FINAL COMPREHENSIVE NARRATIVE REPORT (also is SEMI-ANNUAL REPORT for the period ending December 31, 2003)

Project Title: Canada-China 3x3 University Project Contact Person: Country: China Carol Lai or Ken McGillivray CIDA Project The International Liaison Office Purchase Order No. 7000881 Office of the Associate Vice President International WBS element: A-019736-001-PR1 University of British Columbia GL Account/CC/Fund52302/4130/0300 1871 West Mall Vancouver, BC V6T 1Z2 Vender: 1000539 Telephone: (604) 822-3114 Fax: (604) 822-5597 E-mail: carollai@interchange.ubc.ca Covering the Period: As Semi Annual Report: October 1 – December 31, 2003 As Final Comprehensive Narrative Report: October 1998 – December 2003 Submitted to CIDA on:

Signatures at Conclusion of Research Collaboration: For Canadian Participating Organization : __________________________ (Ken McGillivray for 3x3 Parntership) For Chinese DCP : ____________________________________________ (Prof. Tao Shu for Water Sub Project in China) For Canadian Project Partner: ___________________________________ (Prof. Michael Leaf for Water Sub Project in Canada) For Chinese DCP: ____________________________________________ (Prof. Zhao Nanming for Biotech Sub Project in China) For Canadian Project Partner: ________________________________________ (Prof. David Irwin for Biotech Sub Project in Canada)

Distribution through CIDA: CIDA HQ 3 copies CIDA Post 1 copy

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1. Project Description 1.1 Project Context The CIDA CCHEP 700 3x3 University Project was a partnership between two consortia, the Sustainable Water Resources Management group and the Canada-China Cooperation Biotechnology Working Group. The lead Canadian institutions are the University of British Columbia and the University of Toronto. In China, the lead collaborator is Peking University. The Sustainable Water Resources Management group undertook research and project development on environmental management and sustainability (EMS) in the Beijing-Tianjin region. This work responded directly to the Country Development Policy Framework (CDPF) governing cooperation between China and Canada that stressed environmental sustainability, economic cooperation and good governance as key elements. It follows the CDPF’s encouragement of a “consortia” approach as it involved cooperative efforts among three Chinese and four Canadian universities. Using their own resources, representatives from these universities met in 1994 and April 1995 to formulate this project. The project, therefore, reflected the group’s commitment to a key development issue that is crucial to China’s development that also harnesses their capabilities and expertise. The Biotechnology Working Group’s main goal was to help expedite the attainment of one of China’s national goals as identified by the State Science and Technology Commission under what in China is commonly referred to as the “863 Plan in High Technology Development”. This was done through capacity building at the leading universities and the development of relevant human resources. Technology transfer and the economic application of research results were also a part of this 3x3 project component. 1.2 Project Timeframe 05 October 1998 to 31 December 2003. 1.3 Project Value The project has a total value of $3,111,320. The contributions of each of the partners are: CIDA: $ 1,458,000 Canadian Institutions: $ 1,191,120 Chinese Institutions: $ 462,200

1.4 Project Rationale Sustainable Water Resources Management The issue of providing clean water and disposing of waste and sewage in China’s capital region has long been crucial to China’s development strategy. China’s rapid economic development as it undergoes a transition from central planning to a socialist market economy has severe implications for its environmental sustainability. The availability of water in the Beijing-Tianjin region is not only a matter of supply; Rather, it is a question of management of a scarce resource like water, efficiency in water service delivery, greater awareness of people about water use, proper pricing policies, and more effective coordination among all partners involved in the water management process. These are the areas this project covered. The project was designed to assist local governments, community groups, national agencies and other stakeholders in the Beijing-Tianjin region in formulating and implementing strategies for solving water resources management problems. To those ends, the major foundation project activities included the development of resource guides, data collection and student training. Biotechnology Working Group The Chinese State Science and Technology Commission made the field of biotechnology a national priority for China. In March 1986, the Chinese government identified biotechnology as the highest ranking target in a list of six areas for development under the “863 Plan in High Technology Development”. Since then, Chinese universities and research establishments have taken steps to implement the plan, including building a series of State Key Laboratories. Peking University, Tsinghua University and the Institute of Zoology of the Chinese Academy of Science have accordingly established a joint State Key laboratory in Bio-membranes and Membranes. Another State Key Laboratory in Protein Engineering and Plant Genetic Engineering was established at Peking University. This Biotechnology Working Group cooperated with these key partner universities in their research and development activities. Several important components of this part of the project include assessment of those Chinese agencies’ capacities to meet their stated goals and to contribute to those laboratories’ equipment needs. More importantly, however, this project aimed to help train and upgrade relevant human resources involved in the field of biotechnology research and industry liaison. Industry liaison and continued R&D collaboration was to extend beyond the duration of this project funding and beyond the partners currently involved across China and Canada.

1.5 Key Project Beneficiaries CHINA: Peking University, Nankai University, Tsinghua University CANADA: University of British Columbia, University of Toronto, McGill University, University of Montreal Local beneficiaries of Water Project include: Tianjin Envionmental Protection Agency, local waste water treatment facilities Beijing Water Savings Bureau Tsinghua University Dept. of Environmental Engineering Peking University Dept. of Urban and Environmental Planning Nankai University Dept. of Environmental Sciences 1.6 Logical Framework Analysis (Exhibit 1) Organization Chart (Exhibit 2) Implementation Schedule (Exhibit 3) List of Participants’ Travel Plans (Exhibit 4) Equipment Purchases (Exhibit 5) 1.6a CURRENT STATUS UPDATE : Water Project In brief the Water Research Project aimed to develop a set of tools and resources that would improve the understanding of water resource management issues. Such tools and improved awareness would help identify appropriate ways of improving the system so as to ensure the sustainable use of a limited resource. These same tools would also help inform various governance decisions such as fairness of distribution, more equitable access (physical access and affordability) through pricing and use allocation policy. Among the tools and resources identified were sets of guide and fact books that would give a streamlined assessment of the water resource management chain, addressing the main issues of supply, demand and pricing. GIS and modeling techniques were used to provide integrated analysis of the baseline situations - Prior to this, there were extremely limited resources for this kind of integrated information.

Other activities undertaken in this project were a series of workshops and training seminars that involved participation by both students and local planning authorities. These workshops and training seminars were used to bring in local authorities and perhaps a few community groups to engage in a dialogue about the shared interests of the water resource. Environmental management, health and sustainability were the key target issues on the table at these workshops. The project activity plans and workshop agenda have been completed, though on a extended schedule due to a variety of reasons, including logistical difficulties. Several difficulties in accessing the full range of anticipated data sets and other information resources were encountered due bureaucratic restrictions. The modeling activities that were dependent on certain kinds of data were modified to accept smaller samples instead. This scenario was experienced across the board by all our water demand and supply research groups. By maintaining a common set of measurements and baseline assumptions, the integration of the data collected, and the analysis of such data was found to be nonetheless rendered useful for our resource guides. Some unexpected positive turns in our project arose out of our field research work, household surveys, and in the higher than expected level of participation/ collaboration from some local authorities. While some local authority engagement was an excellent development resulting in some closer local collaboration and opened some opportunities for our Chinese students upon graduation, the ability to affect the larger scale governance issues that are so pertinent to water management was found to be beyond the reach of this project. Separate from the training manuals & seminars, field guides and GIS mapping databases, a final product in the form of a searchable CD-Rom was developed and disseminated. This CD-Rom was originally intended to be a companion to a printed collection of the respective chapters of analysis, integrating the 6 research areas of pricing, demand, supply, policy, GIS and SEA. However, the plans to publish a hard copy of the monograph were cancelled. It was determined that the results and data sets are most efficiently disseminated in digital formats.

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1.6b Current status for the Biotechnology Project The Biotechnology Working Group had planned to improve the capacity of Chinese universities to commercialize biotechnology research by supporting international collaborations between Canadian and Chinese universities. To aid in the achievement of this goal we had proposed to hold three conferences to bring together Canadian and Chinese researchers as a first step to form collaborations. The second step was to support start up collaborative research projects by using seed grants. The initial goal was to announce seed grant competitions at each conference to encourage initiation of collaborations. The goal was to fund 9 projects with a budget of C$10,000 after each conference. As this project was being developed and initiated, it became clear that both the Chinese and Canadian governments recognized the value of Biotechnology research and had increased national funding for this work. A side effect of this change in national research funding was that our seed grants were no longer as attractive to researchers as initially hoped. We proposed changes to fund seed grant programs, after the first seed grant competition, to make the subsequent seed grants more attractive, resulting in ten grants of C$15,000 in the second competition, and three grants of C$30,000 for the third competition. The third competition was also designed to support those projects from the first and second rounds that looked most promising for commercial success. All three proposed Workshops have been held. The first was in Beijing in May of 1999, the second in Vancouver in April 2000, and the third in Tianjin in October 2001. Seed grant competitions were announced at the Beijing and Vancouver meetings (see below). We received seed grant applications after each meeting suggesting that the meetings were successful in generating potential collaborations. More details about participants and programs of the meetings are available in our semi-annual reports. Unfortunately our third Workshop was not as successful (from the Canadian perspective) as originally planned. Our meeting was originally scheduled for September 2001, and had to be postponed due to the events of Sept. 11. Several Canadians were already in China when we postponed the meeting – but the remaining Canadians could not (even if they wanted to) fly to China on schedule. After consultations with Canadian and Chinese participants we rescheduled the meeting for October. The Canadian participation was limited as many individuals could not go in October (our other choices would have probably resulted in less Canadian participation). Fortunately the Nankai group was able to reschedule and hosted a productive meeting. We have awarded all of the seed grants – the first round in 1999, the second round in may of 2001, and the third round in February 2002. Unfortunately the second and third rounds of seed grants were slow at being awarded, as we needed approval from CIDA. The delays between our competition deadlines and award announcements resulted in us only funding eight of ten potential grants in the

eight of ten potential grants in the second round. The loss of two second round seed grants should only have a small impact on the success of our project, reducing the number of students and junior faculty that are trained. All of the seed grant projects have been completed – more details are provided in our semi-annual reports. We have obtained detailed final reports form projects funded in the first and second rounds that outline the benefits of these projects. Our third round seed grants were funded in May 2002. The projects had an end date of March 31, 2003. 1.7 Organization Chart (Exhibit 2) 1.8 Implementation Schedule (Exhibit 3) 1.9 List of Participants’ Travel Plans (Exhibit 4) 2.0 Equipment Purchases (Exhibit 5) 2. Result Based Management This collaborative project had a management structure drawn from all partner universities with coordination delegated to the University of British Columbia. The 3x3 National Coordinating Secretariat, based out of UBC’s International Liaison Office, was tasked with reporting duties of the two sub-projects. This secretariat reported to the Consortium Management Committee. The (EMS) Sustainable Water Resources Management project and the Biotechnology Working Group. At the operational level, the projects had substantive areas of focus in key multidisciplinary, thematic groupings. Each team had its own leader and conducted their own activities within the conceptual framework and the budgetary resources of the project. At the end of each activity component and at each reporting period, the actual outcomes of the activities were assessed and measured against the projected outcomes described in the LFA. Expertise was drawn from all partner universities. Faculty and research trainers were responsible for training curricula, the assessment of research designs and teaching materials. Proper equipment and supplies purchases were made to help guarantee more valid research and better-trained participants. Seminars and workshops provided avenues for cooperation of all stakeholders.

