High Fat Intake Leads to Acute Postprandial Exposure to Circulating Endotoxin in Type 2

Diabetic Subjects

Featured Article:

Alison L. Harte, Ph.D., Madhusudhan C. Varma, MRCP, Gyanedra Tripathi, Ph.D., Kirsty C. McGee, Ph.D., Nasser M. Al-Daghri, Ph.D.,

Omar S. Al-Attas, Ph.D., Shaun Sabico, M.D., Joseph P. O’Hare, M.D., Antonio Ceriello, M.D., Ponnusamy Saravanan, Ph.D., Sudesh Kumar, M.D.,

Philip G. McTernan, Ph.D.

Diabetes Care Volume 35: 375–382

February, 2012

Study Objectives

• To evaluate the changes in circulating endotoxin after a high–saturated fat meal to determine whether these effects depend on metabolic disease state.

Harte A et al. Diabetes Care 2012;35:375-382

Study Design

• Nonobese, obese, IGT, or type 2 diabetes participants were given a high-fat meal after an overnight fast

• Blood was collected before (0 h) and after the meal (1–4 h) for analysis of endotoxin levels

Harte A et al. Diabetes Care 2012;35:375-382

Harte A et al. Diabetes Care 2012;35:375-382

Harte A et al. Diabetes Care 2012;35:375-382

Harte A et al. Diabetes Care 2012;35:375-382

Harte A et al. Diabetes Care 2012;35:375-382

Harte A et al. Diabetes Care 2012;35:375-382

Conclusion

• Exposure to a high-fat meal elevates circulating endotoxin irrespective of metabolic state, as early as 1 h after a meal.

• However, this increase is substantial in IGT and type 2 diabetic subjects, suggesting that metabolic endotoxinemia is exacerbated after high fat intake

Harte A et al. Diabetes Care 2012;35:375-382