Finding of Inquest - Aurora Doreen Maureen Sleep · Web viewCORONERS ACT, 2003 SOUTHAUSTRALIA...
Transcript of Finding of Inquest - Aurora Doreen Maureen Sleep · Web viewCORONERS ACT, 2003 SOUTHAUSTRALIA...
CORONERS ACT, 2003
SOUTH AUSTRALIA
FINDING OF INQUEST
An Inquest taken on behalf of our Sovereign Lady the Queen at
Adelaide in the State of South Australia, on the 28th, 29th and 30th days of August 2013, the 2nd
and 3rd days of September 2013 and the 8th day of July 2014, by the Coroner’s Court of the
said State, constituted of Anthony Ernest Schapel, Deputy State Coroner, into the death of
Aurora Doreen Maureen Sleep.
The said Court finds that Aurora Doreen Maureen Sleep aged 4 days,
died at the Women's and Children's Hospital, 72 King William Road, North Adelaide, South
Australia on the 21st day of November 2011 as a result of hypoxic-ischaemic encephalopathy
attributed to intrapartum asphyxia secondary to uterine rupture and subsequent displacement
of the placenta and baby into the maternal abdominal cavity. The said Court finds that the
circumstances of her death were as follows:
1. Introduction and cause of death
1.1. Aurora Doreen Maureen Sleep was born at Mount Gambier Hospital by way of
emergency caesarean section at 11:32pm on the evening of Thursday 17 November
2011. She died four days later on 21 November 2011. An autopsy was performed by
Dr Nick Manton, a pathologist at SA Pathology. Dr Manton’s post-mortem report 1
states the cause of Aurora’s death to be hypoxic-ischaemic encephalopathy attributed
to intrapartum asphyxia secondary to uterine rupture and subsequent displacement of
the placenta and baby into the maternal abdominal cavity. I find that to have been the
cause of Aurora’s death. Aurora’s mother’s labour had been induced in anticipation
of a vaginal delivery. Her death was the result of irreversible hypoxic brain damage
1 Exhibit C2a
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that was sustained when her mother experienced a uterine rupture during labour. The
uterine rupture resulted in Aurora and the placenta becoming displaced into the
maternal abdominal cavity. This meant that for a period of time Aurora was deprived
of life sustaining oxygen that otherwise would have been delivered through the
placenta. Aurora was at 38 weeks gestation when she was delivered. There is no
reason to conclude that Aurora was anything other than a healthy and viable unborn
child prior to the fatal complication in the course of her delivery.
1.2. Aurora’s mother was Ms Ashlee Brown who at that time resided with her partner at
Mount Gambier. At the time of giving birth to Aurora, Ms Brown was 22 years of
age. Ms Brown had previously undergone a number of pregnancies. Her first
resulted in a miscarriage. She then had two children who were both born to when Ms
Brown was aged 18. Both children had been born by way of vaginal delivery which
had been induced in both instances. Thereafter, Ms Brown unfortunately experienced
terminations as well as another miscarriage. Ms Brown’s most recent pregnancy prior
to Aurora was terminated at 18 or 19 weeks of gestation due to the discovery on
ultrasound that the foetus was anencephalic. This pregnancy was terminated in
December 2010 by Dr George Olesnicky, an obstetrician and gynaecologist who
practised in the South East. The termination occurred by way of dilatation of the
cervix and piece meal evacuation. Ms Brown had not undergone a caesarean section
delivery at any time prior to the delivery of Aurora. I mention Ms Brown’s pregnancy
history in some detail as to my mind it is relevant to Ms Brown’s attitude to the
subjection of an unborn child to risks that might be associated with an induced labour.
1.3. The termination of pregnancy that occurred in December 2010 was subsequently
complicated by the discovery that the uterine contents had not been completely
evacuated. On 14 February 2011 Dr Olesnicky performed a dilatation and curettage
(D&C) which resulted in the remaining foetal tissue from the previous pregnancy
being completely removed. However, in the course of the procedure Dr Olesnicky
caused a perforation to the fundus of Ms Brown’s uterus, a recognised possible
complication of a D&C procedure. Dr Olesnicky, who was called to give evidence in
the Inquest, told the Court that the perforation was caused by the curette and that it
involved a small full thickness perforation of perhaps 8mm. Having identified the
uterine perforation, Dr Olesnicky performed a laparoscopic examination of Ms
Brown’s lower abdomen. He did so in order to define the extent of any damage to,
and bleeding from, the perforated site of the uterus and also to determine whether
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there was any damage to other intra abdominal organs. No significant bleeding from
the perforation at the uterine fundus was defined and so no suturing of the perforation
was required. There was no damage to any other intra abdominal organ. Dr
Olesnicky’s expectation was that the perforation would heal naturally. It was
common ground during the Inquest that there would be some resulting scarring caused
to the uterus at the site of the perforation. Ms Brown was advised by Dr Olesnicky of
the perforation.
1.4. Within a matter of weeks of the D&C that had been performed on 14 February 2011,
Ms Brown again found herself pregnant. She consulted a local general practitioner
about that in April 2011. Thereafter Ms Brown was seen in connection with her
pregnancy by doctors at the Hawkins Clinic in Mount Gambier. Towards the end of
Ms Brown’s pregnancy she developed unstable blood pressure that was characterised
by some significantly high and therefore concerning readings. In order to guard
against the possibility of pre-eclampsia it was decided that Ms Brown’s baby’s
delivery would be induced as soon as possible. On the evening of 17 November 2011
Ms Brown presented at the Mount Gambier Hospital for this purpose. By reason of
the fact that Ms Brown’s cervix was unfavourable and not conducive to artificial
rupture of the membranes at that stage, and also taking into account the position of the
baby’s head, it was decided that induction of the birth would be facilitated in the first
instance by the application of prostaglandin gel to the cervix. I add here that this
measure had been adopted during both of Ms Brown’s successful deliveries of her
two children. Of course, there had been no suggestion of a previous uterine injury at
those times.
1.5. As indicated earlier Ms Brown was induced at 38 weeks gestation. As I understood
the evidence there was no hint or suggestion that Ms Brown would have entered into
labour were it not for the induction that she underwent.
1.6. The application of prostaglandin gel to Ms Brown’s cervix that evening was soon
followed by the commencement of frequent and painful contractions of the uterus
which were then accompanied by non-reassuring cardiotocograph (CTG) traces in
respect of the unborn baby’s heartbeat. There can be no question in my opinion, and
no-one has seriously suggested otherwise, but that the uterine contractions that Ms
Brown experienced were the direct result of the application of prostaglandin gel to the
cervix.
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1.7. Although Ms Brown’s symptomatology was initially thought to be due to a possible
placental abruption, it is clear that her uterus had actually ruptured prior to the baby’s
delivery by way of emergency caesarean section. When the caesarean section was
performed, the uterine rupture and its unfortunate complications, including the entry
of the baby and the placenta into the abdominal cavity, were immediately identified.
The baby was born without overt signs of life and was actively resuscitated with
positive pressure respiration, intubation, CPR and adrenalin. Aurora had profound
metabolic acidosis. A heart rate was detected at 19 minutes and 50 seconds. The
baby was essentially comatose. Aurora was retrieved to the Women’s and Children’s
Hospital where she died four days later from an hypoxic brain injury, undoubtedly
sustained during labour and prior to her caesarean section delivery.
1.8. As a result of the uterine rupture Aurora suffered the fatal hypoxic brain injury to
which I have referred. As part of the same caesarean section procedure, Ms Brown
underwent a necessary subtotal hysterectomy which meant that, at the age of 22, she
was rendered incapable of bearing any more children.
2. Issues at Inquest
2.1. In this Inquest the Court examined a number of issues as follows:
Was there a connection between the uterine rupture experienced by Ms Brown and
the earlier perforation of her uterus during the D&C procedure in February 2011;
Was the uterine rupture contributed to by the administration of prostaglandin gel
to Ms Brown’s cervix in order to induce labour;
Whether in all of the circumstances it was appropriate for Ms Brown to have been
administered prostaglandin gel having regard to the existence of the earlier uterine
perforation;
Whether at the time with which this Inquest is concerned there were in existence
guidelines or protocols in relation to the appropriateness or otherwise of
administering prostaglandin gel in circumstances that pertained to Ms Brown’s
pregnancy;
Whether Ms Brown was furnished with appropriate information and advice in
relation to the proposed method of delivery of Aurora and in respect of the
administration of prostaglandin gel in order to induce that delivery;
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Whether Ms Brown’s labour and caesarean section delivery had been properly
managed;
Whether Aurora’s death could and should have been prevented. It can be said at
the outset that Aurora’s death almost undoubtedly could have been prevented if
Ms Brown had undergone an elective caesarean section and not have undergone
an induction of labour with or without the administration of prostaglandin gel.
The more appropriate question to be answered is whether in all of the
circumstances Aurora’s death should have been prevented by those means and, as
part of that discussion, there is the issue as to whether it was appropriate in all of
the circumstances for Ms Brown to have undergone induction of labour.
3. Induction of labour – prostaglandin gels
3.1. There is no question but that the decision for Ms Brown to undergo an accelerated
delivery of her child was appropriate in all of the circumstances. The choice as to the
modality of delivery in those circumstances could be distilled into the question
whether or not Ms Brown ought to undergo a caesarean section or undergo an
induction of labour with a view to the natural vaginal delivery of her baby. As I
understood the evidence, the question of whether Ms Brown should undergo a
caesarean section was not prominent either in her thinking or in that of her attending
medical practitioners. I find that it was not mentioned to her in any discussion with
her medical practitioners. Ms Brown, who gave oral evidence at the Inquest, told the
Court that she would not have had any compunction about undergoing an elective
caesarean section if it had been considered appropriate in all of the circumstances and
if it had been an advised course of action for her to undertake. I accepted her
evidence in that regard. I find that Ms Brown had no fundamental objection to
undergoing and elective caesarean section had it been considered necessary or
desirable in all of the circumstances. An associated question, however, is whether if
there had been any perceived risk to her baby or to herself posed by the fact of, or
method of, induction and if that perception of risk however small had been conveyed
to her, she would have elected for a safer modality of delivery including a caesarean
section. This is a more difficult question and requires a measure of hindsight to be
brought to bear on its resolution. I will return to that issue in due course.
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3.2. There are a number of methods of inducing labour. Some of those methods are
dependent upon the position of the unborn child within the uterus and also upon the
state of the woman’s cervix. In Ms Brown’s case the position of the child in the
uterus and the state of her cervix meant that in the first instance an artificial rupture of
her membranes, thereby inducing labour, would not have been indicated. An
induction of labour in her case essentially boiled down to a need to commence the
induction process by the administration of prostaglandin gel to prepare the cervix.
This proposed course of action appears to have been decided upon several days before
the evening of 17 November 2011, which was the evening that Ms Brown presented
at the Mount Gambier Hospital for induction of labour. There is no reason to suppose
that this method of induction was inappropriate in her case having regard to her
clinical circumstances. The question of the previously perforated uterus, though, was
another matter that may have required consideration. I leave that issue aside for one
moment.
3.3. Prostaglandin gel can have a number of clinical effects. Included among them are the
contemplated ripening of the cervix. As well, prostaglandin gel can result in stronger
and longer uterine contractions. As explained by Professor Roger Pepperell, an
independent expert obstetrician and gynaecologist who was called to give evidence at
Inquest, some patients may develop an excessive response even to a minimal 1mg
dose of prostaglandin gel, even when used appropriately. For that reason whenever
prostaglandins are used to induce labour, a CTG of the baby’s heartbeat is routinely
utilised following the insertion of the gel. This is done in order to detect whether any
excessive response is taking place and whether it any adverse effect on the baby is
being experienced. It was said in evidence on more than one occasion during the
course of the Inquest that an individual’s reaction to the administration of
prostaglandin gels on any given occasion is not entirely predictable. Professor
Pepperell told the Court, and I accept his evidence, that the risk of uterine rupture is
more likely to occur where there has been surgical damage to the uterus such as that
sustained in the course of a caesarean section. Professor Pepperell believed that one
could extrapolate from this fact that the risk of rupture is enhanced where there has
been uterine perforation at the fundus, which had occurred in Ms Brown’s case.