3. Budget

Financial Statement (Exhibit 6) Financial Forecast (Exhibit 7) Expenditure by Contribution (Exhibit 8) Advance Request (Exhibit 9) 4. Roles and Responsibilities In Canada, the lead institution for the CPO consortia is the University of British Columbia; The UBC Office of Research Services holds the project account under its Director. The 3x3 Project National Coordinator and its Secretariat, in conjunction with the sub-project directors were tasked with the overall project management and reporting functions. In China, Peking University was the counterpart lead institution for the DCP consortia. In each partner university, the principal investigators were: Principal Investigators – Sustainable Water Resources Management Michael Leaf (University of British Columbia) Rodney White (University of Toronto) D. Brown(McGill Univeristy) P. Andre (University of Montreal) Tao Shu and Zhang Shiqiu (Peking University) Dai Shugui (Nankai University) T. Zhang (Tsinghua University) Principal Investigators – Biotechnology Working Group D. Irwin (University of Toronto) D. Kilburn (University of British Columbia) R. Prichard (McGill University) V. DeLuca (University of Montreal) Y. Zhu (Peking University) Y.T. Yu (Nankai University) Nan Ming Zhao (Tsinghua University)

5. Special Considerations Access to and availability of clean water resources are issues that are inextricably linked to basic health and welfare and furthermore have impacts on many levels, ranging from individual household finances to regional as well as national economic considerations. These considerations coincide with our awareness of increasing water demand use and environmental stresses that seem to outpace the current systems’ capacity to provide clean water. It was a hopeful but reasonable expectation that this project helped provide some new elements in the research and development knowledge of water resources stewardship. The project goals were to include community groups as well as higher institutional levels of participation in developing a comprehensive approach to water management. Because water is an absolute basic need in human development but to which not everyone has equal access, some project input and output considerations were aimed at addressing equity and poverty alleviation strategies. The Biotechnology Working Group also has similar approaches to integrating cross-cutting themes such as gender equity and environmental sustainability. Long term effects of this project included China’s improved ability to conduct research and affect sustainable forestry practices as well help in other biotech goals such as gaining higher yields in various crop plants through its genetic research. In order to reach those long-term goals, short-term activities and training material incorporated key concepts of ecological and biological balance and encourage the investigation of the long-term viability and consequences of scientific interceptions in various aspects of genetic manipulation. Project leaders also gave particular attention to encouraging the higher participation of women, especially among the graduate student participants who were supported. .

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EXHIBIT #1 Project/# A-019736-700 1999/2000 Project/Program Performance Report Report Date 2003.10.29

700 – Water Management and Biotechnology Reporting Period: September 30 – December 31, 2003

Country(ies) Cost Center Responsible Officer Total CIDA Budget Disbursed to Date Disbursed Reporting Period Dates Planned Actual China “4130”

David Fournier 1,466,340 1,346,603 16,708 Approved Executing Agency/Partner 3x3 University Consortium EA/Partner Contribution Target Organization Contribution Start 1998.10.05 Sub-priority(ies) Corporate Result(s) 1,191,120 462,200 End 2003.12.31 35% 0604 CAPACITY DEV’T IN ENVIR. MNGT 35% 0502 CAPACITY, SKILL & PRODUCTIVITY 20% 0302 BUILD INSTITUTIONAL & HUMAN 05% 0106 WATER & SANITATION 05% 0101 PRIMARY HEALTH CARE

6040 Individuals and organizations are able to 5020 Improved Capacity of private sector & institutions 3030 Increased capacity to deliver environmental 1010 Improved access by the poor to better health 1010 Improved access by the poor to better health

Branch Result

Status Concluded

General Description The 3x3 consortium involved co-operative efforts among three Chinese universities: Peking, Beijing (lead); Tsinghua, Bejing; and Nankai, Tianjin; and four Canadian universities: U.B.C., Vancouver (lead); Toronto, Toronto; McGill and Montreal, Montreal. The consortium consisted of two different projects, Water Management and Biotechnology, each with separate leadership and investigators that function independently. The Water Project budget contribution from CIDA was $ 830,140 and the Biotechnology budget is $ 636,200. I. SUSTAINABLE WATER RESOURCES MANAGEMENT (SWRM) The Water Project aimed to increase the capacity of agencies and various private and public sector groups / individuals to assess and develop water resource management strategies and in the longer term, also increase their capacity to implement such strategies. This sub-project had 6 different working groups researching aspects of water management that included: supply, demand estimation, strategic environmental analysis, GIS, policy and institutional management and finally, pricing. Secondary data analyses as well as the collection of primary household and agricultural surveys were used to render case studies for both urban and rural areas. The processes of conducting field research and the use of GIS technology as well as computer modeling for supply/demand forecasting served as the training (learning by doing) aspects of the project goals. II. BIOTECHNOLOGY (BIOTECH) The Biotechnology Project improves human resource capabilities to meet China’s biotechnology development priorities.

Performance Assessment

Rating Scale I: SWRM; B. Achieving/Achieved Expected Results Outcomes Achieved to Date 65% Outputs Achieved to Date 100%

Rating Scale II: BIOTECH; B. Achieving/Achieved Expected Results Outcomes Achieved to Date 60% Outputs Achieved to Date 100%

Explanation of Rating and Action Taken or Recommended

WATER : The time between project conception (1996/97) and actual beginning in 1998 and then the further time to project conclusion (ending Dec 31/04) was a long period during which some adjustments to project activities had to be made. The adjustments required were both operational and to small degrees, substantive. Operationally, budgets had to be adjusted to reflect new activities that were deemed necessary but which at conception had not been anticipated. Furthermore, the incidences of September 11 in 2001 as well as the travel restrictions related to SARS in 2003 led to further postponement of other activities. Ultimately, the key goals and output of student training, primary data collection, the development of resource guides and support of linkage activities (such as policy workshops) have been completed. No contracts to Canadian firms have arisen out of this project, however, the research has been of interest to environmental engineering firms both in China and in Canada. The project office at UBC has fielded several calls of interest in the research results and copies of the CD-Rom has since been distributed to these firms. A comprehensive evaluation report outside the pro-forma reports required by CIDA had been planned; A set of evaluation questionnaires had been distributed but very few were returned. Identifiable reasons for this lack of response might be attributable to the long duration of the project whereby many of the students have since long graduated and moved on to the workplace and even other countries, so therefore were difficult to reach. Furthermore, as time passed, it was difficult to make direct claim to certain achievements by project participants since many of them have since accumulated experience and support outside of this project. However, it would be a fair assessment to indicate that many of the graduate students supported by the project achieved strong foundations through this project. Instead of a separate comprehensive report, comments that have come back on evaluation questionnaires have been integrated as updates throughout this report. BIOTECH : outputs – All three conferences and all three seed grant competitions completed. Outcomes – most of the outcomes canot be mearured during the term of this project, but to date, have initiated several collaborations that have long term potential.

General Comment : Consortium approach to project managemnet required strong leadership, particularly when the duration of the project has been so protracted, covering a span where there were 6 changes in leadership at the various levels within the project’s management and directorships across the two sub-groups. While planned outputs and activities have been delivered, the tracking and analyses of medium term outcomes would have better benefitted from more continuity at the higher management level. A key lesson on international collaborations of this nature would be that fewer partners would decrease the risks associated with having too many dispersed leaders and not enough of a core directorship. In spite of this challenge, the deliverables achieved indicated that the scholarship and interests of the individual researchers were sufficient to maintain focus on the key agenda, perhaps likely a reflection of the importance of the research itself. On technical matters of project management, the experience of project participants would lead to the advisement against bringing under one contract two entirely unrelated research projects.

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OUTPUTS/SHORT-TERM RESULTS

Cumulative Project Results Reporting Period Results

Expected Cumulative Outputs (Project LFA)

I. WATER

100-Training & Research & Staff Development

I. Technical reports available as reference and resources for improved understanding of water management challenges and possible solutions.

II. Improved knowledge in water resource management practices and increased critical analytical discussions op topic: Grad students trained. Gov't agencies involved.

III. Handbooks of policy recommendations and program proposals.

IV. Policy dialogues and workshops/training seminars.

V. Improved field research skills & More valid research results (approx. 40 DCP 19 CPO grad students trained – 29 women, 30 men)

Expected Cumulative Outputs (Project LFA)

I. WATER

100-Training & Research & Staff Development 101. three Cdn./ two Chinese researchers trained on GIS

functional structures development (3 women, 2 men). 102. four junior faculty (3 men, 1 woman) & 3 grad

students (2 women, 1 man)from DCP trained in data collection & field research methodology; 3 grad students undertook initial field research (3 women)

103. initial data collection begun on water supply, demand and pricing

104. one summer field study implemented for baseline studies of impact assessment policy / practice & protocol

105. preliminary guidelines for Strategic Environmental Assessment developed (SEA)

106. inventory and assessment of baseline management policy & water pricing mechanisms begun - studies of policy and regulatory framework extant

107. Data sets collected and developed for integration into GIS format; improved ability to analyze / contextualize overall project findings. (via industrial, agricultural & residential surveys conducted by students.

