Relationship of Dopamine Type 2 Receptor Binding Potential With Fasting Neuroendocrine

Hormones and Insulin Sensitivity in Human Obesity

Featured Article:

Julia P. Dunn, M.D., M.S., Robert M. Kessler, M.D., Irene D. Feurer, Ph.D., Nora D. Volkow, M.D., Bruce W. Patterson, Ph.D., Mohammad S. Ansari, M.S.,

Rui Li, M.S., Pamela Marks-Shulman, R.D., M.S., Naji N. Abumrad, M.D.

Diabetes Care Volume 35: 1105-1111

May, 2012

Study Objectives

• Midbrain dopamine (DA) neurons, involved with reward and motivation, are modulated by hormones that regulate food intake (insulin, leptin, and acyl ghrelin [AG])

• Hypothesis: These hormones are associated with deficits in DA signaling in obesity

 

Dunn J et al. Diabetes Care 2012;35:1105-1111

Study Design

• Assessed relationships between fasting levels of insulin and leptin, and AG, BMI, and insulin sensitivity index (SI) with the availability of central DA type 2 receptor (D2R)

• Measured D2R availability using PET and [18F]fallypride in 8 lean and 14 obese females

 • Fasting hormones collected prior to scanning • SI determined by modified OGTT

Dunn J et al. Diabetes Care 2012;35:1105-1111

Dunn J et al. Diabetes Care 2012;35:1105-1111

Dunn J et al. Diabetes Care 2012;35:1105-1111

Dunn J et al. Diabetes Care 2012;35:1105-1111

Dunn J et al. Diabetes Care 2012;35:1105-1111

Dunn J et al. Diabetes Care 2012;35:1105-1111

Conclusions

• Findings provide evidence for an association between the neuroendocrine hormones and DA brain signaling in obese females

Dunn J et al. Diabetes Care 2012;35:1105-1111