Whether that risk exists or is an appreciable one in a case such as Ms Brown’s was an
issue that was debated at the Inquest and a matter that I will discuss. In any event
there are a number of guidelines and protocols operative in South Australia that state
explicitly that the use of prostaglandin gels in order to induce labour is
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contraindicated in a woman who has undergone a previous caesarean section or any
uterine surgery2. These guidelines do not distinguish between on the one hand a
previous classical caesarean section that has involved the upper segment or on the
other a lower segment section. It is well understood, however, that there is greater
risk of uterine rupture in cases of previous classical upper segment caesarean section.
Classic upper segment caesarean sections are nowadays uncommonly performed in
any event.
3.4. The well known publication MIMS3, as it existed at the time with which this Inquest
is concerned, included among a list of contraindications for the use of prostaglandin
gel (specifically Prostin E2) in the induction of labour ‘previous uterine surgery’. It
does not specify what type of previous uterine surgery would be a contraindication,
but it would naturally include a caesarean section. The MIMS publication also lists
‘uterine rupture’ as a possible adverse consequence of the administration of
prostaglandin4. The same publication on the same page identifies the
contraindications for the drug Syntocinon (oxytocins), the IV administration of which
is another measure utilised in the induction of labour and which can also have a
marked effect on the stimulation of the uterus and its contractions. Listed among the
contraindications to its use are ‘uterine scar, previous uterine surgery (incl
caesarean)’. It will be noted that a pre-existing uterine scar, which is one lasting
complication of a uterine perforation such as Ms Brown’s, is a contraindication for the
use of Syntocinon. Some might therefore argue that almost by implication the
absence of any reference to a uterine scar within the listed contraindications for
prostaglandin might mean that the existence of a uterine scar is not a contraindication
for the use of prostaglandins. That paradox was not argued within the confines of my
Inquest and so it is not possible to determine whether any such inference can be
drawn. Suffice it to say, if a uterine scar is in fact a contra-indication to the use of
prostaglandin gel the product information should say so.
3.5. What is clear, however, is that no documentation or medical authority was tendered to
the Inquest that suggested in terms that prostaglandin was contraindicated or indeed
prohibited where the woman to be induced had experienced a previous uterine
perforation that had either required surgical correction or not. It will be remembered
2 Exhibit C16 South Australian Perinatal Practice Guidelines – ‘Induction of Labour Techniques’ and Exhibit C21 Australian College of Rural & Remote Medicine – ‘Rural Clinical Guidelines’ – ‘Obstetrics & Women’s Health’3 Monthly Index of Medical Specialties4 Exhibit C14, page 228
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that in respect of Ms Brown, her uterine perforation had not required any surgical
repair.
3.6. On the other hand, opinions were expressed within the Inquest, including by Dr
Olesnicky, the practitioner who had caused the uterine perforation in Ms Brown in the
first place, that prostaglandin is totally contraindicated in anyone who has a scar on
the uterus5. A question arose during the Inquest as to whether Dr Olesnicky’s view in
this regard was idiosyncratic or an accurate statement of the position. The
independent expert, Professor Pepperell, expressed a slightly less stringent view. The
medical practitioners actively involved in Ms Brown’s management unanimously
expressed the view that a previous uterine perforation was not a contra-indication to
the use of prostaglandin gel and that they had acted in accordance with that belief.
4. The contribution of prostaglandin gel to Ms Brown’s uterine rupture and the loss of
Aurora
4.1. I have already referred to the fact that Ms Brown was at approximately 38 weeks
gestation at the time of her induction of labour. The induction was a scheduled
occurrence. Also, as already indicated, there was no indication that Ms Brown would
have gone into spontaneous labour on the evening that she presented to the Mount
Gambier Hospital. This is an important fact as it supports the contention that, but for
what was to transpire after her presentation at the Mount Gambier Hospital, she would
not have gone into labour.
4.2. The prostaglandin gels were administered to Ms Brown at approximately 8pm. One
milligram of PGE2, which is the minimal dose, was inserted. According to Ms
Brown, approximately 20 minutes after the gels were inserted she was already in pain.
By approximately 9:20pm there were more frequent than usual contractions. Ms
Brown was offered a bath and for a time the CTG monitoring was discontinued. By
10:20am Ms Brown had developed severe abdominal pain that she described as a
‘ripping’ sensation6. A vaginal examination revealed bleeding from the uterus that to
begin with was considered to be possibly the result of a placental abruption.
Although between 10:22pm and 10:33pm Ms Brown’s uterine contractions were
occurring at a greater than ideal rate, the probability was that the baby and the
placenta had not been expelled from the uterus by that latter time. Uterine
5 Transcript, pages 96, 1026 Exhibit C7, Volume 2, page 67
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contractions ceased at 10:34pm and, at a time subsequent to that, a progressive fall of
the foetal heart rate was defined and the heart rate was ultimately found to be
undetectable. A decision was made to perform an emergency caesarean section and
this took place commencing at 11:30pm. The surgery revealed the uterine rupture.
The baby Aurora as well as the placenta were found in the maternal abdominal cavity
which also contained frank blood.
4.3. Dr Olesnicky told the Court that the perforation to the uterus that had been caused
during the D&C procedure that he had performed in February 2011 was to the fundus
of the uterus, which is part of the upper segment of the uterus. Dr Olesnicky gave
evidence about the use of prostaglandins. He told the Court that the application of
prostaglandin gel can give rise to uncontrolled or hypertonic contractions. It was Dr
Olesnicky’s belief that Ms Brown had experienced such hypertonic contractions. In
his view Ms Brown’s contractions had been too frequent and too strong and it was
this that had probably caused the dehiscence of her scar7.
4.4. The surgery that involved both the delivery of Aurora and the subtotal hysterectomy
was performed by Dr Kylie Gayford, who at that time was a third year registrar
trainee with the Royal Australian and New Zealand College of Obstetricians and
Gynaecologists, and Dr Melissa Smith who was a local consultant obstetrician and
gynaecologist. Dr Gayford gave evidence in the Inquest. She told the Court that her
surgical examination revealed a large irreparable fundal uterine rupture that required a
subtotal hysterectomy. Dr Gayford was asked about the aetiology of the uterine
rupture. She said that it was possible that it was related to Ms Brown’s previous
perforation. Dr Gayford was asked to view a report of an ultrasound of Ms Brown’s
uterus taken on 18 March 2011 which had described what is almost certainly the site
of the previously identified uterine rupture. Dr Gayford said that whereas the report
indicated an abnormal appearance towards the left of the fundus, she observed
clinically a rupture to the whole of the fundus during the surgery. She said the two
‘certainly could be related, likely to be related, but I don’t know’. However, she
could see no evidence of any explanation for a uterine rupture other than by reason of
the previous perforation. Dr Olesnicky told the Court that what was described in the
radiological report of 18 March 2011 was consistent with the location of the original
perforation8.
7 Transcript, page 1118 Transcript, page 132
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4.5. The ultrasound report to which I have referred revealed that at the time it was taken
the healing process in respect of the perforation was not complete. No further
imagery specifically designed to ascertain the progress of the healing of the
perforation was obtained before Aurora’s delivery.
4.6. Dr Lucie Walters was the medical practitioner who applied the prostaglandin gel to
Ms Brown. In her oral evidence before the Court she was asked about her view of
what had taken place in respect of Ms Brown’s ruptured uterus. She accepted that
there might be a connection between the original uterine perforation and the rupture
that Ms Brown experienced during labour. She regarded it as a plausible explanation,
but said that one could not define an event categorically as being causative just
because it precedes a certain outcome. When pressed as to whether there was any
other competing explanation, Dr Walters offered that Ms Brown may have been more
sensitive to the prostaglandin on this occasion than she had been in previous labours,
that, unlike previous occasions, this had caused a hypertonic uterus and that a
hypertonic uterus can give rise to a uterine rupture. There is no question here in this
case that Ms Brown did proceed to a hypertonic uterus characterised by frequent and
strong contractions. At one point Dr Walters endeavoured to remove what
prostaglandin gel was remaining around the vagina and cervix in an attempt to
ameliorate its effect. Dr Walters added that the fact that the uterus was contracting
frequently and strongly not long after the prostaglandin gels were administered had
significance in that it was very suggestive that the uterus had immediately responded
to the prostaglandin and within a short period of time had gone from a state where it
was not contracting to a state where it was contracting quite frequently. There was
hyperstimulation at that point which can certainly lead to hypertonia.
4.7. Professor Pepperell told the Court that he agreed with the pathologist’s description of
the cause of death. He also opined that Ms Brown’s previous uterine perforation was
almost certainly the cause of her uterine rupture during her labour with Aurora9. In
his report10 Professor Pepperell expresses the view that the excessive contraction
frequency was due to an excessive effect of the prostaglandin despite the appropriate
dose being given. I accept all of that evidence.
9 Transcript, page 49810 Exhibit C24, page 8
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4.8. I have found on the balance of probabilities that it was the administration of the
prostaglandin gel that in and of itself gave rise to Ms Brown entering into effective
labour. On the balance of probabilities I have found that the prostaglandin gel led to
hyperstimulation of the uterus and then hypertonia. I have further found on the
balance of probabilities that this caused a uterine rupture at the site of the previous
uterine perforation. I have also found on the balance of probabilities that the uterine
rupture would not have occurred but for the existence of the previous uterine
perforation.
5. The evidence of Dr Olesnicky
5.1. As already indicated, Dr Olesnicky was the obstetrician and gynaecologist who
performed Ms Brown’s termination in late 2010. He was also the medical practitioner
who in February 2011 performed the D&C in which Ms Brown’s uterus was
perforated.
5.2. Dr Olesnicky received his basic medical qualification from Adelaide University in
1971. He obtained membership of the Royal College of Obstetrics and
Gynaecologists in 1982 and a Fellowship of the Australian College of Obstetrics and
Gynaecologists in 1984. He received a Doctorate of Medicine from the Melbourne
University in 1986. He also received a Fellowship of the Royal College of Obstetrics
and Gynaecologists in 1996. He was a staff specialist at The Queen Elizabeth
Hospital for two years following which he entered into private practice, with a visiting
medical appointment at that same hospital. From 2004 to 30 June 2011 he practised
as an obstetrician and gynaecologist in Mount Gambier.
5.3. Dr Olesnicky described the perforation as being a small hole in the fundus of Ms
Brown’s uterus. There was no active bleeding, so on laparoscopy he left the
perforation alone, expecting it to heal over time. Dr Olesnicky believed that the
perforation had been caused by the curette. He agreed with counsel, Mr Harris QC,
that the size of the perforation was probably about the size of the tip of a biro 11. He
said elsewhere in his evidence that the hole was probably about 8mm12.
5.4. Dr Olesnicky told the Court that he could not recall any work undertaken in an
endeavour to quantify scarring against future risk of rupture13. 11 Transcript, page 10412 Transcript, page 10813 Transcript, page 108
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5.5. In March 2011 Dr Olesnicky arranged for a pelvic ultrasound of Ms Brown. The
ultrasound report dated 18 March 201114 reported that there was no evidence of
retained products of pregnancy, but reported that there was an abnormal appearance
of the uterus in the fundus on the left with what appeared to be ‘thinning / scarring of
the myometrium with the endometrium extending close to the serosal surface’. The
report suggested that a correlation of this feature with Ms Brown’s previous surgery
be considered. In his oral evidence Dr Olesnicky was questioned about the
significance of this report. He told the Court that he had presumed that the report
reflected the healing process of the perforation that had been caused during the D&C
procedure. In this regard Dr Olesnicky referred to the fact that further scans during
the early stages of Ms Brown’s pregnancy did not report any abnormalities, although
it has to be acknowledged that the state of the myometrium was not the specific
reason for those scans being conducted. To my mind nothing can be inferred from
those subsequent scans in terms of the satisfactory healing or otherwise of the
perforation. In cross-examination by Mr Harris QC, Dr Olesnicky told the Court that
although following the perforation there would be a period of time during which the
myometrium would be thinner than it otherwise would have been, the expectation was
that it would eventually resume its full thickness15. However, he disagreed with
counsel’s suggestion that there would be an expectation with a minor perforation such
as this that it would heal and return to the uterus’ former strength16. He said that one
would still develop a scar and that the scar that could give way and tear upon
expansion.
