FACTS 2015

F R A U N H O F E R I N S T I T U T E F O R M O L E C U L A R B I O L O G Y A N D A P P L I E D E C O L O G Y I M E

160318_Einleger_Titel_210x277_RZindd 3 180316 1855

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With regard to our reporting requirement we compiled information on publications patents and theses as well as on our networks and cooperations in science and industry in this separate booklet You can also download the bdquoFACTS 2015ldquo of the Fraunhofer IME as well as our corresponding annual report from our website

httpwwwimefraunhoferdeenpublikationenjahresberichtehtml

1

With regard to our reporting requirement we compiled information on publications patents and theses as well as on our networks and cooperations in science and industry in this separate booklet You can also download the bdquoFACTS 2015ldquo of the Fraunhofer IME as well as our corresponding annual report from our website

httpwwwimefraunhoferdeenpublikationenjahresberichtehtml

2 3

P U B L I C AT I O N S

PAT E N T S

DOCTORAL MASTERrsquoSDIPLOMA AND BACHELORrsquoS THESES

N E T W O R K S I N S C I E N C E A N D I N D U S T R Y

4

24

28

32

TABLE OF CONTENTS

4 5

PUBLICATIONS

6 7

PUBLICATIONS MB Molecular Biology

A - CAbdellatef E Will T Koch A Imani J Vilcinskas A Kogel K-HSilencing the expression of the sali-vary sheath protein causes transge-nerational feeding suppression in the aphid Sitobion avenaePlant Biotechnology Journal 13 (2015) No 6 849-857 (DOI 101111pbi12322)

Ahmad K Scholz B Capelo R Schweighofer I Kahnt AS Marscha-lek R Steinhilber D AF4 and AF4-MLL mediate transcrip-tional elongation of 5-lipoxygenase mRNA by 1 25-dihydroxyvitamin D3 Oncotarget 6 (2015) No 28 25784-800 (DOI 1018632oncotarget4703)

Arfi ZA Drossard J Hellwig S Fischer R Buyel JFPolyclonal antibodies can effectively detect tobacco host cell proteins af-ter RuBisCO depletion and endotoxin removalBiotechnology Journal Epub 2015 Dec 03 (DOI 101002biot201500271)

Barthelmes J De Bazo AM Pewzner-Jung Y Schmitz K Mayer CA FoerchC Eberle M Tafferner N Ferreiros NHenke M Geisslinger G Futerman AH Grosch S Schiffmann S Lack of ceramide synthase 2 suppres-ses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils Brain Behavior and Immunity 46 (2015)280-92(DOI 101016jbbi201502010)

Baumann A Lehmann R Beckert A Vilcinskas A Franta ZSelection and evaluation of tissue specific reference genes in Lucilia sericata during an immune challengePLoS One 10 (2015) No 8 e0135093

scanning microprobe matrix-assisted laser desorptionionization mass spectrometry imaging in whole-body sections and individual organs of the rove beetle Paederus ripariusAnalytical and Bioanalytical Chemistry 407 (2015) No 8 2189-2201(DOI 101007s00216-014-8327-1)

Blocher R Lamers C Wittmann SK Merk D Hartmann M WeizelL Diehl O Bruggerhoff A BossM Kaiser A Schader T Gobel TGrundmann M Angioni C Hee-ring J Geisslinger G Wurglics MKostenis E Brune B Steinhilber DSchubert-Zsilavecz M Kahnt ASProschak EN-benzylbenzamides a novel mer-ged scaffold for orally available dualsoluble epoxide hydrolaseperoxis-ome proliferator-activated receptorgamma modulatorsJ Med Chem 59 (2016) No 1 61-81(DOI 101021acsjmedchem5b01239)

Boes A Spiegel H Edgue G Kapel-ski S Scheuermayer M Fendel R Remarque E Altmann F Maresch D Reimann A Pradel G Schillberg S Fischer RDetailed functional characterization of glycosylated and nonglycosylated variants of malaria vaccine candida-te PfAMA1 produced in Nicotiana benthamiana and analysis of growth inhibitory responses in rabbitsPlant Biotechnology Journal 13 (2015)No 2 222-234 (DOI 101111pbi12255)

Boes A Spiegel H Voepel N Edgue G Beiss V Kapelski S Fendel R Scheuermayer M Pradel G Bolscher JM Behet MC Dechering KJHermsen CC Sauerwein RW Schill-berg S Reimann A Fischer RAnalysis of a multi-component mul-ti-stage malaria vaccine candidate-ta-ckling the cocktail challenge

(DOI 101371journalpone0135093)

Beckert A Wiesner J Baumann A Poumlppel AK Vogel H Vilcinskas ATwo c-type lysozymes boost the in-nate immune system of the invasive ladybird Harmonia axyridisDevelopmental and Comparative Immu-nology DCI 49 (2015) No 2 303-312(DOI 101016jdci201411020)

Behrens F Canete JD Olivieri I Van Kuijk AW Mchugh N Combe B Tumour necrosis factor inhibitor mo-notherapy vs combination with MTX in the treatment of PsA a systematic review of the literature Rheumatology (Oxford) 54 (2015a) No 5 915-26 (DOI 101093rheumatologykeu415)

Behrens F Koehm M Arndt U Wittig BM Greger G Thaci D Scharbatke E Tony HPBurkhardt H Does concomitant Methotrexate with Adalimumab influence treat-ment outcomes in patients with Psoriatic Arthritis Data from a large observational study J Rheumatol (2015b) (DOI 103899jrheum141596)

Behrens F Koehm M Thaci D Krummel-Lorenz B Greger G Wittig BBurkhardt H Is there an association between skin and joint involvement in patients with psoriatic arthritis treated with Adalimumab - Data-analysis from a large German non-interventional study Annals of the Rheumatic Diseases 72 (2013) 285-285

Behrens F Tak PP Ostergaard M Stoilov R Wiland P Huizinga TW Berenfus VY Vladeva S Rech J Rubbert-Roth A Korkosz M Rekalov D Zupanets IA Ejbjerg BJ Geiseler J Fresenius J Korolkiewicz RP Schot-

PLoS One Online journal 10 (2015) No 7 Art e0131456 (DOI 101371journalpone0131456)

Bolouri Moghaddam M R Vilcinskas A Rahnamaeian MCooperative interaction of antimicro-bial peptides with the interrelated immune pathways in plantsMolecular Plant Pathology (2015) (DOI 101111mpp12299)

Bortesi L Fischer RThe CRISPRCas9 system for plant genome editing and beyond ReviewBiotechnology Advances 33 (2015) No 1 41-52 (DOI 101016jbiotechadv201412006)

Bowes J Budu-Aggrey A Huffmeier U Uebe S Steel K Hebert HL Wallace C Massey J Bruce IN Bluett J Feletar M Morgan AW Marzo-Ortega H Donohoe G Morris DW Helliwell P Ryan AW KaneD Warren RB Korendowych EAlenius GM Giardina E Packham JMcmanus R Fitzgerald O MchughN Brown MA Ho P Behrens FBurkhardt H Reis ABarton ACorrigendum Dense genotyping ofimmune-related susceptibility locireveals new insights into the geneticsof psoriatic arthritisNature Communications 6 (2015a) 7741(DOI 101038ncomms8741)

Bowes J Budu-Aggrey A Huffmeier U Uebe S Steel K Hebert HL Wallace C Massey J Bruce IN Bluett J Feletar M Morgan AW Marzo-Ortega H Donohoe G Morris DW Helliwell P Ryan AW KaneD Warren RB Korendowych EAlenius GM Giardina E Packham JMcmanus R Fitzgerald O MchughN Brown MA Ho P Behrens FBurkhardt H Reis ABarton ADense genotyping of immune-rela-ted susceptibility loci reveals new

telius AJBurkhardt H MOR103 a human monoclonal antibody to granulocyte-macro-phage colony-stimulating factor in the treatment of patients with moderate rheumatoid arthritis results of a phase IbIIa randomised double-blind placebo-controlled dose-escalation trial Annals of the Rheumatic Diseases 74 (2015c) No 6 1058-64 (DOI 101136annrheumdis-2013-204816)

Beiss V Spiegel H Boes A Kapelski S Scheuermayer M Edgue G Sack M Fendel R Reimann A Schillberg S Pradel G Fischer RHeat-precipitation allows the ef-ficient purification of a functional plant-derived malaria transmission-blocking vaccine candidate fusion proteinBiotechnology amp Bioengineering 112 (2015) No 7 1297-1305 (DOI 101002bit25548)

Beiss V Spiegel H Boes A Scheuer-mayer M Reimann A Schillberg S Fischer RPlant expression and characterization of the transmission-blocking vaccine candidate PfGAP50BMC Biotechnology 15108 (2015)(DOI 101186s12896-015-0225-x)

Beyer S Xie L Grafe S Vogel V Dietrich K Wiehe A Albrecht V Mantele WWacker MG Bridging laboratory and large scale production preparation and in vitro-evaluation of photosensiti-zer-loaded nanocarrier devices for targeted drug delivery Pharm Res 32 (2015) No 5 1714-26(DOI 101007s11095-014-1569-y)

Bhandari D R Schott M Rompp A Vilcinskas A Spengler BMetabolite localization by atmo-spheric pressure high-resolution

insights into the genetics of psoriatic arthritis Nature Communications 6 (2015b) 6046 (DOI 101038ncomms7046)

Bowes J Loehr S Budu-Aggrey A Uebe S Bruce IN Feletar M Mar-zo-Ortega H Helliwell P Ryan AW Kane D Korendowych E Alenius GM Giardina E Packham J Mc-manus R Fitzgerald O Brown MABehrens F Burkhardt H Mchugh NHuffmeier U Ho P Reis ABarton APTPN22 is associated with suscepti-bility to psoriatic arthritis but notpsoriasis evidence for a furtherPsA-specific risk locusAnnals of the Rheumatic Diseases 74(2015c) No 10 1882-5(DOI 101136annrheumdis-2014-207187)

Braumlndl B Schneider SA Loring JF Hardy J Gribbon P Muumlller FJStem cell reprogramming Basic implications and future perspective for movement disordersMovement Disorders 30 (2015) No 3 301-312 (DOI 101002mds26113)

Brehm H Hristodorov D Pardo A Mladenov R Niesen J Fischer R Tur MK Barth STargeted killing of rhabdomyosar-coma cells by a MAP-based humancytolytic fusion proteinCancer Letters 365 (2015) No 2 149-155(DOI 101016jcanlet201504004)

Buntru M Vogel S Stoff K Spiegel H Schillberg SA versatile coupled cell-free tran-scriptionndashtranslation system based on tobacco BY-2 cell lysatesBiotechnology amp Bioengineering 112 (2015) No 5 867-878 (DOI 101002bit25502)

Buyel JFProcess development strategies in

4 5

PUBLICATIONS

6 7

PUBLICATIONS MB Molecular Biology

A - CAbdellatef E Will T Koch A Imani J Vilcinskas A Kogel K-HSilencing the expression of the sali-vary sheath protein causes transge-nerational feeding suppression in the aphid Sitobion avenaePlant Biotechnology Journal 13 (2015) No 6 849-857 (DOI 101111pbi12322)

Ahmad K Scholz B Capelo R Schweighofer I Kahnt AS Marscha-lek R Steinhilber D AF4 and AF4-MLL mediate transcrip-tional elongation of 5-lipoxygenase mRNA by 1 25-dihydroxyvitamin D3 Oncotarget 6 (2015) No 28 25784-800 (DOI 1018632oncotarget4703)

Arfi ZA Drossard J Hellwig S Fischer R Buyel JFPolyclonal antibodies can effectively detect tobacco host cell proteins af-ter RuBisCO depletion and endotoxin removalBiotechnology Journal Epub 2015 Dec 03 (DOI 101002biot201500271)

Barthelmes J De Bazo AM Pewzner-Jung Y Schmitz K Mayer CA FoerchC Eberle M Tafferner N Ferreiros NHenke M Geisslinger G Futerman AH Grosch S Schiffmann S Lack of ceramide synthase 2 suppres-ses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils Brain Behavior and Immunity 46 (2015)280-92(DOI 101016jbbi201502010)

Baumann A Lehmann R Beckert A Vilcinskas A Franta ZSelection and evaluation of tissue specific reference genes in Lucilia sericata during an immune challengePLoS One 10 (2015) No 8 e0135093

scanning microprobe matrix-assisted laser desorptionionization mass spectrometry imaging in whole-body sections and individual organs of the rove beetle Paederus ripariusAnalytical and Bioanalytical Chemistry 407 (2015) No 8 2189-2201(DOI 101007s00216-014-8327-1)

Blocher R Lamers C Wittmann SK Merk D Hartmann M WeizelL Diehl O Bruggerhoff A BossM Kaiser A Schader T Gobel TGrundmann M Angioni C Hee-ring J Geisslinger G Wurglics MKostenis E Brune B Steinhilber DSchubert-Zsilavecz M Kahnt ASProschak EN-benzylbenzamides a novel mer-ged scaffold for orally available dualsoluble epoxide hydrolaseperoxis-ome proliferator-activated receptorgamma modulatorsJ Med Chem 59 (2016) No 1 61-81(DOI 101021acsjmedchem5b01239)

Boes A Spiegel H Edgue G Kapel-ski S Scheuermayer M Fendel R Remarque E Altmann F Maresch D Reimann A Pradel G Schillberg S Fischer RDetailed functional characterization of glycosylated and nonglycosylated variants of malaria vaccine candida-te PfAMA1 produced in Nicotiana benthamiana and analysis of growth inhibitory responses in rabbitsPlant Biotechnology Journal 13 (2015)No 2 222-234 (DOI 101111pbi12255)

Boes A Spiegel H Voepel N Edgue G Beiss V Kapelski S Fendel R Scheuermayer M Pradel G Bolscher JM Behet MC Dechering KJHermsen CC Sauerwein RW Schill-berg S Reimann A Fischer RAnalysis of a multi-component mul-ti-stage malaria vaccine candidate-ta-ckling the cocktail challenge

(DOI 101371journalpone0135093)

Beckert A Wiesner J Baumann A Poumlppel AK Vogel H Vilcinskas ATwo c-type lysozymes boost the in-nate immune system of the invasive ladybird Harmonia axyridisDevelopmental and Comparative Immu-nology DCI 49 (2015) No 2 303-312(DOI 101016jdci201411020)

Behrens F Canete JD Olivieri I Van Kuijk AW Mchugh N Combe B Tumour necrosis factor inhibitor mo-notherapy vs combination with MTX in the treatment of PsA a systematic review of the literature Rheumatology (Oxford) 54 (2015a) No 5 915-26 (DOI 101093rheumatologykeu415)

Behrens F Koehm M Arndt U Wittig BM Greger G Thaci D Scharbatke E Tony HPBurkhardt H Does concomitant Methotrexate with Adalimumab influence treat-ment outcomes in patients with Psoriatic Arthritis Data from a large observational study J Rheumatol (2015b) (DOI 103899jrheum141596)

Behrens F Koehm M Thaci D Krummel-Lorenz B Greger G Wittig BBurkhardt H Is there an association between skin and joint involvement in patients with psoriatic arthritis treated with Adalimumab - Data-analysis from a large German non-interventional study Annals of the Rheumatic Diseases 72 (2013) 285-285

Behrens F Tak PP Ostergaard M Stoilov R Wiland P Huizinga TW Berenfus VY Vladeva S Rech J Rubbert-Roth A Korkosz M Rekalov D Zupanets IA Ejbjerg BJ Geiseler J Fresenius J Korolkiewicz RP Schot-

PLoS One Online journal 10 (2015) No 7 Art e0131456 (DOI 101371journalpone0131456)

Bolouri Moghaddam M R Vilcinskas A Rahnamaeian MCooperative interaction of antimicro-bial peptides with the interrelated immune pathways in plantsMolecular Plant Pathology (2015) (DOI 101111mpp12299)

Bortesi L Fischer RThe CRISPRCas9 system for plant genome editing and beyond ReviewBiotechnology Advances 33 (2015) No 1 41-52 (DOI 101016jbiotechadv201412006)

Bowes J Budu-Aggrey A Huffmeier U Uebe S Steel K Hebert HL Wallace C Massey J Bruce IN Bluett J Feletar M Morgan AW Marzo-Ortega H Donohoe G Morris DW Helliwell P Ryan AW KaneD Warren RB Korendowych EAlenius GM Giardina E Packham JMcmanus R Fitzgerald O MchughN Brown MA Ho P Behrens FBurkhardt H Reis ABarton ACorrigendum Dense genotyping ofimmune-related susceptibility locireveals new insights into the geneticsof psoriatic arthritisNature Communications 6 (2015a) 7741(DOI 101038ncomms8741)

Bowes J Budu-Aggrey A Huffmeier U Uebe S Steel K Hebert HL Wallace C Massey J Bruce IN Bluett J Feletar M Morgan AW Marzo-Ortega H Donohoe G Morris DW Helliwell P Ryan AW KaneD Warren RB Korendowych EAlenius GM Giardina E Packham JMcmanus R Fitzgerald O MchughN Brown MA Ho P Behrens FBurkhardt H Reis ABarton ADense genotyping of immune-rela-ted susceptibility loci reveals new

telius AJBurkhardt H MOR103 a human monoclonal antibody to granulocyte-macro-phage colony-stimulating factor in the treatment of patients with moderate rheumatoid arthritis results of a phase IbIIa randomised double-blind placebo-controlled dose-escalation trial Annals of the Rheumatic Diseases 74 (2015c) No 6 1058-64 (DOI 101136annrheumdis-2013-204816)

Beiss V Spiegel H Boes A Kapelski S Scheuermayer M Edgue G Sack M Fendel R Reimann A Schillberg S Pradel G Fischer RHeat-precipitation allows the ef-ficient purification of a functional plant-derived malaria transmission-blocking vaccine candidate fusion proteinBiotechnology amp Bioengineering 112 (2015) No 7 1297-1305 (DOI 101002bit25548)

Beiss V Spiegel H Boes A Scheuer-mayer M Reimann A Schillberg S Fischer RPlant expression and characterization of the transmission-blocking vaccine candidate PfGAP50BMC Biotechnology 15108 (2015)(DOI 101186s12896-015-0225-x)

Beyer S Xie L Grafe S Vogel V Dietrich K Wiehe A Albrecht V Mantele WWacker MG Bridging laboratory and large scale production preparation and in vitro-evaluation of photosensiti-zer-loaded nanocarrier devices for targeted drug delivery Pharm Res 32 (2015) No 5 1714-26(DOI 101007s11095-014-1569-y)

Bhandari D R Schott M Rompp A Vilcinskas A Spengler BMetabolite localization by atmo-spheric pressure high-resolution

insights into the genetics of psoriatic arthritis Nature Communications 6 (2015b) 6046 (DOI 101038ncomms7046)

