First Quarter 2011 Financial ResultsApril 26, 2011

FORWARD-LOOKING STATEMENTS

The financial results in this presentation were determined on the basis of U.S.GAAP. Please refer to the website www.cn.ca for the reconciliation of certainnon-GAAP measures to comparable GAAP measures. To the extent we haveprovided guidance which are non-GAAP financial measures, we may not be ableto provide a reconciliation to the GAAP measures, due to unknown variables anduncertainty related to future results.

Certain information included in this presentation constitutes “forward-lookingstatements” within the meaning of the United States Private Securities LitigationReform Act of 1995 and under Canadian securities laws. CN cautions that, bytheir nature, these forward-looking statements involve risks, uncertainties andassumptions. The Company cautions that its assumptions may not materializeand that current economic conditions render such assumptions, althoughreasonable at the time they were made, subject to greater uncertainty. Suchforward-looking statements are not guarantees of future performance andinvolve known and unknown risks, uncertainties and other factors which maycause the actual results or performance of the Company or the rail industry to bematerially different from the outlook or any future results or performance impliedby such statements. Key assumptions used in determining forward-lookinginformation are set forth below.

Key assumptions

Current 2011 outlook:

CN’s revised 2011 outlook is based on a number of economic and market

assumptions. The Company forecasts that North American industrial production

will increase by about 4.5 per cent in 2011. CN also expects U.S. housing starts

to be about 650,000 units and U.S. motor vehicles sales to be approximately 13

million units for the year. In addition, CN is assuming a weaker 2010/2011

Canadian grain crop, partly offset by a higher carry-over stock, and a 2011/2012

Canadian grain crop that is in-line with the five-year average. With these

assumptions, CN is targeting solid, mid-single-digit carload growth for 2011,

along with continued pricing improvement above inflation. CN assumes the

Canadian-U.S. exchange rate to be in the range of C$1.00 to C$1.05, and that

the price of crude oil (West Texas Intermediate) for the year will be in the range

of US$100 to US$110 per barrel. In 2011, CN plans to invest approximately

C$1.7 billion in capital programs, of which more than C$1 billion will be targeted

on track infrastructure to maintain a safe and fluid railway network. The

Company will also invest in projects to support a number of productivity and

growth initiatives.

Previous 2011 outlook:

CN made a number of economic and market assumptions in preparing its

initial 2011 outlook. The Company had forecast that North American

industrial production for the year would increase by about four per cent. CN

also expected U.S. housing starts to be about 675,000 units and U.S. motor

vehicles sales to be approximately 13 million units for the year. In addition,

CN assumed a weaker 2010/2011 Canadian grain crop, partly offset by a

higher carry-over stock. With those assumptions, CN targeted carload

growth in the mid-single digit range, along with continued pricing

improvement above inflation. CN assumed the Canadian-U.S. exchange

rate would be around par for 2011, and that the price of crude oil (West

Texas Intermediate) for the year would be in the range of US$90-95 per

barrel. In 2011,CN planned to invest approximately C$1.7 billion in capital

programs, of which more than C$1 billion would be targeted on track

infrastructure to maintain a safe and fluid railway network. In addition, the

Company said it would invest in projects to support a number of productivity

and growth initiatives.

Important risk factors that could affect the forward-looking statements

include, but are not limited to, the effects of general economic and business

conditions; industry competition; inflation, currency and interest rate

fluctuations; changes in fuel prices; legislative and/or regulatory

developments; compliance with environmental laws and regulations;

actions by regulators; various events which could disrupt operations,

including natural events such as severe weather, droughts, floods and

earthquakes; labor negotiations and disruptions; environmental claims;

uncertainties of investigations; proceedings or other types of claims and

litigation; risks and liabilities arising from derailments; and other risks

detailed from time to time in reports filed by CN with securities regulators in

Canada and the United States. Reference should be made to

“Management’s Discussion and Analysis” in CN’s annual and interim

reports, Annual Information Form and Form 40-F filed with Canadian and

U.S. securities regulators, available on CN’s website, for a summary of

major risk factors.