108. Visual integration of project sub-components' data beta-tested format of modeling software program/framework

109. Visual identification/ ground-proofing exercises undertaken to verify water supply system and relationship to human settlements - Improved resources for local & regional decision-making.

110. Land-use maps for watershed divisions and transport corridors developed and distributed to project partners.

111. Improved knowledge of demand for water consumption, ie improved ability to plan and forecast distribution, pricing, etc. (via DTM model for watersheds and drainage basins).

112. Water supply modeling analysis papers are refined while modeling programs have been beta tested.

113. Final editing of chapters and maps for production of searchable CD-Rom (changed from production of book).

114. CD-Rom produced. 115. The Water Demand and Estimation group have two

papers that were invited for publication in two different peer-reviewed journals, the first of which is Cities and the second is Habitat International. These papers are co-authored by David Brown, project lead at McGill University and Henry Zhang, a former graduate student with the project and publication was accepted.

Expected Outputs - (AWP LFA 2002/03)

100-Training & Research & Staff Development

Actual Outputs - Reporting Period (2002/03)

100-Training & Research & Staff Development

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Expected Cumulative Outputs (Project LFA)

I. WATER

100-Training & Research & Staff Development

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Actual Cumulative to Date (incl. reporting period)

I. WATER

100-Training & Research & Staff Development

116. Water demand fact book drafted and tested 117. Ground-proofing exercises undertaken to verify continued

relevance of satellite/Radar-Sat imagery distributed - land use, water distribution patterns confirmed/updated to improve resources in technical reports

118. Knowledge and understanding of governance structures improved (eg. Development of Report Card Evaluation approach to situation analysis and benchmarking)

119. Improved knowledge & understanding of relationship between industrial discharge & effects on agricultural output/quality (via wastewater / irrigation field work and study) opens up further potential research on health impacts of proper water management system

120. Resource available for continued training of students in Strategic Environmental Assessment (via finalized training manual of SEA methodology and practices…improved upon drafted through testing at workshop)

121. Resource available for continued dialogue between academic experts and practicing planners / professionals (via finalized software developed for Water Demand Management Forecast and Growth Scenarios)

122. Standardized references made available for students and researchers through continued GIS/Remote sensing research - CD-Rom applicable - wider information dissemination

123. ARCView Training CD-rom available for distribution 124. Remote sensing and GIS manual completed for distribution 125. 6 graduate students closely involved have completed

research / training through project and graduated. 126. "Handbook for Indicators for Water Resource

Sustainability" completed for distribution 127. 7 CPO & 23 DCP students trained in SEA and field research

skills (11 women, 19 men) 128. 6 CPO &15 DCP grad students increased capacity through

training to undertake future leadership of workshops (9 women, 12 men).

129. Water supply models finalized to make resource available for university to use in further collaboration with local planning & environmental agencies.

130. Final integration of water demand simulation model with new social survey analysis & data collected from last 3 summers’ field work.

131. Final editing of GIS maps for printing. 132. Water supply models finalized to make resource available

for university to use in further collaboration with local planning & environmental agencies.

133. Final integration of water demand simulation model with new social survey analysis & data collected from last 3 summers’ field work

134. Establish closer links with Ministry of Construction by completion of wastewater reuse case study.

135. Water supply modeling analysis papers are refined while modeling programs have been beta tested.

136. Final editing of chapters and maps for production of

searchable CD-Rom (changed from production of book). 137. Production of CE-Rom completed

Expected Outputs - (AWP LFA 2002/03)

I. WATER

100-Training & Research & Staff Development

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Actual Outputs - Reporting Period (2002/03)

I. WATER

100-Training & Research & Staff Development

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I. WATER

200-Exchanges & Linkages/Partnerships

I. Improved stakeholders participation (local

community consultation/involvement) II. Improved government-university interactions III. Increased Canada-China exchanges & interactions

(staff, students, faculty, public agencies)

300-Equipment & Capacity Development I. Purchase of updated equipment (computers &

peripherals) II. Purchase / update software III. Diffusion of reference imagery & mapping resources

only available from government sources/RADAR-Sat/ Satellite imagery, etc.

IV. Students & Faculty capacity to use equipment for analysis improved and goes beyond only project participants - production of data analysis / development of modeling programs, etc.

I. WATER

200-Exchanges & Linkages/Partnerships

201. Case study for waste water management modeling

developed /tested with rapid field assessment of Yinluan River, Tianjin - increased local presence & interaction between researchers and community

202. Improved stakeholders participation through 2 local workshops that involved planners, ministry of construction and ministry of energy, representatives of ministry of hydrology, active participation of local wastewater treatment plants in Tianjin

203. Improved capacity for analysis and consultation process through 2 training sessions for SEA held in Tianjin.

204. Good exchanges created between DCP university partners through movement between Beijing & Tianjin based researchers.

205. Improved exchanges between CPO university researchers 206. Field visits and ground-proofing trips made to Guanting &

MiYun Reservoirs, to Lower Bohai catchment region - engagement with local officials

207. Junior Chinese faculty member conducts research and training in Canada for three months

208. Nankai University group becomes involved in Tianjin Environmental Protection Agency's review and update process for establishing policy and practices guidelines in Strategic Environmental Assessment.

209. Increased linkages made with agencies outside DCP university researchers during training workshops and continued growth of network outside China.

210. Networks improved for Chinese partners at major international conferences in Hong Kong, Taiwan, The Netherlands, Cambodia, helped host International Workshop on Qualitative Assessment in Beijing.

211. Networks improved for Canadian counterparts where project findings were presented in Atlanta, GA

212. GIS-based website reconstructed. Due to server hosting problems, this new site was withdrawn from the web. Contents integrated into searchable CD-Rom.

213. Searchable CD-Rom contents being edited in final versions. During this reporting quarter and upcoming Q1 FY 2003/04, the project has undertaken efforts to identify appropriate avenues for distribution of CD-Rom. The following agencies and organizations have been identified as having a receiving program for academic research papers and multi- media products: The National Library Archives of Canada, the AUCC university and college membership, the Commonwealth of Learning in Vancouver BC, the Sustainable Development Research Institute, the International Institute for Sustainable Development, the library collection of CIDA, the National Library Congress in the United States, the campus libraries of partner universities in China, the National Environmental Protection Agency (China), the Water Savings Bureaus (Beijing & Tianjin), the Ministry of Hydrology & Energy (China), the municipal planning departments of the cities of Beijing & Tianjin, the University of Hong Kong Departments of Geography and Urban Planning, and the University Services Centre in Hong Kong.

214. The final project workshop took place in December 2003. Review of key activities concluded, forward-looking discussions on dissemination strategy confirmed.

I. WATER

200-Exchanges & Linkages/Partnerships

I. WATER

200-Exchanges & Linkages/Partnerships

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I. WATER

300-Equipment & Capacity Development

V. Purchase of updated equipment (computers &

peripherals) VI. Purchase / update software VII. Diffusion of reference imagery & mapping resources

only available from government sources/RADAR-Sat/ Satellite imagery, etc.

VIII. Students & Faculty capacity to use equipment for analysis improved and goes beyond only project participants - production of data analysis / development of modeling programs, etc.

400-Project Management & Administration I. Project coordination between CPO & DCP

implementing agencies II. Project coordination between CPO partners & 3x3

Management Committee/Secretariat III. Project management & reporting functions between

CPO and CIDA

I. WATER

300-Equipment & Capacity Development

301. Development of GIS functional structure, allowing more efficient access to relevant data. 302. New computers (7) purchased, enchancing data assessment capabilities for research. Facilities made available for continued improvement of trainers of future workshops and seminars. 303. New software and peripherals available for increased training capacity. 304. 3 Digitizers, 4 mock servers, printers, 2 scanners purchased. New equipment located in Peking, Tsinghua and Nankai.

400-Project Management & Administration

401. Annual project meetings (planning, seminars, workshops) undertaken on rotating basis between 3 Chinese university partners. 402. Periodic project update memos provided electronically on email & via website. 403. Individual research teams maintain their own levels of contact on periodic basis. 404. Financial and activity reports collected quarterly & submitted to CIDA & distributed. 405. Project participation at several CIDA-led workshops / conferences (Chengdu 2000, Ottawa 2001). 406. Canadian partner universities held 2 country team meetings (McGill 2001, UT 2002) 407. Research team’s leaders also meet at venues & locations outside of project auspices (other professional conferences,

and associations, etc.) 408. CIDA Contract Agreement extension amendment drafted, distributed. Not yet fully executed by CIDA 409. 3x3 University Consortium’s Secretariat helps maintain day- to-day functions in all aspects related to financial. 410. Disbursements between two 3x3 projects and final compilation of reports due to CIDA. 411. Draft proposal for re-allocation of funds between Water and Biotech projects. 412. Annual project meeting (planning & administration- May/03 413. Periodic project update memos provided electronically & via

website 414. Participation at CIDA CCHEP project workshop in Ottawa 415. Financial and activity reports collected quarterly &

submitted to CIDA & distributed. 416. Finalize contract amendment with CIDA. 417. Draft proposal for re-allocation of funds between Water and

Biotech projects authorized by CIDA. 418. Confirm/finalize funding re-allocation. 419. Finalized contract amendment with CIDA.

I. WATER

300-Equipment & Capacity Development

No further equipment purchases

400-Project Management & Administration

420.

I. WATER

300-Equipment & Capacity Development

No further equipment purchases

400-Project Management & Administration

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Outputs Comments / Variance – Water Project

1. Participatory Planning Training workshop for community and government agencies planned for summer 2002 cancelled due to funding difficulties: Original proposal involved application for funding outside CIDA sources. Ultimately, workshop facilitator unable to secure funds because of status as a visa student without Canadian citizenship.

2. The final project-wide research workshop was held in Beijing in December of 2003. At this forum, a review of the research initiatives were made. In addition, some analysis as to where the results will best to applied and where they have been most useful were undertaken. There were few new findings from this exploratory exercise but major points have been integrated into this final comprehensive narrative report.