Bowes J Loehr S Budu-Aggrey A Uebe S Bruce IN Feletar M Mar-zo-Ortega H Helliwell P Ryan AW Kane D Korendowych E Alenius GM Giardina E Packham J Mc-manus R Fitzgerald O Brown MABehrens F Burkhardt H Mchugh NHuffmeier U Ho P Reis ABarton APTPN22 is associated with suscepti-bility to psoriatic arthritis but notpsoriasis evidence for a furtherPsA-specific risk locusAnnals of the Rheumatic Diseases 74(2015c) No 10 1882-5(DOI 101136annrheumdis-2014-207187)

Braumlndl B Schneider SA Loring JF Hardy J Gribbon P Muumlller FJStem cell reprogramming Basic implications and future perspective for movement disordersMovement Disorders 30 (2015) No 3 301-312 (DOI 101002mds26113)

Brehm H Hristodorov D Pardo A Mladenov R Niesen J Fischer R Tur MK Barth STargeted killing of rhabdomyosar-coma cells by a MAP-based humancytolytic fusion proteinCancer Letters 365 (2015) No 2 149-155(DOI 101016jcanlet201504004)

Buntru M Vogel S Stoff K Spiegel H Schillberg SA versatile coupled cell-free tran-scriptionndashtranslation system based on tobacco BY-2 cell lysatesBiotechnology amp Bioengineering 112 (2015) No 5 867-878 (DOI 101002bit25502)

Buyel JFProcess development strategies in

6 7

PUBLICATIONS MB Molecular Biology

A - CAbdellatef E Will T Koch A Imani J Vilcinskas A Kogel K-HSilencing the expression of the sali-vary sheath protein causes transge-nerational feeding suppression in the aphid Sitobion avenaePlant Biotechnology Journal 13 (2015) No 6 849-857 (DOI 101111pbi12322)

Ahmad K Scholz B Capelo R Schweighofer I Kahnt AS Marscha-lek R Steinhilber D AF4 and AF4-MLL mediate transcrip-tional elongation of 5-lipoxygenase mRNA by 1 25-dihydroxyvitamin D3 Oncotarget 6 (2015) No 28 25784-800 (DOI 1018632oncotarget4703)

Arfi ZA Drossard J Hellwig S Fischer R Buyel JFPolyclonal antibodies can effectively detect tobacco host cell proteins af-ter RuBisCO depletion and endotoxin removalBiotechnology Journal Epub 2015 Dec 03 (DOI 101002biot201500271)

Barthelmes J De Bazo AM Pewzner-Jung Y Schmitz K Mayer CA FoerchC Eberle M Tafferner N Ferreiros NHenke M Geisslinger G Futerman AH Grosch S Schiffmann S Lack of ceramide synthase 2 suppres-ses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils Brain Behavior and Immunity 46 (2015)280-92(DOI 101016jbbi201502010)

Baumann A Lehmann R Beckert A Vilcinskas A Franta ZSelection and evaluation of tissue specific reference genes in Lucilia sericata during an immune challengePLoS One 10 (2015) No 8 e0135093

scanning microprobe matrix-assisted laser desorptionionization mass spectrometry imaging in whole-body sections and individual organs of the rove beetle Paederus ripariusAnalytical and Bioanalytical Chemistry 407 (2015) No 8 2189-2201(DOI 101007s00216-014-8327-1)

Blocher R Lamers C Wittmann SK Merk D Hartmann M WeizelL Diehl O Bruggerhoff A BossM Kaiser A Schader T Gobel TGrundmann M Angioni C Hee-ring J Geisslinger G Wurglics MKostenis E Brune B Steinhilber DSchubert-Zsilavecz M Kahnt ASProschak EN-benzylbenzamides a novel mer-ged scaffold for orally available dualsoluble epoxide hydrolaseperoxis-ome proliferator-activated receptorgamma modulatorsJ Med Chem 59 (2016) No 1 61-81(DOI 101021acsjmedchem5b01239)

Boes A Spiegel H Edgue G Kapel-ski S Scheuermayer M Fendel R Remarque E Altmann F Maresch D Reimann A Pradel G Schillberg S Fischer RDetailed functional characterization of glycosylated and nonglycosylated variants of malaria vaccine candida-te PfAMA1 produced in Nicotiana benthamiana and analysis of growth inhibitory responses in rabbitsPlant Biotechnology Journal 13 (2015)No 2 222-234 (DOI 101111pbi12255)

Boes A Spiegel H Voepel N Edgue G Beiss V Kapelski S Fendel R Scheuermayer M Pradel G Bolscher JM Behet MC Dechering KJHermsen CC Sauerwein RW Schill-berg S Reimann A Fischer RAnalysis of a multi-component mul-ti-stage malaria vaccine candidate-ta-ckling the cocktail challenge

(DOI 101371journalpone0135093)

Beckert A Wiesner J Baumann A Poumlppel AK Vogel H Vilcinskas ATwo c-type lysozymes boost the in-nate immune system of the invasive ladybird Harmonia axyridisDevelopmental and Comparative Immu-nology DCI 49 (2015) No 2 303-312(DOI 101016jdci201411020)

Behrens F Canete JD Olivieri I Van Kuijk AW Mchugh N Combe B Tumour necrosis factor inhibitor mo-notherapy vs combination with MTX in the treatment of PsA a systematic review of the literature Rheumatology (Oxford) 54 (2015a) No 5 915-26 (DOI 101093rheumatologykeu415)

Behrens F Koehm M Arndt U Wittig BM Greger G Thaci D Scharbatke E Tony HPBurkhardt H Does concomitant Methotrexate with Adalimumab influence treat-ment outcomes in patients with Psoriatic Arthritis Data from a large observational study J Rheumatol (2015b) (DOI 103899jrheum141596)

Behrens F Koehm M Thaci D Krummel-Lorenz B Greger G Wittig BBurkhardt H Is there an association between skin and joint involvement in patients with psoriatic arthritis treated with Adalimumab - Data-analysis from a large German non-interventional study Annals of the Rheumatic Diseases 72 (2013) 285-285

Behrens F Tak PP Ostergaard M Stoilov R Wiland P Huizinga TW Berenfus VY Vladeva S Rech J Rubbert-Roth A Korkosz M Rekalov D Zupanets IA Ejbjerg BJ Geiseler J Fresenius J Korolkiewicz RP Schot-

PLoS One Online journal 10 (2015) No 7 Art e0131456 (DOI 101371journalpone0131456)

Bolouri Moghaddam M R Vilcinskas A Rahnamaeian MCooperative interaction of antimicro-bial peptides with the interrelated immune pathways in plantsMolecular Plant Pathology (2015) (DOI 101111mpp12299)

Bortesi L Fischer RThe CRISPRCas9 system for plant genome editing and beyond ReviewBiotechnology Advances 33 (2015) No 1 41-52 (DOI 101016jbiotechadv201412006)

Bowes J Budu-Aggrey A Huffmeier U Uebe S Steel K Hebert HL Wallace C Massey J Bruce IN Bluett J Feletar M Morgan AW Marzo-Ortega H Donohoe G Morris DW Helliwell P Ryan AW KaneD Warren RB Korendowych EAlenius GM Giardina E Packham JMcmanus R Fitzgerald O MchughN Brown MA Ho P Behrens FBurkhardt H Reis ABarton ACorrigendum Dense genotyping ofimmune-related susceptibility locireveals new insights into the geneticsof psoriatic arthritisNature Communications 6 (2015a) 7741(DOI 101038ncomms8741)

Bowes J Budu-Aggrey A Huffmeier U Uebe S Steel K Hebert HL Wallace C Massey J Bruce IN Bluett J Feletar M Morgan AW Marzo-Ortega H Donohoe G Morris DW Helliwell P Ryan AW KaneD Warren RB Korendowych EAlenius GM Giardina E Packham JMcmanus R Fitzgerald O MchughN Brown MA Ho P Behrens FBurkhardt H Reis ABarton ADense genotyping of immune-rela-ted susceptibility loci reveals new

telius AJBurkhardt H MOR103 a human monoclonal antibody to granulocyte-macro-phage colony-stimulating factor in the treatment of patients with moderate rheumatoid arthritis results of a phase IbIIa randomised double-blind placebo-controlled dose-escalation trial Annals of the Rheumatic Diseases 74 (2015c) No 6 1058-64 (DOI 101136annrheumdis-2013-204816)

Beiss V Spiegel H Boes A Kapelski S Scheuermayer M Edgue G Sack M Fendel R Reimann A Schillberg S Pradel G Fischer RHeat-precipitation allows the ef-ficient purification of a functional plant-derived malaria transmission-blocking vaccine candidate fusion proteinBiotechnology amp Bioengineering 112 (2015) No 7 1297-1305 (DOI 101002bit25548)

Beiss V Spiegel H Boes A Scheuer-mayer M Reimann A Schillberg S Fischer RPlant expression and characterization of the transmission-blocking vaccine candidate PfGAP50BMC Biotechnology 15108 (2015)(DOI 101186s12896-015-0225-x)

Beyer S Xie L Grafe S Vogel V Dietrich K Wiehe A Albrecht V Mantele WWacker MG Bridging laboratory and large scale production preparation and in vitro-evaluation of photosensiti-zer-loaded nanocarrier devices for targeted drug delivery Pharm Res 32 (2015) No 5 1714-26(DOI 101007s11095-014-1569-y)

Bhandari D R Schott M Rompp A Vilcinskas A Spengler BMetabolite localization by atmo-spheric pressure high-resolution

insights into the genetics of psoriatic arthritis Nature Communications 6 (2015b) 6046 (DOI 101038ncomms7046)

Bowes J Loehr S Budu-Aggrey A Uebe S Bruce IN Feletar M Mar-zo-Ortega H Helliwell P Ryan AW Kane D Korendowych E Alenius GM Giardina E Packham J Mc-manus R Fitzgerald O Brown MABehrens F Burkhardt H Mchugh NHuffmeier U Ho P Reis ABarton APTPN22 is associated with suscepti-bility to psoriatic arthritis but notpsoriasis evidence for a furtherPsA-specific risk locusAnnals of the Rheumatic Diseases 74(2015c) No 10 1882-5(DOI 101136annrheumdis-2014-207187)

Braumlndl B Schneider SA Loring JF Hardy J Gribbon P Muumlller FJStem cell reprogramming Basic implications and future perspective for movement disordersMovement Disorders 30 (2015) No 3 301-312 (DOI 101002mds26113)

Brehm H Hristodorov D Pardo A Mladenov R Niesen J Fischer R Tur MK Barth STargeted killing of rhabdomyosar-coma cells by a MAP-based humancytolytic fusion proteinCancer Letters 365 (2015) No 2 149-155(DOI 101016jcanlet201504004)

Buntru M Vogel S Stoff K Spiegel H Schillberg SA versatile coupled cell-free tran-scriptionndashtranslation system based on tobacco BY-2 cell lysatesBiotechnology amp Bioengineering 112 (2015) No 5 867-878 (DOI 101002bit25502)

Buyel JFProcess development strategies in

8 9

PUBLICATIONS MB Molecular Biology

plant molecular farmingCurrent Pharmaceutical Biotechnology (2015) 16(11)966-982

Buyel JFControlling the interplay between Agrobacterium tumefaciens and plants during the transient expressi-on of proteinsBioengineered (2015) 6(4)242-244(DOI 010802165597920151052920)

Buyel JF Buyel JJ Haase C Fischer RThe impact of Pseudomonas syringae type III effectors on transient protein expression in tobaccoPlant Biology 17 (2015) No 2 484-492(DOI 101111plb12264)

Buyel JF Fischer RA juice extractor can simplify the downstream processing of plant-de-rived biopharmaceutical proteins compared to blade-based homoge-nizersProcess Biochemistry 50 (2015) No 5 859-866 (DOI 101016jprocbio201502017)

Buyel JF Fischer RSynthetic polymers are more effec-tive than natural flocculants for the clarification of tobacco leaf extractsJournal of Biotechnology 195 (2015) 37-42(DOI 101016jjbiotec201412018)

Buyel JF Gruchow HM Fischer RDepth filters containing diatomite achieve more efficient particle re-tention than filters solely containing cellulose fibersFrontiers in Plant Science 61134 Epub 2015 Dec 21 (DOI doi 103389fpls201501134)

Buyel JF Opdensteinen P Fischer RCellulose-based filter aids increase the capacity of depth filters du-ring the downstream processing of

Cremer C Vierbuchen T Hein L Fischer R Barth S Nachreiner TAngiogenin mutants as novel effec-tor molecules for the generation of fusion proteins with increased cytotoxic potentialJournal of Immunotherapy 38 (2015) No 3 85-95 (DOI 101097CJI0000000000000053)

D - FDaniell H Streatfield SJ Rybicki EP Advances in molecular farming key technologies scaled up production and lead targets Plant Biotechnology Journal 13 (2015) No 8 1011-1012 (DOI 101111pbi12478)

Deacon RMJ Altimiras FJ Bazan-Le-on E Pyarasani RD Nachtigall FM Santos LS Tsolaki AG Pednekar L Kishore U Biekofsky RR Vasquez R Cogram P Natural AD-Like neuropathology in Octodon degus impaired burrowing and neuroinflammation Current Alzheimer Research 4 (2015)(DOI 1021741567205012666150324181652)

Deacon RMJ Glass L Snape M Hurley M Altimiras FJ Biekofsky RR CogramNNZ-2566 a novel analog of (1ndash3)IGF-1 as a potential therapeuticagent for Fragile X syndromeNeuro Molecular Medicine 17 (2015)(DOI 101007s12017-015-8341-2)

De Bruin NMWJKruse CG 5-HT6 receptor antagonists PotentialEfficacy for the Treatment of Cogniti-ve Impairment in SchizophreniaCurrent Pharmaceutical Design 21(2015) No 26 3739-3759(DOI 1021741381612821666150605112105)

plant-derived biopharmaceutical proteinsBiotechnology Journal 10 (2015) No 4 584-591 (DOI 101002biot201400611)

Buyel JF Twyman RM Fischer RExtraction and downstream proces-sing of plant-derived recombinant proteinsBiotechnology Advances 33 (2015) No 6 902-913 (DOI 101016jbiotechadv201504010)

Cabrol L Urra J Rosenkranz F Kroff PA Plugge CM Lesty Y Chamy RInfluence of phenylacetic acid pulseson anaerobic digestion performanceand archaeal community structure inWWTP sewage sludge digesters Water Science and Technology 71 (2015)

Camarada B Maacuterquez-Miran-da V Araya-Duraacuten I Yeacutevenes A Gonzaacutelez-Nilo FPAMAM G4 dendrimers as inhibitors of the iron storage properties of human L-chain ferritinPhysical Chemistry Chemical Physics 17 (2015) (DOI 101039c5cp02594j)

Carrasco-Saacutenchez V Amalraj J Marican A Santos SL Laurie F Removal of 4-Ethylphenol and 4-Ethylguaiacol with polyaniline-ba-sed compounds in wine-like model solutions and red wineMolecules 20 (2015)(DOI103390molecules200814312)

Cheng X Dimou E Alborzinia H Wenke F Goumlhring A Reuter S Mah N Fuchs H Andrade-Navarro MA Adjaye J Gul S Harms C Utikal J Klipp E Mrowka R Woumllfl S Identification of 2-[4-[(4-Methoxy-phenyl)methoxy]-phenyl]acetonitrile and derivatives as potent Oct34 inducers

De Bruin NM Schmitz K Schiffmann S Tafferner N Schmidt M Jordan H Haussler A Tegeder I Geisslinger G Parnham MJ Multiple rodent models and beha-vioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encepha-lomyelitis Behav Brain Res 300 (2015) 160-174 (DOI 101016jbbr201512006)

Degenkolb T Vilcinskas AMetabolites from nematophagous fungi and nematicidal natural pro-ducts from fungi as an alternative for biological control Part I metabolites from nematophagous ascomycetesApplied Microbiology and Biotechnology (2015) (DOI 101007s00253-015-7233-6)

Dimova V Lotsch J Huhne K Win-terpacht A Heesen M Parthum A Weber PG Carbon R Griessinger N Sittl RLautenbacher S Association of genetic and psycho-logical factors with persistent pain after cosmetic thoracic surgery J Pain Res 8 (2015a) 829-44(DOI 102147JPRS90434)

Dimova V Oertel BG Kabakci G Zimmermann M Hermens H Lauten-bacher S Ultsch ALotsch J A more pessimistic life orientation is associated with experimental inducibility of a neuropathy-like pain pattern in healthy individuals J Pain 16 (2015b) No 8 791-800(DOI 101016jjpain201505004)

Druzinec D Salzig D Kraume M Czermak PMicro-bubble aeration in turbulent stirred bioreactors Coalescence be-havior in Pluronic F68 containing cell culture mediaChemical Engineering Science 126 (2015) 160-168

J Med Chem Jun 25 (2015) 58(12)4976-83 (DOI 101021acsjmedchem5b00144)

Cheng X Yoshida H Raoofi D Saleh S Alborzinia H Wenke F Goumlhring A Reuter S Mah N Fuchs H Andrade-Navarro MA Adjaye J Gul S Utikal J Mrowka R Woumllfl S Ethyl 2-((4-chlorophenyl)amino)thi-azole-4-carboxylate and derivatives are potent inducers of Oct34J Med Chem Aug (2015) 1358(15)5742-50(DOI 101021acsjmedchem5b00226)

Choudhary S Pardo A Rosinke R Batra JK Barth S Verma RSTargeting c-kit receptor in neuro-blastomas and colorectal cancers using stem cell factor (SCF)-based recombinant bacterial toxinsAppl Microbiol Biotechnol 2016 Jan100(1)263-77 Epub ahead of print 2015 Oct 1 (DOI 101007s00253-015-6978-2)

Cremer C Braun H Mladenov R Schenke L Cong X Jost E Bruumlm-mendorf TH Fischer R Carloni P Barth S Nachreiner TNovel angiogenin mutants with increased cytotoxicity enhance the depletion of pro-inflammatory macrophages and leukemia cells ex vivoCancer Immunology and Immunotherapy (2015) Epub ahead of print Oct 15

Cremer C Hehmann-Titt G Schiffer S Melmer G Carloni P Barth S Nachreiner T Engineered versions of granzyme B and angiogenin overcome intrinsic resistance to apoptosis mediated by human cytolytic fusion proteinsVerma RS Bonavida B (eds) Resistance to Immunotoxins in Cancer Therapy Springer International Publishing Swit-zerland 2015 pp 185-219

(DOI 101016jces201412020)

Duraacuten-Lara E Aacutevila-Salas F Galaz S John A Maricaacuten A Gutieacuterrez M Nachtigall MF Gonzalez-Nilo F S Santos LNano-Detoxification of Organo-phosphate Agents by PAMAM Derivatives Journal of the Brazilian Chemical Society 26 (2015) (DOI httpdxdoiorg1059350103-505320150013)

Duraacuten-Lara EF Marple JL Giesen JA Fang Y Jordan JH GodbeyWT Marican A Santos LS GraysonSMInvestigation of lysine- functionalizeddendrimers as dichlorvos Detoxifi-cation AgentsBiomacromolecules 16 (2015)(DOI 101021acsbiomac5b00657)

