Fetal Neck Mass - Lieberman's eRadiology Learning...
Transcript of Fetal Neck Mass - Lieberman's eRadiology Learning...
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Fetal Neck Mass
Beth Israel Deaconess Medical CenterRadiology Core Clerkship
November 2007Elizabeth Asch, MS III
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Fetal Ultrasound
• Standard imaging modality for prenatal screening, diagnosis, perinatal planning, amniocentesis guidance
• No radiation involved• Heats tissues, but minimal time on single
area since transducer moving• Inexpensive
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Limitations of fetal ultrasound
• Poor differentiation of soft tissues• Limited penetration of fatty tissue• Poor visualization with oligohydramnios• Dependent on fetal position• Ossification of calvaria by 33 weeks limits
visualization of intracranial structures
Coakley F, Glenn O, Qayyum A, et al. Fetal MRI: A Developing Technique for the Developing Patient. AJR 2004; 182:243-252.
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Standard Second Trimester Fetal US
• Number of live intrauterine pregnancies• Fetal position• Placental position• Amount of amniotic fluid• Views of head, face, heart, LV/RV out-flow
tracts, stomach, kidneys, bladder, spine, extremities, cord insertion site
• Biometric data: BPD, HC, AC, FL• Age by US and LMP, estimated fetal weight
Courtesy of BIDMC OB/GYN US Dept
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Normal fetal profile by US
http://womenshealth.jhmi.edu/ob-ultrasound/images/ultrasound/18%20weeks_profile.jpg
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Our patient: Sagittal US at 24 weeks 6 days
shows an anterior neck mass Homogeneous, echogenic, solid
BIDMC PACS
Anterior
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Sagittal US shows mass extending posteriorly Concerning for tracheal obstruction
BIDMC PACS
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Sagittal US shows patent esophagus: Fluid (anechoic) passing from oropharynx
BIDMC PACS
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Sagittal US shows fluid passing distally
BIDMC PACS
Anterior
Cranial
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Coronal US: Bilateral, symmetric mass Fluid passing in midline
BIDMC PACS
CranialCaudal
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Doppler US at 28 weeks 5 days demonstrates mass hypervascularity
BIDMC PACS
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Fetal MRI - Indications• Further characterization of abnormal ultrasound
findings, assessment of structures poorly visualized by ultrasound, and surgical planning
• Evaluation of CNS (ventriculomegaly, cortical malformations, posterior fossa)
• Scalp and neck • Trachea (fluid filled) – evaluate for obstruction• Growth (based on liver volume)• Maternal obesity
Prenatal MRI of the central nervous system, head and neck. http://www.medscape.com/viewarticle/470837_4
Coakley F, Glenn O, Qayyum A, et al. Fetal MRI: A Developing Technique for the Developing Patient. AJR 2004; 182:243-252.
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Limitations of Fetal MRI• Prohibited by fetal movement: fast single-shot
T2 images (slice acquisition time < 1 second)• Not FDA approved, but not proven to be
teratogenic or to cause acoustic damage• Gadolinium not approved for use in pregnancy• Incomplete data on indications and expected
findings
Coakley F, Glenn O, Qayyum A, et al. Fetal MRI: A Developing Technique for the Developing Patient. AJR 2004; 182:243-252.
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Our patient: Sagittal T2-weighted MRI at 24 weeks 6 days
Neck mass is hypointense on T2
BIDMC PACS
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BIDMC PACS
Sagittal T2 weighted MRI: fluid passing distally
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BIDMC PACS
Sagittal T1-weighted MRI at 24 weeks 6 days
Neck mass is intermediate intensity on T1
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Sagittal T2-weighted MRI: Fluid trapped in oropharynx
But distal fluid visualized
BIDMC PACS
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No other anomalies
• Female fetus• 3 vessel cord• Normal interval growth • Trisomy screen: 21 - 1/7,001
13/18 – 1/<10,000• Nuchal translucency – 1.2 mm (11-13 wks)• AFI – 21 (Normal 8-18), mild polyhydramnios
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Normal Nuchal Translucency
http://www.aium.org/images/patImgGallery/4.jpg
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Our patient: Neck mass characteristics
• Anterior • Midline • Bilateral • Symmetric • Homogeneous • Echogenic• Hypervascular • Hypointense on T2 • Intermediate intensity on T1
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Differential diagnosis for a fetal neck mass
• Goiter – most likely in this case
• Cervical teratoma • Cystic hygroma • Thyroglossal duct cyst• Hemangioma• Branchial cleft cyst• Neuroblastoma• Rhabdomyoma• Laryngocele• Cervical meningocele
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Maternal Data
• 33 years old (AMA >35)• G2P1• Graves disease, treated with Synthroid
post radioiodine ablation 9 years ago
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Our patient: 3D Ultrasound
Bilobed butterfly-shaped anterior neck mass
BIDMC PACS
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3D Ultrasound: Hyperextended neck
BIDMC PACS
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Neck mass diagnosis:
Goiter
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Causes of fetal goiter
• Maternal Graves disease• Maternal Hashimoto thyroiditis• Maternal iodine ingestion• Maternal use of PTU, methimazole• Primary fetal hypothyroidism
Callen. Ultrasonography in Obstetrics and Gynecology, 4th ed. Philadelphia: Saunders, 2000.