5.6. Dr Olesnicky told the Court that Ms Brown was certainly aware of the fact that there
had been a perforation of her uterus. In addition, he caused the discharge summary
detailing the outcome of Ms Brown’s procedure to be sent to the Hawkins Medical
Clinic in Mount Gambier on 17 February 2011. This discharge summary had read:
'Admitted for evacuation of retained products of conception. Procedure complicated by perforated uterus so laparoscopy performed. No bowel damage noted or active haemorrhage. Stayed overnight for observation and discharged next day.'
The radiology report of 18 March 2011 was not sent to the Hawkins Medical Clinic.
5.7. Dr Olesnicky did not have any further consultation with Ms Brown after the scan of
18 March 2011. He was not consulted at any stage about Ms Brown’s pregnancy, nor
in respect of her delivery. He had left Mount Gambier in mid 2011, but I did not 14 Exhibit C9, page 1215 Transcript, page 11616 Transcript, page 107
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understand that he would have remained uncontactable thereafter. As well, he left his
clinical records with another local obstetrician and gynaecologist, Dr Weatherill.
5.8. Dr Olesnicky gave certain evidence about what in his view had been the potential
implications of Ms Brown’s uterine perforation. He told the Court that a perforation,
or anything like it, that leaves a scar on the uterus might affect the way that a delivery
of a baby occurs in the future17. He said that a scar is a weak spot on the uterus similar
to that which results from caesarean section or uterine surgery in general18. He said
that although in a future delivery there was ‘a small chance it might rupture or
dehiscence’, the fact that a woman has a scar on her uterus has to be taken into
account when a decision is made as to the method of delivery. He suggested that in
all of Ms Brown’s circumstances, she should have had a caesarean section19. She had
an unfavourable cervix and the baby’s head position was also unfavourable. This
would mean, in his view, that induction by way of an amniotomy, otherwise known as
the breaking of the waters, was not indicated. As well, prostaglandin in his view was
‘totally contraindicated in anyone whose (sic) got a scar on the uterus’20. Dr
Olesnicky in this regard pointed out that the MIMS publication suggested that the use
of prostaglandin gels was totally contraindicated in people with a uterine scar. It will
be seen from previously, however, that MIMS did not expressly state that. What it
did indicate was that prostaglandin is contraindicated where there had been ‘previous
uterine surgery’. I have already referred to the fact that Syntocinon, on the other
hand, is suggested in MIMS to be contraindicated where there is a uterine scar as well
as with previous uterine surgery. When it was pointed out to Dr Olesnicky that the
MIMS entry in relation to prostaglandin simply referred to a contraindication in terms
of previous uterine surgery, he said that this description would include perforation of
the uterus. He said that such surgery was in fact synonymous with uterine scarring
such that prostaglandin gels was contraindicated in terms of the MIMS publication21.
Mr Harris QC challenged Dr Olesnicky in respect of the suggestion that a scar to the
fundus could have similar consequences as the surgical scar involved in a classical
caesarean section. Dr Olesnicky suggested that a scar is a weak point in the uterus
regardless of how big or how hard it is as once it ‘starts to give, the tissue around it
can also give’22. As to the significance of any risk posed by a perforation scar and the 17 Transcript, page 9418 Transcript, page 9419 Transcript, page 9520 Transcript, page 9621 Transcript, page 12222 Transcript, page 106
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administration of prostaglandin gels, Dr Olesnicky suggested that the chances were
that if one were to give prostaglandin gels, one would ‘get away with it’23. He put it
colourfully in this way:
'If you're brave enough to give her the prostaglandin gel when it is contraindicated that's fine.' 24
In essence, Dr Olesnicky expressed a firm opinion that prostaglandin gels should not
be administered where there is any scar on the uterus, however caused25.
5.9. In his witness statement Dr Olesnicky stated that in his view following a perforation
of the uterus there is no period of time over which a woman needs to wait before she
falls pregnant again26. In that same statement he said he did not recall providing any
advice to Ms Brown about that issue. In his oral evidence before the Court he also
said that he did not recall having any such discussion with Ms Brown, but that his
view was that in order to allow healing to take place, further pregnancy should not
occur for about six weeks after a perforation. For Ms Brown’s part, she told the Court
that following the perforation she asked Dr Olesnicky whether she would be able to
have more babies, to which Dr Olesnicky had said to her words to the effect that she
should go and start a family and be happy with her current partner27. She believed that
she was in effect ‘fine to go’28. As seen, Ms Brown was pregnant by April 2011. At
Inquest, it was common ground between Ms Brown and Dr Olesnicky that she was
not given any advice by him about future methods of delivery and what implications,
if any, her perforated uterus might carry in that regard. Mr Harris QC asked the
obvious question of Dr Olesnicky as to why, if he held such strong negative views
about the use of prostaglandins where the woman bears a uterine scar, he did not pass
on his concerns in that regard in respect of Ms Brown. He responded by saying that
such matters were the responsibility of the treating obstetricians at the time of
delivery29.
6. The evidence of Drs Zwijnenburg, Dunn and Walters
6.1. It is convenient to deal with the evidence of these medical practitioners together.
Each of the three practitioners were general practitioners with advanced qualifications
23 Transcript, page 11124 Transcript, page 11125 Transcript, page 11126 Exhibit C13, page 327 Transcript, page 2428 Transcript, page 2429 Transcript, page 114
15
in obstetrics. They are not qualified consultant obstetricians and gynaecologists.
6.2. Each of the three medical practitioners had an involvement in Ms Brown’s pregnancy
and presentation at the time of her approaching confinement. Dr Zwijnenburg of the
Hawkins Clinic saw Ms Brown on a number of occasions during the course of Ms
Brown’s pregnancy. Dr Zwijnenburg told the Court that she did not become aware of
the uterine perforation until a visit on 15 September 2011 when Ms Brown was 28
weeks pregnant. On that occasion Ms Brown complained of sharp pains in her right
inferior fossa when the baby moved. Dr Zwijnenburg accessed the discharge
summary in respect of the D&C procedure. However, she did not see the subsequent
ultrasound from March 2011. Dr Zwijnenburg told the Court that she concluded from
the discharge summary that Ms Brown’s uterine perforation had not required surgical
repair, say with sutures. This conclusion was correct. She further concluded that the
uterine perforation must have been small and therefore not likely to be significant in
respect of an ongoing pregnancy and delivery. She also concluded that the uterus
would have fully healed. Dr Zwijnenburg told the Court that she had asked Ms
Brown as to whether Dr Olesnicky had said anything to her about the perforation
having any effect on future pregnancies and that Ms Brown had been very adamant
that there had been none to be concerned about. Ms Brown told her that Dr Olesnicky
had said that ‘she’d be good to go for another pregnancy’30. It will be remembered
that this in essence was the advice that Ms Brown believes she had been given by Dr
Olesnicky.
6.3. Dr Zwijnenburg did not believe the uterine perforation had constituted any
contraindication either to vaginal delivery per se, or with vaginal delivery assisted by
the application of prostaglandin gel for an unfavourable cervix31. Dr Zwijnenburg
indicated that her understanding was that the scar would have been so minimal that it
would not have had any implications on pregnancy or delivery.
6.4. Dr Zwijnenburg could not recall any discussion she had with Ms Brown as to whether
or not the perforation posed any risk for her in respect of her pregnancy32. She said:
'I don't think it's appropriate to counsel women in all risks even if they're minutely small, because first of all it would not leave any room for clinical care and the second thing is that it can only create more anxiety.' 33
30 Transcript, page 17331 Transcript, page 17632 Transcript, page 17933 Transcript, page 179
16
6.5. Dr Zwijnenburg considered that Ms Brown’s pain could be explained by abdominal
adhesions. Ms Brown continued to complain about such pain when she saw Dr
Zwijnenburg again on 2 November 2011. There is no evidence that Ms Brown’s pain
needed to be clinically assigned to her previous uterine perforation.
6.6. Dr Zwijnenburg again saw Ms Brown on 7 November 2011. By this time Ms
Brown’s blood pressure had become an issue and the need to consider induction to
prevent possible complications of pre-eclampsia needed to be considered. Dr
Zwijnenburg did not believe that an elective caesarean section was indicated. She did
not believe that it would be inappropriate to induce Ms Brown with cervix ripening
agents34. This would include prostaglandin.
6.7. Dr Zwijnenburg was asked about the March 2011 ultrasound that Dr Olesnicky had
arranged and had seen the report in respect of, but which Dr Zwijnenburg had not.
She said that she would have had an expectation that if there had been any significant
ultrasound brought into existence she or the patient would have been informed35.
6.8. Dr Zwijnenburg said that she did not think that she had turned her mind to the fact
that Ms Brown had become pregnant so quickly after the insult to her uterus. She said
that when she questioned Ms Brown about that issue she said that she had the ‘green
light’ and that it was ‘all good to go’. Such a statement would be consistent with Ms
Brown’s admitted state of mind at that time and also consistent with the advice that
she says she obtained from Dr Olesnicky.
6.9. In cross-examination by Ms Cacas, counsel assisting, Dr Zwijnenburg stated that she
had never heard of any prohibition, either from any consultant obstetrician or through
literature, that one should not use prostaglandin gel in connection with the induction
of childbirth where there has been a perforation of the fundus of the uterus. In
addition, Dr Zwijnenburg’s research since these events had not revealed any further
relevant information.
6.10. Dr Zwijnenburg would not be involved in the birth of Aurora as she proceeded on
leave prior to that event. Thereafter Ms Brown would be seen on the one occasion on
14 November 2011 by one of Dr Zwijnenburg’s Hawkins Clinic colleagues, Dr
Stephen Dunn.
34 Transcript, page 18435 Transcript, page 174
17
6.11. Dr Dunn is an experienced general practitioner who has practised in Mount Gambier
since 1981 with a 5 year interruption when he practised overseas. Dr Dunn has a
Diploma in Obstetrics from the Royal Australian and New Zealand College of
Obstetricians and Gynaecologists. Dr Dunn gave evidence in the Inquest and told the
Court that he had been performing obstetrics work in Mount Gambier in excess of 30
years. He has delivered somewhere between 1500 and 2000 babies. As indicated, he
saw Ms Brown on 14 November 2011. Dr Dunn made a record of his consultation of
that day. He noted that he was seeing Ms Brown in relation to preparation for query
induction of labour due to increased blood pressure. He performed a vaginal
examination and concluded that induction of labour by way of rupture of the
membranes was not technically possible due to the position of the head and the
inaccessibility of the cervix. He took a swab for Group B streptococcus analysis. He
also took repeat bloods in order to assess the potential impact that raised blood
pressure might have in respect of complications such as stroke, pre-eclampsia or
eclampsia. He made a tentative appointment for Ms Brown’s induction of labour at
the Mount Gambier Hospital to take place the following Thursday, 17 November
2011 at 7pm which was in three days time. Dr Dunn explained in his evidence that
the appointment was tentative pending satisfactory analysis of the blood tests. The
page upon which Dr Dunn made notes of his own examination, which forms part of
the Mount Gambier Hospital record36, suggests that Ms Brown’s actual estimated final
due date was 2 December 2011. On another page of the Mount Gambier Hospital
record, which describes Ms Brown’s pregnancy record among other things, Dr Dunn
noted as against an already existing note relating to Ms Brown’s most recent
termination of pregnancy, the following:
'Uterine perforation with subsequent curettage settled conservatively.' 37
Dr Dunn told the Court that he believed that he had originally received this
information in a handover from Dr Zwijnenburg and that he would have asked Ms
Brown about it during the course of his own antenatal consultation. Dr Zwijnenburg
had also previously noted that Ms Brown possibly had adhesions from her uterine
perforation after her last D&C.
