Fetal Programming: Effects of Gestational Nutrition on Cowherd Fertility and Longevity
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Transcript of Fetal Programming: Effects of Gestational Nutrition on Cowherd Fertility and Longevity
Kimberly A Vonnahme, PhDReproductive PhysiologistFebruary 11, 2010
Fetal Programming: Effects of Gestational Nutrition on Cowherd Fertility and Longevity
North Dakota State UniversityCollege of Agriculture, Food Systems,
and Natural ResourcesFargo, ND 58105-5727
“Healthy Offspring through Optimal Nutrition”
ACKNOWLEDGEMENTS
Collaborators at NDSU Joel Caton Larry Reynolds Dale Redmer Anna Grazul-Bilska Justin Luther Carrie Hammer Greg Lardy Kasey Carlin Eric Berg
Other collaborators Rick Funston—UNL Bret Taylor—USDA-ARS SES
NDSU Animal Nutrition and Physiology Center
OUTLINE
What is Developmental Programming?
Can maternal intake really influence the reproductive success of her offspring?
PHENOTYPE
Classic Animal Breeding Example
Phenotype = Genotype + Environment
Eg. Milk production = Holstein genetics + Mastitis
PHENOTYPE
Future Animal Breeding Example
Phenotype = Genotype + Environment
Eg. Yield grade= Angus genetics + Protein supplementation in utero
THE MATERNAL ENVIRONMENT
PROGRAMMING
The process through which a stimulus or insult establishes a permanent response
Developmental programming hypothesis
Exposure during a critical period in development may influence later metabolic or physiological functions in adult life
PROTEIN SUPPLEMENTATION DURING LATE PREGNANCY
Impacts on female progeny reproductive success
3 yrs: Gudmundsen Sandhills (n=170 heifer calves)
Cows bred
No supplement(NoProt)
Protein (Prot)0.45 kg/d 42% CP
12/1 – 2/28 LG
3 yrs: Gudmundsen Sandhills (n=170 heifer calves)
Cows bred
No supplement(NoProt)
Protein (Prot)0.45 kg/d 42% CP
12/1 – 2/28 LGAve calving date =March 27
3 yrs: Gudmundsen Sandhills (n=170 heifer calves)
Cows bred
No supplement(NoProt)
Protein (Prot)0.45 kg/d 42% CP
Cool season grass hay(HAY)
Sub-irrigated meadow(MDW)
12/1 – 2/28 LG
EL5/1 – 5/30
Ave calving date =March 27
GROWTH PERFORMANCE
Treatmentb P-value
Item Prot NoProt Mdw Hay SEM LG EL
Birth date, Julian d 86 84 85 86 1 0.29 0.67
Birth wt, kg 36 35 35 36 1 0.25 0.15
Act. Wn. wt, kg 212 207 212 206 7 0.14 0.09
Adj. 205 d wt, kg 226 218 225 219 7 0.02 0.07
Pre-breeding wt, kg 276 266 272 270 9 0.04 0.70
Weight at pregnancy diagnosis, kg
400 386 391 395 31 0.03 0.56
GROWTH PERFORMANCE
Treatmentb P-value
Item Prot NoProt Mdw Hay SEM LG EL
Birth date, Julian d 86 84 85 86 1 0.29 0.67
Birth wt, kg 36 35 35 36 1 0.25 0.15
Act. Wn. wt, kg 212 207 212 206 7 0.14 0.09
Adj. 205 d wt, kg 226 218 225 219 7 0.02 0.07
Pre-breeding wt, kg 276 266 272 270 9 0.04 0.70
Weight at pregnancy diagnosis, kg
400 386 391 395 31 0.03 0.56
GROWTH PERFORMANCE
Treatmentb P-value
Item Prot NoProt Mdw Hay SEM LG EL
Birth date, Julian d 86 84 85 86 1 0.29 0.67
Birth wt, kg 36 35 35 36 1 0.25 0.15
Act. Wn. wt, kg 212 207 212 206 7 0.14 0.09