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Ultrasound findings for fetal goiter
• Midline anterior neck mass, usually extending bilaterally• Usually symmetric• Bilobed• Homogeneous • Echogenic, solid • Hypervascular• +/- Neck hyperextension• +/- Tracheal obstruction (echogenic lungs, flat
diaphragms, distally dilated airways)• +/- Esophageal obstruction (polyhydramnios)
Coakley F, Glenn O, Qayyum A, et al. Fetal MRI: A Developing Technique for the Developing Patient. AJR 2004; 182:243-252.
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MR findings for fetal goiter
• Similar location/shape as seen on US• Homogeneous• Hypointense on T2 (normal thyroid is
isointense to muscle on T2)• Intermediate to hyperintense on T1• +/- Fluid trapping in oropharynx
Karabulut N, Martin DR, Yang M, Boyd BK. MR imaging findings in fetal goiter caused by maternal graves disease. J Comput Assist Tomogr. 2002 Jul-Aug;26(4):538-40.
Kondoh M, Miyazaki O, Imanishi Y, et al. Neonatal goiter with congenital thyroid dysfunction in two infants diagnosed by MRI. Pediatric Radiology. 2004 Jul 34(7):570-573.
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Fetal thyroid disease• Fetal thyroid begins functioning at 12 weeks• Fetal TSH increases at 18-22 weeks
(hypothalamic-pituitary axis matures)• Maternal TSH does not cross placenta• Maternal T3 and T4 are deiodinated by placenta• Maternal TRH and antibodies cross the placenta• Synthroid does not readily cross the placenta• Typical findings: tachycardia (>160), hydrops,
IUGR, oligohydramniosBromley B, Frigoletto F, Cramer D, et al. The fetal thyroid: normal and abnormal sonographic measurements. J Ultrasound Med 11:25-28, 1992.
Van Loon A, Derksen J, Bos A, Rouwe C. In utero diagnosis and treatment of fetal goiterous hypothyroidism, caused by maternal use of propylthiouracil. Prenatal Diagnosis 1995 15:599-604.
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Our patient: Diagnosis – hypothyroidism
• Maternal thyroid stimulating/blocking antibodies negative
• Fetal heart rate 140-180 bpm (normal 120-160)• Thyroid width(24w5d): 3.1 cm (US), 3.4 cm (MR)
Normal (95th %-ile at 24 weeks): 2.5 cm• Maximum width (30 weeks): 4.3 cm (MR)• Cordocentesis: TSH 16 (2-11 mU/L), T4 1.7 (10-
20 pmol/L)
Bromley B, Frigoletto F, Cramer D, et al. The fetal thyroid: normal and abnormal sonographic measurements. J Ultrasound Med 11:25-28, 1992. Van Loon A, Derksen J, Bos A, Rouwe C. In utero diagnosis and treatment of fetal goiterous hypothyroidism, caused by maternal use of propylthiouracil. Prenatal Diagnosis 1995 15:599-604.
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Cordocentesis• Ultrasound guided umbilical cord blood sampling• Administer antibiotics to reduce risk of chorioamnionitis• Administer steroids to promote fetal lung maturity in case
emergency C-section is needed• Draw maternal blood sample for quality control• Fetal sample usually drawn from cord insertion site in
placenta (Doppler shows branching of cord vessels) • Umbilical vein puncture is safer than arterial (less post-
procedure bradycardia and bleeding)• Amniocentesis may be necessary prior to sampling to
reduce fluid volume• Risk of fetal loss not documented
Ghidini A. Fetal blood sampling: Technique and complications. Up-To-Date, March 2006.
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Treatment
• Intraamniotic T4 injections• Started at 31 weeks• Data on neurologic/IQ outcomes are
conflicting• Goal to reduce size of goiter and prevent
tracheal obstruction/need for EXIT procedure
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Response to treatment
• Thyroid width decreased to 3.0 cm at 32 weeks (2.9 cm = 95th %-ile)
• AFI decreased to 15-18• Hyperextension resolved
Bromley B, Frigoletto F, Cramer D, et al. The fetal thyroid: normal and abnormal sonographic measurements. J Ultrasound Med 11:25-28, 1992.
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Our patient: Sagittal US post-intraamniotic T4 injections
Mass size reduced
BIDMC PACS
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Mass size reduced (calipers)
BIDMC PACS
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Delivery
• 37 weeks• 5 lbs, 12 ounces• C-section• No EXIT procedure • APGARs 8 and 9 at 1 and 5 minutes
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Other Fetal Neck Masses
Cystic hygromaCervical teratoma
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Companion Patient 1: Cystic hygroma on US (calipers)
EDACTIC
Well circumscribed
Anechoic
Postero-lateral
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Companion Patient 2: Cystic hygroma on coronal US
BIDMC PACS
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EDACTIC
Companion Patient 2:
Cystic hygroma on coronal T2 weighted MRI
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Companion Patient 3: Cervical teratoma on sagittal US (calipers)
and 3D ultrasound
EDACTIC
Heterogeneous cystic and solid mass
Hypovascular
Caused tracheal deviation
Lateral flexion and hyperextension of neck
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Companion Patient 3: Cervical teratoma
on axial US
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Companion Patient 3: Cervical teratoma on T2 weighted MRI
EDACTIC
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Companion Patient 3: Cervical teratoma on T2 weighted MRI
EDACTIC
Coronal Sagittal
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Acknowledgements
Dr. David GrahamDr. Deborah Levine
Dr. Tejas MethaDr. Henry Roque
Dr. Gillian Lieberman