Familial Hypercholesterolaemia - My Family History
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Transcript of Familial Hypercholesterolaemia - My Family History
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Familial Hypercholesterolaemia
- My Family History
By Kenneth Henthorn
as told to Dermot Neely
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Family History - KH
KH
TC 11.0(mmol/L)
Index Case
55 y
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Family History - KH
KH
TC 11.0(mmol/L)
Index Case
55 y
First degree relatives 1 in 2 chanceSecond degree relatives 1 in 4 chance
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Family History - parents
II
I
KH
TC 11.0(mmol/L)
Index Case
K B
55 y
First degree relatives 1 in 2 chanceSecond degree relatives 1 in 4 chance
†76y †75y
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Family History - parents
II
I
KH
TC 11.0(mmol/L)MI age 36
Index Case
K B
55 y
First degree relatives 1 in 2 chanceSecond degree relatives 1 in 4 chance
†76y †75y
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Family History - parents
II
I
KH
TC 11.0(mmol/L)MI age 36
Index Case
K B
55 y
?chol
First degree relatives 1 in 2 chance
†76y †75y
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Family History - siblings
II
I
KH
TC 11.0(mmol/L)MI age 36
Index Case
K B
E
55 y
K JR
54 y 52 y 50 y
?chol?chol
P J
†4y †36 y 55 y
First degree relatives 1 in 2 chance
†76y †75y
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Family History - siblings
II
I
KH
TC 11.0(mmol/L)MI age 36
Index Case
K B
E
55 y
TC >13(mmol/L)
K JR
54 y 52 y 50 y
?chol?chol
P J
†4y †36 y 55 y
First degree relatives 1 in 2 chance
†76y †75y
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Family History - siblings
II
I
KH
TC 11.0(mmol/L)MI age 36
Index Case
K B
E
55 y
TC >13(mmol/L)
K JR
54 y 52 y 50 y
?chol?chol
P J
†4y †36 y 55 y
First degree relatives 1 in 2 chance
†76y †75y
?chol
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Family History - siblings
II
I
KH
TC 11.0(mmol/L)MI age 36
Index Case
K B
E
55 y
TC >13(mmol/L)
?chol
K JR
54 y 52 y 50 y
?chol?chol
P J
†4y †36 y 55 y
First degree relatives 1 in 2 chance
†76y †75y
TC 9.7(mmol/L)
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Family History - siblings
II
I
KH
TC 11.0(mmol/L)MI age 36
?chol
Index Case
K B
E
55 y
TC >13(mmol/L)
?chol
K JR
54 y 52 y 50 y
?chol?chol
P J
†4y †36 y 55 y
First degree relatives 1 in 2 chance
†76y †75y
TC 9.7(mmol/L)
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Family History - siblings
II
I
KH
TC 11.0(mmol/L)MI age 36
?chol
Index Case
K B
E
55 y
TC >13(mmol/L)
TC 9.7(mmol/L)
?chol
K JR
54 y 52 y 50 y
?chol?chol
P J
†4y †36 y 55 y
First degree relatives 1 in 2 chance
†76y †75y
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Family History - siblings
II
I
KH
TC 11.0(mmol/L)MI age 36
?chol
Index Case
K B
E
55 y
TC >13(mmol/L)
TC 9.7(mmol/L)
?chol
K JR
54 y 52 y 50 y
?chol?chol
P J
†4y †36 y 55 y
†76y †75y
First degree relatives 1 in 2 chanceSecond degree relatives 1 in 4 chance
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II
I
KH
?chol
Index Case
K B
E
TC >13(mmol/L)
TC 9.7(mmol/L)
?chol
K JR
54 y 52 y 50 y
?chol?chol
P J
†4y †36 y 55 y
III
Family History – the children
TC 13 TC 11.3
28 y 25 y 22 y 13 y28 y 25 yTC 4.1TC 4.6
J JS H
†76y †75y
Second degree relatives 1 in 4 chance
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II
I
KH
?chol
Index Case
K B
E
?chol
K JR
54 y 52 y 50 y
?chol?chol
P J
†4y †36 y 55 y
III
Family History – second degree
TC 13 TC 11.3
28 y 25 y 22 y 13 yTC >12
30 yTC 428 y
TC 4.1TC 4.6
J JSMD
H
†76y †75y
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II
I
KH
?chol
Index Case
K B
E
?chol
K JR
54 y 52 y 50 y
?chol?chol
P J
†4y †36 y 55 y
III
Family History – second degree
TC 13 TC 11.3
28 y 25 y 22 y 13 yTC >12
30 yTC 428 y
TC 4.1TC 4.6
J JSMD
H G
TC 429 y
†76y †75y