Farquhar and Palade (1963) J Cell Biol:17:375 - · PDF filetvx ZO-1 ZO-2 ZO-3 ACTIN OCCLUDINS...
Transcript of Farquhar and Palade (1963) J Cell Biol:17:375 - · PDF filetvx ZO-1 ZO-2 ZO-3 ACTIN OCCLUDINS...
TGN
AEE
TGN
ARE
CE
BEE
CE
ARE
BEE
Tight junction
1
2
3
4
Selectiveretention
Extracellularassociation
Exocyst Syntaxin 3
4
CLAUDINS
CYTOPLASM
INTERCELLULARSPACEPLASMA MEMBRANE
PDZ
SH3
GUK
tvx
ZO-1
ZO-2
ZO-3
ACTIN
OCCLUDINS
JAM
Rab13 7H6 AF-6
ZONAB
ZAKZAK
ASIP
Rab3b
VAP-33
SEC 6/8
PILT
CINGULINCINGULIN
CLAUDINS
CYTOPLASM
PLASMA MEMBRANE
PDZ
SH3
GUK
tvx
ZO-1
ZO-2
ZO-3
ACTIN
OCCLUDINS
JAM
Rab13 7H6 AF-6
ZONAB
ZAKZAK
ASIP
Rab3b
VAP-33
SEC 6/8
PILT
CINGULINCINGULIN
Nitta 2003 endothelial barrier
Simon 1999ParacellinCln 16 kidney
Furuse 2002 skin
UNION ESTRECHA: BARRERA A LA DIFUSION Y DEPENDENCIA DE CALCIO
Gonzalez-Mariscal et al. (1985). J Membrane Biol 86:113.Gonzalez-Mariscal et al. (1990). Am J Physiol 259:C978.Contreras et al. (1992) Am J Physiol 263:C313.
TIME (h)
0 1 2 3 4 5
CP
M.m
l-1 (
X 1
0-4)
0
1
2
3
4
5
0
100
200
300
400
500
0
20
40
60
80
100
TER(ΩΩΩΩ.cm-2)
TJ(%)
1
B
A
UNION ESTRECHA: ESTRUCTURA MOLECULAR.
Na+,K+- ATPase
Leu-NH-PEPTIDase
INTEGRINS
TJAJ
DES
GJ
OCCLUDINA
CLAUDINAS
ZO-3
ES
PE
CT
RIN
A
7H6RAB13
CINGULINAZO-2
ZO-1
RAB3BJAM
ACTINA
UNION ESTRECHA: ESTRUCTURA MOLECULAR. PROTEINAS DE MEMBRANA
CLAUDINA EN FIBROBLASTOS L
Tsukita et al (2001). Nature Rev Mol Cell Biol 2:285.
UNION ESTRECHA: ESTRUCTURA MOLECULAR. LA OCLUDINA Y LA CLAUDINA FORMAN FILAMENTOS.
Furuse et al (1993).J Cell Biol 123:1777.Furuse et al (1998).J Cell Biol 141:1539.
CLAUDINA
OCLUDINA