Eberle M Ebel P Mayer CA Bart-helmes J Tafferner N Ferreiros N Ulshofer T Henke M Foerch C De Bazo AM Grosch S Geisslinger G Willecke K Schiffmann S Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activationmigration of neutrophils Immunology and Cell Biology 93 (2015)No 9 825-36 (DOI 101038icb2015 47)

Eberle M Ebel P Wegner MS Mannich J Tafferner N Ferreiros N Birod K Schreiber Y Krishnamoorthy G Willecke K Geisslinger G Grosch S Schiffmann S Regulation of ceramide synthase 6 in a spontaneous experimental autoim-mune encephalomyelitis model is sex dependent Biochemical Pharmacology 92 (2014) No 2 326-35 (DOI 101016jbcp201408016)

PUBLICATIONS MB Molecular Biology

10 11

Eisenhardt M Dobler D Schlupp P Schmidts T Salzig M Vilcinskas A Salzig D Czermak P Keusgen M Runkel FDevelopment of an insect metal-loproteinase inhibitor drug carrier system for application in chronic wound infectionsJournal of Pharmacy and Pharmacology 67 (2015) No 11 1481-1491(DOI 101111jphp12452)

Elseberg CL Salzig D Czermak PBioreactor expansion of human mesenchymal stem cells according to GMP requirementsMethods in Molecular Biology 1283 (2015) 199-21 (DOI 1010077651_2014_117)

Epping J van Deenen N Niephaus E Stolze A Fricke J Huber C Eisen-reich W Twyman RM Pruumlfer D and Schulze Gronover CA rubber transferase activator is necessary for natural rubber biosyn-thesis in dandelionNature Plants Advance Online Publication (2015) (DOI 101038nplants201548)

Escobar MA Trofymchuk OS Rodriguez BE Lopez-Lira C Tapia R Daniliuc C Berke H Nachtigall FM Santos LS Rojas RSLewis acid enhanced ethene dimeriz-ation and alkene isomerization - ESI-MS identification of the catalytically active pyridyldimethoxybenzimida-zole nickel(II) hydride speciesACS Catalysis 12 (2015) (DOI 101021acscatal5b02003)

Fan R Ebrahimi M Quitmann H Czermak PLactic acid production in a membra-ne bioreactor system with thermo-philic Bacillus coagulans performan-ce of the used ceramic membranesSeparation Science and Technology 50

(DOI 101007s11248-015-9864-x)

Fritsch LD Schillberg S Schroumlper F Duplex-Real-Time-PCR zur Zygo-sitaumlts-bestimmung in transgenen PflanzenBIOspektrum 21 (2015) No 5 511-514 (DOI 101007s12268-015-0611-x)

Forero-Doria O Gallego J Valdes O Pinzon-Topal C S Santos L Guzmaacuten LRelationship between oxidative sta-bility and antioxidant activity of oil extracted from the peel of Mauritia flexuosa fruitsJournal of Thermal Analysis and Calori-metry (2015) (DOI 101007s10973-015-4822-7)

G - IGilbert B Ahmad K Roos J Leh-mann C Chiba T Ulrich-Ruckert S Smeenk L Van Heeringen S Maier TJ Groner BSteinhilber D5-Lipoxygenase is a direct p53 targetgene in humansBiochim Biophys Acta 1849 (2015)No 8 1003-16(DOI 101016jbbagrm201506004)

Gorshkov V Blenau W Koeniger G Rompp A Vilcinskas A Spengler BProtein and peptide composition of male accessory glands of Apis mel-lifera drones investigated by mass spectrometryPloS One 10 (2015) No 5 e0125068(DOI 101371journalpone0125068)

Grimm M Tischner D Troidl K Al-barran Juarez J Sivaraj KK Ferreiros Bouzas N Geisslinger G Binder CJ Wettschureck N S1P2G1213 Signaling negatively regulates macrophage activation and indirectly shapes the atheroprotecti-ve B1-Cell population

(2015) 14 2177-2189 (DOI 010800149639520151031401)

Farnik H Zimmermann T Herrmann E Bechstein WO Kronenberger B Galle PR Labocha S Ferreiros N Geisslinger G Zeuzem S Sarrazin C Welker MW Telaprevir drug monitoring during antiviral therapy of hepatitis C graft infection after liver transplantation Liver Int 35 (2015) No 1 176-83(DOI 101111liv12532)

Feuchtenberger M Kleinert S Scharbatke EC Gnann H Behrens F Wittig BM Greger GTony HP The impact of prior biologic therapy on adalimumab response in patients with rheumatoid arthritis Clinical and Experimental Rheumatology 33 (2015) No 3 321-9

Fischer R Vasilev N Twyman RM Schillberg SHigh-value products from plants the challenges of process optimizationCurrent Opinion in Biotechnology 32

Arterioscler Thromb Vasc Biol 36 (2016) No 1 37-48 (DOI 101161ATVBAHA115306066)

Gul SCell-based assays for screening A practical workshopEuropean Pharmaceutical Review 20 (2015) No 2 70

Gupta S K Kupper M Ratzka C Feldhaar H Vilcinskas A Gross R Dandekar T Forster FScrutinizing the immune defence inventory of Camponotus florida-nus applying total transcriptome sequencingBMC Genomics 16 (2015) 540(DOI 101186s12864-015-1748-1)

Guzman L Duran-Lara EF Donoso W Nachtigall FM Santos LSIn vivo nanodetoxication for acute uranium exposureMolecules 20 (2015)(DOI 103390molecules200611017)

Hanke T Merk D Steinhilber D Geisslinger G Schubert-Zsilavecz M Small molecules with anti-inflammat-ory properties in clinical develop-ment Pharmacol Ther 157 (2016) 163-87(DOI 101016jpharmthera201511011)

Homann J Suo J Schmidt M De Bruin N Scholich K Geisslinger G Ferreiros N In vivo availability of pro-resolving lipid mediators in oxazolone induced dermal inflammation in the mouse PLoS One 10 (2015) No 11 e0143141(DOI 101371journalpone0143141)

Hristodorov D Mladenov R von Felbert V Huhn M Fischer R Barth S Thepen TTargeting CD64 mediates elimination of M1 but not M2 macrophages in vitro and in cutaneous inflammation

(2015) 156-162 (DOI 101016jcopbio201412018)

Fischer M Kuckenberg M Kastilan R Muth J Gebhardt CNovel in vitro inhibitory functions of potato tuber proteinaceous inhibitorsMolecular Genetics and Genomics MGG 290 (2015) No 1 387-398(DOI 101007s00438-014-0906-5)

Fitting J Blume T ten Haaf A Blau W Gattenloumlhner S Tur MK Barth SPhage display-based generation of novel internalizing antibody frag-ments for immunotoxin-based treat-ment of acute myeloid leukemiamAbs 7 (2015) No 2 390-402(DOI 010801942086220151007818)

Fritsch L Fischer R Wambach C Dudek M Schillberg S Schroumlper F Next-generation sequencing is a robust strategy for the high-through-put detection of zygosity in transge-nic maize Transgenic Research 24 (2015) No 4 615-623

in mice and patient biopsiesMAbs 20157(5)853-62(DOI 1010801942086220151066950)

Hunzelmann N Riemekasten G Becker M Moinzadeh P Kreuter A Melchers I Mueller-Ladner U Meier F Worm M Lee H Herrgott I Pfeif-fer C Fierlbeck G Henes J Juche A Zeidler G Mensing H Gunther C Sardy M Burkhardt H Koehm M Kuhr K Krieg TSunderkotter C The predict study Low risk for digital ulcer development in systemic sclero-sis patients with increasing disease duration and lack of topoisomera-se-1 antibodies Br J Dermatol (2015)(DOI 101111bjd14367)

J - LJayamani E Rajamuthiah R Larkins-Ford J Fuchs B B Conery A L Vilcinskas A Ausubel F M Mylonakis E Insect-derived cecropins display acti-vity against Acinetobacter baumannii in a whole-animal high-throughput Caenorhabditis Elegans Model Antimicrobial Agents and Chemotherapy 59 (2015) No 3 1733-1742(DOI 101128Aac04198-14)

Jones RM Chichester JA Manceva S Gibbs SK Musiychuk K Shamloul M Norikane J Streatfield SJ van de Vegte-Bolmer M Roeffen W Sauer-wein RW Yusibov V A novel plant-produced Pfs25 fusion subunit vaccine induces long-lasting transmission blocking antibody responses Human Vaccines amp Immunotherapeutics 11 (2015) No 1 124-132 (DOI 104161hv34366)

Kahl M Gokcen A Fischer S Baumer M Wiesner J Lochnit G Wygrecka

PUBLICATIONS MB Molecular Biology

12 13

M Vilcinskas A Preissner K TMaggot excretion products from the blowfly Lucilia sericata contain contact phaseintrinsic pathway-like proteases with procoagulant func-tionsThrombosis and Haemostasis 114 (2015) No 2 277-288 (DOI 101160Th14-06-0499)

Kapelski S Almeida M de Fischer R Barth S Fendel RAntimalarial activity of granzyme B and its targeted delivery by a granzy-me B-single-chain Fv fusion proteinAntimicrobial Agents and Chemotherapy59 (2015) No 1 669-672 (DOI 101128AAC04190-14)

Kapelski S Boes A Spiegel H Almei-da M de Klockenbring T Reimann A Fischer R Barth S Fendel RFast track antibody V-gene rescue recombinant expression in plants and characterization of a PfMSP4-specific antibodyMalaria Journal Online Journal 14 (2015) Art 50 11 S (DOI 101186s12936-015-0577-7)

King TS Russe OQ Moser CV Ferreiros N Kynast KL Knothe C Olbrich K Geisslinger G Niederberger EAMP-activated protein kinase is activated by non-steroidal anti-in-flammatory drugs European Journal of Pharmacology 762 (2015) 299-305 (DOI 101016jejphar201506001)

King-Himmelreich TS Moser CV Wolters MC Olbrich K Geisslinger G Niederberger E Age-dependent changes in the inflammatory nociceptive behavior of mice Int J Mol Sci 16 (2015) No 11 27508-19 (DOI 103390ijms161126041)

In siacutelico identification and characte-rization of putative DotIcm secreted virulence effectors in the fish patho-gen Piscirickettsia salmonisMicrobial Pathogenesis 92 (2016) (DOIhttpdxdoiorg101016jmicpa-th201512002)

Laibach N Post J Twyman RM Schulze Gronover C Pruumlfer DThe characteristics and potential ap-plications of structural lipid droplet proteins in plantsJournal of Biotechnology 201 (2015) 15ndash27 (DOI 101016jjbiotec201408020)

Lehmann C Homann J Ball AK Blocher R Kleinschmidt TK Basava-rajappa D Angioni C Ferreiros N Hafner AK Radmark O Proschak E Haeggstrom JZ Geisslinger G Parn-ham MJ Steinhilber D Kahnt AS Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activa-ting protein FASEB J 29 (2015) No 12 5029-43(DOI 101096fj15-275487)

Liang Y Coffin MV Manceva SD Chichester JA Jones RM Kiick KL Controlled release of an anthrax toxin-neutralizing antibody from hy-drolytically degradable polyethylene glycol hydrogels Journal of Biomedical Materials Research Part A Epub ahead of print 2015 Jul 30

Liljeqvist M Ossandon F Gonzalez C Rajan S Stell A Valdes J Holmes D Dopson M Metagenomic analysis reveals ad-aptations to a cold adapted lifestyle in a low temperature acid mine drainage stream FEMS Microbiology Ecology 4 (2015)(DOI httpdxdoiorg101093femsecfiv011)

Klose H Guumlnl M Usadel B Fischer R Commandeur UCell wall modification in tobacco by differential targeting of recombinant endoglucanase from Trichoderma reeseiBMC Plant Biology Online journal 15 (2015) Art 54 (DOI 101186s12870-015-0443-3)

Knape T Flesch D Kuchler L Sha LK Giegerich AK Labocha SFerreiros N Schmid T Wurglics MSchubert-Zsilavecz M Proschak EBrune B Parnham MJVon Knethen AIdentification and characterisation ofa prototype for a new class of com-petitive PPARgamma antagonistsEuropean Journal of Pharmacology 755(2015) 16-26(DOI 101016jejphar201502034)

Knorr E Schmidtberg H Arslan D Bingsohn L Vilcinskas ATranslocation of bacteria from the gut to the eggs triggers maternal transgenerational immune priming in Tribolium castaneumBiology Letters 11 (2015) No 12(DOI 101098rsbl20150885)

Knothe C Doehring A Ultsch ALotsch J Methadone induces hypermethylati-on of human DNA Epigenomics (2015) (DOI 102217epi1578)

Koch M Ferreiros N Geisslinger G Dehghani F Korf HW Rhythmic control of endocannabi-noids in the rat pineal gland Chronobiol Int 32 (2015) No 6 869-74(DOI 031090742052820151041596)

Kohm M Behrens F Pharmacotherapy of psoriatic arth-ritis Treatment recommendations against the background of limited evidence

Loers G Saini V Mishra B Gul S Chaudhury S Wallqvist A Kaur G Schachner M Vinorelbine and epirubicin share common features with polysialic acid and modulate neuronal and glial functionsJ Neurochem 2016 Jan136(1)48-62(DOI 101111jnc13383)

Lopez-Cabana ZE Valdes O Vergara CE Camarada MB Nachtigall FMGonzalez-Nilo FD Santos LSPhotophysical studies of the interac-tions of poly(amidoamine) genera-tion zero (PAMAM G0) with copperand zinc ionsJournal of Luminescence 16 (2015)(DOI 101016jjlumin201503019)

Lotsch J Daiker H Hahner A Ultsch A Hummel T Drug-target based cross-sectional analysis of olfactory drug effects European Journal of Clinical Pharmaco-logy 71 (2015a) No 4 461-71(DOI 101007s00228-015-1814-2)

Lotsch J Dimova V Hermens H Zim-mermann M Geisslinger G Oertel BG Ultsch APattern of neuropathic pain inducedby topical capsaicin application inhealthy subjectsPain 156 (2015b) No 3 405-14(DOI 10109701jpain000046032810515c9)

Lotsch J Dimova V Lieb I Zimmer-mann M Oertel BGUltsch A Multimodal distribution of human cold pain thresholds PLoS One 10 (2015c) No 5 e0125822(DOI 101371journalpone0125822)

Lotsch J Dimova VOertel BG Reply to raquoCan topical capsaicin in-duce a neuropathic painlaquo Pain 156 (2015d) No 7 1369-70(DOI 101097jpain0000000000000184)

Z Rheumatol 74 (2015) No 5 398-405(DOI 101007s00393-014-1530-9)

Kohm M Burkhardt H Behrens F Anti-TNFalpha-therapy as an evi-dence-based treatment option for different clinical manifestations of psoriatic arthritis Clinical and Experimental Rheumatology 33 (2015) No 5 Suppl 93 S109-14

Kringel DLotsch J Pain research funding by the European Union Seventh Framework Programme European Journal of Pain 19 (2015) No 5 595-600 (DOI 101002ejp690)

Kronenberger T Keminer O Wrenger C Windshuumlgel BNuclear receptor modulators ndash current approaches and future perspectivesVallisuta amp Olimat (ed) raquoDrug Discovery and Development - From Molecules to Medicinelaquo Chapter 5 InTech Croatia (2015) ISBN 978-953-51-2128-2

Kuhn J Muumlller H Salzig D Czermak PA rapid method for an offline gly-cerol determination during microbial fermentationElectronic Journal of Biotechnology EJB 18 (2015) No 3 252-255(DOI 101016jejbt201501005)

Laibach N Hillebrand A Twyman RM Pruumlfer D Schulze Gronover CIdentification of a Taraxacum bre-vicorniculatum rubber elongationfactor protein that is localized onrubber particles and promotes rub-ber biosynthesisThe Plant Journal 82 (2015) No 4609-620(DOI 101111tpj12836)

Labra A Arredondo-Zelada O Flores-Herrera P Marshall HS Goacutemez AF

Lotsch J Dimova V Ultsch A Lieb I Zimmermann M Geisslinger G Oertel BG A small yet comprehensive subset of human experimental pain models emerging from correlation analysis with a clinical quantitative sensory testing protocol in healthy subjects European Journal of Pain (2015e)(DOI 101002ejp803)

Lotsch J Hummel T Cannabinoid-related olfactory neu-roscience in mice and humans Chem Senses 40 (2015) No 1 3-5(DOI 101093chemsebju054)

Lotsch J Knothe C Lippmann C Ultsch A Hummel TWalter C Olfactory drug effects approached from human-derived data Drug Discov Today 20 (2015f) No 11 1398-406 (DOI 101016jdrudis201506012)

Lotsch J Niederberger EUltsch A Computational functional geno-mics based analysis of pain-relevant micro-RNAs Human Genetics 134 (2015g) No 11-12 1221-38 (DOI 101007s00439-015-1600-3)

Lotsch J Reither N Bogdanov V Hahner A Ultsch A Hill KHummel T A brain-lesion pattern based algo-rithm for the diagnosis of posttrau-matic olfactory loss Rhinology 53 (2015) No 4 365-70(DOI 104193Rhin15010)

Lotsch JUltsch A A computational functional geno-mics based self-limiting self-concen-tration mechanism of cell specializa-tion as a biological role of jumping genes Integr Biol (Camb) (2015) (DOI 101039c5ib00203f)

PUBLICATIONS MB Molecular Biology

14 15

Lu R Bausch AE Kallenborn-Ger-hardt W Stoetzer C Debruin N Ruth P Geisslinger G Leffler A Lukowski R Schmidtko A Slack channels expressed in sensory neurons control neuropathic pain in mice J Neurosci 35 (2015) No 3 1125-35(DOI 101523JNEUROSCI2423-142015)

M - OMadeira LM Szeto TH Henquet M Raven N Runions J Huddleston J Garrard I Drake PMW Ma JK-CHigh-yield production of a human monoclonal IgG by rhizosecretion in hydroponic tobacco culturesPlant Biotechnology Journal (2015) Online First (DOI 101111pbi12407)

Major D Chichester JA Pathirana RD Guilfoyle K Shoji Y GuzmanCA Yusibov V Cox RJIntranasal vaccination with a plant-derived H5 HA vaccine protects miceand ferrets against highly pathoge-nic avian influenza virus challengeHuman Vaccines amp Immunotherapeutics11 (2015) No 5 1235-1243(DOI 104161216455152014988554)

Maacuterquez-Miranda V Camarada MB Araya-Duraacuten I Varas-Concha I Almo-nacid DE Gonzaacutelez-Nilo FDBiomimetics from bioinformatics to rational design of dendrimers as gene carriers PLoS One 18 (2015)(DOI101371journalpone0138392)

Martinez M Poirrier P Chamy R Pruuml-fer D Schulze-Gronover C Jorquera L Ruiz G Taraxacum officinale and related species - An ethnopharmacological review and its potential as a com-

studies synthesis of pyrrolo[21-a]isoquinolines and indolizino[87-b]indolesRSC Advances 6 (2016) (DOI 101039C5RA24629F)

Niederberger E King TS Russe OQ Geisslinger G Activation of AMPK and its impact on exercise capacity Sports Med 45 (2015a) No 11 1497-509 (DOI 101007s40279-015-0366-z)