3. The reference searchable CD-Rom was also presented at this final workshop. 4. Local university partners in China were each given a small inventory of CD-Rom disks which they can post-project continue to distribute to their respective circles of

academic and institutional partners. Likewise the Canadian university partners will continue to do the same beyond the project grant period. In addition, the Centre for Human Settlements where the project is led out of the University of British Columbia, has disseminated the research results (CD-Rom, GIS maps, related monographs) to libraries and other depositories within and outside of the academic institutional setting.

5. Due to the further extension of this project’s effective contract term, a regularly appointed coordinator has not been in place. However, through short contract terms and voluntary service, final workshop facilitation and reporting activities and obligations have been undertaken.

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Expected Cumulative Outputs (Project LFA)

II. BIOTECHNOLOGY

#1. Linkage Created. #2. Staff Development: Visiting scholars: 20 junior faculty to Canada for skills upgrading to learn biotechnology: genetic engineering; gene and chromosome mapping and exploration techniques; and other. #3. Curriculum/Facilities Development: not applicable. #4. Research: Seed funding grants for biotechnology research. Research: Seed funding biotech research grants –9x10K in Y1; 10X15K in Y2; 3X30K (selected pilot projects) in year 3. 9 seed grants to be supported in November 1999. 10 projects (15K) to be funded Spring of 2001, 3 project (30K) in Fall of 2001. #5. Exchanges/Linkages: 3 Workshops. Abstracts/research findings distributed for workshops. 2nd workshop held in Vancouver (April 2000). 3rd workshop scheduled for September 2001. #6. Project Management: Smooth running of project, financial accountability and transparency of all activities/decisions. LFA for the biotechnology component to be developed with outputs, outcomes and impact statements developed and incorporated with the WTR LFA.

Actual Cumulative Outputs To Date

(Including Reporting Period)

II. BIOTECHNOLOGY

#1. Linkage: Leading Biotechnology toward 21st Century. # 2. Staff Development: 39 Chinese Faculty and students have come to Canada for skills upgrading through Workshop and Seed Grants; 29 Canadian faculty have gone to China to assist Chinese counterparts through Workshops and Seed Grants. #3. Curriculum/Facilities Development: not applicable. #4. Research: 9 seed grants supported in November 1999. All complete. 1. Rice Dwarf Disease (McGill/Peking) 2. Water Deficit Sterility in Rice (Montreal/Peking) 3. Novel Bioinsecticides (Peking/Montreal) 4. Chrystalography (Tsinghua/Montreal) 5. Metalloproteinasis (UBC/Nankai) 6. Genetically Engineered Cells (McGill/Nankai) 7. Lipid Vesicle Ligands (Nankai/Montreal) 8. Zebra Fish (Tsinghua/UofT) 9. Gene and Chromosome Mapping (Tsinghua/UofT). Eight seed grants supported in May 2001. All projects now completed listed: SEED GRANTS 2001: 1. McGill/ Nankai: New type microbial fertilizer secreting phytase 2. UT/Tsinghua: Stat signalling in RA 3. UBC/Peking: LFY expression in SAM 4. McGill/ Nankai: Molecular Regulation of Signalling in Potato 5. UT/Peking: Relationship between zinc and APP gene regulation 6. UT/Tsinghua: Epilepsy genes 7. UT/ Tsinghua: Functional Genomics 8. UBC/Tsinghua: Osteoporosis Three seed grants third round seed grants supported in February 2002. 1.McGill/Peking. Large-scale cloning and functional characterization of fibre-specific genes from different cotton cultivars 2.UBC/Nankai. The abnormal expression of matrix metalloprteinases and their tissue inhibitors in the prostatic diseases. 3.UT/Tsinghua. Commercial application of gene discovery in the Progressive Myoclonus Epilepsies: From clinical and prenatal diagnosis to protein replacement therapy #5. Exchanges/Linkages: : 1st workshop held in Beijing (May 1999); 2nd workshop held in Vancouver (April 2000). 3rd Workshop held in Tianjin (October 2001). #6. Project Management: LFA for the biotechnology component with outputs, outcomes and impact statements developed and incorporated with the WTR LFA.

Expected Outputs Reporting Period

(Annual Workplan LFA)

II. BIOTECHNOLOGY

=========

Actual Outputs - Reporting Year

II. BIOTECHNOLOGY

=========

II. BIOTECHNOLOGY

(for final reporting period) # 2. Staff Development: not applicable #3. Curriculum/Facilities Development: not applicable. #4. Research: Final reports cfor third round grants completed Three third round seed grants of $30,000 announced in Feb. 2002, funded in May 2002, and completed March31, 2003 1.McGill/Peking. Large-scale cloning and functional characterization of fibre-specific genes from different cotton cultivars 2.UBC/Nankai. The abnormal expression of matrix metalloprteinases and their tissue inhibitors in the prostatic diseases. 3.UT/Tsinghua. Commercial application of gene discovery in the Progressive Myoclonus Epilepsies: From clinical and prenatal diagnosis to protein replacement therapy

#6. Project Management: not applicable

13

Outputs Comments/Variance BIOTECHNOLOGY: Original end date for second round seed grants was Dec. 31, 2001. This was changed to June 30, 2002 due to events in Sept. 2001 that prevented planned travel.

OUTCOME/MEDIUM-TERM RESULT

Expected Outcome /Medium-term Results

I. WATER MANAGEMENT

Improved Capacity for water management of DCP agencies; potential to influence management & distribution policy:

1. Efficiency gains in water management system; Logical organizational charts depicting rational allocation of

authority and power, presence of an organizational procedures manual; conformity of all agencies involved in water resources management to recommended processes and procedures in the manual.

2. A core group of young, up & coming scholars will have improved understanding of interaction btw water supply, demand and pricing and some technical abilities to forecast supply / demand and also have understanding of environmental impacts of water management mechanisms (or lack thereof). Improved capacity to influence younger generations of students and future practitioners.

3. Academic researchers and field specialists become engaged and networked with government agencies; potential for future collaboration and for research to influence policy.

4. Universities become more competitive / improved capacity to be engaged by outside agencies / companies to act as resources for research and policy dialogue.

II. BIOTECHNOLOGY

1. Chinese universities will become more effective in conducting research and be better able to move towards commercialization of research results; Canadian universities will develop linkages internationally with the partners in China

Cumulative Outcomes/Medium-term Results (with Indicators)

I. WATER MANAGEMENT Improved capacity: 1. Outputs of source guides, reference manuals, etc prepared but to what extent they will be put to use beyond the university research

community is difficult to assess at the moment. However, several government agencies have been involved in the development of some aspects of these guidebooks and we take this to be an indication of "buy-in".

2. Students between Chinese university partners have been sharing information and collaborating research; crossing traditional geographic and even

3. Early signs of responsiveness from government agencies who have assisted students with data gathering and research interviews; willingness of agency representatives to attend project workshops and to comment on training activities. Most promising outside interest comes from environmental protection authorities and from water treatment sectors.

4 Injection of new equipment improves university ability to attract new faculty or enhance other international linkages and other research linkages

II. BIOTECHNOLOGY Workshops : There were three sucessful workshops, the first in Bejing (May 1999), the second at Vancouver (April 2000), and the third in Tianjin (October 2001). At the first two workshops a seed grant competition was announced, and the establsishment of collaborations was fostered. The sucessful submission of seed grant applications indicates that potential collaborations had been identified at each meeting. Seed Grants : Total number of young Chinese faculty/students trained 1999 seed grant projects: 32 Disease categories studied (7): kidney/liver failure; artificial organs/heart disease/epilepsy/cancer/arthritis Agricultural categories studied (4) : rice disease; biological insecticides/rice sterility/tomato See note A on pages 26 – 36 for details.

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Outcome Comments/Explanation of Variance

WATER PROJECT & BIOTECHNOLOGY PROJECT

It has been extremely difficult to achieve "conformity of all agencies involved in water resources management to recommended processes and procedures in the manual." Various units involved in water management and distribution are governed by extremely isolated bodies that have own sets of policies and directives -many of which are at odds from one agency to another. This long standing institutional isolation cannot be easily brought closer together within timeframe of project funding or under current political environment. Recommended processes are based on fundamental idea of "streamlining" responsibilities of different agencies but this would require much longer term nurturing of relationships and state level policy to drive institutional change. A modest and reasonable expectation of outcome in this regard will come in form of different water agencies first developing working relationships with researchers who have a more general and holistic view of water situation. Inter-dependence of various aspects of water management will become more apparent and more immediate only through constant association and dialogue about issues; universities in this respect have a very special role to act as "facilitators" of this long-term dialogue. AS IT IS IN CANADA, UNIVERSITIES IN CHINA HAVE HUGE POTENTIAL TO PROMOTE TENANTS OF A CIVIL SOCIETY APPROACH TO GOVERNANCE AND ECONOMIC/SOCIAL WELFARE. Here, we include the participation of educators in partnership with government in environmental stewardship as a key tenant in the emergence of a civil society in China. --No change in reporting period for September to December 2003.

IMPACT/LONG-TERM RESULTS Expected Impact/Long-term Result Actual Impact/Long-term Result (with indicators)

I. WATER MANAGEMENT

Growth of economic linkages in environmental technologies and services. Growth of research and policy linkages between research and government bodies. (No additions or changes to this

period)

II. BIOTECHNOLOGY

Leading edge biotechnology research and commercialization of research results contribute to long-term economic growth in China.

I. WATER MANAGEMENT

Too early to assess. Too early to assess but seems moderately promising with current direction of lead researchers who are developing important data sets and sophisticated analysis of water situation. (no additions or changes this period.) Because of participation of some of Chinese partners in the review & renewal of Tianjin's Strategic Environmental Assessment laws (through the Tianjin Environmental Protection Agency), it is possible that the projects' research findings and methodologies may have some influence of input into that review process.

II. BIOTECHNOLOGY Discussions between academic groups and industry were initiated but as of reporting date, no outcomes to report.