6.12. Dr Dunn explained the timing of Ms Brown’s appointment for induction at the Mount
Gambier Hospital. The explanation was that the expected method of induction would
36 Exhibit C7, page 5437 Exhibit C7
18
be the use of prostaglandin gels and it was expected that they would work gently
overnight with the aim of conducting the labour during the daylight hours of the
following day. His expectation was that the ripening process caused by the
application of the gel would be a gradual one. When he made the appointment for Ms
Brown, doing so in the expectation that her induction of labour would be facilitated
by way of cervical ripening using prostaglandin gels, he also knew that Ms Brown
had experienced a prior uterine perforation in connection with the previous
termination. In this regard Dr Dunn told the Court that he had no belief at that time,
nor at the time of the Inquest, that the induction of labour with prostaglandin gel in a
woman who had experienced a perforation of her uterus was absolutely prohibited38.
Dr Dunn explained that through conversation with Ms Brown herself his belief had
been that the perforation had been managed conservatively in accordance with his
own notation, that is to say that there had not been any necessity for surgical repair of
the perforation39. Thus Dr Dunn appears to have made an assumption at the time that
the perforation had represented a very minor wound which would heal itself
satisfactorily and would therefore not having any subsequent bearing on later
pregnancy events40. In respect of the materials that suggested that previous uterine
surgery, including caesarean section, were contraindications for cervical ripening with
prostaglandins, Dr Dunn told the Court that he would not have regarded a perforation
of the uterus at D&C to constitute uterine surgery41. In any event he did not regard Ms
Brown as a person who had a history of previous uterine surgery. Dr Dunn said that
literature about risks relating to uterine perforation and subsequent labour was
difficult to locate. I pause here to observe that none was produced at the Inquest.
6.13. Dr Dunn acknowledged that he made no further inquiry nor conducted any further
investigation in order to obtain more information about the implications of a previous
uterine perforation. In this regard Dr Dunn said that he had an expectation in a case
such as Ms Brown’s that along the chain of clinical events since her perforation and in
respect of those in connection with her current pregnancy, and having regard to the
fact that Dr Dunn was seeing the patient at 37½ weeks gestation, that any relevant
information from a treating specialist would have been transferred to Ms Brown’s
general practice in the usual way42.
38 Transcript, page 29039 Transcript, pages 290-29140 Transcript, page 29241 Transcript, page 29342 Transcript, page 297
19
6.14. In his evidence before the Court I posed to Dr Dunn that the risk of uterine rupture
after a previous fundal perforation cannot be known with certainty. Dr Dunn agreed
that this proposition was correct because the size of the perforation can vary. When
asked whether by virtue of that uncertainty there would be a natural reluctance to
perform an induction by way of prostaglandin gel, Dr Dunn disagreed because he
believes it was reasonable to assume that a perforation is often a minor, if not trivial,
wound that heals well43. He did not regard these circumstances in a practical sense as
giving rise to an increased risk to rupture44.
6.15. Dr Dunn stated in his evidence that in determining risk they did not take into account
the interval between the insult to the uterus and the delivery of the woman’s baby
notwithstanding that there are guidelines suggesting that significant intervals are
called for when vaginal birth after caesarean section is contemplated.
6.16. Dr Dunn said that he also disagreed with Professor Pepperell’s extrapolation that the
same degree of risk or incidence of rupture could be expected in respect of a
perforation as with an upper segment caesarean section. Dr Dunn made the point that
he did not think that a wound which might be half a centimetre across, such as one
that might result from a uterine perforation, automatically carried the same degree of
risk of subsequent rupture as a wound that might be 15cm across45.
6.17. In cross-examination Dr Dunn accepted that even a perforation that is treated
conservatively will leave some scarring, but added that the question was whether the
scarring would lead to any functional weakness46. Dr Dunn’s understanding at the
time was that it would likely have been a scar of small dimensions, that is to say the
dimension of the instrument used, and that the healing would be complete with no
functional impairment. He suggested that scarring can be just as strong as the original
tissue47.
6.18. Dr Dunn was also cross examined as to whether any risk associated with Ms Brown’s
previous uterine perforation should have been explained to her. In this regard Dr
Dunn made a general comment to the effect that medical practitioners do not
‘bombard people right at the start with a long list of common or rare potential
43 Transcript, page 31044 Transcript, page 31345 Transcript, page 31746 Transcript, page 33347 Transcript, page 333
20
outcomes’48. In any event he said that he was entitled to assume that discussion about
possible adverse effects of the induction process would have taken place prior to his
involvement49. In cross-examination by counsel assisting, Dr Dunn’s attention was
drawn to the South Australian Perinatal Practice Guidelines for the induction of
labour techniques where it is stated that an induction of labour should only follow
informed consent by the woman and that the potential risks of induction, among other
things, should be explained to her50. To this Dr Dunn suggested that the person who
made the initial decision that labour be induced would be expected to have that
discussion and in this case that would have been Dr Zwijnenburg. Dr Dunn
acknowledged that he did not ask Ms Brown whether Dr Zwijnenburg had discussed
any risks that might be posed by the induction51. He also suggested that the person
who was to actually administer the induction process would also have some obligation
in that regard52. In any event Dr Dunn suggested that any discussion concerning risk
would more likely have centred on the risks of not inducing labour as compared to
those involved in inducing labour. In any event he also suggested that the use of
prostaglandin gel was a commonly practised and low risk procedure and that they
would not normally during the course of an antenatal consult spend a long time
discussing the theoretical pros and cons or the theoretical risk associated with that
particular method of induction. As to the fact that this procedure in Ms Brown’s case
contained the added complication of a previous perforation, Dr Dunn responded by
saying that Ms Brown knew of the perforation and that in any case his understanding
at the time as shared by his colleagues was that the proposed course of action was
reasonable and that there was no indication from Ms Brown that there was a different
perception of risk. When challenged as to whether Ms Brown herself could seriously
be considered as having some personal responsibility to fully inform herself as to the
risk associated with perforation and the use of gels, Dr Dunn responded by saying that
Ms Brown had seen a specialist and that he would have expected that had the events
at the hands of the specialist carried any substantial risk, she would have been aware
of them and that she would readily transmit them to him and his colleagues.
6.19. To my mind Dr Dunn’s evidence can be succinctly summarised by saying that he did
not believe that the previous perforation carried any significant risk in an induction
48 Transcript, page 33749 Transcript, page 33850 Exhibit C16, page 251 Transcript, page 34252 Transcript, page 342
21
procedure that would be stimulated by the use of prostaglandin gels and that it was
not a risk that needed to be explained to the patient.
6.20. Dr Lucie Walters is an Associate Professor in Rural Medicine Education at the
Flinders Medical Centre. As part of her role at Flinders University she teaches
general practice obstetrics, gynaecology and paediatrics to medical students. She,
together with other colleagues including Dr Dunn, has developed a clinical training
course known as Rural Obstetric Emergency Training for members of the Australian
College of Rural and Remote Medicine. At the time of giving evidence she was a
Vice President Elect of that College. Dr Walters received her primary medical degree
in 1989. She underwent training in England and obtained Diplomas in Paediatrics and
Obstetrics at Birmingham in England. She has practised at the Hawkins Medical
Clinic in Mount Gambier, eventually becoming a partner in the practice for a period
of about 10 years until 2002. At that time she became a fulltime employee at Flinders
University. Although a fulltime employee with that University, Dr Walters still
resided in Mount Gambier at the time with which this Inquest is concerned. She has
had a clinical role at the Mount Gambier Hospital. In 1996 she and a number of other
doctors in Mount Gambier with obstetric qualifications formed a group whereby
24 hour cover would be provided to the Mount Gambier Hospital.
6.21. Dr Walters was the general practitioner who managed Ms Brown’s induction and was
the practitioner who administered the prostaglandin gels. Following her involvement
Dr Walters prepared typewritten retrospective notes in relation to these events53. The
retrospective notes made by Dr Walters state in effect that she was fully aware of the
previous uterine perforation in respect of Ms Brown’s most recent termination of
pregnancy. The note states:
'I did not seek out further information regarding the uterine perforation as this is a common and usually minor complication of evacuation of retained products and I did not at the time think this was relevant to the current induction of labour.' 54
6.22. Dr Walters who gave oral evidence told the Court that she probably would have seen
the final separation summary in relation to the D&C procedure that had taken place on
14 February 2011. Although she had no independent recollection of sighting it at the
time, she said that she would have checked the Group B streptococcus status of Ms
Brown and have seen the separation summary as part of that investigation. If Dr
53 Exhibit C7, pages 73-7654 Exhibit C7, page 73
22
Walters had seen the separation summary it would have informed her that a
laparoscopy had been performed and that no bowel damage or active haemorrhage
had been noted. From this she believes she might have inferred that it was not a
significant injury and one which had not required suturing55.
6.23. That Dr Walters was aware of the previous uterine perforation in my opinion cannot
be questioned. The statement of witness of Jennifer Estelle Aston56 who was a
registered nurse midwife on duty at the Mount Gambier Hospital on the evening in
question states that before the gels were applied she herself mentioned to Dr Walters
that Ms Brown had a previously perforated uterus. She mentioned this to Dr Walters
because the information was contained in the pre-admission obstetric record. It is
worthwhile observing that Ms Aston, who has practised as a registered nurse and
registered midwife over various periods since 1972 and has occupied the position of
Head of Nursing in Community Health, and who has a Bachelor of Health
Administration from the University of New South Wales, states that at the time with
which this Inquest is concerned she was not aware that there was any increased risk
involved in the use of prostaglandin gels where there has been a previous perforation
of the uterus57. Thus she had no discussion with Dr Walters about the question of risk,
although she makes it plain in her statement that she left any decisions about the
method of induction to the medical practitioner. On the other hand, another nurse
who commenced duty at a time after the prostaglandin gels had been administered to
Ms Brown, namely Ms Kristal Heading a registered nurse and midwife of many years
experience, told the Court that she believed that it is contraindicated to induce a
woman with a previous perforated uterus58. She said that this had always been her
understanding and it was part of her training as a midwife. She said:
'No, I’m aware of that people with, women who have had previous injury to their uterus such as perforation or caesarean shouldn’t be induced with prostaglandins.' 59
She added her belief was that in such circumstances induction is not undertaken often,
if at all, with prostaglandin. She said it is not recommended. I was not entirely
certain that Nurse Heading had always been of that view or whether her view is
coloured by the events in question here. For instance, she did not draw any inference
that Ms Brown’s difficulties that evening were the result of a uterine rupture. Rather,
55 Transcript, page 36956 Exhibit C2557 Exhibit C25, paragraph 1758 Transcript, page 26259 Transcript, page 264
23
she appears to have shared the view that Ms Brown was experiencing a placental
abruption.
6.24. In any event it is clear that Dr Walters knew of the perforation at the time she
administered the prostaglandin gels. There was some discussion during the Inquest as
to the extent of Dr Walters’ knowledge about the nature of the previous perforation
and in particular whether she had understood that it was a perforation that had not
required suturing or other surgical intervention for its correction. This debate was
somewhat arid in that regardless of what Dr Walters understood, the fact of the matter
was that Ms Brown’s perforation had been a small one and had not required surgical
correction.
6.25. Dr Walters testified that she did not believe there was any prohibition on inducing
labour by the application of prostaglandin gels in a patient who had a uterine
perforation of the type under discussion60. Dr Walters still maintains that belief. She
regarded a perforation of that type as posing only a ‘small and indefinable increase in
potential risk’61. Dr Walters also gave evidence that she would not have characterised
a perforation where no form of surgical suturing was required as ‘uterine surgery’ as
described within the guidelines62. As to the question of residual scarring following
perforation, Dr Walters stated that there is a period of time before scarring achieves
its greatest strength and that is around six weeks. Prior to the expiry of that period
scars tend to be less strong than they will ultimately be, but once scars form they may
or may not be stronger or weaker than the tissue was before. She acknowledged also
that a scar would be placed under pressure more at the time the uterus was contracting
than when it was relaxed and so one could certainly say that the whole uterus, scarred
and unscarred area, would be under more pressure when the uterus was hypertonic
than it would be under normal contraction.