Niederberger E Kuner R Geisslinger G Pharmacological aspects of pain research in Germany Schmerz 29 (2015b) No 5 531-8(DOI 101007s00482-015-0042-0)

Niesen J Brehm H Stein C Berges N Pardo A Fischer R Ten Haaf A Gattenlohner S Tur MK Barth SIn vitro effects and ex vivo binding of an EGFR-specific immunotoxin on rhabdomyosarcoma cellsJ Cancer Res Clin Oncol (2015)(DOI 101007s00432-014-1884-z)

Niesen J Stein C Brehm H Heh-mann-Titt G Fendel R Melmer G Fischer R Barth SNovel EGFR-specific immunotoxins based on panitumumab and cetuxi-mab show in vitro and ex vivo activi-ty against different tumor entitiesJournal of Cancer Research and Clinical Oncology 141 (2015) No 12 2079-2095 (DOI 101007s00432-015-1975-5)

Nollmann FI Heinrich AK Brachmann AO Morisseau C Mukherjee K Ca-sanova-Torres AM Strobl F Kleinhans D Kinski S Schultz K Beeton ML Kaiser M Chu YY Ke LP Thanwisai A Bozhuumlyuumlk KAJ Chantratita N Goumltz F Waterfield NR Vilcinskas A Stelzer EHK Goodrich-Blair H Ham-mock BD Bode HBA Photorhabdus natural product

mercial medicinal plantJ Ethnopharmacol (2015) Jul 1 169244-62(DOI101016jjep201503067)

Maskus DJ Bethke S Seidel M Kapelski S Addai-Mensah O Boes A Edgu G Spiegel H Reimann A Fischer R Barth S Klockenbring T Fendel RIsolation production and characte-rization of fully human monoclonal antibodies directed to Plasmodium falciparum MSP10Malaria Journal 14 (2015)(DOI 101186s12936-015-0797-x)

Mayer CA De Bazo AM Foerch C Eberle M Ebel P Barthelmes J Tafferner N Ferreiros N Ulshofer T Henke M Grosch S Geisslinger G Willecke K Schiffmann S Ceramide synthase6 C16-ceramides mediate anti-inflammatory effects during the development of EAE and MS possibly by suppressing the migration and by deactivation of neutrophils a new target for anti-in-flammatory therapy in MS Multiple Sclerosis Journal 21 (2015a) 235-235

Mayer CA Tafferner N Barthelmes J Eberle M Ferreiros N Ulshofer T Henke M De Bruin N Geisslinger G Foerch C Parnham MJ Schiffmann S Different pathophysiological relevan-ce of branched fatty acid metabolism in mice and men alpha-methylacyl-CoA racemase regulates the T cell response only in experimental autoimmune encephalomyelitis but not in multiple sclerosis Multiple Sclerosis Journal 21 (2015b) 149-150

Mladenov R Hristodorov D Cremer C Hein L Kreutzer F Stroisch T Nie-sen J Brehm H Blume T Brummen-dorf T Jost E Thepen T Fischer R

inhibits insect juvenile hormone epoxide hydrolaseChemBioChem 16 (2015) No 5 766-771 (DOI 101002cbic201402650)

Oertel BG Huynh TT Hummel TLotsch J Lack of fluconazole effects on hu-man chemosensation Int J Clin Pharmacol Ther 53 (2015) No 1 13-20 (DOI 105414CP202193)

Olesch C Sha W Angioni C Sha LK Acaf E Patrignani P JakobssonPJ Radeke HH Grosch S Geisslin-ger G Von Knethen A Weigert ABrune BMPGES-1-derived PGE2 suppressesCD80 expression on tumor-associatedphagocytes to inhibit anti-tumorimmune responses in breast cancerOncotarget 6 (2015) No 12 10284-96(DOI 1018632oncotarget3581)

Ortega-Berlanga B Patintildeo-Rodriacuteguez O Shoji Y Musiychuk K Chichester JA Yusibov V Noyola-Cherpitel DEAlpuche-Soliacutes AProduction in plants of an antiviralpeptide (RhoA) against respiratorysyncytial virus infectionsPlanta Epub Ahead of Print 2015 Oct 16

Ortiz-Espin A Locato V Camejo D Schiermeyer A De Gara L Sevilla F Jimenez AOver-expression of Trxo1 increases the viability of TBY-2 cells under H2O2 treatmentAnnals of Botany 116 (2015) No 4 571-582 (Doi 101093aobmcv076)

P - RPalais C Chichester JA Manceva S

Stockmeyer B Barth S Stein CThe Fc-alpha receptor is a new target antigen for immunotherapy of mye-loid leukemiaInt J Cancer (2015) 137(11)2729-38(DOI 101002ijc29628)

Moser CV Stephan H Altenrath K Kynast KL Russe OQ Olbrich K Geisslinger G Niederberger E TANK-binding kinase 1 (TBK1) modu-lates inflammatory hyperalgesia by regulating MAP kinases and NF-kap-paB dependent genes J Neuroinflammation 12 (2015) 100(DOI 101186s12974-015-0319-3)

Muumlller H Salzig D Czermak PConsiderations for the process development of insect-derived anti-microbial peptide productionBiotechnology Progress 31 (2015) No 1 1-11 (DOI 101002btpr2002)

Mukherjee K Twyman RM Vilcinskas AInsects as models to study the epige-netic basis of diseaseProgress in Biophysics and Molecular Biology 118 (2015) No 1-2 69-78(DOI 101016jpbiomolbio201502009)

Namgaladze D Snodgrass RG Angioni C Grossmann N Dehne N Geisslinger G Brune B AMP-activated protein kinase sup-presses arachidonate 15-lipoxygena-se expression in interleukin 4-polari-zed human macrophages J Biol Chem 290 (2015) No 40 24484-94 (DOI 101074jbcM115678243)

Nekkanti S Kumar N-P Sharma P Kamal A Nachtigall MF Forero-Doria O Santos SL Shankaraiah NTBAITBHP-catalyzed [3 + 2]cycload-ditionoxidationaromatization casca-de and online ESI-MS mechanistic

Yusibov V Arvinte T Influence of protein formulation and carrier solution on asymmetrical flow field-flow fractionation a case study of the plant-produced recombinant anthrax protective antigen pp-PA83 Journal of Pharmaceutical Science 104 (2015) No 2 612-617 (DOI 101002jps24280)

Pavlov MS Lira F Martiacutenez JL Olivares J Marshall SH Draft genome sequence of Antarctic Pseudomonas sp strain KG01 with full potential for biotechnological applications Genome Announcement 4 (2015)(DOI101128genomeA00906-15)

Peschen D Schillberg S Fischer RAntibody-mediated pathogen re-sistance in plants Methods in Molecular Biology (2016) No 1385 273-291 (Doi 101007978-1-4939-3289-4_19)

Poumlppel A-K Vogel H Wiesner J Vilcinskas AAntimicrobial peptides expressed in medicinal maggots of the blow fly Lucilia sericata show combinatorial activity against bacteriaAntimicrobial Agents and Chemotherapy 59 (2015) No 5 2508-2514(DOI 101128AAC05180-14)

Popovic M Prodanovic R Ostafe R Schillberg S Fischer R Gavrovic-Jan-kulovic MYeast surface display is a novel tool for the rapid immunological cha-racterization of plant-derived food allergensImmunologic Research 61 (2015) No 3 230-239(DOI 101007s12026-014-8614-0)

Prokhnevsky A Mamedov T Leffet B Rahimova R Ghosh A Mett V Yusibov V

16 17

PUBLICATIONS MB Molecular Biology

Development of a single-replicon miniBYV vector for co-expression of heterologous proteins Molecular Biotechnology 57 (2015) No 2 101-110 (DOI 101007s12033-014-9806-5)

Rahnamaeian M Cytrynska M Zdy-bicka-Barabas A Dobslaff K Wiesner J Twyman RM Zuchner T Sadd B Regoes RR Schmid-Hempel P Vilcinskas AInsect antimicrobial peptides show potentiating functional interactions against Gram-negative bacteriaProceedings of the Royal Society of London Series B Biological sciences 282 (2015) No 1806 Art 20150293 10 S(DOI 101098rspb20150293)

Rahnamaeian M Vilcinskas AShort antimicrobial peptides as cos-metic ingredients to deter dermato-logical pathogensApplied Microbiology and Biotechnology 99 (2015) No 21 8847-8855 (DOI 101007s00253-015-6926-1)

Schneider K Schiermeyer A Dolls A Koch N Herwartz D Kirchhoff J Fischer R Russell SM Cao Z Corbin DR Sastry-Dent L Ainley WMWebb SR Schinkel H Schillberg STargeted gene exchange in plantcells mediated by a zinc finger nuc-lease double cutPlant Biotechnology Journal (2015)Online First(DOI101111pbi12483)

Schott M Klein B Vilcinskas ADetection of illicit drugs by trained honeybees (Apis mellifera)PLoS One Online journal 10 (2015) No 6 e0128528 (DOI 101371journalpone0128528)

Schubert M Houdelet M Kogel K-H Fischer R Schillberg S Noumllke GThanatin confers partial resistance against aflatoxigenic fungi in maize (Zea mays)Transgenic Research 24 (2015) No 5 885-895(DOI 101007s11248-015-9888-2)

Seid CA Curti E Jones M Hudspeth E Rezende W Pollet J Center L Versteeg L Pritchard S Musiychuk K Yusibov V Hotez PJ Bottazzi ME Expression purification and charac-terization of the Necator americanus aspartic protease-1 (Na-APR-1 (M74)) antigen a component of the biva-lent human hookworm vaccine Human Vaccines amp Immunotherapeutics 11 (2015) No 6 1474-1488(DOI 010802164551520151036207)

Sha LK Sha W Kuchler L Daiber A Giegerich AK Weigert A Knape T Snodgrass R Schroder K Brandes RP Brune BVon Knethen ALoss of Nrf2 in bone marrow-derivedmacrophages impairs antigen-drivenCD8(+) T cell function by limitingGSH and Cys availability

Rajamuthiah R Jayamani E Conery A L Fuchs B B Kim W Johnston TVilcinskas A Ausubel F M Mylonakis EA defensin from the model beetleTribolium castaneum acts synergisti-cally with telavancin and daptomycinagainst multidrug resistant Staphylo-coccus aureusPloS One 10 (2015) No 6 e0128576(DOI 101371journalpone0128576)

Ratjen L Vantomme G Lehn JMStrain-induced reactivity in the dyna-mic covalent chemistry of macrocyclic Imines Chemistry-A European Journal 21 (2015) (DOI 101002chem201501192)

Raven N Rasche S Kuehn C Anderlei T Kloumlckner W Schuster F Henquet M Bosch D Buumlchs J Fischer R Schillberg SScaled-up manufacturing of recom-binant antibodies produced by plant cells in a 200-L orbitally-shaken disposable bioreactorBiotechnology amp Bioengineering 112 (2015) No 2 308-321

Free Radic Biol Med 83 (2015) 77-88 (DOI 101016jfreeradbiomed201502004)

Sisignano M Parnham MJ Geisslin-ger G Drug repurposing for the develop-ment of novel analgesics Trends Pharmacol Sci (2015)(DOI 101016jtips201511006)

Smolen JS Emery P Ferraccioli GF Samborski W Berenbaum F Davies OR Koetse W Purcaru O BennettB Burkhardt HCertolizumab pegol in rheumatoidarthritis patients with low to mode-rate activity the CERTAIN doub-le-blind randomised placebo-cont-rolled trialAnnals of the Rheumatic Diseases 74(2015) No 5 843-50(DOI 101136annrheumdis-2013-204632)

Spiegel H Boes A Kastilan R Kapel-ski S Edgue G Beiss V Chubodova I Scheuermayer M Pradel G Schill-berg S Reimann A Fischer RThe stage-specific in vitro effi-cacy of a malaria antigen cocktail provides valuable insights into the development of effective multi-stage vaccinesBiotechnology Journal 10 (2015) No 10 1651-1659 (DOI 101002biot201500055)

Spiegel H Boes A Voepel N Beiss V Edgue G Rademacher T Sack M Schillberg S Reimann A Fischer RApplication of a scalable plant tran-sient gene expression platform for malaria vaccine developmentFrontiers in Plant Science (2015)(DOI 103389fpls201501169)

Shoji Y Prokhnevsky A Leffet B Vetter N Tottey S Satinover S Mu-siychuk K Shamloul M Norikane J Jones RM Chichester JA Green BJ

(DOI 101002bit25352)

Raven N Schillberg S Rasche SPlant cell-based recombinant anti-body manufacturing with a 200 L or-bitally shaken disposable bioreactor Methods in Molecular Biology (2016)No 1385 161-172 (DOI 101007978-1-4939-3289-4_12)

Rees S Gribbon P Birmingham K Janzen WP Pairaudeau GTowards a hit for every targetNature Reviews Drug Discovery aop (2015) (DOI 101038nrd201519)

Rettcher S Jungk F Kuumlhn C Krause HJ Noumllke G Commandeur UFischer R Schillberg S Schroumlper FSimple and portable magneticimmunoassay for rapid detectionand sensitive quantification ofplant virusesApplied and Environmental Microbiology81 (2015) No 9 3039-3048(DOI 101128AEM03667-14)

S - USack M Hofbauer A Fischer R Stoger EThe increasing value of plant-made proteinsCurrent Opinion in Biotechnology 32 (2015) 163-170 (DOI 101016jcopbio201412008)

Sack M Rademacher T Spiegel H Boes A Hellwig S Drossard J Sto-ger E Fischer RFrom gene to harvest insights into upstream process development for the GMP production of a monoclo-nal antibody in transgenic tobacco plantsPlant Biotechnology Journal 13(8) (2015) 1094-1105 (DOI 101111pbi12438)

Streatfield SJ Yusibov VImmunogenicity of H1N1 influenza virus-like particles produced in Nico-tiana benthamiana Human Vaccines amp Immunotherapeutics 11 (2015) No 1 118-123(DOI 104161hv34365)

Spiegel H Schinkel H Kastilan R Dahm P Boes A Scheuermayer M Chudobovaacute I Maskus D Fendel R Schillberg S Reimann A Fischer ROptimization of a multi-stage mul-ti-subunit malaria vaccine candidate for the production in Pichia pastoris by the identification and removal of protease cleavage sites Biotechnology amp Bioengineering (2015) No 112 659-667 (DOI 101002bit25481)

Spohner SC Muumlller H Quitmann H Czermak PExpression of enzymes for the usage in food and feed industry with Pichia pastorisJournal of Biotechnology 202 (2015) 118-134(DOI 101016jjbiotec201501027)

Spohner S C Zahn D Schaum V Quitmann H Czermak PRecombinant α-L-Rhamnosidase from Aspergillus terreus in selective trimming of α-L-Rhamnose from steviol glycosidesJournal of Molecular Catalysis B Ency-matic 122 (2015) 12 248-254(DOI101016jmolcatb201509009)

Streatfield SJ Kushnir N Yusibov V Plant-produced candidate coun-termeasures against emerging and reemerging infections and bioterror agents Plant Biotechnology Journal 13 (2015) No 8 1136-1159 (DOI 101111pbi12475)

18 19

PUBLICATIONS MB Molecular Biology

Su J Zhu L Sherman A Wang X Lin S Kamesh A Norikane JH Stre-atfield SJ Herzog RW Daniell H Low cost industrial production of coagulation factor IX bioencapsula-ted in lettuce cells for oral tolerance induction in hemophilia B Biomaterials 70 (2015) 84-93 (DOI 101016jbiomaterials201508004)

Syhr KM Boosen M Hohmann SW Longen S Kohler Y Pfeilschifter J Beck KF Geisslinger G Schmidtko A Kallenborn-Gerhardt W The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain Brain Res 1624 (2015a) 380-9(DOI 101016jbrainres201507058)

Syhr KM Oertel BG Geisslinger G Drug interactions in pain therapy Schmerz 29 (2015b) No 6 595-603(DOI 101007s00482-015-0017-1)

Tafferner N Barthelmes J Eberle M Ulshofer T Henke M Debruin N Mayer CA Foerch C Geisslinger G Parnham MJ Schiffmann S Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses associated with unchanged course of EAE Eur J Immunol (2015) (DOI 101002eji201545782)

Tafferner N Mannich J Eberle M Ferreiros N Debruin N Geisslinger G Parnham MJ Schiffmann S Role of alpha-metylacyl-CoA racemase in immune cells during the development of experimental autoimmune encephalomyelitis Journal of Neuroimmunology 275 (2014) No 1-2 121-122 (DOI 101016jjneuroim201408324)

Tapia-Venegas E Cabrol L Brandhoff B Hamelin J Trably E Steyer JP Ruiz-Filippi G

Von Knethen A Sha LK Knape T Kuchler L Giegerich AK Schulz M Hauser IA Brune B Activation of the peroxisome proli-ferator-activated receptor gamma counteracts sepsis-induced T cell cytotoxicity toward alloantigenic target cells J Mol Med (Berl) 93 (2015) No 6 633-44 (DOI 101007s00109-014-1249-8)

Walter C Dimova V Bu J Parnham MJ Oertel BG Lotsch JInverted perceptual judgment ofnociceptive stimuli at threshold levelfollowing inconsistent cuesPLoS One 10 (2015a) No 7 e0132069(DOI 101371journalpone0132069)

Walter C Knothe C Lotsch J Abuse-deterrent opioid formula-tions pharmacokinetic and pharma-codynamic considerations Clin Pharmacokinet (2015b)(DOI 101007s40262-015-0362-3)

Walter C Oertel BG Felden L Kell CA Noth U Vermehren J Kaiser JDeichmann R Lotsch JBrain mapping-based model ofdelta-tetrahydrocannabinol effectson connectivity in the pain matrixNeuropsychopharmacology (2015c)(DOI 101038npp2015336)

Walter C Oertel BG Lotsch J THC may reproducibly induce electrical hyperalgesia in healthy volunteers European Journal of Pain 19 (2015d) No 4 516-8(DOI 101002ejp575)

Weiss K Gerstenberger J Salzig D Muumlhlebach M Cichutek K Poumlrtner R Czermak POncolytic measles viruses produced at different scales under serum-free conditionsEngineering in Life Sciences 15 (2015)

Adaptation of acidogenic sludge to increasing glycerol concentrations for biohydrogen productionApplied Microbiology and Biotechnology 19 (2015) (DOI 101007s00253-015-6832-6)

Thaci D Behrens F Greger G Burk-hardt H Gnann H Schopf RWittig BMAssociation between skin and jointinvolvement in patients with psori-atic arthritis treated with adalimu-mab analysis of data from a Germannon-interventional studyDermatology 230 (2015) No 3 213-21(DOI 101159000371546)

Thomas D Herold N Keppler OT Geisslinger G Ferreiros N Quantitation of endogenous nucleo-side triphosphates and nucleosides in human cells by liquid chromatogra-phy tandem mass spectrometry Anal Bioanal Chem 407 (2015) No 13 3693-704 (DOI 101007s00216-015-8588-3)

