The bioavailability of orally
administered Fluconazole is over 90%
Absorption of fluconazole is unaffected by food or gastric acidity
Pharmacokinetics The bioavailability of orally
administered Fluconazole is over 90%
Absorption of fluconazole is unaffected by food or gastric acidity
PharmacokineticsPharmacokineticsPeak plasma concentrations (C-max)
occur between 1 and 2 hours with a terminal plasma elimination half-life of approximately 30 hours after oral administration
PharmacokineticsPharmacokinetics
Fluconazole lipophillicity will achieve tissue levels exceeding the required MICs for all pathognomonic fungi for a complete week.
Effective Against Candida Species Infection At Wide Range Of Body Sites And Tissues.
Flucoral®Pharmacokinetics
Fluconazole(FLUCORAL) is cleared primarily by renal excretion, with approximately 80% of the administered dose appearing in the urine as unchanged drug. About 11% of the dose is excreted in the urine as metabolites.
Excellent EradicationFlucoral is well established as a first
line management option for the treatment of localized and systemic C.albicans infections.
Micheal V. Martin;Journal of Antimicrobial Chemotherapy (1999) 44.429-437
Excellent eradication rates in PityriasisVersicolor
Single dose fluconazole Vs Itraconazole
60
15
0
10
20
30
40
50
60
Flucoral Itraconazole
Excellent eradication rates in Onychomycosis
53% 59% 61%
16%
0%
20%
40%
60%
80%
150 mg 300 mg 450 mg Placebo
Clinical microbiology Review.1998 July;11(3):415-429
Treatment of Toenail OnychomycosisIn 362 Patients for 6 months.
Flucoral penetrates the nails and persists after twice weekly doses for 6 months in toenails and fingernails
Amalia del Palacio et al ,dermatophytosis treatment (2000).Madrid,Spain
Indications:1: tinea Capitis.
2: Tinea cruris
Tinea Barbe.
Tinea Corporis.Tinea Corporis.
Tinea Pedis.
Tinea Versicolor.
Onychomycosis.
Candidiasis.
Flucoral®
SafetySafety
Fluconazole is contraindicated in
lactating women and category C in
pregnant women.
Monitoring of liver enzymes is not Monitoring of liver enzymes is not recommended during therapy with fluconazole recommended during therapy with fluconazole (FLUCORAL)(FLUCORAL)
American Family Physician,February American Family Physician,February 15,200115,2001;Volume ;Volume 6363,Number ,Number 44
Itraconazole is not suitable for the Itraconazole is not suitable for the routine treatment of infections in routine treatment of infections in patients with raised liver patients with raised liver enzymes,history of liver diseases enzymes,history of liver diseases when treatment prolonged when treatment prolonged ((>>11 monthmonth)) liver enzyme monitoring liver enzyme monitoring should be undertakenshould be undertaken
Journal of antimicrobial chemotherapy.1999Journal of antimicrobial chemotherapy.1999
Flucoral is available as a box containing 2 capsules each containing Fluconazole 150mg with a price of 14.60 LE.
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