6.26. Ms Cacas, counsel assisting, questioned Dr Walters about the need for a woman in Ms
Brown’s situation to be informed as to potential risks. She referred Dr Walters to the
South Australian Perinatal Practice Guidelines that I have already referred to, which
suggest that there is a need to explain the potential risks involved in induction of
labour, which should only follow informed consent by the woman. To this Dr 60 Transcript, page 37061 Transcript, page 37162 Transcript, page 374
24
Walters stated that at the time she did not believe that perforation was a potential risk.
She added that even with the hindsight that this case now produces, she does not
believe that there is any evidence that a perforation that requires no suturing is
actually a risk factor for induction of labour with prostaglandin. As to the short time
between the perforation and Ms Brown becoming pregnant again, Dr Walters
acknowledged that she did not have an appreciation of the small magnitude of that
period, but said that she believed that time was a matter that one would consider in a
vaginal birth after a caesarean section. She did not think that a perforation was of
significance in this regard63. Like Dr Dunn, Dr Walters did not believe that there was
any documentation or literature that specifically suggested that a perforation such as
this posed an increased risk64. She said that it did not cross her mind to consult with
an on-call obstetric registrar or an obstetric consultant about the question of risk
because she was confident that there was no risk factor involved65.
6.27. Dr Walters disagreed with Professor Pepperell’s extrapolation relating to the risk
posed by an upper segment caesarean section scar. She said that she found that very
difficult to believe66 and has not found any evidence in the literature that would
suggest such a frequency.
7. The evidence of Dr Gayford
7.1. I have already referred to Dr Gayford. She was the obstetric registrar who, with the
obstetrician Dr Smith, was involved in the emergency caesarean section surgery and
Ms Brown’s subtotal hysterectomy.
7.2. As well as describing the surgery, Dr Gayford gave evidence of a conversation about
Ms Brown that she had with Dr Dunn earlier in the evening. This conversation had
occurred in the setting of a routine perinatal meeting at the Mount Gambier Hospital
that involved local practitioners. She told the Court that Dr Dunn had indicated to her
that there was a young lady, undoubtedly Ms Brown, who had experienced two
previous normal births, who was pregnant and who was developing gestational
hypertension. He wanted to know whether she agreed with induction of labour for a
woman in that situation. Dr Gayford told the Court that Dr Dunn did not mention 63 Transcript, page 41264 Transcript, page 41365 Transcript, page 41466 Transcript, page 421
25
anything about the woman having suffered a previous perforation of the uterus67. I
understood that Dr Gayford had not disagreed with the proposed course. Dr Dunn, in
his evidence, could not recall this conversation, but accepted that it may have
occurred. He added that if such a conversation had taken place it is likely that he
would have mentioned the previous perforation of the uterus. I am not certain that Dr
Dunn would have mentioned the previous perforation to Dr Gayford, but to the extent
that there is a suggestion that he may have, it is difficult to regard Dr Gayford as
being a completely independent witness not necessarily interested in the outcome of
these proceedings. That said, she did give evidence apparently in an impartial manner
to the effect that, like the three general practitioners to whom I have referred, she did
not consider a perforation of the uterus that did not require surgical repair to fall
within the description of ‘uterine surgery’ for the purposes of the documented
contraindications to the use of prostaglandin gels as set out in the guidelines. Dr
Gayford did say that she had never used prostaglandin gels to induce labour in a
woman who had a previously perforated uterus68. However, she added that if it came
to her for a decision as to whether it would be appropriate to administer gels in a
woman who had suffered a previous perforation, that she would never make that
decision alone and would discuss the issue with a senior colleague69. She agreed that
at that time a source of senior opinion would have been available in Mt Gambier in
the form of Dr Smith to whom I have already referred and in Dr Weatherill who was
also a local consultant obstetrician. In cross-examination by Ms Cacas, counsel
assisting, Dr Gayford stated what other doctors had stated, namely that there is not a
great deal of evidence to guide management in this situation. She acknowledged that
prostaglandin gels would increase the risk, but that at that time she had no good idea
as to the extent of the enhancement of risk. She did state also that if Dr Dunn had
mentioned Ms Brown’s previous perforation she would have needed to have had a
closer look at the particular case and to have discussed the issue with a senior
colleague70. She would not have been unable to give Dr Dunn an off-the-cuff opinion.
She also said that in her view it would have been appropriate to consult Ms Brown
herself about the matter71, the reason being that it was Ms Brown’s labour after all. In
addition, essentially it was Ms Brown’s decision as to the medical care that she
undertook, and that where there is ‘clinical equipoise’, often the patient’s opinion is 67 Transcript, page 43168 Transcript, page 44169 Transcript, page 44370 Transcript, page 45071 Transcript, page 452
26
highly sought when making clinical decisions72, the decision in question here being
whether the patient would proceed with the suggested induction of labour as against
proceeding with an elective caesarean section. Dr Gayford did imply that the
discussion with the patient about risk would be difficult in a case such as this because
there was not much good quality evidence to guide the decision. I return to that issue
later when discussing Ms Brown’s evidence about what she may or may not have
decided had she been informed about risk.
8. The evidence of Professor Roger Pepperell
8.1. Professor Pepperell is a retired Professor of Obstetrics and Gynaecology. He was a
Specialist in Obstetrics and Gynaecology at the Royal Women’s Hospital in
Melbourne. He is a Fellow of the Royal Australian College of Physicians, a Fellow of
the Royal College of Obstetricians and Gynaecologists and a Fellow of the Royal
Australian and New Zealand College of Obstetricians and Gynaecologists. He has
been a Professor at the Melbourne University from 1997 until 2009 when he took up a
position as Professor of Obstetrics and Gynaecology in the Penang Medical College in
Malaysia. Professor Pepperell continues to perform clinical work, teaching and
examining in obstetrics and gynaecology in Melbourne. He currently examines for
the Australian Medical Council. Professor Pepperell had no involvement in Ms
Brown’s clinical management. He provided a written report73 in relation to his
assessment of Aurora’s management and he gave oral evidence in the Inquest.
8.2. In his written report Professor Pepperell quoted statistics in relation to the incidence
of uterine rupture. His report indicates that uterine rupture occurring in a woman who
is attempting a vaginal delivery after a previous lower uterine segment caesarean
section (LUSCS) is about 0.5% - 1%, but is increased further if labour is induced,
particularly if prostaglandin preparations or a Syntocinon infusion is used during the
induction process, or where the next delivery occurs less than 18 months after the
previous LUSCS. On the other hand where a previous classical caesarean section has
been performed, involving an upper segment uterine incision which does not heal as
well as a LUSCS incision, the risk of uterine rupture during the pregnancy and in
labour is increased and is generally accepted to be between 5% and 10%. Professor
Pepperell’s report then extrapolates those figures to embrace a situation where a
72 Transcript, page 45273 Exhibit C24
27
surgical or other insult has been inflicted into the upper part of the uterus including
the fundus, either by way of surgical removal of a uterine fibroid or other uterine
operative procedure. He goes on to suggest that the same incidence of rupture would
also be expected to apply to previous uterine perforation at the uterine fundus. In
other words, the report suggests that the incidence of uterine rupture where there has
been a perforation of the uterine fundus, and where the method of delivery involves
induction by way of prostaglandin gels, is between 5% and 10%. That is an
appreciable risk, and I do not believe any person represented at the Inquest suggested
otherwise. It is for that reason, as the evidence displayed, that induction by way of
use of prostaglandin gels where there had been a previous classical caesarean section
is contraindicated. Indeed, and in any event, classical caesarean sections are rarely
performed in current times.
8.3. During the course of this Inquest I did not see any literature that deals specifically
with the risk of uterine rupture, or the incidence of it, in cases involving induction of
labour with the use of prostaglandin gel in a woman who has had a previous uterine
fundus perforation that has not required surgical correction. The only document that
was produced at the Inquest that suggests that the existence of a uterine scar, not
associated with previous uterine surgery as such, is a contraindication in the case of
induction of labour, is the MIMS publication in respect of the use of Syntocinon.
8.4. Professor Pepperell’s report goes on to state that patients need to be informed of the
risks that his report has identified, and which I have set out above, who would then, in
the light of that information, need to decide on the mode of delivery in respect of a
subsequent pregnancy.
8.5. Professor Pepperell’s report also states that it is well known that the uterine response
to vaginally administered prostaglandin gel cannot be predicted absolutely, with some
patients having an excessive response which can cause foetal hypoxia and which
increases the risk of uterine rupture. Because of these difficulties, even when
induction of labour is indicated on obstetric grounds, many obstetricians would not
use prostaglandin when a previous uterine scar is known to be present. He states:
'Because of all of these facts, informed consent for an attempt at a vaginal delivery after a previous operative procedure has caused uterine damage, needs to have these facts
28
explained and then the decision made by the patient concerning the mode of delivery desired and accepted.' 74
8.6. Professor Pepperell’s report recites the history of Ms Brown’s confinement. He
suggests that it would have been advisable for Dr Olesnicky to have been contacted
and, in particular, for him to have been asked for advice as to whether the induction
that was planned was appropriate. The clear conclusion that I draw from Dr
Olesnicky’s own evidence is that he would have advised strongly against it and have
advised delivery by way of a caesarean section.
8.7. As to the administration of prostaglandin in Ms Brown’s case, Professor Pepperell
stated that the dose of 1mg that was given ‘is the common dose used initially when a
patient has had previous deliveries, or when a uterine scar is known to be present’75.
This comment suggested to me that Professor Pepperell did not at the time of
compiling his report hold the view that prostaglandin in that small dosage is
completely contraindicated where a uterine scar is known to be present. I will deal
with Professor Pepperell’s views as expressed in his oral evidence in a moment.
8.8. Professor Pepperell’s report also contains an analysis of the arrangements that were
made when Ms Brown’s condition significantly deteriorated and the efforts that were
made to arrange for an emergency caesarean section. I deal with that issue in a
separate section.
8.9. Professor Pepperell’s report concludes by stating that Aurora’s death was preventable
in that she would have been born alive and in good condition had she been delivered
by elective caesarean section rather than Ms Brown’s labour being induced. He also
concludes by suggesting that the risks of induction needed to be explained to Ms
Brown and that the options regarding delivery considered for informed consent for
induction. He states:
'Although the risk of uterine rupture was still only about 5-10%, when uterine rupture occurs the likelihood of the baby being subjected to severe hypoxia was very high.' 76
This statement again reprises the suggestion that in Ms Brown’s case there would be
an incidence of uterine rupture of between 5% and 10% in circumstances such as hers,
a figure that was not at the Inquest shown to be directly supported by literature or by
other persuasive evidence. 74 Exhibit C24, page 575 Exhibit C24, page 776 Exhibit C24, page 11
29
8.10. In his oral evidence Professor Pepperell repeated the figure stated in his report that the
risk of uterine rupture using prostaglandin gels where there has been a previous
perforation in the upper segment of the uterus was probably about 5% to 10%, that is
to say the risk where there has been a previous classical caesarean section or previous
myomectomy. He did go on to say that the risk of rupture might depend upon the size
of the wound that had been inflicted in the first instance in that the larger the wound,
the more likely it is to undergo further damage in subsequent labour, but he conceded
that he did not know whether there was ‘good clear data’ as to the increased
likelihood77. However, the mere presence of the previous wound may well increase
the risk in respect of future pregnancies and deliveries78.
8.11. Professor Pepperell expanded upon the relevance of the interval from uterine
perforation to next pregnancy and delivery. It appears that Ms Brown had conceived
around six weeks from the time of the uterine perforation. Professor Pepperell
suggested that this would mean that the child would be delivered less than 12 months
since the perforation. He suggested there was data clearly implicating delivery within
18 months as increasing the risk of uterine rupture in a subsequent vaginal delivery. It
will be noted, however, that the timeframes quoted in various guidelines and
publications that were tendered to the Inquest spoke of such timeframes in the context
of pregnancies and deliveries following previous caesarean section. Professor
Pepperell suggested that the relevance of the timeframe is connected to the possible
lack of complete healing that may have occurred. In this context Professor Pepperell
suggested that the ultrasound that was taken in March 2011 appeared to reveal that
healing to that point had been inadequate and would be associated with potential
increased risk of rupture later in the pregnancy, either during the antenatal period of
the pregnancy, or particularly during labour. This was a proposition that Dr
Olesnicky strenuously resists.