Tonk M Cabezas-Cruz A Valdes J J Rego R O M Grubhoffer L Estra-da-Pena A Vilcinskas A Kotsyfakis M Rahnamaeian MIxodes ricinus defensins attack dis-tantly-related pathogensDevelopmental and Comparative Immu-nology 53 (2015) No 2 358-365(DOI 101016jdci201508001)

Tonk M Knorr E Cabezas-Cruz A Valdes J J Kollewe C Vilcinskas ATribolium castaneum defensins are primarily active against gram-positi-ve bacteriaJournal of Invertebrate Pathology 132 (2015) 208-215(DOI 101016jjip201510009)

Ultsch A Lotsch J Computed ABC analysis for rational selection of most informative variab-

les in multivariate data PLoS One 10 (2015) No 6 e0129767(DOI 101371journalpone0129767)

Ultsch A Thrun MC Hansen-Goos OLotsch J Identification of molecular finger-prints in human heat pain thresholds by use of an interactive mixture model R Toolbox (AdaptGauss) Int J Mol Sci 16 (2015) No 10 25897-911(DOI 103390ijms161025897)

V - ZVasilev N Smales C M Fischer R Schillberg S Schiermeyer AMucosal antibodies produced in plantsBiotechnology Advances Epub aheadof print (DOI 101016jbiotechadv201511002)

Vilcinskas APathogens as biological weapons of invasive speciesPLoS Pathogens 11 (2015) No 4 Art e1004714 5 S (DOI 101371journalppat1004714)

Vilcinskas A Schmidtberg H Estoup A Tayeh A Facon B Vogel HEvolutionary ecology of microspori-dia associated with the invasive ladybird Harmonia axyridisInsect Science 22 (2015) No 3 313-324 (DOI 1011111744-791712159)

Villa Nova M Janas C Schmidt M Ulshoefer T Grafe S Schiffmann S De Bruin N Wiehe A Albrecht V Parnham MJ Luciano Bruschi M Wacker MG Nanocarriers for photodynamic the-rapy-rational formulation design and medium-scale manufacture Int J Pharm 491 (2015) No 1-2 250-60(DOI 101016jijpharm201506024)

4 425-436 (DOI 101002elsc201400165)

Weth D Benetti C Rauch C Gs-traunthaler G Schmidt H Geisslinger G Sabbadini R Proia RL Kress M Activated platelets release sphingosi-ne 1-phosphate and induce hyper-sensitivity to noxious heat stimuli in vivo Front Neurosci 9 (2015) 140(DOI 103389fnins201500140)

Will T Vilcinskas AThe structural sheath protein of aphids is required for phloem feedingInsect Biochemistry and Molecular Biolo-gy 57 (2015) 34-40 (DOI 101016jibmb201412005)

Wu Y Sinden RE Churcher TS Tsuboi T Yusibov V Development of malaria transmissi-on-blocking vaccines from concept to product Advances in Parasitology 89 (2015) 109-152 (DOI 101016bsapar201504001)

Yusibov V Kushnir N Streatfield SJ Advances and challenges in the de-velopment and production of effecti-ve plant-based influenza vaccines Expert Review of Vaccines 14 (2015) No 4 519-535 (DOI 101586147605842015989988)

Zeller T Haase T Muumlller C Riess H Lau D Zeller S Krause J Baumert J Pless O Dupuis J Wild PS Elefthe-riadis M Waldenberger M Zeilinger S Ziegler A Peters A Tiret L Proust C Marzi C Munzel T Strauch K Prokisch H Lackner KJ Herder C Thorand B Benjamin EJ Blanken-berg S Koenig W Schnabel RBMolecular characterization of the NLRC4 expression in relation to interleukin-18 levelsCirc Cardiovasc Genet 2015 Oct 8(5)717-26 Epub 2015 Sep 11 (DOI 101161CIRCGENETICS115001079)

Zhang DD Linke B Suo J Zivkovic A Schreiber Y Ferreiros N Henke M Geisslinger G Stark H Scholich K Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors Biological Chemistry 396 (2015) No 6-7 783-94 (DOI 101515hsz-2014-0276)

Zischewski J Sack M Fischer ROvercoming low yields of plant-ma-de antibodies by a protein enginee-ring approachBiotechnology Journal (2015)(DOI 101002biot201500255)

20 21

PUBLICATIONS AE Applied Ecology

A - CBarieacute N Buumlcking M Stahl U Rapp MDetection of coffee flavour ageing by solid-phase microextractionsurface acoustic wave sensor array technique (SPMESAW) Food Chemistry 176 (2015) 212ndash218 (DOI 101016jfoodchem201412032)

Bischof I Segner H Schlechtriem CIn-vitro-Biotransformationstests zur Vorhersage der Bioakkumulation von Chemikalien in Fisch Mitteilungen der Fachgruppe Umwelt-chemie und Oumlkotoxikologie der Gesell-schaft Deutscher Chemiker [online] 21 (2015) No 2 46-48 Available from httpswwwgdchdenetzwerk-strukturenfachstrukturenumweltchemie-und-oekotoxikologiemitgliederzeitschriftenmitteilungsblattarchiv2015html

Bos P M J Gottardo S Scott-Fordsmand J J van Tongeren M Semenzin E Fernandes T F Hristozov D Hund-Rinke K Hunt N Irfan M-A Landsiedel R Peijnenburg W J G M Saacutenchez Jimeacutenez A van Kesteren P C E Oomen A GThe MARINA risk assessment stra-tegy A flexible strategy for efficient information collection and risk assessment of nanomaterials International Journal of Environmental Research and Public Health 12 (2015) 15007ndash15021 (DOI 103390ijerph121214961)

Brock T C M Hammers-Wirtz M Hommen U Preuss T G Ratte H-T Roessink I Strauss T Brink P J van denThe minimum detectable difference (MDD) and the interpretation oftreatment-related effects of pesticidesin experimental ecosystemsEnvironmental Science and PollutionResearch International ESPR 22 (2015)No 2 1160ndash1174(DOI 101007s11356-014-3398-2)

nt_of_a_test_protocol_to_study_the_transformationpdf

Hommen U Forbes V Grimm V Preuss T G Thorbek P Ducrot VHow to use mechanistic effect mod-els in environmental risk assessment of pesticides Case studies and recommendations from the SETAC workshop MODELINK Integrated Environmental Assessment and Management 12 (2016) No 1 21ndash31 [online first 2015] (DOI 101002ieam1704)

Hommen U Schmitt W Heine S Brock T C M Duquesne S Manson P Meregalli G Ochoa-Acuntildea H van Vliet P Arts GHow TK-TD and population mod-els for aquatic macrophytes could support the risk assessment for plant protection products Integrated Environmental Assessment and Management 12 (2016) No 1 82-95[online first 2015] (DOI 101002ieam1715)

Huumlben M Leng Z Oeser M Wang D Steinauer BHerstellung und Laboruntersuchun-gen von TiO2-haltigem Abstreuma-

D - FEFSA Panel on Plant Protection Products and their Residues (panel members at the time of adoption Aagaard A Brock T Capri E Du-quesne S Filipic M Hernandez-Jerez A-F Hirsch-Ernst K I Hougaard Ben-nekou S Klein M Kuhl T Laskowski R Liess M Mantovani A Ockleford C Ossendorp B Pickford D Smith R Sousa P Sundh I Tiktak A van der Linden T)Scientific opinion addressing the state of the science on risk assess-ment of plant protection products for non-target arthropods EFSA Journal (2015) 13 (2) 3996 [212 pp](DOI 102903jefsa20153996)

EFSA Panel on Plant Protection Products and their Residues (panel members at the time of adoption Aagaard A Brock T Capri E Du-quesne S Filipic M Hernandez-Jerez A-F Hirsch-Ernst K I Hougaard Ben-nekou S Klein M Kuhl T Laskowski R Liess M Mantovani A Ockleford C Ossendorp B Pickford D Smith R Sousa P Sundh I Tiktak A van der Linden T) Statement on the suitability of the BEEHAVE model for its potential use in a regulatory context and for the risk assessment of multiple stressors in honeybees at the landscape level EFSA Journal (2015) 13 (6) 4125 [91 pp](DOI 102903jefsa20154125)

EFSA Panel on Plant Protection Products and their Residues (panel members at the time of adoption Aagaard A Brock T Capri E Du-quesne S Filipic M Hernandez-Jerez A-F Hirsch-Ernst K I Hougaard Ben-nekou S Klein M Kuhl T Laskowski R Liess M Mantovani A Ockleford C Ossendorp B Smith R Sousa P

terial zum Stickstoffdioxidabbau Bauingenieur 90 (2015) No 3140ndash146 Available from httpwwwbauingenieurdebauingarticlephpdata[article_id]=83027

Hund-Rinke K Herrchen M Schlich K Schwirn K Voumllker DTest strategy for assessing the risks of nanomaterials in the environ-ment considering general regulatory procedures Environmental Sciences Europe ESEU [online] (2015) 2724 (DOI 101186s12302-015-0053-6)

J - LKlein J Klein M Schlechtriem CDietary burden calculation for aqua-culture diets A linear programming approach 127 VDLUFA-Kongress Boumlden ndashLebensgrundlage fuumlr Pflanze und TierVDLUFA-Schriftenreihe 712015VDLUFA-Verlag Darmstadt pp 667-672 ISBN 978-3-941273-20-7

Koschorreck J Heiss C Wellmitz J Fliedner A Ruedel H

Sundh I Tiktak A van der Linden T) Statement on the FERA guidance proposal rdquoGuidance on how aged sorption studies for pesticides should be conducted analysed and used in regulatory assessmentsrdquo EFSA Journal (2015) 13 (7) 4175 [54 pp] (DOI 102903jefsa20154175)

Fenske M Muth-Koumlhne E Delov V Sonnack L Kampe S Schaumlfers CDetection and validation of molecu-lar biomarkers for neurotoxicity in fish embryos Neurotoxicology and Teratology 49 (2015) 110 (DOI 101016jntt201504037)

G - IGergs A Classen S Strauss T Otter-manns R Brock T C M Ratte H T Hommen U Preuss T GEcological recovery potential of freshwater organisms Consequences for environmental risk assessment of chemicals P de Voogt ed Reviews of Environ-mental Contamination and Toxicology 236 (2016) 259-294 [online first 2015] Springer International PublishingSwitzerland (DOI 101007978-3-319-20013-2_5)

Hennecke D Atorf C Bickert C Herrchen M Hommen U Klein M Weinfurtner K H Heusner E Knacker T Junker T Roumlmbke J Merrettig-Bruns UDevelopment of a test protocol to study the transformation of veteri-nary pharmaceuticals and biocides in liquid manure Texte 782015 Umweltbundesamt Dessau (ed) 142 pp ISSN 1862-4804 Available from httpswwwumweltbundesamtdesitesdefaultfilesmedien378publikationentexte_78_2015_developme

The use of monitoring data in EU chemicals management ndash experiences and considerations from the German Environmental Specimen Bank Environmental Science and Pollution Research International ESPR 22 (2015) No 3 1597ndash1611 (DOI 101007s11356-014-2897-5)

Kotthoff MGeruch und Ernaumlhrung Tl1 Die Grundlagen des Riechens Ernaumlhrungs-Umschau 62 (2015) No 5 82ndash91 (DOI 104455eu2015014)

Kotthoff M Muumlller J Juumlrling H Schlummer M Fiedler DPerfluoroalkyl and polyfluoroalkyl substances in consumer products Environmental Science and Pollution Research International ESPR [online] (2015) 22 14546ndash14559 (DOI 101007s11356-015-4202-7)

M - ONguetseng R Fliedner A Knopf B Lebreton B Quack M Ruumldel HRetrospective monitoring of mercury in fish from selected European fresh-water and estuary sitesChemosphere 134 (2015) 427ndash434 (DOI 101016jchemosphere201504094)

Oomen A G Bleeker E A J Bos P M J Broekhuizen F van GottardoS Groenewold M Hristozov DHund-Rinke K Irfan M-A MarcominiA Peijnenburg W J G M Rasmus-sen K Saacutenchez Jimeacutenez A Scott-Fordsmand J J Tongeren M vanWiench K Wohlleben W Landsiedel RGrouping and read-across approachesfor risk assessment of nanomaterialsInternational Journal of EnvironmentalResearch and Public Health 12 (2015)

22 23

PUBLICATIONS AE Applied Ecology

No 10 13415-13434 (DOI 103390ijerph121013415)

P - RPachernegg S Muumlnster Y Muth-Koumlh-ne E Fuhrmann G Hollmann MGluA2 is rapidly edited at the QR site during neural differentiation in vitro Frontiers in Cellular Neuroscience [online] 9 (2015) Art 69 [14 pp] (DOI 103389fncel201500069)

Paulus M Teubner D Ruumldel H Klein RBioaccumulation and long-term monitoring in freshwater ecosystems ndash knowledge gained from 20 years ofzebra mussel analysis by the GermanEnvironmental Specimen BankIn RH Armon O Haumlnninnen (eds)Environmental Indicators Springer Sci-ence+Business Media Dordrecht (2015)781ndash803 ISBN 978-94-017-9498-5(DOI 101007978-94-017-9499-2_44)

Petersen E J Diamond S A Kennedy A J Goss G G Ho K Lead J Han-na S K Hartmann N B Hund-RinkeK Mader B Manier N Pandard PSalinas E R Sayre PAdapting OECD aquatic toxicity testsfor use with manufactured nano-materials Key issues and consensusrecommendationsEnvironmental Science and Technology49 (2015) No 16 9532-9547(DOI 101021acsest5b00997)

Pohl P Dulio V Botta F Schwarzbau-er J Ruumldel H Environmental monitoring of bio-cides in Europe ndash compartment-specific strategies Workshop Report (June 25ndash26 2015 in Berlin) Umweltbundesamt FKZ 360 04 036 (2015) [45 pp] Available from httpwwwnorman-networknetsites

Environmental Sciences Europe ESEU [online] (2015) 271 Art 5 [10 pp] (DOI 101186s12302-014-0036-z)

Schlechtriem C Bischof I Atorf C Bergendahl E Seymour P Whalley PDevelopment of a regulatory testing procedure to study the metabolism of pesticides in farmed fish Pest Management Science 72 (2016) Issue 2 362ndash370 [online first 2015] (DOI 101002ps4007)

Schlich K Hund-Rinke KInfluence of soil properties on the effect of silver nanomaterials on microbial activity in five soils Environmental Pollution 196 (2015) 321ndash330 (DOI 101016jenvpol201410021)

Schulz F Hahn S Ruumldel H Uhlig S Hettwer K Kaltenbach H-MIntegrierte Bewertung von Quecksil-ber anhand der Erhebungen der Um-weltprobenbank des Bundes (UPB) Umweltbundesamt Projektnummer 32 842 (2015) [236 pp] Available from httpswwwumweltprobenbankdeupb_staticfckdownloadEndbericht_Integrierte_Bewertung_Hg_2015_08_10_Webpdf

Simon M Herrchen M Graf N Foumlrster B Roumlmbke JConcept development for an extend-ed plant test in the environmental risk assessment of veterinary medici-nal products Texte 152015 Umweltbundesamt Dessau (ed) 270 pp ISSN 1862-4804 Available from httpswwwumweltbundesamtdesitesdefaultfilesmedien378publikationentexte_15_2015_ebert_tierarzneimittelpdf

Sonnack L Kampe S Muth-Koumlhne E Erdinger L Henny N Hollert H Schaumlfers C Fenske MEffects of metal exposure on motor

defaultfilesfilesreportsUBA_NORMAN _biocides_monitoring_workshop_re-port_final_17112015pdf

Ruumldel H Weingaumlrtner M Klein R Deutsch A Richtlinie zur Probenahme und Pro-benbearbeitung Transport von Um-weltproben unter Cryobedingungen Umweltprobenbank des Bundes Verfahrensrichtlinien fuumlr Probenahme Transport Lagerung und chemische Charakterisierung von Umwelt- und Humanproben Maumlrz (2015) V 301 Available from httpswwwumweltprobenbankdeupb_staticfckdownloadSOP_TransportpdfGuidelines for sampling and sample processing Transporting environ-mental samples under cryogenic conditions Umweltprobenbank des Bundes Guide-lines for Sampling Transport Storage and Chemical Characterization of En-vironmental and Human Samples March (2015) V 301 Available from httpswwwumweltprobenbankdeupb_staticfckdownloadSOP_Transport_ENpdf

neuron development neuromasts and the escape response of zebrafish embryos Neurotoxicology and Teratology 50 (2015) 33ndash42 (DOI 101016jntt201505006)

Topping C J Craig P S Jong F de Klein M Laskowski R Manachini B Pieper S Smith R Sousa J P Streissl F Swarowsky K Tiktak A Linden T van derTowards a landscape scale man-agement of pesticides ERA using changes in modelled occupancy and abundance to assess long-term popu-lation impacts of pesticides Science of the Total Environment 537 (2015) 159-169 (DOI 101016jscitotenv201507152)

Treu G Drost W Joumlhncke U Rauert C Schlechtriem CThe Dessau workshop on bioaccu-mulation state of the art challenges and regulatory implications Environmental Sciences Europe ESEU [online] (2015) 2734 (DOI 101186s12302-015-0067-0)

V - ZVoelker D Schlich K Hohndorf L Koch W Kuehnen U Polleichtner C Kussatz C Hund-Rinke KApproach on environmental risk assessment of nanosilver released from textiles Environmental Research 140 (2015) 661ndash672 (DOI 101016jenvres201505011)

Wasmuth C Ruumldel H Duumlring R A Klawonn TAssessing the suitability of the OECD 29 guidance document to investigate the transformation and dissolutionof silver nanoparticles in aqueos media Chemosphere 144 (2016) 2018ndash2023

Ruumldel H Diacuteaz Muntildeiz C Garelick H Kandile N G Miller B W Pantoja Munoz L Peijnenburg W J G M Purchase D Shevah Y Sprang P van Vijver M Vink J P MConsideration of the bioavailabilityof metalmetalloid species in fresh-waters Experiences regarding the implementation of biotic ligand model-based approaches in risk assessment frameworks Environmental Science and Pollution Research International ESPR 22 (2015) No 10 7405ndash7421 (DOI 101007s11356-015-4257-5)

S - USchaumlfer S Buchmeier G Claus E Due- ster L Heininger P Koumlrner A Mayer P Paschke A Rauert C Reifferscheid G Ruumldel H Schlechtriem C Schrouml-ter-Kermani C Schudoma D Smedes F Steffen D Vietoris FBioaccumulation in aquatic systemsMethodological approaches monitor- ing and assessment

[online first 2015] (DOI 101016jchemosphere201510101)

Wenzel A Schlich K Shemotyuk L Nendza MRevision der Umweltqualitaumltsnormen der Bundes-Oberflaumlchengewaumlsserver-ordnung nach Ende der Uumlbergangs-frist fuumlr Richtlinie 200611EG und Fortschreibung der europaumlischen Umweltqualitaumltsziele fuumlr prioritaumlre Stoffe Texte 472015 Umweltbundesamt Ber-lin (ed) (2015) 182 pp Available from httpswwwumweltbundesamtdeenpublikationenrevision-der-umweltqualitaetsnormen-der-bundes)

