Features and Benefits of Snap Combo Plus

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Antigen and Antibodies -The Battle Begins The body has an army of soldiers consisting of white cells and

antibodies waiting for the invasion by the enemy (antigens). The antigen stimulates production of the antibody. When the

antigen and antibody come into contact, the antibody locks on to the antigen. This process is called “binding.” The result is the antigen antibody immune complex.

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Why should a vet use IDEXX products rather than competition?

IDEXX Snap Combo is the only test that can identify the proteins P15, P24, and GP40.

All of these antigen proteins are indicators of the FIV Virus.

IDEXX can identify more cases of FIV than any other test on the

market because the other tests only identify the protein GP40.

Only in-clinic test that uses Elisa Technology Conjugate – enhances ur - identifies weak positives

Bi-directional Flow – twice the time allows for greater sensitivity

Wash Solution – eliminates non-specific binding

Amplification of results – identifies weak positives

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Enzyme-Linked Immuno-Sorbent Assay

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SNAP Technology Only ELISA technology rapid test in the market

Bi-directional flow of samples and wash allows for efficient washing

of the samples which removes any background interference. This

makes the test easy to read even when the sample is damaged.

True blue color means the test spots amplify blue, not red (the color

of blood) like the competitors (in US)

Highest sensitivity due to the enzyme amplifier that is present in the

conjugate

Highest specificity due to wash step

Patented technology

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What is Sensitivity?Sensitivity = # of detected positives / # of known

positives = a true positive. Example: 100 known positive parvo dogs. If Snap test

detects 95 positive dogs from the original 100 then Snap has 95% sensitivity. 5 false negatives.

We missed 5 samples that were true positives.

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What is Specificity? Specificity = # of detected negatives / # of known negatives = a

true negative. If Snap called a true negative a positive = false

positive.

For example, if 100 dogs are truly negative for the Parvo Virus but

our test says that 5 are positive than our test is 95% specific.

It falsely identified 5 dogs as positive even though they do not have

Parvo.

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How is Accuracy Determined? Accuracy is presented in a percentage form based upon the

sensitivity and specificity. The higher the sensitivity and specificity, the more accurate the assay. Accuracy = sensitivity + specificity / 2.

Example: 95(SENS) + 100(SPEC) divided by 2 = 97.5%.

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10 © 2005 IDEXX LABORATORIES, INC. | Proprietary and Confidential | Apr 20, 2023

11 © 2005 IDEXX LABORATORIES, INC. | Proprietary and Confidential | Apr 20, 2023

- Amplification of signal via enzyme reactions (ELISA)

(increased sensitivity)

- Bi-lateral flow (SNAP)

- hits reactive spot twice, increasing signal- includes wash step for clear background

(increased specificity)

-Simultaneous detection of:FIV with FeLV

Why Snap®?

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Signal Amplification

The Snap® device uses an enzyme to AMPLIFY the signal from one

antigen or antibody molecule to 100s of color molecules. Think of one

blue bubble bursting onto 100 clear bubbles turning ALL the bubbles

blue. This technology allows are tests to achieve the HIGHEST

sensitivity

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The Wash Step The Snap® device includes a wash step that removes non-specific

binding. Think of the wash as a cleaner that clears away any of the blue

that sticks to the wrong types of bubbles. This allows us to achieve the

Highest specificity.

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SNAP Technology Only ELISA technology rapid test in the market

Bilateral flow of samples and wash allows for efficient washing of the

samples which removes any background “noise”. This makes the test easy

to read even with bad samples.

True blue color means the test spots amplify blue, not red (the color of

blood) like the competitors

Highest sensitivity due to the enzyme amplifier that is present in the

conjugate

Highest specificity due to wash step

Patented technology

Most used test in the Veterinary industry