8.12. As to the distinction that was sought to be drawn between the accepted
contraindication of ‘previous uterine surgery’ and a simple perforation of the kind
under discussion here, Professor Pepperell suggested that a perforation during a D&C
that did not require surgical repair would in his view fall into the gambit of previous
uterine surgery because a perforation was known to have occurred and that under
77 Transcript, page 46878 Transcript, page 468
30
those circumstances the risk involved in prostaglandin use are increased79. He said
that where any perforation has occurred, regardless of whether it needs to be repaired
or not, it is an indication that there has been some damage to the uterus, thereby
increasing the potential risk80. This would give rise to a predisposition to rupture
which he suggested clearly occurred in this case81. As to the wording of the various
guidelines, Professor Pepperell suggested that regardless of whether a known
perforation had been surgically repaired, the perforation should be considered as a
damaged area of the uterus and one which would be predisposed to rupture and that
reference to this predisposition needed to be included in the various guidelines82.
8.13. There is one important matter in which Professor Pepperell appeared to differ from
the position explained by Dr Olesnicky. As already hinted at in his report, Professor
Pepperell in his oral evidence stated that he did not consider a uterine perforation to
be a total contraindication for the use of prostaglandin gels. He suggested that if a
practitioner was to provide the patient with appropriate information then it is up to the
patient to make the final decision. He said:
'No, I think you've got to give them the information and that they ultimately will make the final decision. Patients today do - are very keen to be involved in that decision-making process and many of them, even though they're told the risk of rupture is - is low and is increased if it's been an upper segment incision, will still decide they wish to proceed with an induction process, and it's something then that you need to bear in mind when you're making that decision, but you're not getting informed consent if those matters are never discussed.' 83
On the other hand, in that same context Professor Pepperell would not agree with the
proposition that the risk of rupture during labour in those circumstances is so
negligible as not to warrant patient advice as to risk or as to other alternative methods
of delivery. He said that it is up to the patient in effect to decide whether they can
‘live with’ the known risk84. As well, all of this contemplates a situation where there
is available within the hospital the necessary facilities to adequately monitor the baby
during the labour and where an urgent caesarean section can be effected85.
79 Transcript, page 48080 Transcript, page 48181 Transcript, pages 481-48282 Transcript, page 48283 Transcript, page 48284 Transcript, page 48385 Transcript, page 483
31
8.14. In cross-examination by Mr Harris QC, Professor Pepperell accepted that the risk
associated with uterine perforation which had not required suture repair was low but
not nil86. He acknowledged that not every risk associated with a perforation will
equate to 5% - 10%, which is the same risk that is associated with a classic caesarean
section. He also acknowledged that the risk profile would be less the smaller the hole,
but it would never constitute a nil risk profile87. Professor Pepperell also appeared to
accept the proposition that a perforation by an instrument during a D&C procedure
where the wall of the uterus was compromised but where no surgical repair was
necessary, would not necessarily satisfy the definition ‘prior uterine surgery’ as it
would be generally understood by medical practitioners. On the other hand, Professor
Pepperell stated that his personal interpretation is that if a woman had a perforation of
the uterus, she had effectively had previous uterine surgery and that therefore the risk
of rupture is increased88. He acknowledged that this was not the interpretation of the
general practitioner obstetricians involved in this case89.
8.15. During his evidence Professor Pepperell was not in any way shaken as to the need for
the patient to be given appropriate advice in relation to risk in cases such as Ms
Brown’s. He told the Court that a woman in her position would ‘clearly need to be
informed’ of a number of matters including a description of the uterine damage, the
likelihood of the damage healing satisfactorily, that because uterine rupture in
pregnancy is more likely where the time interval between damage and subsequent
pregnancy is short a woman should avoid becoming pregnant within the next 12 to 18
months, that the woman would ultimately need to make a decision as to whether in
fact a vaginal delivery would be an appropriate method of proceeding or whether,
because of the increased risk of rupture during labour, caesarean section as the
primary method of delivery would be something to be considered as more
appropriate. In addition, it would need to be explained to the patient that one might
not always recognise complications early enough to ensure that a baby is delivered in
good condition if rupture actually does occur. Professor Pepperell also stated that in
the light of the result of Ms Brown’s ultrasound in March 2011, a patient in her
position would need to be advised of those findings with an indication that if she did
become pregnant there would be an increased risk of uterine rupture during the
pregnancy and/or the labour and that therefore she should avoid pregnancy until there
86 Transcript, page 50987 Transcript, page 50988 Transcript, page 52189 Transcript, page 521
32
is as good as possible healing and this would mean probably waiting 18 months. This
piece of advice would undoubtedly be resisted by Dr Olesnicky who did not have any
belief that the ultrasound signified anything of special concern.
8.16. Professor Pepperell also suggested that there was a need to discuss risk with the
woman regardless of the fact that it might be low90. Taking into account a measure of
uncertainty within the first 12 months of the degree of healing that had taken place
following perforation, the uncertainty about the relationship between the known size
of the perforation and the incidence of rupture (although it would be accepted that it
was greater that nil risk), and the fact that in the case of a individual woman it is
difficult to predict her response to the administration of prostaglandin, Professor
Pepperell suggested that one would explain to the patient that the risk of uterine
rupture is increased by virtue of those unknown factors. As well, the fact that a large
proportion of babies will be lost if a rupture does occur, especially where the foetus is
expelled into the abdominal cavity as was the case with Ms Brown’s baby, needs to be
explained and considered. Professor Pepperell said that such information would also
need to be given by the practitioner who was involved in the care of the patient at the
time the perforation occurred. He suggested that the advice ought to be:
'Under normal circumstances the safest thing will be to deliver you by caesarean section but you need to make that final decision.' 91
90 Transcript, pages 482-48391 Transcript, page 515
33
9. Ms Brown’s decision to proceed with induction by way of prostaglandin gel
9.1. The decision of the High Court of Australia in Rogers v Whitaker (1992) 175 CLR
479 made it plain that the patient’s consent to treatment may be valid once he or she is
informed in broad terms of the nature of the procedure which is intended, but that the
choice in reality is meaningless unless it is made on the basis of relevant information
and advice. The majority of the High Court in their joint judgment explained that the
duty to warn a patient of an inherent risk in any treatment arises where the risk is
‘material’. They explained that a risk is material if, in the circumstances of the
particular case, a reasonable person in the patient’s position if warned of the risk,
would be likely to attach significance to it, or if the medical practitioner is or should
reasonably be aware that the particular patient, if warned of the risk, would be likely
to attach significance to it92.
9.2. In the case of F v R (1984) 33 SASR 189, King CJ suggested that the duty of the doctor
to explain the implications of a course of treatment extends to the disclosure of real risks
of misfortune inherent in the treatment93.
9.3. I find that Ms Brown was not provided with any information about whether or not the
use of prostaglandin gels in the induction of her baby would pose a risk of uterine
rupture. She did not obtain that advice from Dr Olesnicky and she did not get it from
the three general practitioners who were involved in her care towards the end of her
pregnancy. She told the Court that she was not concerned about her unborn child
because the doctors were not concerned94.
9.4. On the night of her confinement neither Dr Walters nor anyone else had informed her
about the possibility of risk. As well, no practitioner mentioned the possibility that in
the alternative she could have a caesarean section. Although I did not understand Ms
Brown to be saying that she had no idea that an elective caesarean section was
available, what I took from her evidence was that the question of an elective
caesarean section simply did not arise in her case, that there was no discussion with
her as to whether that should be considered as a viable alternative to induction95 and
that as a result the question of her undergoing an elective caesarean section was not
the subject of any consideration in her own mind or in anybody else’s. She was not
92 Ibid 48393 Ibid 19194 Transcript, page 4095 Transcript, page 60
34
told of any possible complications, difficulties or risks involved in what was going to
happen to her and to her baby and in particular of any issue that might be posed by the
previous perforation. She did not have any knowledge from any other source about
the risk that a perforated uterus might pose96. She said that she had no specific plans
for her birthing process which I took to mean that she had an open mind about the
type of delivery that she might undergo, depending on the circumstances97. On many
occasions during the course of Ms Brown’s oral evidence she was absolutely insistent
that if the question of risk had been discussed with her at all and that the possibility of
having a caesarean section in the alternative had been raised with her, she would have
elected for a caesarean section. She said ‘I wouldn’t have put my baby at risk’98. She
stated that she would not have wanted to go ahead with the induction of labour if,
because of her perforated uterus, she had been told that inducing labour had any
potential to cause harm to her baby99. She said that she would have had an elective
caesarean section ‘if I had known there was any risk at all. I wouldn’t have put my
baby at any risk’100. When challenged about those statements by Mr Harris QC, she
repeated that she would not have put her baby at risk, even to the point of suggesting
that she would not have done so even if the risk was miniscule101. Ms Brown adopted
the same stance when questioned closely on the same topic by Ms Cacas, counsel
assisting.
9.5. There is an obvious element of hindsight involved in a consideration of what Ms
Brown would or would not have done had she known of the risk that might be posed
either to herself or her baby by virtue of the previous perforation and the
administration of prostaglandin gel during induction. Clearly her reaction would have
largely depended upon the description of the risk, both in terms of what adverse event
might happen and in terms of the likelihood of that occurring.
9.6. It is difficult to know what Ms Brown’s attitude would have been if she had
specifically enquired of any of the three general practitioners who were involved in
her care as to whether or not the perforated uterus posed a risk in terms of the
proposed induction and its method. The answer probably would have been in the case
of each of those doctors that the risk, if any, was negligible. She may even have been
96 Transcript, pages 62-6397 Transcript, page 6398 Transcript, page 6199 Transcript, page 64100 Transcript, page 64101 Transcript, pages 74-75
35
told that there is no literature or other medical information that suggest that a risk is
posed in those circumstances. It is not totally impossible that with advice to that
effect Ms Brown would have elected to go ahead with the proposed method of
induction. I do, however, receive a very strong impression from Ms Brown, and
particularly taking into account the circumstances involved in her other failed
pregnancies and the need to avoid further negative outcomes, that if she had been
advised that there was a risk that was low but which was nevertheless not nil, she
would have elected for a caesarean section. This was her seventh pregnancy and
although she had given birth to two healthy children in the past, she had undergone a
number of other unsuccessful pregnancies, including two miscarriages. She was only
22 years of age at the time of her confinement with Aurora and there is reason to
suppose that in all of the circumstances Ms Brown would have gone down the path of
least risk and have elected for a caesarean section.
9.7. In my view it can be concluded with some certainty that if she had received advice
specifically from Dr Olesnicky that use of prostaglandins in an induction of labour
where there has been a perforation of the kind that he saw is totally contraindicated,
Ms Brown would have elected for a caesarean section.
10. Ms Brown’s management at Mount Gambier Hospital
10.1. At this point it is necessary to explain some of the salient features and events of Ms
Brown’s confinement. Ms Brown was admitted at about 7:15pm on Thursday, 17
November 2011. At about 7:20pm a CTG was commenced. This was implemented
to monitor the quality of the unborn child’s heart beat and heart rate. At
approximately 8:00pm Dr Walters administered the prostaglandin gel at a dose of
1mg. The CTG monitoring continued in accordance with the usual practice following
administration of prostaglandin gel. Dr Walters then left the hospital. Ms Brown was
left in the care of nursing staff. A note timed at 9:20pm made by registered midwife
Nurse Heading, to whom I have already referred, states that the CTG showed a
‘reassuring trace’. Monitoring was discontinued at that time102. In fact the CTG trace
showed regular contractions at the rate of 5 to 6 in 10 minutes which is not ideal and,
if anything, excessive. Ideally the contraction rate at this juncture should have been
less than 5 in 10 minutes. It is clear, and I so find, that these contractions were
stimulated by the prostaglandin gel. Nurse Heading’s note records that it was
102 Exhibit C7, page 25
36
suggested that Ms Brown, for the sake of relaxation and pain relief, have a bath.
