Figure 1 Regulation of systemic functions by signaling through G protein pathways.

S R Neves et al. Science 2002;296:1636-1639

Published by AAAS

Backpropagation of action potentials (APs)in different morphologies with identical channel types and distributions

Philipp Vetter, Arnd Roth and Michael Häusser J Neurophysiol 85:926-937, 2001.

Sensitivity of backpropagation to voltage-gated channel density in different cell types

Morphological determinants of backpropagation. A: relationship between the number of dendritic branchpoints and gNa,thresh

B: rate of increase in membrane area withdistance from the soma (dA/dx)

C: relationship between the maximum slope of the smoothed dA/dx distribution and gNa,thresh

Forward propagation depends on dendritic geometry. A–C: forward propagation of a dendritic AP was simulated successively at all dendritic locations in a nigral dopamine neuron (A), a layer 5 pyramidal cell (B), and a cerebellar Purkinje neuron (C)

Dendritic Plateau Potentials

X. Cai, C.W. Liang, S. Muralidharan, J.P. Kao, C.M. Tang and S.M. Thompson Neuron 44 (2004), pp. 351–364

Block of SK Channels in Distal Dendrites Facilitates the Triggering of Action Potential with Dendritic Glutamate Application

Apamin-Sensitive Ca2-Activated K Channels in the Distal Dendrites Are Responsible for Repolarization of Plateau Potentials

Nickel-sensitive T-type and apamin-sensitive SK channels maintained the high precision of pacemaker spiking in dopaminergic neurons.

Wolfart J , Roeper J J. Neurosci. 2002;22:3404-3413

Inhibition of T-type channels evoked bursting in a subpopulation of

dopaminergic midbrain neurons.

Focal activation of mGluRs induces a wave of Ca2+

Morikawa H, Khodakhah K, Williams JT J Neurosci. 2003 Jan 1;23(1):149-57

Simultaneous blockade of IP3- and cADPR-induced signaling inhibits mGluR IPSCs. A, Intracellular dialysis of both heparin (1 mg/ml) and 8-NH2-cADPR (50 μm) nearly abolished mGluR IPSCs. The cell was first recorded with a control internal solution to obtain a control

IPSC amplitude (IPSC1) at ∼10 min after the onset of recording.

Morikawa H et al. J. Neurosci. 2003;23:149-157

Proposed intracellular signaling cascade mediating the mGluR-induced Ca2+ mobilization.

Morikawa H et al. J. Neurosci. 2003;23:149-157

Block of SK channels increases the firing rate of Purkinje neurons.

Womack M D , Khodakhah K J. Neurosci. 2003;23:2600-2607

SK channels affect the action potential afterhyperpolarization in Purkinje neurons.

Womack M D , Khodakhah K J. Neurosci. 2003;23:2600-2607

Block of SK channels increases the firing rate but maintains the trimodal pattern in cells that have the trimodal pattern of activity.

Womack M D , Khodakhah K J. Neurosci. 2003;23:2600-2607