CN assumes no obligation to update or revise forward-looking statements

to reflect future events, changes in circumstances, or changes in beliefs,

unless required by applicable Canadian securities laws. In the event CN

does update any forward-looking statement, no inference should be made

that CN will make additional updates with respect to that statement, related

matters, or any other forward-looking statement.

Claude Mongeau President and Chief Executive Officer

Q1 2011 Highlights

(1) Please see website, www.cn.ca/nonGAAP, for an explanation and/or reconciliation of these non-GAAP measures.

Revenues of C$2,084M

up 9% at constant currency (1)

Operating ratio of 69.0%

0.3 pts better than last year

Adjusted Diluted EPS of C$0.90

up 12.5% on adjusted basis (1)

YTD Free Cash flow of C$445M (1)

Solid start to the year

4

Keith CreelExecutive Vice-President and Chief Operating Officer

Performing well despite challenging environment6

Q1 Operating HighlightsGTM’s per train mile Cars per yard switching hour

Car miles per dayTrailing GTM’s per total

horsepower

Terminal Dwell (entire railroad, hours)

Train Speed (mph)

* Excluding EJ&E

7

Delivering Service To Our Customers

Supply Chain Collaboration

End-to-end coal plan

Scheduled grain plan

Terminal service level agreements

Capacity Available for Growth

Hiring, training and onboarding

Cars, DP power and extended sidings

Precision Engineering

Operational and Service Excellence

Jean-Jacques RuestExecutive Vice-President and Chief Marketing Officer

2011 2010

%

Change

Favorable

(Unfavorable)

%

Change at

constant

currency(1)

Favorable

(Unfavorable)

Petroleum and chemicals $ 342 $ 321 7% 10%

Metals and minerals 209 210 - 3%

Forest products 299 288 4% 8%

Automotive 115 114 1% 5%

Coal 141 132 7% 10%

Grain and fertilizers 406 372 9% 12%

Intermodal 392 351 12% 13%

Total rail freight revenues $ 1,904 $ 1,788 6% 10%

Other revenues 180 177 2% 4%

Total revenues $ 2,084 $ 1,965 6% 9%

In millions of Canadian dollars, unless otherwise indicated

(1) Please see website, www.cn.ca/nonGAAP, for an explanation of this non-GAAP measure.

9

Q1 Revenues

As Reported

Supply chain collaboration agreements

producing results

Continued strength in both import and export

traffic

Acquired 1,000 new heated containers for

domestic traffic

(1) Revenues at constant currency - Please see website, www.cn.ca/nonGAAP, for an explanation of this non-GAAP measure. 10

Intermodal

Market Breakdown

First Quarter (2011 vs 2010)

Revenues (1)

RTMs

¢ / RTM (1)

Carloads

Revenue / car (1)

2011 Q1 Revenues

Scheduled Grain Plan supports growth and

high commodity prices support fertilizers and

potash applications

Continued high demand for thermal and

metallurgical coal

Ridley coal terminal planned for expansion at

year end 2011 Q1 Revenues

(1) Revenues at constant currency - Please see website, www.cn.ca/nonGAAP, for an explanation of this non-GAAP measure.11

Bulk

Commodity Breakdown

Revenues (1)

RTMs

¢ / RTM (1)

Carloads

Revenue / car (1)

First Quarter (2011 vs 2010)

Lumber, wood pulp and wood pellets

exports continue to trend up

P&C developing innovative solutions

Steel and concentrates market share gains

(1) Revenues at constant currency - Please see website, www.cn.ca/nonGAAP, for an explanation of this non-GAAP measure. 12

Commodity Breakdown

2011 Q1 Revenues

First Quarter (2011 vs 2010)

Revenues (1)

RTMs

¢ / RTM (1)