Panadol was also given at that point. Ms Brown herself told the Court that within 15
minutes of the gels being administered she experienced excruciating pain. She says
that it was as a result of this that the bath was suggested. She then went into another
room in which there was a bath. She went in there with her partner. Another note
made by Nurse Heading timed at 10:20pm records that by that time Ms Brown was
out of the bath and was now very distressed with constant abdominal pain. The
precise period of time that Ms Brown was in the bathroom is not entirely clear, but it
must have been a substantial period of time between 9:20pm and 10:20pm. During
that period the CTG trace had been discontinued. I understood the evidence to be
clear that during that period of time Ms Brown was not seen by the nursing staff.
However, to my mind the evidence is not clear as to the point in time when significant
concern was felt about Ms Brown’s situation for the first time. In particular, I am not
entirely certain that at the point that Ms Brown was taken to the bathroom that any
concern was felt or recorded at that time. There is nothing in the clinical record to
suggest that any significant distress or pain was detected until shortly before Nurse
Heading’s note was made at 10:20pm. In her evidence Ms Brown suggested that the
doctor was telephoned at a time when she was still in the bathroom, but the evidence
as a whole would tend to suggest otherwise as no attempt was made to contact Dr
Walters until about 10:20pm. The notation by Nurse Heading at 10:20pm had
indicated that the contractions that Ms Brown was experiencing were now in excess
of 6 in 10 minutes. At that stage there was foetal tachycardia, that is to say an
excessive heart rate, at 179 to 190 beats per minute.
10.2. Dr Walters is noted to have arrived at the Mount Gambier Hospital at about 10:40pm.
Dr Walters noted that Ms Brown was significantly distressed with severe and constant
pain. By then the baby was experiencing obvious foetal bradycardia. On examination
Ms Brown’s uterus was extremely tender. Ms Brown could not tolerate uterine
palpation. A working diagnosis of hypertonic uterus was made at that point and this
was attributed to the effect of the gel. Dr Walters made an attempt to perform a
vaginal examination to clear the gel but she was unable to do this due to Ms Brown’s
distress. I am not certain as to whether Dr Walters made the decision to perform an
emergency section at that stage or whether the arrival of Dr Gayford prompted this.
Certainly by the time Dr Gayford arrived some preparations had already been made to
have Ms Brown sent to the operating theatre.
37
10.3. Dr Gayford was called at 10:52pm. She gave certain advice on the phone and she
travelled to and arrived at the hospital a few minutes later. At that point Dr Gayford
also entertained an impression of placental abruption. The obstetrician Dr Smith was
also summoned to attend and ultimately the incision for the caesarean section was
made by Dr Gayford at 11:30pm.
10.4. According to Nurse Heading there was foetal tachycardia for a period of time which
was then followed by bradycardia at around 60 beats per minute. Nurse Heading
recorded bradycardia at 10:36pm within the clinical record. The bradycardia together
with absent variability was a very concerning sign. Clinically Ms Brown was noted to
be in constant pain and was very distressed. At 10:50pm the foetal heart rate was
noted by Nurse Heading to be less than 80 beats per minute with absent variability,
which is again very concerning. At 10:55pm when Ms Brown was in the waiting bay
of the operating theatre the heart rate was recorded at being less than 60 beats per
minute. At 11:00pm, after CTG monitoring had been replaced with sonic aid
monitoring, again the heart rate was less than 60 beats per minute. At 11:05pm the
heart beat was still heard at around 60 beats per minute. A vaginal examination
performed by Dr Gayford at that point demonstrated bright blood. At 11:10pm Nurse
Heading recorded that she was unable to detect a foetal heart rate which would be
consistent with the baby being in extremis if not in foetal cardiac arrest.
10.5. In his evidence Professor Pepperell expressed the opinion that any delay that occurred
in respect of the setting up of the emergency caesarean section was not excessive 103.
He was referring there to the period of time that elapsed between the phone call to
Dr Gayford at 10:52pm and the commencement of the caesarean section with knife to
skin at 11:30pm. It took approximately two minutes to deliver the baby. In the same
context Professor Pepperell expressed the opinion that Ms Brown’s uterine rupture
probably occurred when the foetal heart rate was first detected to be abnormal.
However, there was a foetal heart rate still present and Ms Brown still continued to
contract until 10:33pm. He was of the opinion that the baby was still in the uterus at
that stage but had not yet been expelled into the peritoneal cavity. He believed that
there perforation of the uterus occurred at around 10:22pm, but that it was not
complete until 10:33pm104. From that point Professor Pepperell believed that there
was a window of opportunity of approximately 10 to 15 minutes following that time
103 Transcript, page 519104 Transcript, page 486
38
to perform a successful caesarean section, that is to say there was a 10 or 15 minute
opportunity for the baby to have any chance of survival. This would have required
the baby’s delivery at a time before 11:00pm. Professor Pepperell added that unless a
hospital is a Level 3 institution with theatre staff already present, including an
anaesthetist, there were virtually no hospitals that could have delivered this baby by
way of emergency caesarean section within that stipulated timeframe. It is
noteworthy that in this context Professor Pepperell agreed with the proposition of
counsel assisting that perhaps the risks involved with Ms Brown’s induction and
especially the method of induction are not worth taking unless one is in a hospital that
has all facilities available and can expedite delivery105. Certainly in this particular case
with no doctors physically at the hospital and with only nursing staff in attendance the
chances of securing an emergency caesarean section in time to deliver a healthy and
uncompromised baby were extremely thin. The only manner in which an emergency
caesarean section could have been effected in this case was if Dr Walters had called
an emergency caesarean section at 10:40pm, had secured the necessary theatre staff,
including surgeon and anaesthetist, to attend within the next 10 or 15 minutes and had
applied knife to skin at or before 11:00pm. It is difficult to see how with the best will
in the world this could have been carried out106.
10.6. There are some matters about Ms Brown’s management that have been questioned.
At 9:20pm it was clear that Ms Brown was experiencing a greater than ideal number
of contractions in a period of 10 minutes. It was also recorded that she was
experiencing pain. Although I was not totally persuaded that at that point Ms Brown
was experiencing and demonstrating alarming symptoms, Dr Walters told the Court
that the pattern of 5 to 6 contractions in 10 minutes recorded at 9:20pm was very
suggestive that the uterus had immediately responded to the prostaglandin and that it
indicated hyperstimulation of the uterus that could lead to hypertonia107. Dr Walters
said that she would have regarded that as a ‘red flag’108 and something that they
needed to be concerned about. This, she said, could have prompted continuous CTG
to ensure that the baby was not becoming distressed by the uterine contractions and to
ensure that proper oxygenation of the baby was maintained. It will be remembered
that the CTG was discontinued in order to allow Ms Brown to enter the bath. Dr
Walters also told the Court that the CTG trace required correlation with Ms Brown’s 105 Transcript, page 487106 Dr Walters is not qualified to perform a caesarean section 107 Transcript, page 403108 Transcript, pages 404, 407
39
clinical picture. She would ask whether the contractions reflected by the CTG were
painful and, if they were not painful, that would be reassuring109. The fact that Ms
Brown was given Panadol for pain relief and the fact that she was offered a bath was
something that Dr Walters said she would have liked to have been told about110. I
asked Dr Walters what she may have done if she had been contacted at about 9:20pm.
She said that having regard to the frequency of contractions so soon after the giving of
prostaglandin and that the contractions were painful enough to require pain relief, she
probably would have returned to the hospital and have examined Ms Brown111. If Dr
Walters had detected evidence of hyperstimulation and that the uterus was not
relaxing completely between contractions, she probably would have phoned the
obstetric registrar at that point. She would have considered providing Ms Brown with
the medication to reverse the effect of the prostaglandin gel. Dr Walters said it may
have meant that she could have started the treatment that she ultimately did start at an
earlier time. As well, the question of an emergency caesarean section may have been
considered earlier if it was believed that the perforation had become a risk factor after
all112. Dr Walters surmised that although she could not predict what the obstetric
registrar and the specialist may have decided, it was possible that they would have
decided that a caesarean section was the alternative. However, Dr Walters added that
at the time she arrived to see Ms Brown displaying abdominal pain and foetal distress,
her diagnosis was of a hypertonic uterus and that she still did not consider that uterine
perforation was a relevant problem at that point. Dr Walters summarised by agreeing
with counsel that all of these matters required consideration at 9:20pm.
10.7. Professor Pepperell expressed a view about this issue which was perhaps more
conservative than that of Dr Walters. Professor Pepperell said that while the
contraction frequency as revealed by the CTG needed to be slightly less than 5, it was
nevertheless quite common to see frequency magnitudes of 6 in 10 minutes when
prostaglandin gel is first administered. Professor Pepperell added that contractions of
that magnitude of frequency usually settle down spontaneously with time; if one
watches the frequency the matter can be proceeded with, providing that the foetal
heart rate itself is satisfactory. Professor Pepperell did not suggest that it was
necessary for the nursing staff to have contacted the medical practitioner at 9:20pm113,
109 Transcript, page 408110 Transcript, page 409111 Transcript, page 415112 Transcript, page 415113 Transcript, page 496
40
although it would not have been unreasonable for her to have been so contacted. As I
understood Professor Pepperell’s evidence there is no suggestion at that point in time
the baby’s heart parameters had been revealed as abnormal. In fact his report
suggests that at 9:30pm the ceasing of the CTG was not inappropriate because the
heart rate was normal.
10.8. That said, by the time Ms Brown was next seen following her having been offered a
bath, which in the event she did not have, Ms Brown was in some considerable
distress and had constant abdominal pain. The contractions were then in excess of 6
in 10 minutes and the child was detected as being bradycardic once the CTG was
reapplied. The evidence as to how such a significant change in Ms Brown’s
presentation was not detected earlier was to my mind unsatisfactory.
10.9. The remaining issue concerns the fact that when arrangements were being made to
effect an emergency caesarean section there was an omission to contact an
anaesthetist. The delay that was occasioned was not a considerable one, and one
which Professor Pepperell would not have considered as having created an
abnormally significant delay to the procedure being commenced. In any event it
appears that the child may well have been in extremis and have been irretrievable
even prior to 11:00pm. Thus, further delay may not have altered the outcome.