Platform Presentations and Posters Applied Ecology 2015

httpwwwimefraunhoferdecontentdamimededocumentsAEPresenta-tions_Posters20Applied20Ecolo-gy_2015pdf

24 25

PATENTS

26 27

PATENTS

N-terminally truncated interleukin-38PCTEP2015066084

Sisignano M Brenneis C Geisslinger G Scholich K Zinn SCYP2J2 antagonists in the treatment of painPCTEP2015068767

Fendel R Kapelski S Barth S Fischer R Reimann AAnti-parasitic complexesPCTEP2015069247

Scholich K Zinn S Geisslinger G de Bruin NBLT2 antagonists for the treatment of painPCTEP2015074520

Fischer R Reimann A Maskus D Fendel R Klockenbring T Barth SAnti-plasmodium parasite antibodiesEP 15 163 2973

Kreuzaler F Noumllke G Schillberg S Barsoum M Fischer RGenetically modified higher plants with increased photosynthesis andor biomass production methods and uses thereofPCTEP2015077803

Genoveva O di Fiore S Fischer RMethod for providing stable isoindo-le derivativesUS 14944662

Edguuml G Sack M Beiss V Boes A Spiegel H Reimann A Fischer RMalaria immunoassemblins ndash combi-natorial vaccines against Plasmodium falciparumPCTEP2015076194

Noumllke G Schubert M Schillberg SNovel aflatoxin and fungal infection control methodsPCTEP2015057943

Patent applications in 2015

Blessing D Sack M Holland TFermentation systemsPCTEP2015000867

Barth S Thepen T Barral-Netto M Barral A van Weyhenberg JAn immunotoxin for use in the treat-ment of leishmaniasisEP 15 151 8768

Hristodorov D Thepen T Barth SUse of CD-64-blocking agents as enhancer of an anti-TNF-alpha anti-body therapyPCTEP2015056622

Boes A Spiegel H Edguuml G Beiss V Sack M Reimann A Fischer RThree component-multistage malaria vaccinePCTEP2015070044

Boes A Spiegel H Edguuml G Beiss V Sack M Reimann A Fischer RMulti-component-multistage malaria vaccinePCTEP2015056693

Salzig M Vilcinskas A Fischer RUse of metalloproteinase inhibitors against bacterial infectionsPCTEP2015065210

von Knethen A Parnham M Sha LRekombinantes B7-H1-Fusionsprotein als Therapiekonzept des multiplen Organversagens bei SepsisEP 15 181 8002

Knappe T von Knethen A Parnham M Schubert-Zsilavecz M Wurglics M Flesch DCompetitive PPAR-gamma antago-nistsPCTEP2015066085

Weigert A Mora J Bruumlne B Dill-mann C Parnham M Geisslinger G

Barth S Fischer R Hussain ANovel specific photoimmuno-thera-nostics for detection and elimination of skin cancer cellsPCTEP2015063422

Stein C Mladenov R Stockmeyer B Barth S Hein L Fischer RAnit-CD89 cytotoxic complexPCTEP2015056386

Nuumlsing RM Bernau M Parnham M Geisslinger G(R)-Fluriprofen for the prevention andor treatment of diabetesEP 15 193 6903

Wacker M Beyer S Parnham M Xie L Maumlntele W Vogel VComposition comprising a biocom-patible and biodegradable polymer nanocarriers and a drug and me-thods of making and using the sameEP 15 193 3827

Jennewein S Gaida S McElroy C Fischer RRecombinant cell and 14-butanediol production methodPCTJP201574979

Patents issued in 2015

Barth S Tur M K Stoumlcker M Fischer RImmunokinasesUS patent US 9045739 B2

Barth S Schmies S Kolberg K Puumlttmann CMonoclonal antibody for the detection of SNAPCLIP tagUS patent US 9079963

Barth S Schmies S Kolberg K Puumlttmann C

Monoclonal antibody for the detecti-on of SNAPCLIP tagBritish patent EP (GB) 2 782 936 French patent EP (FR) 2 782 936German patent DE 60 2012 011 4142Spanish patent EP (ES) 2 782 936 B1Swiss patent EP (CH) 2 782 936

Jennewein S Engels B Grothe T Stadler MProtoilludene synthaseUS patent US 9005939Chinese patent CN 103052709 B

Scholich K Geisslinger GUse of S1PChinese patent CN 1838961 B

28 29

DOCTORAL MASTERrsquoSDIPLOMAAND BACHELORrsquoS THESES

30 31

DOCTORAL MASTERrsquoSDIPLOMA AND BACHELORrsquoS THESES

Bachelorrsquos MasterrsquosDiploma and Doctoral Theses

Bacheloracutes Theses (BSc)

19

2

21

Doctoral Theses

16

2

18

Masteracutes (MA) or Diploma Theses

21

3

24

Total

56

7

63

IME-MB

IME-AE

IME

Doctoral Theses

Ahvari HoutanCharacterization and subcellular localization of endomembrane pro-teases from tobacco BY-2 cellsRWTH Aachen University

Barthelmes Julia (geb Maumlnnich)Die Rolle der Ceramidsynthase 2 bei der Pathogenese von Multipler SkleroseGoethe-Universitaumlt Frankfurt

Busch SaskiaRegulation of the 5-lipoxygenase by miRNAGoethe-Universitaumlt Frankfurt

Delov VeraFluoreszierende Toxizitaumltsendpunkte als vielversprechende Werkzeuge zur Weiterentwicklung des Fischembryo-tests fuumlr praktische Screening-An-wendungenRWTH Aachen University

Fuhrmann DominikChronic hypoxia in human macro-phages - adaption and functional consequencesGoethe-Universitaumlt Frankfurt

Gilbert BiancaDie Charakterisierung der humanen 5-Lipoxygenase als direktes Target-gen des Tumorsuppressors p53 und seine Relevanz fuumlr die TumorgeneseGoethe-Universitaumlt Frankfurt

Henke NinaRole of HIF-1α and HIF-2α in macro-phages during tumor progressionGoethe-Universitaumlt Frankfurt

Ibrahim LaraIdentification and modelling of a representative vulnerable fish species for pesticide risk assessment in EuropeRWTH Aachen University

Kemmerer MarinaElucidation of lipid metabolism pathways mediated by AMPK and nuclear receptors PPARdelta and LXRalpha in human macrophagesGoethe-Universitaumlt Frankfurt

Knape TiloDie Antagonisierung von PPARγ als neues Therapiekonzept bei SepsisGoethe-Universitaumlt Frankfurt

Mora JavierNovel IL-1 family ligands and recep-tors in the interaction of macropha-ges with apoptotic cellsGoethe-Universitaumlt Frankfurt

Salgado DanielaPurification and characterization of the plant-produced human surfac-tant protein D (hSPndashD)RWTH Aachen University

Scherzberg Maria-ChristinaMolecular Characterization of anticancer and metabolic activities of resveratrol analog 34rsquo5-(Z)-trime-thoxystilbene and interaction with AMPK inhibitor compound CGoethe-Universitaumlt Frankfurt

Schmitz KatjaThe role of endocannabinoid mo-dulators on the pathogenesis and therapy in different mouse models of multiple sclerosis and metabolic syndromeGoethe-Universitaumlt Frankfurt

Schroumlder MirjamIsolierung und Charakterisierung der isolierten regulatorischen Domaumlne der humanen 5 LipoxygenaseGoethe-Universitaumlt Frankfurt

Schubert MaxHerstellung und Charakterisierung von rekombinanten scFv-Fusionspro-teinen zur Generierung Aspergillus flavus -resistenter MaispflanzenRWTH Aachen University

Wanger RuthRegulation von Ceramidsynthasen in Kolonkarzinom-ZellenGoethe-Universitaumlt Frankfurt

Wegner Marthe-SusannaHormonelle Regulation von Ceramid-synthasen in BrustkrebszellenGoethe-Universitaumlt Frankfurt

32 33

NETWORKS IN SCIENCE AND INDUSTRY

34 35

NETWORKS IN SCIENCE AND INDUSTRY

Dr Andreas Ernst holds seminars at the Goethe University Hospital Frankfurt

Dr Martina Fenske holds lectures for the Ecotoxicology Post-Gradual Training Program of SETAC-EUROPE (German Language Branch) eV amp Gesellschaft Deutscher Chemiker at the University of Heidelberg

Prof Dr Dr Gerd Geisslinger is director of the Institute for Clinical Pharmacology of the University Medical Center Frankfurt

PD Dr Bruno Oertel holds seminars at the Goethe University Hospital Frankfurt

Prof Dr Michael Parnham is Professor of Pharmacology and Toxicology in the Faculty of Biochemistry Chemistry and Pharmacy at Goethe University Frankfurt

Dr Ole Pless hold lectures seminars and work placements as part of the academic linking of the IME-ScreeningPort to the Faculty of Medicine of the University of Hamburg (UKE)

Prof Dr Dirk Pruumlfer is Professor of Plant Biotechnology at the University of Muumlnster

Dr Nicole Raven Dr Andreas Schiermeyer Holger Spiegel and Prof Dr Stefan Schillberg provide lectures on Plant Biotechnology at the Fachhochschule AachenProf Schillberg is also Honorary Professor at the Justus-Liebig University of Giessen

Prof Dr Christoph Schaumlfers holds an extraordinary professorship for eco(system)toxicology at the University of Muumlnster

PD Dr Susanne Schiffmann holds seminars at the Goethe University Hospital Frankfurt

Prof Dr Christian Schlechtriem is Honorary Professor for Ecotoxicology at the University of Siegen

Matthias Teigeler provides lectures on Ecotoxicology at the Fachhochschule Bingen

Prof Dr Andreas Vilcinskas is Professor for Applied Entomology at the Justus-Liebig University of Giessen

Dr Bjoumlrn Windshuumlgel holds lectures at the Jacobs University of Bremen

International activities and cooperation with the industryThe Fraunhofer IME cooperates with many internationalresearch partners and remains in close contact with universitiesand other research organizations The aim is to recognizetrends and developments as they emerge and to developand implement novel research strategies and technologies

In 2015 the Fraunhofer IME co-operated with around 100national and international industrial clients and several international industrial associations for whom confidential projects were carried out

Lecturing Assignments

Cooperation with RWTH Aachen University

Fraunhofer IME has close ties with RWTH Aachen University in terms of personnel and basic research areas Prof Dr Rainer Fischer is Chair and Director of the Institute for Molecular Biotechnology (IMB) The Fraunhofer IME offers Diploma Bachelors Masters and PhD courses in association with the RWTH Aachen University as well as lectures practical courses and seminars

The Fraunhofer IME Applied Ecology Division also gives lectures in applied ecology and collaborates with the RWTH research institute for ecosystem analysis and assessment (gaiac) performing mesocosm and other ecotoxicological studies for industrial clients

Additional Lecturing Assignments

Dr Mark Buumlcking and Dr Matthias Kotthoff hold lectures in the degree program food chemistry at the University of Wuppertal

Dr Natasja de Bruin holds seminars at the Goethe University Hospital Frankfurt and is guest lecturer at the Donders Institute for Brain Cognition and Behavior MSc Cognitive Neuroscience (Radboud University Nijmegen the Netherlands)

Prof Dr Carsten Claussen is honorary professor for information systems at the Heinz-Nixdorf Institute of the Paderborn UniversityHe also hold lectures seminars and work placements as part of the academic linking of the IME-ScreeningPort to the Faculty of Medicine of the University of Hamburg (UKE)

36 37

NETWORKS IN SCIENCE AND INDUSTRY

Memberships of Editorial Boards and Commitees

Scientific Journals

Current Research in Drug DiscoveryEditorial Board Dr Sheraz Gul

Drug Target ReviewEditor in chief Dr Sheraz Gul

Environmental Science and Pollution Research SpringerCo-editor of the series Chemical and Biological Environmental Monitoring Dr Heinz Ruumldel

Environmental Sciences Europe SpringerAdvisory Board Dr Kerstin Hund-Rinke

European Pharmaceutical ReviewEditorial board Dr Sheraz Gul

Fraunhofer Group for Life SciencesChairman Prof Dr Rainer Fischer

Frontiers in Plant Biotechnology Frontiers Media SAAssociate Editor Prof Dr Dirk Pruumlfer

Handbuch der Bodenuntersuchung Wiley-VCHBeirat Dr Dieter Hennecke

Journal of Applied Ichthyology Wiley-BlackwellEditorial Board Prof Dr Christian Schlechtriem

Journal of PharmaceuticsEditorial Board Dr Sheraz Gul

Plant Cell Reports SpringerEditorial Board Prof Dr Stefan Schillberg

Transgenic Research Kluwer Academic PublishersAssociate Editor Prof Dr Stefan Schillberg

Committees

AltmetricAmbassador Dr Sheraz Gul

Anti-Doping-Beauftragter des Landessportbundes HessenProf Dr Dr Gerd Geisslinger

Assay DepotBusiness Advisory Board Dr Sheraz Gul

Ausschuss fuumlr Innovation Handelskammer HamburgProf Dr Carsten Claussen

BioOumlkonomieRat AG BiotechnologieProf Dr Rainer Fischer

BMELV Wissenschaftlicher Beirat fuumlr DuumlngungsfragenStellvertretende Vorsitzende Dr Kerstin Hund-Rinke

Bundesinstitut fuumlr Risikobewertung (BfR) Kommission fuumlr Kontaminanten und andere gesundheitlich uner-wuumlnschte Stoffe in der Lebensmittel-ketteDr Mark Buumlcking

Bundesinstitut fuumlr Risikobewertung (BfR) Kommission fuumlr Pflanzenschutz-mittel und ihre RuumlckstaumlndeDr Michael Klein

BVL Expertengruppe zur Erstellung einer Richtlinie fuumlr Fischfuumltterungs-studienProf Dr Christian Schlechtriem

COST Action CM1307 1406Management Committee Substitute Dr Sheraz Gul

DAkkS Fachbegutachter bei der Deutschen AkkreditierungsstelleDr Kerstin Hund-Rinke Dr Josef Muumlller

Deutsche Gesellschaft fuumlr industrielle ZelltechnikBoard Dr Mira Graettinger

DFG Steering Group SystembiologieProf Dr Rainer Fischer

DFG Fachkollegium MedizinProf Dr Dr Gerd Geisslinger

DFG Senatskommission fuumlr klinische ForschungProf Dr Dr Gerd Geisslinger

DFG Allianz-AG raquoInfrastrukturen in der terrestrischen ForschunglaquoProf Dr Christoph Schaumlfers

DIBT Projektgruppe raquoModellierunglaquo des Deutschen Instituts fuumlr BautechnikDr Michael Klein

DIN NA 062 Normenausschuss Materialpruumlfungndashndash NA 062-02-93-AA Photokatalyse AK2 LuftreinhaltungDr Michael Huumlben

DIN NA 119 Normenausschuss Wasserwesen (NAW)ndashndash NA 119-01-02-05 UA Elutions-verfahrenDr Dieter Hennecke

ndashndash NA 119-01-02-02-01 AK Bioverfuumlg-barkeitDr Kerstin Derz

ndashndash NA 119-01-02-02-53 AK Sprengstofftypische VerbindungenDr Dieter Hennecke

ndashndash NA 119-01-02-04 UA Biologische VerfahrenDr Kerstin Hund-Rinke

ndashndash NA 119-01-02 AA Abfall- und Bo-denuntersuchung UA 1 ProbenahmeKarlheinz Weinfurtner

ndashndash NA 119-01-02-06 UA Bodenschutz Entsorgung Altlastensanierung UA 2 EntsorgungKarlheinz Weinfurtner

DIN NA 172-00-10 GA Gemeinschafts-arbeitsausschuss NAGUSNAL Nach-haltigkeitskriterien fuumlr BiomasseKarlheinz Weinfurtner

Dutch NeuroFederationDr Natasja de Bruin

EFSA Scientific Panel on Plant Pro-tection Products and their ResiduesDr Michael Kleinndashndash Working Group on the new gui-dance document about persistence in soilndashndash Working Group on non-target ar-thropods and in-soil risk assessment (Rapporteur)

EU-OPENSCREEN ndash The European Research Infrastructure for Chemical BiologyCoordinator Dr Philip Gribbon

FBU Fachbeirat BodenuntersuchungenDr Dieter Hennecke

Fachbeirat zum Masterstudiengang raquoBoden Gewaumlsser Altlastenlaquo an derHochschuleUniversitaumlt OsnabruumlckDr Kerstin Hund-Rinke

FENS Federation of European Neu-roscience Societies Dr Natasja de Bruin

FET Directorate General for Communications Networks Content and Technology raquoFuture amp Emerging Technologieslaquo Advisory Group European CommissionProf Dr Rainer Fischer

FOCUS (Forum for international coordination of pesticide fate models and their use) Work group ldquoVersion ControlldquoDr Michael Klein

Forschungsausschuss des Fachverban-des raquoAngewandte Photokatalyselaquo im Verband der MineralfarbenindustrieDr Kerstin Hund-Rinke

FPI eV Food-Processing InitiativeVorstandsvorsitzender Dr Mark Buumlcking

Forum Gesundheit der Bundes-regierungProf Dr Rainer Fischer

GDCh Fachgruppe Umweltchemie und Oumlkotoxikologiendashndash Arbeitskreis Bodenchemie und BodenoumlkologieLeitung Dr Dieter Hennecke

ndashndash Arbeitskreis ChemikalienbewertungDr Martin Muumlller

ndashndash Arbeitsgruppe Persistenz und Ab-baubarkeit im Arbeitskreis Chemika-lienbewertungDr Dieter Hennecke Dr Markus Simon

ndashndash Arbeitskreis UmweltmonitoringLeitung Dr Heinz Ruumldel

GDK (Gemeinschaft Deutscher Kryo-banken)Kassenpruumlfer Dr Heinz Ruumldel

Hochschulforum der Hamburger WirtschaftProf Dr Carsten Claussen

House of Pharma and HealthcareVorstandsmitglieder Prof Dr Dr Gerd Geisslinger Dr Frank Behrens

ILSI-HESI ndash Animal Alternatives in Environmental Risk Assessment Technical Committee

Dr Martina Fenske

Industrial Quality and Productivity Centre (IQPC) Pharmaceutical Advisory Board Dr Sheraz Gul

Initiative Gesundheitsindustrie HessenMitglied des Lenkungskreises Prof Dr Dr Gerd Geisslinger

International Association of Inflam-mation Societies (IAIS)Ex-officio Member Prof Dr Michael J Parnham

ISOTC 190 SC2 WG10 Soil quality ndashElaborating general aspects of samplingKarlheinz Weinfurtner

ISOTC 190 SC3 WG11 Explosive compoundsDr Dieter Hennecke

ISOTC 190 SC7 WG6 Leaching testsDr Dieter Hennecke

ISOTC 190 SC7 WG8 BioavailabilityDr Dieter Hennecke

ISPE Community of Practice Process analytical technologies Active Pharmaceutical IngredientsDr Juumlrgen Drossard