15

GENDER EQUALITY

Gender Measures Contribution of Gender Measures to Overall Development Results

I. WATER MANAGEMENT

1. Target: Involve women at a participation rate of 50%, acquiring skills in water resource management practices. 2. Make use of CIDA in-country Gender Advisor where necessary & appropriate 3. Address women as a discreet and significant demographic and social group in all surveys, questionnaires, etc. 4. Gender integration given a focus at each annual strategic planning meeting.

II. BIOTECHNOLOGY 1. Women with a participation rate of between 25-30% as both recipients of seed grant funding and participation in workshops. �

I. WATER MANAGEMENT

Active and meaningful participation of women was on average about 45% of all participants in project, varying between 33% - 55% of all participants at any one time. There was special effort put into identifying what and how gender issues can be integrated into the project in 2 ways; (1) operationally in project implementation, and (2) as an area of research. However, it was deemed difficult to bring in women participants just for that sake so a natural inclusion of interested parties took place where slightly less than half of participants turned out to be women. In research areas such as survey questions and concerns about the training of water management professionals, issues of gender equality were addressed.

II. BIOTECHNOLOGY

Eight Chinese female participants attended the first workshop in 1999 out of approximately 60 Chinese participants(13%); This percentage increased to 22% at the next conference: that is, six in 27 Chinese participants were women at conference in Vancouver in 2000. Forty of the 100 Chinese participants at the Tianjin Workshop (Oct.. 2001) were female. In seed grants: 15 women are expected to participate of a total of 33 participants (46%).

16

OTHER RESULTS

Benefits to Canada

Unexpected Results

I. WATER MANAGEMENT Comments: No commercial contracts made. Expected Number of Contracts: Estimated Total Amount: _____ Actual Number of Contracts: _____ Actual Total Amount: _____

II. BIOTECNOLOGY Initiated discussions between academic groups and industry – no contracts yet.

I. WATER MANAGEMENT Very positive exchanges between lead investigators as well as graduate students both within each China side and Canadian side as well as addition of several prominent scholars in our field. Also, very dynamic use of internet access for communicating and peer review stands a great potential for increasing project cohesion.

17

RISK MANAGEMENT Project Risk Rating: _____________ Risk Mitigation Strategy Output Risks

I. WATER MANAGEMENT Low Risk –Very minimal possibility that results of research can be misinterpreted or mi-appropriated by different agencies for their own benefit. Medium Risk -- Possibility of data sets becoming outdated. This has been upgraded from previous report designating this same risk as "Low Risk". Reason for this is that we are discovering great discrepancies in data available from different agencies and in some cases continue to have difficulty collecting other sets of data. These situations lead us to believe that some of the modeling samples may not be as sound an useful as was originally hoped for. (no additions or changes to this period)

II. BIOTECHNOLOGY

A. Limited participation of Canadian researchers in seed grants due to lack of sufficient resources in the budget to cover costs (CIDA investment is very limited when compared to what is normally supported for biotechnology research).

B. Visa problems for Chinese junior faculty to come to Canada. e.g. Several key presenters not able to attend workshop as visas were not issued.

C. Chinese researchers have expressed that there are difficulties in accessing round 1 seed grants which have been set up at their universities.

D. Consortium approach requires strong leadership and management and second level report from Biotech project to 3X3 secretariat and this could result in timing and ineffective reporting problems.

I. WATER MANAGEMENT

Will try to ensure that research will be translated both in English and Chinese so that there is at least little risk of language mis-interpretation. Translations will be verified by participants working in project and not by outside translators who may not necessarily understand the proper context of research. Many young scholars are being groomed to stay on to undertake further higher education and accreditation (ie. Masters level students continuing on for PhD or PhD graduates staying on as junior faculty). Equipment and software have longer life span beyond project and flexibility is built into data analysis and modeling projects: Therefore, data and analysis can reflect changes and these are adaptable over time. Some measure of assurance can be found in continued participation by students currently funded by project. (no additions or changes this report)

II. BIOTECHNOLOGY

A. Mitigation strategy: Ramp-up in funding ceiling from round 1-3 creates some incentive for the potential commercialization of research results.

B. Mitigation strategy: CCHEP program to assist by identifying CIDA personnel in Beijing that can help to expedite processing.

C. Mitigation strategy: Set up seed grants at Canadian universities for rounds 2 and 3. Chinese researchers will be reimbursed for expenses from sub-grants set up at Canadian universities.

D. Mitigation strategy – duplicate CIDA reporting schedule with a UofT to UBC reporting sched., ensure effective integration of all biotech information in overall 3X3 reports and LFA’s before submission. UBC to subgrant the biotech portion of the overall project to UofT to improve effectiveness and efficiency.

18

Outcome Risks I. WATER MANAGEMENT

Med. Risk – Policy recommendations may be discarded or ignored by implementing agencies of water management.

II. BIOTECHNOLOGY A. Funded research projects will not result in commercialization due to need for

additional investment (beyond seed funding) to take them to commercialization. Mitigation strategy: encourage identification of potential private sector partners early in the process of developing the projects.

B. Preliminary publication of research results will prevent commercialization/patentability.

I. WATER MANAGEMENT

Will put special effort into getting “buy-in” from a few key people from agencies who are like-minded in these issues.

II. BIOTECHNOLOGY

A. Mitigation strategy: encourage identification of potential private sector partners early in the process of developing the projects.

B. Mitigation strategy: increase awareness of commercialization processes via call for proposals, and workshops.

Impact Risks �

I. WATER MANAGEMENT

The essential goal of this project is to render the different aspects of water management into a construct that integrates supply/demand/pricing with considerations of environmental as well as social risk. The project does not include activities that result in any physical product per se. The development of skills and tools used for impact assessment, wastewater treatment and environmental mitigation, for example, are among our work activities. In this sense, we see minimal “risks” per se but rather we anticipate “potentials”.

II. BIOTECHNOLOGY

Uncertain receptor capacity or enabling environment within the Chinese biotechnology private sector to take the results of research and commercialize it. Capital, market expertise, regulatory environment are all factors which are required to ensure commercialization can take place. Mitigation strategy – we are conducting commercialization capacity building within the project with the view that this will help to develop receptor capacity/create enabling environment in China

II. BIOTECHNOLOGY Mitigation strategy – we are conducting commercialization capacity building within the project with the view that this will help to develop receptor capacity/create enabling environment in China.

19

KEY SUCCESS FACTORS AND LESSONS-LEARNED

Cost-Effectiveness Is the relationship between costs and results reasonable?

WATER MANAGEMENT

We put money into students first and foremost. They tend to be able to deliver the best results for a minimum of costs as they have incentive to perform for the sake of their educational credits and lay a foundation for professional credentials. We also minimize international travel and concentrate key meetings into one session annually. The use of internet technology also greatly enhances cost-effectiveness.

BIOTECHNOLOGY Lesson Learned: Very limited funding for seed grants may be inhibiting factor for effective participation.

Relevance of results Does the initiative make sense in terms of the conditions, needs or problems it is intended to respond to?

WATER MANAGEMENT Lesson Learned: Beijing & Tianjin face challenges in water management for many reasons; supply shortage, distribution problems, increasing population, increasing pollution, etc. This is a key time to at least join the dialogue if not take positive steps to investigate how those factors are inter-related. Students remain a key element in “getting the word out” as they have access to a more open audience of peers and a better grasp of different venues for exchange of ideas.

BIOTECHNOLOGY Lesson Learned: The initiative has been developed by the Chinese partners in terms of their conditions, needs, problems in biotech capacity building.

Sustainability of Results Will results/benefits continue after CIDA’s involvement ends?

WATER MANAGEMENT

We will require more “buy-in” from key players from the water management agencies. At present, while there is some interest, it is not wide spread. Interest is limited to the few agencies in the local areas where our research takes place. This, however, can be seen as a positive for changes to rise from the local community and outwards.

BIOTECHNOLOGY Lesson Learned: Possibly, especially if pilot projects are found to be commercially viable.

Partnership Is there shared responsibility and accountability?

WATER MANAGEMENT Within the Water Management group there is a high level of accountability and transparency for both finances and research achievements. There is no substantive interaction between the Water and Biotech groups. Lesson Learned: Consortium approach to project management requires a dedicated leader, otherwise it will be difficult for the members of the consortium to make good progress.

BIOTECHNOLOGY Lesson Learned: Consortium approach to project management requires a dedicated leader, otherwise it will be difficult for the members of the consortium to make good progress.

20

Appropriateness of Design Is the design appropriate and based on sound understanding of local context? Were risks identified and assessed and strategies developed for ongoing monitoring? How were innovative and creative ideas and approaches explored to achieve results?

WATER MANAGEMENT The significant involvement of local students strengthens local knowledge. The placement of CPO students and researchers into the local region for extended periods of time also enhances local relevance. The project itself has a focus on impact assessment and in some ways, risk identification and mitigation strategies are “built-in”.

BIOTECHNOLOGY Lesson Learned: Project design was determined by the Chinese partners as the most effective method of contributing to their development needs. Risks were identified and strategies are in place for ongoing monitoring. Selection of three pilot projects for commercialization potential will move project closer to achieving expected results.

Appropriateness of Resource Utilization Are suitable human, financial, and physical resources involved and used well? Is financial information complete, accurate and reliable? Are prudence and probity adequately exercised?

WATER MANAGEMENT More constant monitoring is used to ensure proper financial reporting. Where necessary, money transfers will be withheld by lead agency until proper reporting and supporting documents are submitted. One significant cost savings is the retention of a project manager who has other work in China. Carefully planned travel itineraries maximize the savings in cost of travel.

BIOTECHNOLOGY Lesson Learned: Consortium approach to project management requires strong financial and other coordination, otherwise it will be difficult for the members of the consortium to make good progress. The UBC/U of T relationship has required strengthening since the beginning of the project to ensure financial and other accountabilities, efficiencies and effectiveness.

Informed and Timely Action Did we anticipate and respond to change based on adequate information? Did we take appropriate action to manage risks?

WATER MANAGEMENT Lesson Learned: Most changes took place among a few lead investigators of the project. In one instance, a replacement PI was brought into the project one year before the official changeover while in other instances, replacements were announced as it happened. It is difficult to enforce a “warning announcement” approach as universities or even faculty members sometimes do not know about certain changes until last minute. Wherever possible, we encourage due notice of faculty change to be given.