11. Conclusions
11.1. The Court reached the following conclusions.
1) The cause of Aurora’s death was hypoxic-ischaemic encephalopathy attributed
to intrapartum asphyxia secondary to uterine rupture and subsequent
displacement of the placenta and baby into the maternal abdominal cavity;
2) Prostaglandin gel was administered to the cervix of Ms Brown in order to induce
labour. I find that the administration of prostaglandin gel caused Ms Brown to
experience excessively strong and frequent uterine contractions;
3) I find that the excessively strong and frequent uterine contractions experienced
by Ms Brown caused her uterus to rupture;
4) I find that the scar on Ms Brown’s uterus, being the result of a perforation of her
uterus during a D&C procedure on 14 February 2011, was the site of, and source
of, the uterine rupture;
41
5) I find that the administration of prostaglandin gels contributed to Ms Brown’s
uterine rupture;
6) I find that Ms Brown’s uterine rupture caused the expulsion of Aurora and the
placenta into the abdominal cavity. I find that this event was the cause of the
irreversible hypoxic brain injury that was the cause of Aurora’s death;
7) I find that Aurora was a viable unborn foetus prior to the induction of Ms
Brown’s labour. I find that Aurora’s death could have been prevented if the use
of prostaglandin gels to induce Ms Brown’s labour had been avoided. In the
circumstances the use of prostaglandin gels could have been avoided if Ms
Brown had undergone the delivery of her baby by way of elective caesarean
section;
8) I find that Ms Brown knew of the fact that her uterus had been perforated during
the D&C procedure that occurred on 14 February 2011. However, I find that
Ms Brown did not have an appreciation of the risk that the uterine perforation
posed in respect of the chosen method of delivery of Aurora;
9) I find that Ms Brown was informed by Dr Olesnicky that the uterine perforation
did not pose any impediment to Ms Brown becoming pregnant again. I am not
certain that Dr Olesnicky stated or implied that she could do so in the near
future, but I find that Ms Brown formed the belief from whatever Dr Olesnicky
did say that she could become pregnant in the near future without risk;
10) Ms Brown underwent an abdominal ultrasound on 18 March 2011 which
demonstrated that the uterine perforation was in the process of healing. It is not
possible to assess whether the degree of healing that the ultrasound
demonstrated at that time carried any implications as to whether in time the
perforation would heal satisfactorily;
11) I find that Dr Olesnicky at all material times held the view that a uterine
perforation of the kind experienced by Ms Brown would, in respect of any
future pregnancy of Ms Brown, amount to a total contraindication to the use of
prostaglandin gel in connection with the induction of labour;
12) I find that Dr Olesnicky did not impart that view to Ms Brown, nor to any of Ms
Brown’s usual general practitioners. Dr Olesnicky did not have any
involvement in respect of Ms Brown’s confinement in November 2011. If, say,
42
Dr Olesnicky had assumed contemporary involvement in Ms Brown’s delivery
of Aurora, he would undoubtedly have advised Ms Brown to have Aurora
delivered by way of caesarean section114. Alternatively, Dr Olesnicky may have
considered induction by way of simple amniotomy. In any event it is clear in
my view that Dr Olesnicky would not have induced Ms Brown’s labour by way
of the administration of prostaglandin gel115. Nor would he have advised the
same if he had been consulted at the time. In fact, it is clear that he would have
strongly advised against it. Dr Olesnicky was at no time consulted by any of Ms
Brown’s general practitioners at or around the time of her induction of labour in
respect of Aurora. It would have been far better if he had been so consulted, or
if one of the local consultant obstetricians had been consulted;
13) I find that Dr Olesnicky should have communicated his views about the
potential consequences posed by Ms Brown’s perforated uterus to both Ms
Brown and to her general practitioners. I note in this regard that Dr Olesnicky,
through his counsel Ms Cliff, accepts that criticism116. In my view Dr
Olesnicky’s failure to so communicate is mitigated by the fact that it was his
genuine belief that the medical practitioners who would be involved in the
delivery of Ms Brown’s next baby would hold the same professional beliefs as
his and be in a proper position to be able to advise Ms Brown and to safely
manage any future pregnancy and labour of her117;
14) To my mind the evidence in this case has demonstrated that the use of
prostaglandin gels in the induction of labour in respect of a woman who has
experienced a previous uterine fundal perforation that has not required surgical
intervention poses a material risk of uterine rupture during labour;
15) Although the issue is not free from difficulty, having carefully assessed the
evidence of Dr Zwijnenburg, Dr Dunn and Dr Walters, the Court is not
persuaded that those three general practitioners, either singly or collectively,
should have appreciated that the risk of uterine rupture posed by Ms Brown’s
previous uterine perforation and the administration of prostaglandin gels was a
material risk that needed to be conveyed to Ms Brown. In this regard I have
found that each of those three medical practitioners at the time genuinely
114 Transcript, page 124115 Transcript, page 129116 Transcript, pages 592, 594117 Transcript, page 140
43
believed that no risk of the kind described was posed to Ms Brown. Also in this
regard I have found that contraindications within the relevant guidelines
concerning the use of prostaglandin gels in the induction of labour could
reasonably have been interpreted by medical practitioners of the type,
qualifications and experience of the three practitioners I have identified as being
confined to a previous uterine surgical procedure per se, not including a uterine
perforation that had not required surgical intervention.
16) On balance I have found that at about 9:20pm on the night of 17 November
2011 it was reasonable for the Mount Gambier Hospital nursing staff not to have
contacted Dr Walters in respect of the nature of Ms Brown’s uterine
contractions at that point in time. I was not persuaded that at that point there
were any CTG or clinical signs in respect of Ms Brown that were alarming.
However, I find that within a short space of time, and at a time before 10:20pm,
Ms Brown had become very distressed and was in constant and severe pain. As
well, the reconnected CTG demonstrated excessively strong and frequent uterine
contractions as well as foetal tachycardia;
17) I find that having regard to the type of hospital and the available facilities and
personnel, there was no unreasonable delay in effecting Ms Brown’s emergency
caesarean section save and except by a small delay that was occasioned by the
failure to contact the anaesthetist in the first instance;
18) Any delay that was occasioned in the management of the emergency caesarean
section, and which could have been avoided, cannot be demonstrated to have
materially contributed to the fatal outcome for Aurora;
19) I find beyond any doubt that if Ms Brown had been advised to undergo an
elective caesarean section in respect of her delivery of Aurora, she would have
elected to do so. Equally I am certain that if Ms Brown had been advised that
the risk of uterine rupture was a substantial risk or that it was a risk that would
be best avoided, she would have elected for a caesarean section. I am less
convinced that she would have elected to undergo a caesarean section if she had
been told that the use of prostaglandin gels in an induction of labour would have
posed some but not a substantial degree of risk of uterine rupture. However, I
have found that it is more probable than not that in those circumstances she
would have elected for a caesarean section.
44
12. Recommendations
12.1. Pursuant to Section 25(2) of the Coroners Act 2003 I am empowered to make
recommendations that in the opinion of the Court might prevent, or reduce the
likelihood of, a recurrence of an event similar to the events that were the subject of
the Inquest.
12.2. I have already referred to the firm view of Dr Olesnicky that a uterine perforation of
the kind experienced by Ms Brown should be regarded as a contraindication to the use
of prostaglandin gels in a subsequent childbirth. I understood Dr Olesnicky’s view to
be that there ought to be a total prohibition placed upon the use of prostaglandin gels
in cases such as Ms Brown’s. I do not think that Professor Pepperell’s view was as
extreme as that. The focus of Professor Pepperell’s opinions in this regard had more
to do with the need to proffer appropriate advice to a woman in Ms Brown’s position.
That is to say, there is a need to explain the risks that are involved in the use of
prostaglandin gels where there has been a previous uterine perforation. It is
worthwhile observing that according to Professor Pepperell one in two women who
experience a uterine rupture during labour will lose the baby. There is also, of course,
the risk of hysterectomy once a uterine rupture has occurred. Having regard to the
fact that in Professor Pepperell’s view there is a very limited window of opportunity
to deliver a baby by way of emergency caesarean section following a uterine rupture,
something of the order of 10 to 15 minutes118, and taking into account that such
timeframes would probably only be achievable in Level 3 institutions, some may
reasonably argue that the risk associated with undergoing an induced childbirth by the
use of prostaglandin gels where there has been a prior perforation of the uterus is
indeed a risk not worth taking unless one is in such an institution. It is clear,
therefore, that one matter that a woman would need to consider in deciding whether or
not she should undergo an induction as opposed to a caesarean section is the nature of
the facilities and resources that would be available in the worst case scenario. This
then gives rise to a question as to whether or not induction of labour in circumstances
of risk such as those that applied to Ms Brown ought to take place in country
hospitals. I was told during the Inquest that in order to ameliorate the difficulty that I
have described, the Mount Gambier Hospital has, as part of an emergency caesarean
regime, instituted a practice whereby two registered midwives acting together have
the authority to declare that an emergency caesarean section should be carried out.
This measure has the effect of avoiding the delay that is occasioned by the responsible 118 Transcript, page 486
45
medical practitioner having to be called, having to travel to the hospital, having to
make their own assessment and then calling the emergency caesarean section. I
understand the practice now to be that the nursing staff may make the call for the
emergency caesarean section and may start making the necessary arrangements for
theatre staff to be assembled without having to wait for the responsible medical
practitioner to come in and make that call.
12.3. Professor Pepperell expressed the view that there is a need for the relevant protocols
and guidelines to be amended to reflect the predisposition of a previous perforation
site to rupture, regardless of whether it could be equated to, viewed as or otherwise
characterised as previous uterine surgery. Professor Pepperell expressed the view that
there should be an inclusion in the relevant guidelines, which I took to mean the South
Australian Perinatal Practice Guidelines – Induction of Labour Techniques as well as
the Australian College of Rural and Remote Medicine Guidelines, to the effect that
where a known perforation of a uterus has previously occurred, it should be regarded
as a uterine area of damage predisposed to rupture. Mr O'Leary of counsel who
appeared for and on behalf of Country Health SA Incorporated and the Minister for
Health and Ageing submitted that if the Court considered making any
recommendation in accordance with Professor Pepperell’s views that the
recommendation should be confined to a referral of the Court’s findings to the South
Australian Maternal and Neonatal Clinical Network, which is the working group
responsible for the Induction of Labour guidelines, for its formal consideration. I will
certainly draw these findings to the attention of that entity, but I have been persuaded
that Professor Pepperell is correct when he suggests that the guidelines should in
some specific manner refer to the risk posed by previous uterine rupture not involving
surgical correction, as well as to previous uterine surgery. To my mind it is obvious
that for the guidelines to remain as they are they would be misleading.
12.4. I would also add in this context that I intend to draw these findings to the attention of
those responsible for the MIMS publication and in particular what appears to be an
incongruity between the product information relating to Prostaglandin gel and that
relating to Syntocinon. In addition, the product information, and in particular that
relating to contraindications for the use of Prostaglandin gel might also be considered
as misleading.
12.5. In his evidence before the Court Professor Pepperell on a number of occasions
emphasised the need for women in the position of Ms Brown to receive appropriate
46
information and advice concerning risk, having regard to matters such as the
uncertainties that I have earlier described in terms of the degree of healing of the
perforation, the relationship between the size of the perforation and the incidence of
rupture, the fact that there will be a risk of rupture that is greater than nil and the fact
that a person’s response to prostaglandin administration may be unpredictable.
12.6. I make the following recommendations:
1) That these findings be drawn to the attention of the Minister for Health and
Ageing, the Chief Executive of the Department of Health, the Chair of the South
Australian Maternal and Neonatal Clinical Network, the Editorial Board of
MIMS Australia, the Chief Executive Officer of the Royal Australian and New
Zealand College of Obstetricians and Gynaecologists and the President of the
South Australian Branch of the Australian Medical Association for the
education of its members;
2) That clinical guidelines be developed, including within the Australian College of
Rural and Remote Medicine Rural Clinical Guidelines and the South Australian
Perinatal Practice Guidelines – Induction of Labour Techniques, and the South
Australian Perinatal Practice Guidelines – Uterine Rupture, relating to the risk
of uterine rupture occasioned by the administration of prostaglandin gel in a
woman who has had a previous uterine perforation whether surgically repaired
or not. Such guidelines should include reference to:
a) the specific outcome in this case;
b) uncertainty in respect of the degree of healing of the uterine rupture;
c) the need to take into consideration the time that has elapsed between the
uterine perforation and a subsequent labour;
d) the need to take into account any relationship between the size of the
perforation and the incidence of rupture;
e) that there will be a risk of rupture, whether calculable or not, which is
greater than nil;
f) the need to consider that the individual woman’s response to prostaglandin
may not be predicted with certainty.
47
3) That members of the medical profession be advised that in the case of a uterine
perforation that has not required surgical repair, there is a need to explain to the
patient any risks associated with that rupture and any possible future
consequences resulting from it;
4) That the medical profession be advised that in all cases where induction of
labour is to be effected by way of prostaglandin gel, that consideration needs to
be given to the matters described in subparagraph 2 herein and that those matters
be explained to the particular woman in question with advice to the woman in
each case that there is a risk involved in the administration of prostaglandin gel
in cases where the woman has experienced a previous uterine perforation
regardless of whether or not it has been the subject of surgical repair;
5) That general practitioners, including those with obstetric qualifications, be
advised that in cases of doubt they should consult a consultant obstetrician about
the use of prostaglandin gel in cases involving a previous uterine perforation;
6) That medical practitioners be advised that in cases involving induction of labour
by way of the administration of prostaglandin gel where there has been a
previous perforation of a uterus, that consideration is given as to whether in the
event of a uterine rupture during labour the facilities within the relevant
institution or hospital are capable of facilitating an emergency caesarean section
without undue delay.
Key Words: Induction of Labour; Foetal Monitoring
In witness whereof the said Coroner has hereunto set and subscribed his hand and
Seal the 8th day of July, 2014.
Deputy State Coroner
Inquest Number 24/2013 (1870/2011)