Figure S1.Fatty acid elongation related to capsaicinoids.
2
O CoA-S O CoA-S O CoAS O CoAS O CoAS C O O- O CoAS O K A S-S C O O- O A C P-S O K A S-S O K A S-S O K A S-S O K A S-S O A C P-S O O A C P-S O O A C P-S O O A C P-S O O A C P-S O O A C P-S OH O A C P-S OH O A C P-S OH O A C P-S OH O A C P-S OH O A C P-S O A C P-S O A C P-S O A C P-S O A C P-S O A C P-S O A C P-S O A C P-S O A C P-S O A C P-S O A C P-S O O A C P-S O O A C P-S O O A C P-S O O A C P-S O O A C P-S O A C P-S O A C P-S O A C P-S O A C P-S O A C P-S O O A C P-S O A C P-S O O A C P-S O O A C P-S O A C P-S O A C P-S O A C P-S O A C P-S O A C P-S O A C P-S O O A C P-S O A C P-S O O A C P-S O A C P-S O O A C P-S O A C P-S O O A C P-S O O A C P-S O O A C P-S O O O H O O H O O H O O H O O H O O H O O H O O H O O H O CoA-S O CoA-S O CoA-S O CoA-S O CoA-S O CoA-S O CoA-S O CoA-S O CoA-S ADP,Pi ATP,CoA A cyl-CoA S ynthetase (A C S) 2 N A D P H 2 N A D P ,H 2 O + 2 NADPH 2 N A D P ,H 2 O + NADP + NADP + A cetyl-C oA C arbxylase (A CC ase) A cetyl-C oA Isovaleryl-C oA Isobutyryl-C oA P ropionyl-C oA M alonyl-CoA A nteisovaleryl-C oA ATP,CO 2 ADP,Pi M alonyl-ACP NADPH H 2 O Ketoacyl-A CP D ehydratase(D H ) NADPH Enoyl-A C P R eductase (EN R ) CO 2 Ketoacyl-A CP R eductase (K R ) KR DH ENR KR DH ENR CO 2 M al-ACP CO 2 M al-ACP CO 2 M al-ACP K etoacyl-AC P Synthase I(K A SI) KA SIII KR K etoacyl-A CP S ynthase I(K A S I) DH ENR KR DH ENR KASI KASI KR DH ENR A cyl-C oA Synthetase (A C S) FAT KR DH ENR KASI KASI KR DH ENR FAT KR DH ENR KASI KASI KR DH ENR FAT KR DH ENR KASI KASI KR DH ENR FA T KR DH ENR KASI KASI KR DH ENR FAT KR DH ENR KASI KASI KR DH ENR FA T KA SIII KR DH ENR KASIII KR DH ENR KASIII KR DH ENR ACS Ketoacyl-A CP Synthase III(K A SIII) FA T N onanoic A cid D ecananoic A cid O ctanoic A cid 8-m ethylnonanoic A cid 8-m ethyldecanoic A cid 7-m ethyloctanoyl-C oA 9-m ethyldecanoic A cid 9-m ethyl-6-decenoic A cid 8-m ethyl-6-nonenoic A cid ACS ACS ACS ACS ACS ACS FA T ACS N onanoyl-C oA D ecanoyl-C oA O ctanoyl-C oA 8-m ethylnonanoyl-C oA 8-m ethyldecanoyl-C oA 7-m ethyloctanoyl-C oA 9-m ethyldecanoyl-C oA 9-m ethyl-6-decenoyl-C oA 8-m ethyl-6-nonenoyl-C oA ACP H 2 O FA T KR DH ENR 2 NADPH 2 N A D P ,H 2 O +
description
Figure S1.Fatty acid elongation related to capsaicinoids. - PowerPoint PPT Presentation
Transcript of Figure S1.Fatty acid elongation related to capsaicinoids.
