Fig. S1 Changes of the levels of metabolites in Arabidopsis leaves under various abiotic stress...
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Transcript of Fig. S1 Changes of the levels of metabolites in Arabidopsis leaves under various abiotic stress...
Fig. S1 Changes of the levels of metabolites in Arabidopsis leaves under various abiotic stress conditions. Each data represents the relative metabolite levels in the fold change value against control growth conditions at one time point. The values are taken from studies on dehydration (Dehy) [28], salt [79], heat and cold [57], high light (HL) [65], light quality change (PSI-II vs PSI and PSII-I vs PSII) [71], UV light (UV) [74], low nitrogen (LN) [104], sulphur limitation (S-) [65]and potassium limitation (K-) [116] stresses. The data set used for the analysis is found in Supplementary data, Table S1. The selected metabolites are also presented in Fig. 1.
Lysine
-2
-1
0
1
2
3
4
5
6
7
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Aspartate
-2
-1
0
1
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Threonine
-2
-1
0
1
2
3
4
5
6
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
dAsparagine
-3
-2
-1
0
1
2
3
4
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Isoleucine
-2
-1
0
1
2
3
4
5
6
7
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Methionine
-2
-1
0
1
2
3
4
5
6
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Valine
-2
-1
0
1
2
3
4
5
6
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Leucine
-2
-1
0
1
2
3
4
5
6
7
8
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Amino acids 1F
old
chan
ge (
log 2
)
Conditions
Glutamate
-2
-1
0
1
2
3
4
5
6
7
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
dGlutamine
-2
-1
0
1
2
3
4
5
6
7
8
9
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
dProline
-3
-2
-1
0
1
2
3
4
5
6
7
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Arginine
-2
-1
0
1
2
3
4
5
6
7
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Glycine
-3
-2
-1
0
1
2
3
4
5
6
7
8
9
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Serine
-3
-2
-1
0
1
2
3
4
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Alanine
-2
-1
0
1
2
3
4
5
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Amino acids 2
Phenylalanine
-3
-2
-1
0
1
2
3
4
5
6
7
8
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Fol
d ch
ange
(lo
g 2)
Conditions
GABA
-2
-1
0
1
2
3
4
5
6
7
8
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
beta-Alanine
-2
-1
0
1
2
3
4
5
6
7
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
dHomoserine
-3
-2
-1
0
1
2
3
4
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Pyroglutamate
-2
-1
0
1
2
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Tyrosine
-2
-1
0
1
2
3
4
5
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Tryptophan
-3
-2
-1
0
1
2
3
4
5
6
7
8
9
10
11
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Amino acids 3
Ornithine
-2
-1
0
1
2
3
4
5
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Fol
d ch
ange
(lo
g 2)
Conditions
Dehydroascorbate
-3
-2
-1
0
1
2
3
4
5
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Glycerate
-2
-1
0
1
2
3
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Threonate
-3
-2
-1
0
1
2
3
4
5
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Shikimate
-2
-1
0
1
2
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Organic acids 1F
old
chan
ge (
log 2
)
Conditions
Fumarate
-4
-3
-2
-1
0
1
2
3
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Malate
-1
0
1
2
3
4
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Citrate
-2
-1
0
1
2
3
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d2-oxoglutarate
-2
-1
0
1
2
3
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Succinate
-2
-1
0
1
2
3
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Organic acids 2F
old
chan
ge (
log 2
)
Conditions
Sucrose
-1
0
1
2
3
4
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Maltose
-1
0
1
2
3
4
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Fructose
-2
-1
0
1
2
3
4
5
6
7
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Glucose
-3
-2
-1
0
1
2
3
4
5
6
7
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Sugars 1F
old
chan
ge (
log 2
)
Conditions
myo -Inositol
-1
0
1
2
3
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Trehalose
-5
-4
-3
-2
-1
0
1
2
3
4
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Raffinose
-4
-3
-2
-1
0
1
2
3
4
5
6
7
8
9
10
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Xylose
-1
0
1
2
3
4
5D
ehy
2.5h
Deh
y 5h
Deh
y 10
hD
ehy
15h
salt
Hea
t 5m
inH
eat
15m
inH
eat
30m
inH
eat
60m
inH
eat
120m
inH
eat
240m
inC
old
1hC
old
4hC
old
12h
Col
d 24
hC
old
48h
Col
d 96
hH
L 1d
HL
2dH
L 3d
HL
6dP
SI-
II v
s P
SI
PS
II-I
vs
PS
IIU
V1
UV
4LN
22d
LN26
dLN
30d
LN32
dLN
35d
LN39
dS
- 0d
S-
1dS
- 2d
S-
3dS
- 6d
K-
10d
K-
12d
K-
14d
K-
16d
K-
18d
Erythritol
-1
0
1
2
3
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Sugars 2F
old
chan
ge (
log 2
)
Conditions
Phosphate
-2
-1
0
1
2
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Putrescine
-2
-1
0
1
2
3
4
5
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Glycerol
-1
0
1
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Others
Glucose-6-phosphate
-3
-2
-1
0
1
2
3
4
5
Deh
y 2.
5hD
ehy
5hD
ehy
10h
Deh
y 15
hsa
ltH
eat
5min
Hea
t 15
min
Hea
t 30
min
Hea
t 60
min
Hea
t 12
0min
Hea
t 24
0min
Col
d 1h
Col
d 4h
Col
d 12
hC
old
24h
Col
d 48
hC
old
96h
HL
1dH
L 2d
HL
3dH
L 6d
PS
I-II
vs
PS
IP
SII
-I v
s P
SII
UV
1U
V4
LN22
dLN
26d
LN30
dLN
32d
LN35
dLN
39d
S-
0dS
- 1d
S-
2dS
- 3d
S-
6dK
- 10
dK
- 12
dK
- 14
dK
- 16
dK
- 18
d
Fol
d ch
ange
(lo
g 2)
Conditions