BIOTECHNOLOGY Lesson Learned: Seed-grant process was adjusted half-way through project in order to move the project closer to achieving its expected results.

Other If there are success factors that may be of interest to programmers that do not fit into any of the above categories they may be entered here.

WATER MANAGEMENT, & BIOTECHNOLOGY Lesson Learned: N/A

21

Beneficiaries Reach - Target Population

Beneficiaires Reach

Characteristics�

Beneficiary Organizations�

Expected Direct

Actual Direct

Expected Indirect

Actual Indirect

% # % # % # % # Direct Indirect Disabled # #

People Reach Governmental Total WTR approx.

100 BIO 40

WTRapprox. 67 BIO 60

BIO 1.1B

Food Insecure BIO X Supra-National

National WTR 4 Sex Homeless Sub-National WTR 4 Male WTR 50

BIO 64 WTR 55

BIO 52

BIO 500M Municipal

WTR 3

Female WTR 50 BIO 16**

WTR 45 BIO 8

BIO 500M

Indigenous populations

Not disagregated Internally displaced people Civil Society

Age International NGI Children 0-4 Landless National NGI Children 5-11 Sub-National NGI Children 12-17 Minority Ethnics/Religous

Group Regional NGI

Children Total

International NGO

Youth 18-30 BIO 40 BIO 30

Out-of-school Sub-National NGO

Adults 31-60 BIO 40

BIO 30

Community Based NGO

Elderly 61 & up Poor BIO X Non-Canadian Profit - Making

Adult Total

RefugeesLocality

Rural

BIO X Unemployed

Urban

BIO X

Peri-urban

BIO X Victims of conflict

Victims of Natural Disaster

* Chinese researchers attending conferences including those involved in seed grants

** if female participation increases

Victims of Human Disaster

22

Exhibit 2 (Purchase Order No. 7000881, WBS element: A-019736-001-PR1, GL Account/CC/Fund 52302/4130/0300, Vender: 1000539, Project Manager: David Fournier) ORGANIZATION CHART - CIDA 3x3 University Consortium Project GOC GOPRC CIDA MOFCOM MOE JPSC Contracted Lead Institution 3x3 Nat'l Mngt Committee UBC - Research Services Ken McGillivray, UBC

(Nat'l Coordinator) Canada-Side China-Side

Water Project - UBC (Lead – Michael Leaf) Water Project - Peking (Lead – Tao Shu) Biotech Project - Toronto (Lead – David Irwin) Biotech Project - Peking (Lead – Zhao, Nanming) UBC- Toronto - McGill - Montreal - Nankai Tsinghua Peking M. Leaf (Water) R. White (Water) D. Brown (Water) P. Andre (Water) S.G. Dai (Water) T. Zhang (Water) S. Tao (Water) D. Kilburn (Biotech) D. Irwin (Biotech) R. Prichard (Biotech) V. de Luca (Biotech) Y. Yu (Biotech) N. M. Zhao (Biotech) Y. Zhu (Biotech)

23

Exhibit 3 (Purchase Order No. 7000881, WBS element: A-019736-001-PR1, GL Account/CC/Fund 52302/4130/0300, Vender: 1000539, Project Manager: David Fournier) IMPLEMENTATION SCHUDULE

Inputs

Description

Timeframe for Expected Results to be Achieved

FY98/99 FY 99/00 FY 00/01 FY 01/02 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4

100 Training & Research 101 GIS researcher training 102 Data collection (policy

analysis)

103 Field trip 104 SEA guidelines/impact

assessment

105 Social survey (demand estimation)

106 Develop GIS system 107 Training for GIS tech.

Transfer

108 Data collection (water pricing)

109 Report for water pricing 200 Exchanges & Workshops

201 System planning/management

meeting

202 Workshop on SEA & fact book prod'n

203 Policy & projectmanagement workshop I

204 Model workshop/watersupplies study

205 Scoping & scientific workshops

206 Policy worshop II 207

Project management

workshop II

24

FY98/99 FY 00/01 FY 01/02 FY 02/03 FY 03/04 Q4 Q1 3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3

300 Equipment & CapacityBldg / Grants

301 Development of GIS functional structure

302 Seed grants/ biotech research

303 Computer and Peripheralequipment

400 Project Management 401 Project Coordination

Secretariat

402 Administration &coordination by and

between CPO & DCP

403 Liaison functions with CIDA

Green = completed

Grey = ongoing

99/00 2 Q

FYQ

25

Exhibit 4A Travel Plans for Water for Sep 2003 – December 2003, List of Participants Travel for Final Workshop, December 2003 (Beijing)

o Bernard Lafargue o Donna Yeung o Michael Leaf o David Brown o Henry Zhang o Dai Shugui o Zhu Lin o Jin Zhaohui o Zhu Tan o Gerhardt Schmitt

Exhibit 4B Travel Plans for Biotech for Apr 2003 – Sep 2003, List of Participants No traveling occurred during reporting period.

26

Exhibit 5A (Purchase Order No. 7000881, WBS element: A-019736-001-PR1, GL Account/CC/Fund 52302/4130/0300, Vender: 1000539, Project Manager: David Fournier) EQUIPMENT PURCHASES BY THE WATER PROJECT Peking University Serial/Catalogue # Make XpsR450 Awaiting Serial # from China IBM Legend x2 Zi Guang HP Printer Digitizer Laptop PC Desktop Awaiting Serial # from China Awaiting Serial # from China Sub-total Tsinghua University Serial/Catalogue # Make ZY2000 – NY02235668 ASUS-MP83-8200 91C-99-G2899 6L-JP2P025301 Sub-total TOTAL BUDGET TOTAL

Description 1 computer 1 computer IBM laptop Legend x2 PC Zi Guang Scanner HP Printer (??) Digitizer (??) Laptop (Make?) Laptop Processor Description Desktop PC Portable computer Portable computer Printer

Price per unit $3,446 $8,000 $3,900 $4,200 $900 $1,100 $8,000 $4,000 $2,500 $3,375 $1,100 $40,521 Price per unit $1,500 $3,200 $3,816 $630 $9,146

Total $3,446 $8,000 $3,900 $4,200 $900 $1,100 $8,000 $4,000 $2,500 $3,375 $1,100 $40,521 Total $1,500 $3,200 $3,816 $630 $9,146 $49,667 $50,000

Exhibit 5B (Agreement 28451 RC/Project 282/19736 Project Manager: David Fournier) EQUIPMENT PURCHASES BY THE BIOTECHOLOGY PROJECT U of Toronto XpsR400 TOTAL BUDGET TOTAL

1 computer

$4,757 $4,757

$4,757

$4,757

$5,000

27

Note A : pages 26 — 36, providing details for Biotech reports on page 13 Actual Outcomes – Skills learned in Canada and transferred to China: 61 Brush border membrane vesicle preparation; light scattering assay and data analysis; bioinformatics analysis. physical crosslinking method, chemical crosslinking method, APA microcapsules preparation, 15 skills related to yeast two-hybrid system, cDNA library construction, identification of genes from cDNA library, isolation of nucleic acids, whole mount hybridization, labelling RNA probes, microinjection, in vitro RNA synthesis, PCR, northern hybrid and gene expression techniques. nuclear magnetic resonance spectrometry; differential scanning colorimetry; Elisa; protein expression of E coli; confocal laser scanning microscopy; protein engineering skills; protein expression; denaturing’; protein purification; crystallography; protein folding. Techniques incorporated into teaching. 17 Promotion for participating young scientist 4 Job for young Chinese scientist 2 Publications related to project: 14 Ongoing collaboration between universities 7 Grants: (7) $380,000 total Commercial Application: 6 Patents possible 4 Confidentiality agreement signed 1 Below is a description of seed grant projects 1999.

Agricultural Biotechnology Projects 1. Marc Fortin (McGill) and Li Yi (Peking), New strategies for rice dwarf disease protection. Understanding the host factors involved in plant defense against Rice Dwarf Disease, a major pathogen rice pathogen in China is of major practical agricultural as well as theoretical and scientific importance. This project is expected to generate research papers for international journals and/or grant applications for additional long term funding. • Project status: Completed – identified gene maybe involved in rice dwarf disease • Yi Li (senior faculty) • Gang Wu (male post doc) • Chunhong Wei (female technician) • Quiling Ren (female student) • Chunbo Li (male student) • Skills learned: yeast protein-protein interaction trap, ELISA, Protein expression in E coli, confocal laser scanning microscope • Any commercial application for project? Vaccines against viruses for plants, says Marc Fortin • Should we send cheques in future to Canadian or Chinese universities to administer? Canada – because Canadian universities can account for spending in clear and transparent manner • Publications: one published; one submitted • NSF grant (average 30,000) • No Patent • No confidentiality agreement

