Female Genital Tract

Pathology Practical:

The SlidesThe Slides

Slide 1:Slide 1: Intraductal Carcinoma of the Breast Intraductal Carcinoma of the Breast Slide 2:Slide 2: Invasive Duct Carcinoma of the Invasive Duct Carcinoma of the

BreastBreast Slide 3:Slide 3: Paget’s Disease of the Breast Paget’s Disease of the Breast Slide 4:Slide 4: Dermoid Cyst of the Ovary Dermoid Cyst of the Ovary

Intraductal Carcinoma of the BreastIntraductal Carcinoma of the BreastSlide shows the following:Slide shows the following:

Large ducts are distended by neoplastic Large ducts are distended by neoplastic epithelial cells which are pleomorphic with epithelial cells which are pleomorphic with hyperchromatic nuclei; some exhibiting Mitoseshyperchromatic nuclei; some exhibiting Mitoses

Cells form imperfect acini and show Cribriform Cells form imperfect acini and show Cribriform patternpattern

Small groups of necrotic cells in the center of Small groups of necrotic cells in the center of many ductsmany ducts

No invasion of Basement Membrane of the No invasion of Basement Membrane of the ductsducts

Brest Tissue replaced by grayish-pink fleshy tumor

Orange Peel (Peau de Orange) appearance of skin

Retracted Nipple surrounded by Thickened Areola

Large distended ducts with necrotic cells in center

Cribriform pattern & Imperfect Acini

Invasive Duct Carcinoma of the BreastInvasive Duct Carcinoma of the BreastSlide shows the following:Slide shows the following:

Cords, Sheets & nests of tumor cells Cords, Sheets & nests of tumor cells surrounded by dense fibrous tissue, stroma surrounded by dense fibrous tissue, stroma containing scattered lymphocytescontaining scattered lymphocytes

Tumor cells are Round or Polygonal with Tumor cells are Round or Polygonal with deeply stained nuclei & occasional mitosesdeeply stained nuclei & occasional mitoses

Focal tumor cells necrosisFocal tumor cells necrosis Invasion of Breast Adipose tissue by Tumor Invasion of Breast Adipose tissue by Tumor

cellscells Few tumor cells form Duct-Like structuresFew tumor cells form Duct-Like structures

Tumor cell nest

Dense Fibrous tissue Stroma

Invasion of Breast Adipose Tissue

Deeply Stained Round or Polygonal cells

Tumor cells forming DUCT-LIKE structures

Paget’s Disease of the BreastPaget’s Disease of the BreastSlide shows the following:Slide shows the following:

Ulceration and invasion of epidermis by ductal Ulceration and invasion of epidermis by ductal carcinoma cells (Paget cells), present between basal carcinoma cells (Paget cells), present between basal cells in elongated rete pegscells in elongated rete pegs

Paget cells are Large, anaplastic cells having pale Paget cells are Large, anaplastic cells having pale cytoplasm, hyperchromatic nuclei with occasional cytoplasm, hyperchromatic nuclei with occasional mitosismitosis

Paget cells are present in either singly or in small Paget cells are present in either singly or in small groups of 2 or 3 surrounded by a clear zone groups of 2 or 3 surrounded by a clear zone “Halo”“Halo”

Deeper tissue shows Intraductal proliferation of Deeper tissue shows Intraductal proliferation of neoplastic epithelial cellsneoplastic epithelial cells

Rete Pegs

Ulceration & Invasion of epidermis by Paget Cells

Paget Cells

Paget Cells Showing all previously mentioned Features:-Large, anaplastic, pale cytoplasm, hyper chromatic Nuclei, clear Halo zone

Dermoid Cyst of OvaryDermoid Cyst of OvarySlide shows the following:Slide shows the following:

Stratified squamous epitheliumStratified squamous epithelium with underlying with underlying appendagesappendages ( (sweat glandssweat glands, , sebaceous glandssebaceous glands, , hair follicleshair follicles), ), columnar ciliated epitheliumcolumnar ciliated epithelium, , mucous & serous glandsmucous & serous glands and structures from and structures from other germ layers such as other germ layers such as BoneBone, , CartilageCartilage, , Lymphoid tissueLymphoid tissue, , Smooth muscleSmooth muscle and large and large area of area of Brain TissueBrain Tissue containing containing NeuronsNeurons and and Glial cells.Glial cells.

Dermoid Cyst of the Ovary Containing Brain Tissue

Growth of Hair Follicles in Ovary