Fine Chemistry Services Expands high-Pressure Reaction Capabilities
2
Albemarle has a history of safely developing, scaling up and running high-pressure reactions with materials such as hydrogen, carbon monoxide and ethylene. In order to meet increased cGMP and non-cGMP customer demand and grow our capabilities, our Fine Chemistry Services (FCS) division recently invested in additional high-pressure reaction equipment and expertise at two U.S. facilities. The result: even broader opportunities to get exactly what you need from a relationship-driven organization committed to your success. The Enhancements In early 2007, Albemarle modified a 6,000-gallon reactor at our Pasadena, Texas, plant to allow NaK alkylations at pressures up to 1,000 psig. Later in 2007, we upgraded the existing high-pressure hydrogenation capability at our Orangeburg, South Carolina, facility — a location that has long manufactured bulk ibuprofen and other active pharmaceutical ingredients (APIs). Both sites have associated multi-state, high-efficiency distillation equipment and other supporting process equipment, and can accommodate rail car service. Greater Capabilities and Flexibility With these recent enhancements, we’re now more equipped than ever to perform custom reactions at high pressure and respond more flexibly to custom, non-cGMP high-pressure requests. Albemarle FCS can now carry out hydrogenations at up to 1,080 psig, 300° C and up to 1,200 gallons in volume. In addition, we can perform cGMP carbonylation and alkylation reactions at 1,000-gallon scale and pressures up to 400 psig, as well as non-cGMP, multi-thousand-gallon-scale reactions at pressures from 500 psig to 1,000 psig. High Pressure at Low Volume Albemarle’s advanced capabilities even extend to a unique “high pressure lab” in Baton Rouge, Louisiana, which allows us to demonstrate high-pressure and potentially hazardous reactions at the 5- to 10-gallon scale, then quickly and safely move to commercial-size reactors. More Expertise Across the U.S. Albemarle’s South Haven, Michigan, site features cGMP manfacturing of APIs and advanced intermediates for leading pharmaceutical innovators. Our Tyrone, Pennsylvania, facility provides non-cGMP manufacturing services for cosmetics, specialty polymers, agricultural chemicals, electronics, starting pharmaceutical materials and intermediates, and much more. ALBEMARLE HIGH-PRESSURE REACTORS cGMP • Two ~400 psig, 1,000 gal (stainless steel and Hastelloy ® B alloy) Non-cGMP • Two ~1000 psig, 6,000-gallon carbon steel • One ~1000 psig, 1,200-gallon Inconel ® alloy • One ~700 psig, 300-gallon, Hastelloy alloy • One ~250 psig, 2,500-gallon Hastelloy alloy • One ~400 psig, 4,000-gallon stainless steel • One ~1800 psig, 500-gallon carbon steel THE ALBEMARLE ADVANTAGE Seamless service from bench-scale development to commercial production • Range of manufacturing services, including unique chemistry capabilities and assets • Highly skilled R&D teams to assist with synthesis route selection, process development and analytical support • Hands-on assistance during manufacturing campaigns Fine Chemistry Services expands high-pressure reaction capabilities.
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Transcript of Fine Chemistry Services Expands high-Pressure Reaction Capabilities
Albemarle has a history of safely developing, scaling up and running
high-pressure reactions with materials such as hydrogen, carbon monoxide
and ethylene. In order to meet increased cGMP and non-cGMP customer
demand and grow our capabilities, our Fine Chemistry Services (FCS)
division recently invested in additional high-pressure reaction equipment and
expertise at two U.S. facilities. The result: even broader opportunities to
get exactly what you need from a relationship-driven organization
committed to your success.
The Enhancements
In early 2007, Albemarle modified a 6,000-gallon reactor at our Pasadena, Texas, plant to allow
NaK alkylations at pressures up to 1,000 psig. Later in 2007, we upgraded the existing
high-pressure hydrogenation capability at our Orangeburg, South Carolina, facility — a location
that has long manufactured bulk ibuprofen and other active pharmaceutical ingredients (APIs).