Adj. 205 d wt, kg 226 218 225 219 7 0.02 0.07
Pre-breeding wt, kg 276 266 272 270 9 0.04 0.70
Weight at pregnancy diagnosis, kg
400 386 391 395 31 0.03 0.56
REPRODUCTIVE PERFORMANCE
Treatment P-values
Item Prot NoProt Mdw Hay SEM LG EL
Age at Puberty, d 339 334 341 332 10 0.70 0.48
Cycling at beginning of breeding season, %
61 67 56 73 - 0.45 0.15
Calved in first 21 d, % 77 49 63 63 - 0.005 0.89
Overall pregnancy rate, % 93 80 83 91 - 0.05 0.18
Calving date, Julian d 71 75 73 73 3 0.15 0.94
Calf birth wt, kg 33 33 32 33 1 0.94 0.25
Unassisted births, % 78 64 76 66 - 0.24 0.21
REPRODUCTIVE PERFORMANCE
Treatment P-values
Item Prot NoProt Mdw Hay SEM LG EL
Age at Puberty, d 339 334 341 332 10 0.70 0.48
Cycling at beginning of breeding season, %
61 67 56 73 - 0.45 0.15
Calved in first 21 d, % 77 49 63 63 - 0.005 0.89
Overall pregnancy rate, % 93 80 83 91 - 0.05 0.18
Calving date, Julian d 71 75 73 73 3 0.15 0.94
Calf birth wt, kg 33 33 32 33 1 0.94 0.25
Unassisted births, % 78 64 76 66 - 0.24 0.21
REPRODUCTIVE PERFORMANCE
Treatment P-values
Item Prot NoProt Mdw Hay SEM LG EL
Age at Puberty, d 339 334 341 332 10 0.70 0.48
Cycling at beginning of breeding season, %
61 67 56 73 - 0.45 0.15
Calved in first 21 d, % 77 49 63 63 - 0.005 0.89
Overall pregnancy rate, % 93 80 83 91 - 0.05 0.18
Calving date, Julian d 71 75 73 73 3 0.15 0.94
Calf birth wt, kg 33 33 32 33 1 0.94 0.25
Unassisted births, % 78 64 76 66 - 0.24 0.21
WHAT’S HAPPENING??
Ovaries??Uterus??Brain??
FETAL OVARIES
Maternal intake
CON RES
Fet
al o
varia
n w
eigh
t, m
g
0
20
40
60
80
100
120
a
b
P = 0.03
FUTURE DIRECTIONS
Time period of supplementation
Specific nutrients that are important
Maternal efficiencies
Factors that impact uterine and placental blood flow
Developmental Programming
IMPORTANT TO ANIMAL HEALTH AND PRODUCTIVITY: Growth and
nutrient transfer
Reproductive capacity
Aging and lifetime productivity
GOAL: HEALTHY OFFSPRING!!!
VONNAHME, MARCH 2008
ACKNOWLEDGEMENTS
NDSU Animal Nutrition and Physiology Center
LARSON ET AL., JOURNAL OF ANIMAL SCIENCE
Objective: Impacts of male progeny from cows
grazing winter range vs. corn crop residue
with or without protein supplementation
Pregnant 3 year olds
2005 (109 cows)
2006 (114 cows)
2007 (116 cows)
Steer Data
WR CR P Values
PS NS PS NS SEM SYS Suppl SxS
HCW, kg 376a 357b 368ab 371a 8 0.52 0.10 0.02
12th rib fat, cm 1.26 1.16 1.21 1.19 0.08 0.84 0.31 0.58
Marbling score 503 457 482 430 20 0.12 <0.01 0.86
Yield grade 2.94 2.69 2.74 2.77 0.18 0.55 0.26 0.16
Quality grade, % Sm or greater
84.5 76.5 88.2 64.6 9.0 0.57 0.04 0.28
Quality grade, % Md or greater
43.2 26.6 35.4 15.0 1.0 0.34 0.03 0.81
VONNAHME, FEBRUARY 2009
Nutrition during pregnancy impacts on milk yield
Day postpartum
0 2 4 6 8 10 12 14 16 18 20
Milk
yie
ld,
g
500
600
700
800
900
1000
1100
60% NRC100% NRC140% NRC
P < 0.001
Selenium during pregnancy effects on milk yield
P < 0.001
Days postpartum
0 2 4 6 8 10 12 14 16 18 20
Milk
yie
ld,
g
500
600
700
800
900
1000
1100
ASeHSe