O
CoA-S
O
CoA-S
O
CoAS
O
CoAS
O
CoASCOO-
O
CoAS
O
KAS-SCOO-
O
ACP-S
O
KAS-S
O
KAS-S
O
KAS-SO
KAS-S
O
ACP-S
O O
ACP-S
O O
ACP-S
O O
ACP-S
O O
ACP-S
O
O
ACP-S
OH O
ACP-S
OH O
ACP-S
OH O
ACP-S
OH O
ACP-S
OH
O
ACP-S
O
ACP-S
O
ACP-S
O
ACP-S
O
ACP-S
O
ACP-S
O
ACP-S
O
ACP-S
O
ACP-S
O
ACP-S
O
ACP-S
O O
ACP-S
O O
ACP-S
O O
ACP-S
O O
ACP-S
O
O
ACP-S
O
ACP-S
O
ACP-S
O
ACP-S
O
ACP-S
O
ACP-S
O
O
ACP-S
O
ACP-S
O O
ACP-S
O
O
ACP-S
O
ACP-S
O
ACP-S
O
ACP-S
O
ACP-S
O
ACP-S
O
ACP-S
O
O
ACP-S
O
ACP-S
O
O
ACP-S
O
ACP-S
O
O
ACP-S
O
ACP-S
O O
ACP-S
O O
ACP-S
O
O
ACP-S
O O
OH
O
OH
O
OH
O
OH
O
OH
O
OH
O
OH
O
OH
O
OH
O
CoA-S
O
CoA-S
O
CoA-S
O
CoA-S
O
CoA-S
O
CoA-S
O
CoA-S
O
CoA-S
O
CoA-S
ADP, Pi
ATP, CoA Acyl-CoASynthetase (ACS)
2 NADPH
2 NADP , H2O+
2 NADPH
2 NADP , H2O+
NADP+
NADP+
Acetyl-CoACarbxylase (ACCase)
Acetyl-CoA Isovaleryl-CoA Isobutyryl-CoA Propionyl-CoAMalonyl-CoA Anteisovaleryl-CoA
ATP, CO2ADP, Pi
Malonyl-ACP
NADPH
H2OKetoacyl-ACP Dehydratase(DH)
NADPHEnoyl-ACP Reductase (ENR)
CO2
Ketoacyl-ACPReductase (KR)
KRDHENR
KRDHENR
CO2
Mal-ACP
CO2
Mal-ACP
CO2
Mal-ACP
Ketoacyl-ACP Synthase I (KASI)
KASIII
KR
Ketoacyl-ACP Synthase I (KASI)
DH
ENR
KRDHENR
KASI
KASI
KRDHENR
Acyl-CoASynthetase (ACS)
FAT
KRDHENR
KASI
KASI
KRDHENR
FAT
KRDHENR
KASI
KASI
KRDHENR
FAT
KRDHENR
KASI
KASI
KRDHENR
FAT
KRDHENR
KASI
KASI
KRDHENR
FAT
KRDHENR
KASI
KASI
KRDHENR
FAT
KASIII
KR
DH
ENR
KASIII
KR
DH
ENR
KASIII
KR
DH
ENR
ACS
Ketoacyl-ACP Synthase III (KASIII)
FAT Nonanoic Acid
Decananoic Acid
Octanoic Acid
8-methylnonanoic Acid 8-methyldecanoic Acid
7-methyloctanoyl-CoA
9-methyldecanoic Acid9-methyl-6-decenoic Acid8-methyl-6-nonenoic Acid
ACS ACS ACS ACS ACS ACS
FAT ACS Nonanoyl-CoA
Decanoyl-CoA
Octanoyl-CoA
8-methylnonanoyl-CoA 8-methyldecanoyl-CoA
7-methyloctanoyl-CoA
9-methyldecanoyl-CoA9-methyl-6-decenoyl-CoA8-methyl-6-nonenoyl-CoAACP
H2OFAT
KRDHENR
2 NADPH
2 NADP , H2O+
Figure S1.Fatty acid elongation related to capsaicinoids.Complete reactions are shown for the leftmost pathway. Acyl carrier protein is abbreviated as ACP. Sources: Kopp and Jurenitsch, 1981; Kopp and Jurenitsch, 1982; Suzuki and Iwai, 1984; Leonard et al., 1997; Dehesh et al., 1998; Schutt et al., 1998; Suh et al., 1999; Abbadi et al., 2000; van der Hoeven and Steffens, 2000; Dehesh et al., 2001; Markai et al., 2002; Schutt et al., 2002; White et al., 2005; Filichkin et al., 2006; Abraham-Juarez et al., 2008; Slocombe et al., 2008; Thiele et al., 2008
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