Both sites have associated multi-state, high-efficiency distillation equipment and other supporting
process equipment, and can accommodate rail car service.
Greater Capabilities and Flexibility
With these recent enhancements, we’re now more equipped than ever to perform custom
reactions at high pressure and respond more flexibly to custom, non-cGMP high-pressure
requests. Albemarle FCS can now carry out hydrogenations at up to 1,080 psig, 300° C and up to
1,200 gallons in volume. In addition, we can perform cGMP carbonylation and alkylation reactions
at 1,000-gallon scale and pressures up to 400 psig, as well as non-cGMP,
multi-thousand-gallon-scale reactions at pressures from 500 psig to 1,000 psig.
High Pressure at Low Volume
Albemarle’s advanced capabilities even extend to a unique “high pressure lab” in Baton Rouge,
Louisiana, which allows us to demonstrate high-pressure and potentially hazardous reactions at
the 5- to 10-gallon scale, then quickly and safely move to commercial-size reactors.
More Expertise Across the U.S.
Albemarle’s South Haven, Michigan, site features cGMP manfacturing of APIs and advanced
intermediates for leading pharmaceutical innovators. Our Tyrone, Pennsylvania, facility provides
non-cGMP manufacturing services for cosmetics, specialty polymers, agricultural chemicals,
electronics, starting pharmaceutical materials and intermediates, and much more.
ALBEMARLE HIGH-PRESSURE REACTORS
cGMP
• Two ~400 psig, 1,000 gal (stainless steel and Hastelloy® B alloy)
Non-cGMP
• Two ~1000 psig, 6,000-gallon carbon steel
• One ~1000 psig, 1,200-gallon Inconel® alloy
• One ~700 psig, 300-gallon, Hastelloy alloy
• One ~250 psig, 2,500-gallon Hastelloy alloy
• One ~400 psig, 4,000-gallon stainless steel
• One ~1800 psig, 500-gallon carbon steel
THE ALBEMARLE ADVANTAGE
Seamless service from bench-scale
development to commercial production
• Range of manufacturing services, including unique chemistry capabilities and assets
• Highly skilled R&D teams to assist with synthesis route selection, process development and analytical support
• Hands-on assistance during manufacturing campaigns
Fine Chemistry Services expands high-pressure reaction capabilities.
High Pressure Reactions
The information presented herein is believed to be accurate and reliable, but is presented without guarantee or responsibility on the part of Albemarle Corporation. It is the responsibility of the user to comply with all applicable laws and regulations and to provide for a safe workplace. The user should consider any information contained herein, including information about any health or safety hazards, only as a guide, and should take those precautions that are necessary or prudent to instruct employees and to develop work practice procedures in order to promote a safe work environment. Further, nothing contained herein shall be taken as an inducement or recommendation to manufacture or use any of the herein described materials or processes in violation of existing or future patents.
Find out how we say yes to hundreds of fine chemistry projects annually.
Albemarle is experienced and equipped to provide high-quality products and services to customers worldwide.
To move your high-pressure project into production, contact your Albemarle Representative today.
www.albemarle.com
A M E R I C A S
Fine Chemistry Services
Tel: +1 225 388 7402
E U RO PE , M I D D L E E A ST, A F R I C A
EMA Fine Chemistry Services
Tel: +32 10 48 1711
FCS-0005 (01/11)
A1 catalyst
1000 psigethylene
Ortho-alkylations
A1 catalyst
1000 psigethylene
Aluminum Alkyls
600 psig, 160°C
ethylene, hydrogenAluminum metal Triethylaluminum
Hydrogenation
500-1000 psighydrogen
catalyst
300 psig, 140°C
NaK
R=H or Me R=H or Me
Heck reactions
450 psig, 95°Cethylene
Pd catalyst
350 psig, 75°Ccarbon monoxide
Pd catalyst
Naproxen