Carloads

Revenue / car (1)

Manufacturing

Luc JobinExecutive Vice-President and Chief Financial Officer

2011 2010

Change

Favorable

(Unfavorable)

Revenues $ 2,084 $ 1,965 6%

Operating expenses 1,439 1,362

Operating income 645 603 7%

Interest expense (86) (92)

Other income 300 162

Income before income taxes 859 673

Income tax expense (191) (162)

Net income $ 668 $ 511 31%

Diluted EPS $ 1.45 $ 1.08 34%

Adjusted diluted EPS(1) $ 0.90 $ 0.80 12.5%

Shares (diluted in millions) 461.8 474.9

Operating ratio 69.0% 69.3% 0.3 pts

In millions of Canadian dollars, except EPS data, unless otherwise indicated

(1) 2011 and 2010 exclude items that affect the comparability of the results of operations.

Please see website, www.cn.ca/nonGAAP, for a reconciliation of this non-GAAP measure.

14

Q1 Results

2011 2010

%

Change

Favorable

(Unfavorable)

%

Change at

constant

currency(1)

Favorable

(Unfavorable)

Labor and fringe benefits $ 473 $ 470 (1%) (3%)

Purchased services and material 286 258 (11%) (14%)

Fuel 327 253 (29%) (36%)

Depreciation and amortization 218 205 (6%) (8%)

Equipment rents 51 60 15% 12%

Casualty and other 84 116 28% 26%

Total operating expenses $ 1,439 $ 1,362 (6%) (9%)

In millions of Canadian dollars, unless otherwise indicated

(1) Please see website, www.cn.ca/nonGAAP, for an explanation of this non-GAAP measure.

15

Q1 Operating Expenses

As Reported

Net income $ 668

Non-cash adjustments 34

Payments for income taxes (138)

Other working capital items (65)

Capital expenditures (net) (220)

Proceeds on rail-line sale 299

Other investing 14

Dividends (149)

Effect of foreign exchange fluctuations on

US dollar-denominated cash and cash equivalents 2

Free cash flow $ 445

Financing activities (excluding dividends) $ (342)

Total net indebtedness at end of period $ 5,332

Adjusted debt-to-total capitalization (1) 35.9%

Adjusted debt-to-adjusted EBITDA (1)(2) 1.63x

In millions of Canadian dollars, unless otherwise indicated

(1) Debt adjusted to include the present value of operating lease commitments.

(2) EBITDA refers to earnings before interest, income taxes, depreciation and amortization, and is adjusted to exclude Other income and the deemed interest

on operating leases.

See website, www.cn.ca/nonGAAP, for a reconciliation of the various non-GAAP measures presented on this slide. 16

Q1 2011 Free Cash Flow

See Forward-Looking Statements at the beginning of the presentation for a summary of key assumptions and important risk factors underlying CN’s 2011 outlook

Continue to leverage the recovery

Pipeline of productivity initiatives

Solid mid-single-digit carload growth

Pricing above inflation

Some headwinds in 2011

Canadian dollar, Depreciation and Fuel

Higher cash taxes

Expecting up to 15% growth over

2010 adjusted diluted EPS (1)

Free cash flow in the order of

C$1.2B (1) (2)

(1) Please see website, www.cn.ca/nonGAAP, for an explanation and/or reconciliation of these non-GAAP measures.

(2) CN’s revised 2011 free cash flow outlook is based on the Company’s first-quarter performance, its higher earnings forecast for the year, cash proceeds from the first-

quarter Toronto rail-line sale, and a potential C$200M additional voluntary pension contribution.

17

2011 Financial Outlook

Strong shareholder value focus

Claude Mongeau President and Chief Executive Officer

19

Delivering on Our Strategic Agenda

Operational

and Service

Excellence

Sustainable

top line

growth

Next level

of Precision

Railroading

Smart

stakeholder

engagement

Connect

with our

people