Ferrous BisglycinateFerrous Bisglycinate

The haemoglobin enhancer with a difference

o

o

o

o

NH 2

H 2 N

Fe

0

9.5

15.4

33.3

0

5

10

15

20

25

30

35

Fe Bis (30 mg) Fe Bis (60 mg) Fe Bis (120 mg) FeSO4 (120 mg)

GI side effect(% incidence)

FERROUS BISGLYCINATE

1.Am J Clin Nutrition 1998;67:664-82.Arch Latinoam Nutr. 2001 Mar;51(1 Suppl 1):7-12.3.Nutrition 2001,17,381-844.IMG- 2006.5.http://www.efsa.europa.eu/EFSA/efsa_locale-1178620753812_1178620765635.htm

5GI tolerability

Advantages of the chelated ferrous bisglycinate

l

l

l

l

l

l

Absorbed intact

Easily absorbed into the mucosal tissue

Highest bioabsorption

High bioavailability even in presence of phytates, tannates, oxalates etc.

Less likely to cause intestinal side effects such as nausea, constipation and bloating

Does not interact with multivitamins

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Tel : +91-22-61367000 Fax : +91-22-61367067 Email : info@puneetlabs.com Web : www.puneetlabs.com

The Mark of Innovative Chemistry

Puneet Laboratories Pvt. Ltd.

The Mark of Innovative Chemistry

FERROUS BISGLYCINATE

Iron supplement Elemental iron

Bioavailale iron

AmountAbsorbed (mg)

Ferrous sulfate

33%

26.7%

9

Ferrous ascorbate

12%

40%

4.8

Ferrous fumarate

32%

28%

8.9

Ferrous bisglycinate 19 - 21% 90.9% 17 - 19

4Efficacy in pregnant women

Baseline 21 days

8.2

Hb

- g

m/d

l

42 Days

8.2

8.9

8.4

8.6

8.8

9.0

9.2

9.4

9.6

9.8

9.6

Significant changesin Hb levels after

6 weeks

Significant changesin Hb levels after

28 days

Ferrous sulfate Ferrous bisglycinate

1.5

Hb

-g

m/d

l

Infants 6 - 336 months

1.6

1.7

1.8

1.9

2.0

2.1

2.22.3

2.4

2.5

1.8

2.5

Bioabsorption90.9 % - Fe bisgly

27.% - FeSO4

FERROUS BISGLYCINATEFERROUS BISGLYCINATE

Iron deficiency anaemia

Treatment options

Ferrous salts

Ferric salts

Iron (Fe) deficiency is probably the most common single nutrient deficiency throughout the world. It is

estimated that more than 500 million people throughout the world suffer from severe iron deficiency

anaemia.

Iron deficiency anemia is better controlled along with diet rich in iron source and supplementation of

external source of Iron formulations. Various iron salts are available for supplementation in the

treatment of anaemia. They are:

All dietary iron has to be reduced to ferrous form to enter the mucosal cells. Hence bivalent iron salts

like ferrous sulfate, fumarate, gluconate, succinate, glutamate and lactate have been preferred over

ferric salt preparations.

These salts have uniform bioavailability. However, the bioavailability decreases markedly in the

presence of dietary inhibitors like phytates, oxalates, tannates etc., which are abundantly

available in foods.

Despite being efficacious and cheap with good bioavailability, ferrous salts have several

disadvantages particularly the high incidence of gastrointestinal side effects (~23 %). Ferrous

sulphate has a salty astringent taste which is not palatable for most children.

Ferric salts have traditionally not been preferred over ferrous salts as the ferric ion first requires

reduction to ferrous form in the intestinal lumen and usually this reducing capacity is not enough to

reduce doses of iron therapeutically administered. The bio-availability of iron from ferric salts is 3 to 4

times less than that of ferrous sulphate.

l

l

Bioavailability

Tolerability

H2

H2

H C2

C

C

CH2OO

O ON

N

Fe

Ferrous bisglycinate - The

haemoglobin enhancer with a

difference

Ferrous bisglycinate consists of one molecule of

ferrous iron bound to two molecules of glycine.

Ferrous bisglycinate has been successfully sold in

the United States as dietary supplement for over 25

years and has received GRAS (Generally

Recognized as Safe) approval from the US FDA. Many countries like the Canada, United Kingdom, the

Netherlands, Spain, Denmark, France, Italy, China and Japan have approved ferrous bisglycinate.

Ferrous bisglycinate enjoys the privilege of being a highly absorbable iron supplement exceeding

ferrous salts.

Following oral administration, ferrous bisglycinate is absorbed intact into the mucosal cells of the

intestine, and is subsequently hydrolysed into its iron and glycine components. The iron component of 1ferrous bisglycinate is metabolised like any other source of iron. The solubility of iron from ferrous

bisglycinate is not affected by changes in pH.

The bioavailability of the ferrous bisglycinate chelate and ferrous sulfate is 90.9% and 26.7%. Ferrous

bisglycinate has a relatively high bioavailability in the presence of dietary inhibitors like tannins and

oxalates.

Absorption

Bioavailability

3,4Clinical efficacy