IUPAC Division of Chemistry and theEnvironment (DCE)Titular Member Dr Heinz Ruumldel

IUPAC Subcommittee on Chemical and Biophysical Processes in the EnvironmentSecretary Dr Heinz Ruumldel

KGITTC Korean-German Industrial TechnologyCooperation Committee Prof Dr Rainer Fischer

38 39

NETWORKS IN SCIENCE AND INDUSTRY

Kommission Bodenschutz beim UmweltbundesamtDr Kerstin Hund-Rinke

Kommission zur Bewertung wasser-gefaumlhrdender Stoffe (KBwS) des BMUProf Dr Christoph Schaumlfers

LebensmittelwirtschaftWissenschaftlicher Beirat Dr Mark Buumlcking

Lundbeckfonden Center of ExcellenceNanomedicine Research Centerfor Cancer Stem Cell TargetingTherapeutics (NanoCAN) (OdenseDenmark)Scientific advisory board member Dr Ole Pless

NORMAN ndash Network of reference laboratories research centres and related organisations for monitoring of emerging environmental substancesndashndash Working Group ldquoPrioritization of emerging substancesldquoDr Heinz Ruumldel

OECD Expert Group on Fish Bioaccu-mulationProf Dr Christian Schlechtriem

OECD Fish Drafting GroupProf Dr Christoph Schaumlfers Matthias Teigeler

OECD Working Party on Manufac-tured Nanomaterials (WPMN) ndash SG4 Drafting Group for Guidance on Sample Preparation and Dosimetry (DG-GSPD)Dr Kerstin Hund-Rinke

Pharma-Dialog der BundesregierungProf Dr Rainer Fischer

SETAC Europe Advisory Group on Mechanistic Effect Models for Ecological Risk Assessment of Chemicals (MEMoRisk)Co-chair Dr Udo Hommen

SETAC Global Advisory Group on Bioaccumulation ScienceProf Dr Christoph SchaumlfersCo-chair Prof Dr Christian Schlechtriem

SETAC Global Advisory Group on PlantsSteering Committee Dr Udo Hommen SETAC Global Advisory Group on Animal Alternatives in Environmen-tal ScienceDr Martina Fenske Prof Dr Christian Schlechtriem

SETAC Europe 26th Annual Meeting Nantes 2016Scientific Committee Dr Udo Hommen

Single Technologies (Stockholm Sweden)Scientific advisor Dr Sheraz Gul

Society for Neuroscience Dr Natasja de Bruin

Standardisierungsgremium Big Data VDIVDEFounding member Dr Manfred Kohler

Stiftung fuumlr Unternehmensrecht an der Heinrich Heine Universitaumlt DuumlsseldorfKuratoriumsmitglied Prof Dr Carsten Claussen

Stiftungsrat der Dr Robert Pfleger StiftungProf Dr Dr Gerd Geisslinger

Stiftungsrat der Freundlich-StiftungProf Dr Dr Gerd Geisslinger

UBA Arbeitskreis Fortentwicklung von Pruumlfmethoden im Rahmen des Stoffrechts AK Oumlkotoxikologie Akkumulation und Abbau in der UmweltProf Dr Christoph Schaumlfers

VDIVDE raquoDatenmanagement im Bereich Life ScienceslaquoVice chairman Dr Manfred Kohler

Wissenschaftlicher Beirat des Life Science-Center der Universitaumlt HohenheimProf Dr Rainer Fischer

Organization of Scientific Meetings and Courses (Applied Ecology)

Workshop ldquoEnvironmental monitoring of biocides in Europe ndash compartment-specific strategiesrdquoBerlin 25-2662015 carried out by Fraunhofer IME on behalf of the German Federal Environment Agency (Umweltbundesamt) and the NORMAN network

Lehrveranstaltung raquoGrundlagen der Oumlkotoxikologielaquo im Rahmen der Ausbildung zum Fachtoxikologen der DGPT (German Society for Experimental and Clinical Pharmacology and Toxicology) excursion day Fraunhofer IME Schmallenberg 2472015

Summer School WWU MuumlnsterUniversitaumlt Siegen raquoAquatische Oumlko(system)toxikologielaquoFraunhofer IME Schmallenberg 248ndash492015

Scientific Workshop on ldquoIdentifying limitations of the OECD water-sediment test (OECD 308) and developing suitable alternatives to assess persistencerdquoDuumlbendorf Switzerland 6102015 organized by EAWAG in cooperation with Fraunhofer IME ECT and Fraunhofer ITEM

wwwimefraunhoferde

160318_Einleger_Titel_210x277_RZindd 2 180316 1855

26 27

PATENTS

N-terminally truncated interleukin-38PCTEP2015066084

Sisignano M Brenneis C Geisslinger G Scholich K Zinn SCYP2J2 antagonists in the treatment of painPCTEP2015068767

Fendel R Kapelski S Barth S Fischer R Reimann AAnti-parasitic complexesPCTEP2015069247

Scholich K Zinn S Geisslinger G de Bruin NBLT2 antagonists for the treatment of painPCTEP2015074520

Fischer R Reimann A Maskus D Fendel R Klockenbring T Barth SAnti-plasmodium parasite antibodiesEP 15 163 2973

Kreuzaler F Noumllke G Schillberg S Barsoum M Fischer RGenetically modified higher plants with increased photosynthesis andor biomass production methods and uses thereofPCTEP2015077803

Genoveva O di Fiore S Fischer RMethod for providing stable isoindo-le derivativesUS 14944662

Edguuml G Sack M Beiss V Boes A Spiegel H Reimann A Fischer RMalaria immunoassemblins ndash combi-natorial vaccines against Plasmodium falciparumPCTEP2015076194

Noumllke G Schubert M Schillberg SNovel aflatoxin and fungal infection control methodsPCTEP2015057943

Patent applications in 2015

Blessing D Sack M Holland TFermentation systemsPCTEP2015000867

Barth S Thepen T Barral-Netto M Barral A van Weyhenberg JAn immunotoxin for use in the treat-ment of leishmaniasisEP 15 151 8768

Hristodorov D Thepen T Barth SUse of CD-64-blocking agents as enhancer of an anti-TNF-alpha anti-body therapyPCTEP2015056622

Boes A Spiegel H Edguuml G Beiss V Sack M Reimann A Fischer RThree component-multistage malaria vaccinePCTEP2015070044

Boes A Spiegel H Edguuml G Beiss V Sack M Reimann A Fischer RMulti-component-multistage malaria vaccinePCTEP2015056693

Salzig M Vilcinskas A Fischer RUse of metalloproteinase inhibitors against bacterial infectionsPCTEP2015065210

von Knethen A Parnham M Sha LRekombinantes B7-H1-Fusionsprotein als Therapiekonzept des multiplen Organversagens bei SepsisEP 15 181 8002

Knappe T von Knethen A Parnham M Schubert-Zsilavecz M Wurglics M Flesch DCompetitive PPAR-gamma antago-nistsPCTEP2015066085

Weigert A Mora J Bruumlne B Dill-mann C Parnham M Geisslinger G

Barth S Fischer R Hussain ANovel specific photoimmuno-thera-nostics for detection and elimination of skin cancer cellsPCTEP2015063422

Stein C Mladenov R Stockmeyer B Barth S Hein L Fischer RAnit-CD89 cytotoxic complexPCTEP2015056386

Nuumlsing RM Bernau M Parnham M Geisslinger G(R)-Fluriprofen for the prevention andor treatment of diabetesEP 15 193 6903

Wacker M Beyer S Parnham M Xie L Maumlntele W Vogel VComposition comprising a biocom-patible and biodegradable polymer nanocarriers and a drug and me-thods of making and using the sameEP 15 193 3827

Jennewein S Gaida S McElroy C Fischer RRecombinant cell and 14-butanediol production methodPCTJP201574979

Patents issued in 2015

Barth S Tur M K Stoumlcker M Fischer RImmunokinasesUS patent US 9045739 B2

Barth S Schmies S Kolberg K Puumlttmann CMonoclonal antibody for the detection of SNAPCLIP tagUS patent US 9079963

Barth S Schmies S Kolberg K Puumlttmann C

Monoclonal antibody for the detecti-on of SNAPCLIP tagBritish patent EP (GB) 2 782 936 French patent EP (FR) 2 782 936German patent DE 60 2012 011 4142Spanish patent EP (ES) 2 782 936 B1Swiss patent EP (CH) 2 782 936

Jennewein S Engels B Grothe T Stadler MProtoilludene synthaseUS patent US 9005939Chinese patent CN 103052709 B

Scholich K Geisslinger GUse of S1PChinese patent CN 1838961 B

28 29

DOCTORAL MASTERrsquoSDIPLOMAAND BACHELORrsquoS THESES

30 31

DOCTORAL MASTERrsquoSDIPLOMA AND BACHELORrsquoS THESES

Bachelorrsquos MasterrsquosDiploma and Doctoral Theses

Bacheloracutes Theses (BSc)

19

2

21

Doctoral Theses

16

2

18

Masteracutes (MA) or Diploma Theses

21

3

24

Total

56

7

63

IME-MB

IME-AE

IME

Doctoral Theses

Ahvari HoutanCharacterization and subcellular localization of endomembrane pro-teases from tobacco BY-2 cellsRWTH Aachen University

Barthelmes Julia (geb Maumlnnich)Die Rolle der Ceramidsynthase 2 bei der Pathogenese von Multipler SkleroseGoethe-Universitaumlt Frankfurt

Busch SaskiaRegulation of the 5-lipoxygenase by miRNAGoethe-Universitaumlt Frankfurt

Delov VeraFluoreszierende Toxizitaumltsendpunkte als vielversprechende Werkzeuge zur Weiterentwicklung des Fischembryo-tests fuumlr praktische Screening-An-wendungenRWTH Aachen University

Fuhrmann DominikChronic hypoxia in human macro-phages - adaption and functional consequencesGoethe-Universitaumlt Frankfurt

Gilbert BiancaDie Charakterisierung der humanen 5-Lipoxygenase als direktes Target-gen des Tumorsuppressors p53 und seine Relevanz fuumlr die TumorgeneseGoethe-Universitaumlt Frankfurt

Henke NinaRole of HIF-1α and HIF-2α in macro-phages during tumor progressionGoethe-Universitaumlt Frankfurt

Ibrahim LaraIdentification and modelling of a representative vulnerable fish species for pesticide risk assessment in EuropeRWTH Aachen University

Kemmerer MarinaElucidation of lipid metabolism pathways mediated by AMPK and nuclear receptors PPARdelta and LXRalpha in human macrophagesGoethe-Universitaumlt Frankfurt

Knape TiloDie Antagonisierung von PPARγ als neues Therapiekonzept bei SepsisGoethe-Universitaumlt Frankfurt

Mora JavierNovel IL-1 family ligands and recep-tors in the interaction of macropha-ges with apoptotic cellsGoethe-Universitaumlt Frankfurt

Salgado DanielaPurification and characterization of the plant-produced human surfac-tant protein D (hSPndashD)RWTH Aachen University

Scherzberg Maria-ChristinaMolecular Characterization of anticancer and metabolic activities of resveratrol analog 34rsquo5-(Z)-trime-thoxystilbene and interaction with AMPK inhibitor compound CGoethe-Universitaumlt Frankfurt

Schmitz KatjaThe role of endocannabinoid mo-dulators on the pathogenesis and therapy in different mouse models of multiple sclerosis and metabolic syndromeGoethe-Universitaumlt Frankfurt

Schroumlder MirjamIsolierung und Charakterisierung der isolierten regulatorischen Domaumlne der humanen 5 LipoxygenaseGoethe-Universitaumlt Frankfurt

Schubert MaxHerstellung und Charakterisierung von rekombinanten scFv-Fusionspro-teinen zur Generierung Aspergillus flavus -resistenter MaispflanzenRWTH Aachen University

Wanger RuthRegulation von Ceramidsynthasen in Kolonkarzinom-ZellenGoethe-Universitaumlt Frankfurt

Wegner Marthe-SusannaHormonelle Regulation von Ceramid-synthasen in BrustkrebszellenGoethe-Universitaumlt Frankfurt

32 33

NETWORKS IN SCIENCE AND INDUSTRY

34 35

NETWORKS IN SCIENCE AND INDUSTRY

Dr Andreas Ernst holds seminars at the Goethe University Hospital Frankfurt

Dr Martina Fenske holds lectures for the Ecotoxicology Post-Gradual Training Program of SETAC-EUROPE (German Language Branch) eV amp Gesellschaft Deutscher Chemiker at the University of Heidelberg

Prof Dr Dr Gerd Geisslinger is director of the Institute for Clinical Pharmacology of the University Medical Center Frankfurt

PD Dr Bruno Oertel holds seminars at the Goethe University Hospital Frankfurt

Prof Dr Michael Parnham is Professor of Pharmacology and Toxicology in the Faculty of Biochemistry Chemistry and Pharmacy at Goethe University Frankfurt

Dr Ole Pless hold lectures seminars and work placements as part of the academic linking of the IME-ScreeningPort to the Faculty of Medicine of the University of Hamburg (UKE)

Prof Dr Dirk Pruumlfer is Professor of Plant Biotechnology at the University of Muumlnster

Dr Nicole Raven Dr Andreas Schiermeyer Holger Spiegel and Prof Dr Stefan Schillberg provide lectures on Plant Biotechnology at the Fachhochschule AachenProf Schillberg is also Honorary Professor at the Justus-Liebig University of Giessen

Prof Dr Christoph Schaumlfers holds an extraordinary professorship for eco(system)toxicology at the University of Muumlnster

PD Dr Susanne Schiffmann holds seminars at the Goethe University Hospital Frankfurt

Prof Dr Christian Schlechtriem is Honorary Professor for Ecotoxicology at the University of Siegen

Matthias Teigeler provides lectures on Ecotoxicology at the Fachhochschule Bingen

Prof Dr Andreas Vilcinskas is Professor for Applied Entomology at the Justus-Liebig University of Giessen

Dr Bjoumlrn Windshuumlgel holds lectures at the Jacobs University of Bremen

International activities and cooperation with the industryThe Fraunhofer IME cooperates with many internationalresearch partners and remains in close contact with universitiesand other research organizations The aim is to recognizetrends and developments as they emerge and to developand implement novel research strategies and technologies

In 2015 the Fraunhofer IME co-operated with around 100national and international industrial clients and several international industrial associations for whom confidential projects were carried out

Lecturing Assignments

Cooperation with RWTH Aachen University

Fraunhofer IME has close ties with RWTH Aachen University in terms of personnel and basic research areas Prof Dr Rainer Fischer is Chair and Director of the Institute for Molecular Biotechnology (IMB) The Fraunhofer IME offers Diploma Bachelors Masters and PhD courses in association with the RWTH Aachen University as well as lectures practical courses and seminars

The Fraunhofer IME Applied Ecology Division also gives lectures in applied ecology and collaborates with the RWTH research institute for ecosystem analysis and assessment (gaiac) performing mesocosm and other ecotoxicological studies for industrial clients

Additional Lecturing Assignments

Dr Mark Buumlcking and Dr Matthias Kotthoff hold lectures in the degree program food chemistry at the University of Wuppertal

Dr Natasja de Bruin holds seminars at the Goethe University Hospital Frankfurt and is guest lecturer at the Donders Institute for Brain Cognition and Behavior MSc Cognitive Neuroscience (Radboud University Nijmegen the Netherlands)

Prof Dr Carsten Claussen is honorary professor for information systems at the Heinz-Nixdorf Institute of the Paderborn UniversityHe also hold lectures seminars and work placements as part of the academic linking of the IME-ScreeningPort to the Faculty of Medicine of the University of Hamburg (UKE)

36 37

NETWORKS IN SCIENCE AND INDUSTRY

Memberships of Editorial Boards and Commitees

Scientific Journals

Current Research in Drug DiscoveryEditorial Board Dr Sheraz Gul

Drug Target ReviewEditor in chief Dr Sheraz Gul

Environmental Science and Pollution Research SpringerCo-editor of the series Chemical and Biological Environmental Monitoring Dr Heinz Ruumldel

Environmental Sciences Europe SpringerAdvisory Board Dr Kerstin Hund-Rinke

European Pharmaceutical ReviewEditorial board Dr Sheraz Gul

Fraunhofer Group for Life SciencesChairman Prof Dr Rainer Fischer

Frontiers in Plant Biotechnology Frontiers Media SAAssociate Editor Prof Dr Dirk Pruumlfer

Handbuch der Bodenuntersuchung Wiley-VCHBeirat Dr Dieter Hennecke

Journal of Applied Ichthyology Wiley-BlackwellEditorial Board Prof Dr Christian Schlechtriem

Journal of PharmaceuticsEditorial Board Dr Sheraz Gul

Plant Cell Reports SpringerEditorial Board Prof Dr Stefan Schillberg

Transgenic Research Kluwer Academic PublishersAssociate Editor Prof Dr Stefan Schillberg

Committees

AltmetricAmbassador Dr Sheraz Gul

Anti-Doping-Beauftragter des Landessportbundes HessenProf Dr Dr Gerd Geisslinger

Assay DepotBusiness Advisory Board Dr Sheraz Gul

Ausschuss fuumlr Innovation Handelskammer HamburgProf Dr Carsten Claussen

BioOumlkonomieRat AG BiotechnologieProf Dr Rainer Fischer

BMELV Wissenschaftlicher Beirat fuumlr DuumlngungsfragenStellvertretende Vorsitzende Dr Kerstin Hund-Rinke

Bundesinstitut fuumlr Risikobewertung (BfR) Kommission fuumlr Kontaminanten und andere gesundheitlich uner-wuumlnschte Stoffe in der Lebensmittel-ketteDr Mark Buumlcking

Bundesinstitut fuumlr Risikobewertung (BfR) Kommission fuumlr Pflanzenschutz-mittel und ihre RuumlckstaumlndeDr Michael Klein

BVL Expertengruppe zur Erstellung einer Richtlinie fuumlr Fischfuumltterungs-studienProf Dr Christian Schlechtriem

COST Action CM1307 1406Management Committee Substitute Dr Sheraz Gul

DAkkS Fachbegutachter bei der Deutschen AkkreditierungsstelleDr Kerstin Hund-Rinke Dr Josef Muumlller

Deutsche Gesellschaft fuumlr industrielle ZelltechnikBoard Dr Mira Graettinger

DFG Steering Group SystembiologieProf Dr Rainer Fischer

DFG Fachkollegium MedizinProf Dr Dr Gerd Geisslinger

DFG Senatskommission fuumlr klinische ForschungProf Dr Dr Gerd Geisslinger

DFG Allianz-AG raquoInfrastrukturen in der terrestrischen ForschunglaquoProf Dr Christoph Schaumlfers

DIBT Projektgruppe raquoModellierunglaquo des Deutschen Instituts fuumlr BautechnikDr Michael Klein

DIN NA 062 Normenausschuss Materialpruumlfungndashndash NA 062-02-93-AA Photokatalyse AK2 LuftreinhaltungDr Michael Huumlben