28

2. H S Saini (U of Montreal) and Yuxian Zhu (Peking University), Identification of targets for biotechnological interventions to prevent water-deficit-induced sterility in rice and wheat. Rice and wheat are enormously important agricultural crops in China and lack of water leading to decrease in fertility is an important cause of reduced rice yield. This project is designed to identify targets for interventions to prevent sterility in rice and wheat. The technology can then be easily transferable to the Chinese laboratory for ongoing research. - Project status? Completed - Number involved in project – Dr Y Zhu (senior faculty) male graduate student (Xu Jian) and female grad student (Li Jun) - Male student travelled to the US to work on the project in Berkeley stayed six months, Dr Zhu claimed that he had difficulty establishing contact with collaborator, and so sent student to United States to work on project. Dr Saini

claimed he had difficulty establishing contact with Dr Zhu and lost touch with project. - What specific skills will students be learning? Techniques of gene expression, northern hybridization and quantitative PCR - Any commercial application for project? Within ten years, develop potential intervention to regulate genes responsible for reproductive failure of rice during drought – either through biotechnology or by conventional methods - Should we send cheques in future to Canadian or Chinese universities to administer? – Strongly advises sending cheques to Canadian universities, says “appalled” by idea that money that is to be spent in Canada is sent to China,

says its just a “PR exercise” and excessively convoluted - Skills learned: PCR, northern hybrid and gene expression techniques. - Student received raise - 1 Article published in Chinese Journal of Botany, 2 articles in preparation - Collaboration will not continue - Scientist received a Chinese Science Foundation Grant – $50,000 (one fifth of 12 million Yuan) - Confidentiality agreement signed with Biotechnology Company: Transcentury - No patent potential - Dr Zhu signed document explaining expenses; final accounting sent Dec 2001 3. Su Yanhui (Peking) and R Laprade (U of M), Development of novel bioinsecticides against insects of agricultural importance. The development of new and less environmentally harmful bioinsecticides against agricultural insect pests is crucial for China’s long term agricultural development. This project will fund Ms Yanhui in her research to learn the techniques to develop new insecticides against target insects which are considerable pests of agricultural importance in China. She will work in Montreal for three months in order to acquire the skills necessary to the study insect pests. This is the type of highly relevant agriculturally vital technology likely to be sponsored by private industry or national governments. • Project status – Finished –Final Report complete January 2001 • Number involved in project – Su Yanhui(Jr Faculty) and additional one male junior faculty Jie Zhang and one female postdoc Hong Qu. • Female Jr Faculty Su travelled to Montreal for four months in Summer 2000 • What specific skills did learn? Purification of Bt Toxin • Any commercial application for project? Yes, new and improved bioinsecticides to use against rice, soybean and cotton insect pests of China • Should we send cheques in future to Canadian or Chinese universities to adminster? • Skills learned in Canada and transferred to China: brush border membrane vesicle preparation; light scattering assay and data analysis; bioinformatics analysis. Techniques incorporated into teaching. • Promotion for participating young scientist • Publications related to project: 1 • Ongoing collaboration with University of Montreal • Grant: App Chinese National Nature Foundation $30,000 Can • Commercial possibility: New environmental Bt toxin insecticide • Trained: 3 jr faculty/students

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4. Z Rao (Tsinghua) and D Matton (U of Montreal). Crystallography of a plant notchless homologue: structure function relationships in a plant WD40 repeat protein. How do cells diversify? This has been an important question for animal and plant biologists. Understanding the fundamental mechanisms that affect cells and organ formation will lead to an increased understanding of these events. This is a basic science project and may provide research papers for international journals. This grant helped get an important laboratory established at Tsinghua; now one of the main crystallography groups in China, with strong collaborations with Netherlands, Japan, S Korea and UK. - Status of project: Project completed - Number involved in project – Dr Rao (M senior faculty); Zhou WH (Female, postdoc) Wong GG (male student) Ti Li (F student) - Skills learned protein expression; denaturation; protein folding; crystallography - Any commercial application for project? Seedless tomatoes possible in future - Should we send cheques in future to Canadian or Chinese universities to adminster? Dr Matton has not yet been reimbursed for the 2,500 outlay he has made on antibodies and peptides for experiments – I suggested he send the

bill to Dr Rao to be reimbursed and to let us know if there is a problem - One promotion to distinguished professor; two student scholarships - Grant National Frontier Research Programme Grant $200,000 - Collaboration to continue with U of M Medical biotechnology projects 5. C M Overall (UBC) and Ju Zhang (Nankai). Expression of matrix metalloproteinases and tissue inhibitors in human prostate tissue and cancer. An understanding of the biology of prostate cancer in the 21st century will depend on the understanding of the basic genes involved in this disease. This project is designed to elucidate some of the relevant aspects of the genetic mechanisms in prostate cancer. Histological and cell culture data will be developed in the laboratory at Nankai University. • Project completed • Number involved in project : • Ju Zhang (Female – senior faculty) • Feng Liang (student male) • Zhao Hong (female young faculty) • No Chinese travelling to Canada • Specialized expertise in this field will be developed in China: protein engineering skills • Any commercial application for project? Potential kit for diagnosis of prostate cancer • He says Canadian universities should administer: it was difficult and slow getting the money out of China and in Canada the accounting would be transparent and it would be easy to get the money. • Jobs: student got placement in Montreal, Ju Zhang got promotion to professor • 4 meeting abstracts; publication in process • no grant • Collaboration to continue with UBC 6. T Chang (McGill) and Yaoting Yu (Nankai). New Membrane Construction for microencapsulated genetically engineered cells for oral administration in uremia therapy. Dr Chang holds patent on these microcapsules, which may enable hemodialysis patients to be freed of the onerous hemodialysis filters that are now the standard therapy for kidney failure. Such a drug would be considered a true breakthough in medicine and has great commercial prospects when fully developed. Chinese unable now to afford hemodialysis and cheaper methods of treatment would be desirable. Project expected to generate research grant proposals, publication in international journals and larger and long term research collaboration. Skills learned in Canada and transferred to China: 3 physical crosslinking method, chemical crosslinking method, APA microcapsules preparation Techniques incorporated into teaching. 3

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Promotion for participating young scientist Publications related to project: 1 preliminary paper Ongoing collaboration with McGill Grant: App Chinese National Nature Foundation $30,000 Commercial Application: Commercial applications under arrangement with McGill Trained 2 jr faculty one male one female Number involved in project – Dr Yu ( male senior faculty) and (Y Wang Male Junior)(Yu S. Female Student). Dr Chang travelled China 4 days September 2001 What specific skills will he be learning – methods of encapsulation of cells and microorganisms Any commercial application for project? There are two patents pending on this work from Dr Changs lab, which companies have been interested in pursing. This project will further perfect these encapsulated cells. In the future such genetically engineered cells could be used to treat people with kidney and liver failure Should we send cheques in future to Canadian or Chinese universities to administer? Dr Chang says that as long as money is being spent in China, it makes most sense to send money to China 7. Kong Deling (Nankai) and Julian Zhu (U of M). Binding interaction between lipid vesicle ligands and polymers for development of new materials in biotechnology. Understanding the interface between artificial materials and cells is crucial in order to further develop tissue engineering and artificial organs. This project which explores the interface between the materials of biomaterials and cells has great commercial applicability, for example, for the development of artificial organs, such as livers. • Number involved in project – Julian Zhu (senoir faculty) Wang Zheng (postdoc) and Y Wang (F young faculty) - Julian Zhu travelled to Nankai for 2 weeks in summer 2001 • Female Wang Zheng young postdoc travelled to Canada in Summer July 2001 for six months. The collaboration involves combining the expertise of Institute of Molecular Biology (Chinese) with the Chemistry department at U

of M. The U of M people involved in making polymers that are biocompatible with cells. Polymer materials will be returned to China for experiments there. • What specific skills will she be learning? Specific expertise in chemistry as applied to biology: how to make biocompatible polymers. Specific instrumentation: nuclear magnetic resonance spectrometry and differential scanning

colorimetry. • Any commercial application for project? – Yes, definitely: this work is applicable to the development of artificial organs, for example, liver, which will be of benefit to those with liver failure. • Should we send cheques in future to Canadian or Chinese universities to adminster? He prefers cheques go to Canadian universities, sending to China involves converting currencies, and sending back to Canada involved

reconverting them – lose money in the transaction – much simpler overall if Canadian universities administer. • Postdoc received teaching position at Nankai • 2 publications in preparation – to be submitted to Macromolecules or Polymer • Collaboration will continue • Grant obtained : NSFC $30,000 8. Anming Meng (Tsinghua) and CC Liew (U of T). Isolation of somite speicfic genes in zebrafish. The zebrafish is a new vertebrate model with human disease applications. Understanding the molecular mechanisms in zebrafish will be important as part of the human understanding of disease and disease processes, such as heart disease. This is a basic science project designed to develop techniques in bioscience that will improve biotechnology research in China. The gene library will be constructed at Tsinghua University and the sequencing of the genes will be carried out at the University of Toronto. This project is already partly sponsored by the Chinese government and is expected to lead to publication and or further funding support for ongoing collaboration. Outcomes - Skills: 7 cDNA library construction, identification of genes from cDNA library, isolation of nucleic acids, whole mount hybridization, labelling RNA probes, microinjection, in vitroRNA synthesis - Collaboration: Ongoing with U of T - Grant: App. National Natural Science Collaboration $160,000 - Patent: possible - Trained: one jr male faculty; one female and two male grad students - Number involved in project – Anming Meng (Jr faculty) and Lixia Zhang(female grad student) and Chengtian Zhao (Male Grad student) and Kehui Shi (Male grad student) - Meng travelled to Canada 4 days 31

- Liew travelled to China 4 days - What specific skills will she be learning? Specialized expertise: will learn microarray analysis and development of microarray resource for zebrafish 9. Zihjie Chang (Tsinghua) and Steve Scherer (U of Toronto). Disease study through the isolation of interacting proteins for important genes and chromosome mapping. This project focuses on the gene/s that cause a type of epilepsy. Epilepsy is an imortant disease in China and has no cure. Probably the most important development in biological research in the last twenty years has been the ability to study genetic mechanisms though isolating and cloning genes. Genome research is the primary approach to delineating basic molecular structures underlying diseases such as cancer and developmental disorders. Both scientists are attempting to set up the technology for this project in their own laboratories and each lab has technology that the other is interested in establishing. Thus the respective technologies can be transferred through this project. The project is expected to generate seminars and lectures. The exchange of fellows and students will be encouraged in order that the project can continue long term. The applicants will work together to solicit further research funds. Commerical applications likely for genes for epilepsy. Outcomes: - Skills learned in Canada and transferred to China: approx 15 technical skills related to yeast two hybrid technique - Techniques incorporated into teaching. - Job: young scientist received 4 month research job in Canada - Publications related to project: 2 / 2 abstracts - Ongoing collaboration with U of Toronto - Grant: National Scientisfic Funding grant $20,000 - Commercial Application: Intellectual property of Epilepsy gene - Patent possible - Number involved in project Zijie Chang (Male Junior faculty) and Xinjun Zhang male graduate student and Xiaochu Zhao female research assoc - Chang Male Jr Faculty travelled to Canada – 4 weeks April 2000 – Female res associate Zhao travelled in Canada Oct 2000 – April or later 2001 - Canadian went to China for week in October 2000 to lecture and attend symposium - What specific skills did Dr Chang and graduate student learn? DNA sequencing – has access to DNA sequencers in Canada and can take results back to China for research. - Any commercial application for project? Basically, searching for the gene for epilepsy. Commercial applications in diagnostic and therapy of epilepsy. - Should we send cheques in future to Canadian or Chinese universities to adminster? Canadian universities, simpler and Chinese investigator claims that Chinese university (Tsinghua) taking 5% overhead on funds. Eight seed grants supported in May 2001. Our initial intent had been to support ten (10) second round seed grants. We felt that only eight (8) of the submitted proposals merited support. We have received final reports from six of the eight projects Summary of outcomes (details below) Total number of Chinese faculty/students trained: 18 Skills learned ; 27 RNA extraction, DNA primer design, reverse PCR, plasmid construction, Yeast transformation, Southern Blotting, in situ hybridization, nucleic cell isolation, recombinant techniques; cell culture, cell transfection, PCR, Northern Blot, Microscopy; Western Blot; cell cycle analysis. : techniques in micropropagation. Air lift fermentation. Gene discovery techniques, Protein gel, immunoprecipitation, DNA cloning, cDNA library, protein sequencing, knockout strategies, immunohistochemistry yeast two hybrid Disease categories: 2 epilepsy and cancer Agricultural categories: 3 plant development, potato, fertilzer Jobs/promotions: 4 Publications: 13

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Collaborations ongong: 4 Grants 5 ($580,000) Commercial applications 7 Patents ossible: 2 Partners in industry: 2 Details: 1. Marc Fortin (McGill) and Li Minggang (Nankai) Genetic engineering of Phytase Phytate is the major storage form of phosphorus, accounting for more than 50% of the total organic phosphorus in the soil. Plants are not able to utilize organic phosphorus directly from their surroundings. Phytase however can hydrolyse phytate and then release inorganic phosphorus. Thus phytase greatly increases the bioavailability of soil phosphorus to plants. This project will construct a transgenic engineering strain that can produce functional extracellular phytase by cloning the phytase gene into a yeast strain. The successful construction of this engineering yeast strain will lay the groundwork for further research on the microbial fertilizer. • Personnel • M Li Prof M 50 days project • J Zhu St M 200 days • J Chen St F 200 days • J Sun St M 200 days • G Li St F 200 days • Z Wu St M 200 days • L Wang St M 200 days • Skills learned: 6: RNA extraction, DNA primer design, reverse PCR, plasmid construction, Yeast transformation, Southern Blotting • 2 publications • collaboration will not continue • Cooperation Grant from Yunnan Province • Commercial potential: new kind of fertilizer secreting phytase • Patent potential NO • Confidentiality NO • One promotion; one higher education in USA 2. David Irwin (University of Toronto) and Zhijie Chang (Tsinghua) Stat signalling in RA The initial goal of this project was to find proteins that might be involved in rheumatoid arthritis, and several proteins important for regulating immune response in RA were identified. In addition the research on this project led to the discovery of a novel gene that appears to be involved in cell-cycle regulation. This novel gene may have a role in cell proliferation. Alterations in gene expression were detected in some cancer cell lines suggesting that this may be a potential target for regulating tumor cell growth.

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Personnel Z Chang JF M worked 60 d China D Irwin P M China 14 d/Canada 20d G Kim St F China 300d X Hao St M China 60 d • Techniques: 9 nucleic cell isolation, recombinant techniques; cell culture, cell transfection, PCR, Northern Blot, Microscopy; Western Blot; cell cycle analysis. • One job from project - PhD in Korea • One publication • Collaboration will continue • Beijing Scientific Committee 200,000 RMB ($30,000) • Commercial application: markers for early detection of cancer; new therapies for cancer. • Patents: no • Confidentiality agreements: no 3. George Haughn (University of British Columbia) and Shunong Bai (Peking) LFY expression during early developmental stages and its role in SAM formation Shoot apical meristem (SAM) gives rise to the entire postembryonic shoot. But little is known about the molecular mechanisms of SAM formation. Previous research in the Bai laboratory has suggested that the LFY promoter is activated at a very early stage of embryogenesis as well as in the SAM progenitor cells during tissue culture, suggesting that the LFY gene can be used as a molecular marker for SAM formation. This study explored the role of LFY in SMA formation and molecular mechanisms of MA formation during shoot regeneration. Personnel Tao Han male student travelled UBC 65 days Shunong Bai male professor worked in China • Techniques learned (1): in situ hybridization • Publications: 2 publications in preparation • Project collaboration to continue • Grants: one in preparation, one obtained "Chinese Research Grant" • Commercial Applications: markers for shoot apical meristem (facilitate development of transgenic plants) • Commercial collaborations: Sinar Mas Corp in China • Patents: no • Confidentiality agreements: none 4. Danielle Donnelly (McGill) and Chen DF (Nankai)

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Molecular Regulation of Signalling in Potato This project involved the development of bioreactors/air lift fermenters for micropropagation and microtuberization of potato. Bioreactors are of great interest in the maximization of potato crop productivity in commercial microtuberization systems for seed tuber production. As China has more land cultivated in potato than any other country in the world, every effort should be made to increase Chinese expertise in micropropagation and microtuberization systems for potato certification industry in China. Personnel X Q Li; Nankai; junior faculty; Male - 8 months Canada Dr DF Chen; Associate professor • Skills learned: techniques in micropropagation. Air lift fermentation. Gene discovery techniques • 3 publications from project • Collaboration will continue • One Fellowship from this project • Commercial applications: air lift bioreactor for micropropagation • Patent potential on fermentors • No confidentiality agreements • Commercial collaboration - some interest from Quebec growers 5. Berge Minassian (University of Toronto) and Zhang Shuping (Tsinghua) Disease study through isolation of interacting proteins for epilepsy genes and chromosome mapping Epilepsy occurs in 1% of the population and is the most common neurological disorder in children. This project concentrates on Lafora disease, a form of adolescent epilepsy. This project utilized the yeast two-hybrid system to identify a protein interacting with laforin, the laforin epilepsy protein. The discoveries of PME genes make it possible now to envision cures through gene therapy for these forms of epilepsy. Personnel Xiaochu Zhang female student visited U Toronto: 8 months/ China 1.5 mos • Specific skills learned (7) Protein gel, immunoprecipitation, DNA cloning, cDNA library, protein sequencing, knockout strategies, immunohistochemistry yeast two hybrid • Publications 5 published; three submitted • Collaboration will continue • Grants 2: CIDA $30,000, CIHR: $173,336/yr for 5 years • Commercial application: new interacting protein' diagnostics value and future treatment value • Patent potential: new interacting protein will be patented. • Confidentiality agreements: NO

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6. Peter Hyslop (U of Toronto) and Ru Bingenn (Peking) Relationship between zinc and APP gene regulation THIS PROJECT NEVER WENT AHEAD 7. Clive Roberts (UBC) and Rong Zhang (Tsinghua) Effects of soy isoflavones on osteoblast metabolism a potential link between diet and protection from osteoporosis THIS PROJECT NEVER WENT AHEAD UNREPORTED 8. Sandy Der (U of Toronto) and Zihe Rao (Tsinghua) Functional Genomics: functional linkage derived annotations of disease related genesOne Canadian student to visit China One Chinese student to visit Toronto Third round seed grants supported in February 2002, with outcomes. Summary of outcomes (details below) Total number of Chinese faculty/students trained: 10 Skills learned ; 17 • yeast two hybrid, immunoprecipitation, immunofluorescence, northern, western blot; other molecular biotechniques, mutant generation; knowledge of cotton and fibre development, gelatin zymography, western blot, northern

blot, microencapsulation, gene recombination, bacteria cluster analysis, physical and chemical crosslink analysis, microcapsules character analysis, ABA microcapsules analysis Disease categories: 2 epilepsy and cancer Agricultural categories: 1 plant development Jobs/promotions: 1 Publications: 10 Collaborations ongong: 2 Commercial applications 7 Confidentiality agreement: 1 signed Patents: in progress Partners in industry: 1 1. Steve Scherer (University of Toronto) and Chang (Tsinghua) Commercial applications of gene discovery in the progressive myoclonus epilepsies

This project has two aims: the first is to establish a gene-based sensitive and specific test for the clinical and prenatal diagnosis of Laforas Disease, a severe from of adolescent epilepsy for potential commercialization. The second aims to perform preliminary experiments exploring the possibility of protein replacement therapy in Laforas and related epilepsies. Beyond what has been achieved in our laboratory there is no gene base test for Laforas. Dr Sherer in China - one week Dr Zhang in Canada - one week Dr. Xiao chu Zhou in Canada six months 1 job likely from project 5 publications potential application: medical test. Patent application in progress Potential commercial collaborator. Collaboration will continue 2. Tom Bureau (McGill) and Yuxian Zhu (Peking University) Large scale cloning and functional characterization of fibre specific genes from different cotton cultivars This project involves the exploration of the biological function of fibre specific DNAs and the development of some of these DNAs in order to improve the quality of cotton fibre. This study proposes to use fibre specific genes cloned from Sea Island and Upland cotton plants to improve the quality of color cottons. Color cotton is an environmentally friendly crop as fibres from these plants can be made into textiles with natural colours rather than ultilizing chemical colorants. Confidentiality agreement signed with Trans century Biotech 3 Overall C (UBC) and Zhang Ju (Nankai) Investigation of matrix metalloproteinases and genetically engineered cells DH5 for biomedical application. This project has two parts. One is a continuation of Overall and Zhang (above) Expression of matrix metalloproteinases and tissue inhibitors in human prostate tissue and cancer. In this project the applicants propose to develop a new clinical test kit in order to detect prostate cancer metastasis using new DNA chip technology. The second part is a continuation of Thomas Chang and Yaoting Yu New Membrane Construction for microencapsulated genetically engineered cells for oral administration in uremia therapy. Genetically engineered cells for oral administration to hemodialysis patients. This project will continue to work towards the oral administration of microengineered cells to improve the treatment of hemodialysis patients. Both projects have the support of biotechnology companies in China. Travelers Dr. Ju Zhang, one week in Canada Hong Zhao, grad student, one week in Canada Dr. T. Chang, 3 days in China 1 job acquired 5 publications Collaboration will continue

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Exchanges and linkages: 1st workshop held in Beijing 1999; 2nd workshop held in Vancouver 2000; 3rd workshop held in Tianjin 2001

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