DIN NA 119 Normenausschuss Wasserwesen (NAW)ndashndash NA 119-01-02-05 UA Elutions-verfahrenDr Dieter Hennecke

ndashndash NA 119-01-02-02-01 AK Bioverfuumlg-barkeitDr Kerstin Derz

ndashndash NA 119-01-02-02-53 AK Sprengstofftypische VerbindungenDr Dieter Hennecke

ndashndash NA 119-01-02-04 UA Biologische VerfahrenDr Kerstin Hund-Rinke

ndashndash NA 119-01-02 AA Abfall- und Bo-denuntersuchung UA 1 ProbenahmeKarlheinz Weinfurtner

ndashndash NA 119-01-02-06 UA Bodenschutz Entsorgung Altlastensanierung UA 2 EntsorgungKarlheinz Weinfurtner

DIN NA 172-00-10 GA Gemeinschafts-arbeitsausschuss NAGUSNAL Nach-haltigkeitskriterien fuumlr BiomasseKarlheinz Weinfurtner

Dutch NeuroFederationDr Natasja de Bruin

EFSA Scientific Panel on Plant Pro-tection Products and their ResiduesDr Michael Kleinndashndash Working Group on the new gui-dance document about persistence in soilndashndash Working Group on non-target ar-thropods and in-soil risk assessment (Rapporteur)

EU-OPENSCREEN ndash The European Research Infrastructure for Chemical BiologyCoordinator Dr Philip Gribbon

FBU Fachbeirat BodenuntersuchungenDr Dieter Hennecke

Fachbeirat zum Masterstudiengang raquoBoden Gewaumlsser Altlastenlaquo an derHochschuleUniversitaumlt OsnabruumlckDr Kerstin Hund-Rinke

FENS Federation of European Neu-roscience Societies Dr Natasja de Bruin

FET Directorate General for Communications Networks Content and Technology raquoFuture amp Emerging Technologieslaquo Advisory Group European CommissionProf Dr Rainer Fischer

FOCUS (Forum for international coordination of pesticide fate models and their use) Work group ldquoVersion ControlldquoDr Michael Klein

Forschungsausschuss des Fachverban-des raquoAngewandte Photokatalyselaquo im Verband der MineralfarbenindustrieDr Kerstin Hund-Rinke

FPI eV Food-Processing InitiativeVorstandsvorsitzender Dr Mark Buumlcking

Forum Gesundheit der Bundes-regierungProf Dr Rainer Fischer

GDCh Fachgruppe Umweltchemie und Oumlkotoxikologiendashndash Arbeitskreis Bodenchemie und BodenoumlkologieLeitung Dr Dieter Hennecke

ndashndash Arbeitskreis ChemikalienbewertungDr Martin Muumlller

ndashndash Arbeitsgruppe Persistenz und Ab-baubarkeit im Arbeitskreis Chemika-lienbewertungDr Dieter Hennecke Dr Markus Simon

ndashndash Arbeitskreis UmweltmonitoringLeitung Dr Heinz Ruumldel

GDK (Gemeinschaft Deutscher Kryo-banken)Kassenpruumlfer Dr Heinz Ruumldel

Hochschulforum der Hamburger WirtschaftProf Dr Carsten Claussen

House of Pharma and HealthcareVorstandsmitglieder Prof Dr Dr Gerd Geisslinger Dr Frank Behrens

ILSI-HESI ndash Animal Alternatives in Environmental Risk Assessment Technical Committee

Dr Martina Fenske

Industrial Quality and Productivity Centre (IQPC) Pharmaceutical Advisory Board Dr Sheraz Gul

Initiative Gesundheitsindustrie HessenMitglied des Lenkungskreises Prof Dr Dr Gerd Geisslinger

International Association of Inflam-mation Societies (IAIS)Ex-officio Member Prof Dr Michael J Parnham

ISOTC 190 SC2 WG10 Soil quality ndashElaborating general aspects of samplingKarlheinz Weinfurtner

ISOTC 190 SC3 WG11 Explosive compoundsDr Dieter Hennecke

ISOTC 190 SC7 WG6 Leaching testsDr Dieter Hennecke

ISOTC 190 SC7 WG8 BioavailabilityDr Dieter Hennecke

ISPE Community of Practice Process analytical technologies Active Pharmaceutical IngredientsDr Juumlrgen Drossard

IUPAC Division of Chemistry and theEnvironment (DCE)Titular Member Dr Heinz Ruumldel

IUPAC Subcommittee on Chemical and Biophysical Processes in the EnvironmentSecretary Dr Heinz Ruumldel

KGITTC Korean-German Industrial TechnologyCooperation Committee Prof Dr Rainer Fischer

38 39

NETWORKS IN SCIENCE AND INDUSTRY

Kommission Bodenschutz beim UmweltbundesamtDr Kerstin Hund-Rinke

Kommission zur Bewertung wasser-gefaumlhrdender Stoffe (KBwS) des BMUProf Dr Christoph Schaumlfers

LebensmittelwirtschaftWissenschaftlicher Beirat Dr Mark Buumlcking

Lundbeckfonden Center of ExcellenceNanomedicine Research Centerfor Cancer Stem Cell TargetingTherapeutics (NanoCAN) (OdenseDenmark)Scientific advisory board member Dr Ole Pless

NORMAN ndash Network of reference laboratories research centres and related organisations for monitoring of emerging environmental substancesndashndash Working Group ldquoPrioritization of emerging substancesldquoDr Heinz Ruumldel

OECD Expert Group on Fish Bioaccu-mulationProf Dr Christian Schlechtriem

OECD Fish Drafting GroupProf Dr Christoph Schaumlfers Matthias Teigeler

OECD Working Party on Manufac-tured Nanomaterials (WPMN) ndash SG4 Drafting Group for Guidance on Sample Preparation and Dosimetry (DG-GSPD)Dr Kerstin Hund-Rinke

Pharma-Dialog der BundesregierungProf Dr Rainer Fischer

SETAC Europe Advisory Group on Mechanistic Effect Models for Ecological Risk Assessment of Chemicals (MEMoRisk)Co-chair Dr Udo Hommen

SETAC Global Advisory Group on Bioaccumulation ScienceProf Dr Christoph SchaumlfersCo-chair Prof Dr Christian Schlechtriem

SETAC Global Advisory Group on PlantsSteering Committee Dr Udo Hommen SETAC Global Advisory Group on Animal Alternatives in Environmen-tal ScienceDr Martina Fenske Prof Dr Christian Schlechtriem

SETAC Europe 26th Annual Meeting Nantes 2016Scientific Committee Dr Udo Hommen

Single Technologies (Stockholm Sweden)Scientific advisor Dr Sheraz Gul

Society for Neuroscience Dr Natasja de Bruin

Standardisierungsgremium Big Data VDIVDEFounding member Dr Manfred Kohler

Stiftung fuumlr Unternehmensrecht an der Heinrich Heine Universitaumlt DuumlsseldorfKuratoriumsmitglied Prof Dr Carsten Claussen

Stiftungsrat der Dr Robert Pfleger StiftungProf Dr Dr Gerd Geisslinger

Stiftungsrat der Freundlich-StiftungProf Dr Dr Gerd Geisslinger

UBA Arbeitskreis Fortentwicklung von Pruumlfmethoden im Rahmen des Stoffrechts AK Oumlkotoxikologie Akkumulation und Abbau in der UmweltProf Dr Christoph Schaumlfers

VDIVDE raquoDatenmanagement im Bereich Life ScienceslaquoVice chairman Dr Manfred Kohler

Wissenschaftlicher Beirat des Life Science-Center der Universitaumlt HohenheimProf Dr Rainer Fischer

Organization of Scientific Meetings and Courses (Applied Ecology)

Workshop ldquoEnvironmental monitoring of biocides in Europe ndash compartment-specific strategiesrdquoBerlin 25-2662015 carried out by Fraunhofer IME on behalf of the German Federal Environment Agency (Umweltbundesamt) and the NORMAN network

Lehrveranstaltung raquoGrundlagen der Oumlkotoxikologielaquo im Rahmen der Ausbildung zum Fachtoxikologen der DGPT (German Society for Experimental and Clinical Pharmacology and Toxicology) excursion day Fraunhofer IME Schmallenberg 2472015

Summer School WWU MuumlnsterUniversitaumlt Siegen raquoAquatische Oumlko(system)toxikologielaquoFraunhofer IME Schmallenberg 248ndash492015

Scientific Workshop on ldquoIdentifying limitations of the OECD water-sediment test (OECD 308) and developing suitable alternatives to assess persistencerdquoDuumlbendorf Switzerland 6102015 organized by EAWAG in cooperation with Fraunhofer IME ECT and Fraunhofer ITEM

wwwimefraunhoferde

160318_Einleger_Titel_210x277_RZindd 2 180316 1855

28 29

DOCTORAL MASTERrsquoSDIPLOMAAND BACHELORrsquoS THESES

30 31

DOCTORAL MASTERrsquoSDIPLOMA AND BACHELORrsquoS THESES

Bachelorrsquos MasterrsquosDiploma and Doctoral Theses

Bacheloracutes Theses (BSc)

19

2

21

Doctoral Theses

16

2

18

Masteracutes (MA) or Diploma Theses

21

3

24

Total

56

7

63

IME-MB

IME-AE

IME

Doctoral Theses

Ahvari HoutanCharacterization and subcellular localization of endomembrane pro-teases from tobacco BY-2 cellsRWTH Aachen University

Barthelmes Julia (geb Maumlnnich)Die Rolle der Ceramidsynthase 2 bei der Pathogenese von Multipler SkleroseGoethe-Universitaumlt Frankfurt

Busch SaskiaRegulation of the 5-lipoxygenase by miRNAGoethe-Universitaumlt Frankfurt

Delov VeraFluoreszierende Toxizitaumltsendpunkte als vielversprechende Werkzeuge zur Weiterentwicklung des Fischembryo-tests fuumlr praktische Screening-An-wendungenRWTH Aachen University

Fuhrmann DominikChronic hypoxia in human macro-phages - adaption and functional consequencesGoethe-Universitaumlt Frankfurt

Gilbert BiancaDie Charakterisierung der humanen 5-Lipoxygenase als direktes Target-gen des Tumorsuppressors p53 und seine Relevanz fuumlr die TumorgeneseGoethe-Universitaumlt Frankfurt

Henke NinaRole of HIF-1α and HIF-2α in macro-phages during tumor progressionGoethe-Universitaumlt Frankfurt

Ibrahim LaraIdentification and modelling of a representative vulnerable fish species for pesticide risk assessment in EuropeRWTH Aachen University

Kemmerer MarinaElucidation of lipid metabolism pathways mediated by AMPK and nuclear receptors PPARdelta and LXRalpha in human macrophagesGoethe-Universitaumlt Frankfurt

Knape TiloDie Antagonisierung von PPARγ als neues Therapiekonzept bei SepsisGoethe-Universitaumlt Frankfurt

Mora JavierNovel IL-1 family ligands and recep-tors in the interaction of macropha-ges with apoptotic cellsGoethe-Universitaumlt Frankfurt

Salgado DanielaPurification and characterization of the plant-produced human surfac-tant protein D (hSPndashD)RWTH Aachen University

Scherzberg Maria-ChristinaMolecular Characterization of anticancer and metabolic activities of resveratrol analog 34rsquo5-(Z)-trime-thoxystilbene and interaction with AMPK inhibitor compound CGoethe-Universitaumlt Frankfurt

Schmitz KatjaThe role of endocannabinoid mo-dulators on the pathogenesis and therapy in different mouse models of multiple sclerosis and metabolic syndromeGoethe-Universitaumlt Frankfurt

Schroumlder MirjamIsolierung und Charakterisierung der isolierten regulatorischen Domaumlne der humanen 5 LipoxygenaseGoethe-Universitaumlt Frankfurt

Schubert MaxHerstellung und Charakterisierung von rekombinanten scFv-Fusionspro-teinen zur Generierung Aspergillus flavus -resistenter MaispflanzenRWTH Aachen University

Wanger RuthRegulation von Ceramidsynthasen in Kolonkarzinom-ZellenGoethe-Universitaumlt Frankfurt

Wegner Marthe-SusannaHormonelle Regulation von Ceramid-synthasen in BrustkrebszellenGoethe-Universitaumlt Frankfurt

32 33

NETWORKS IN SCIENCE AND INDUSTRY

34 35

NETWORKS IN SCIENCE AND INDUSTRY

Dr Andreas Ernst holds seminars at the Goethe University Hospital Frankfurt

Dr Martina Fenske holds lectures for the Ecotoxicology Post-Gradual Training Program of SETAC-EUROPE (German Language Branch) eV amp Gesellschaft Deutscher Chemiker at the University of Heidelberg

Prof Dr Dr Gerd Geisslinger is director of the Institute for Clinical Pharmacology of the University Medical Center Frankfurt

PD Dr Bruno Oertel holds seminars at the Goethe University Hospital Frankfurt

Prof Dr Michael Parnham is Professor of Pharmacology and Toxicology in the Faculty of Biochemistry Chemistry and Pharmacy at Goethe University Frankfurt

Dr Ole Pless hold lectures seminars and work placements as part of the academic linking of the IME-ScreeningPort to the Faculty of Medicine of the University of Hamburg (UKE)

Prof Dr Dirk Pruumlfer is Professor of Plant Biotechnology at the University of Muumlnster

Dr Nicole Raven Dr Andreas Schiermeyer Holger Spiegel and Prof Dr Stefan Schillberg provide lectures on Plant Biotechnology at the Fachhochschule AachenProf Schillberg is also Honorary Professor at the Justus-Liebig University of Giessen

Prof Dr Christoph Schaumlfers holds an extraordinary professorship for eco(system)toxicology at the University of Muumlnster

PD Dr Susanne Schiffmann holds seminars at the Goethe University Hospital Frankfurt

Prof Dr Christian Schlechtriem is Honorary Professor for Ecotoxicology at the University of Siegen

Matthias Teigeler provides lectures on Ecotoxicology at the Fachhochschule Bingen

Prof Dr Andreas Vilcinskas is Professor for Applied Entomology at the Justus-Liebig University of Giessen

Dr Bjoumlrn Windshuumlgel holds lectures at the Jacobs University of Bremen

International activities and cooperation with the industryThe Fraunhofer IME cooperates with many internationalresearch partners and remains in close contact with universitiesand other research organizations The aim is to recognizetrends and developments as they emerge and to developand implement novel research strategies and technologies

In 2015 the Fraunhofer IME co-operated with around 100national and international industrial clients and several international industrial associations for whom confidential projects were carried out

Lecturing Assignments

Cooperation with RWTH Aachen University

Fraunhofer IME has close ties with RWTH Aachen University in terms of personnel and basic research areas Prof Dr Rainer Fischer is Chair and Director of the Institute for Molecular Biotechnology (IMB) The Fraunhofer IME offers Diploma Bachelors Masters and PhD courses in association with the RWTH Aachen University as well as lectures practical courses and seminars

The Fraunhofer IME Applied Ecology Division also gives lectures in applied ecology and collaborates with the RWTH research institute for ecosystem analysis and assessment (gaiac) performing mesocosm and other ecotoxicological studies for industrial clients

Additional Lecturing Assignments

Dr Mark Buumlcking and Dr Matthias Kotthoff hold lectures in the degree program food chemistry at the University of Wuppertal

Dr Natasja de Bruin holds seminars at the Goethe University Hospital Frankfurt and is guest lecturer at the Donders Institute for Brain Cognition and Behavior MSc Cognitive Neuroscience (Radboud University Nijmegen the Netherlands)

Prof Dr Carsten Claussen is honorary professor for information systems at the Heinz-Nixdorf Institute of the Paderborn UniversityHe also hold lectures seminars and work placements as part of the academic linking of the IME-ScreeningPort to the Faculty of Medicine of the University of Hamburg (UKE)

36 37

NETWORKS IN SCIENCE AND INDUSTRY

Memberships of Editorial Boards and Commitees

Scientific Journals

Current Research in Drug DiscoveryEditorial Board Dr Sheraz Gul

Drug Target ReviewEditor in chief Dr Sheraz Gul

Environmental Science and Pollution Research SpringerCo-editor of the series Chemical and Biological Environmental Monitoring Dr Heinz Ruumldel

Environmental Sciences Europe SpringerAdvisory Board Dr Kerstin Hund-Rinke

European Pharmaceutical ReviewEditorial board Dr Sheraz Gul

Fraunhofer Group for Life SciencesChairman Prof Dr Rainer Fischer

Frontiers in Plant Biotechnology Frontiers Media SAAssociate Editor Prof Dr Dirk Pruumlfer

Handbuch der Bodenuntersuchung Wiley-VCHBeirat Dr Dieter Hennecke

Journal of Applied Ichthyology Wiley-BlackwellEditorial Board Prof Dr Christian Schlechtriem

Journal of PharmaceuticsEditorial Board Dr Sheraz Gul

Plant Cell Reports SpringerEditorial Board Prof Dr Stefan Schillberg

Transgenic Research Kluwer Academic PublishersAssociate Editor Prof Dr Stefan Schillberg

Committees

AltmetricAmbassador Dr Sheraz Gul

Anti-Doping-Beauftragter des Landessportbundes HessenProf Dr Dr Gerd Geisslinger

Assay DepotBusiness Advisory Board Dr Sheraz Gul

Ausschuss fuumlr Innovation Handelskammer HamburgProf Dr Carsten Claussen

BioOumlkonomieRat AG BiotechnologieProf Dr Rainer Fischer

BMELV Wissenschaftlicher Beirat fuumlr DuumlngungsfragenStellvertretende Vorsitzende Dr Kerstin Hund-Rinke

Bundesinstitut fuumlr Risikobewertung (BfR) Kommission fuumlr Kontaminanten und andere gesundheitlich uner-wuumlnschte Stoffe in der Lebensmittel-ketteDr Mark Buumlcking

Bundesinstitut fuumlr Risikobewertung (BfR) Kommission fuumlr Pflanzenschutz-mittel und ihre RuumlckstaumlndeDr Michael Klein

BVL Expertengruppe zur Erstellung einer Richtlinie fuumlr Fischfuumltterungs-studienProf Dr Christian Schlechtriem

COST Action CM1307 1406Management Committee Substitute Dr Sheraz Gul

DAkkS Fachbegutachter bei der Deutschen AkkreditierungsstelleDr Kerstin Hund-Rinke Dr Josef Muumlller

Deutsche Gesellschaft fuumlr industrielle ZelltechnikBoard Dr Mira Graettinger

DFG Steering Group SystembiologieProf Dr Rainer Fischer

DFG Fachkollegium MedizinProf Dr Dr Gerd Geisslinger

DFG Senatskommission fuumlr klinische ForschungProf Dr Dr Gerd Geisslinger

DFG Allianz-AG raquoInfrastrukturen in der terrestrischen ForschunglaquoProf Dr Christoph Schaumlfers

DIBT Projektgruppe raquoModellierunglaquo des Deutschen Instituts fuumlr BautechnikDr Michael Klein

DIN NA 062 Normenausschuss Materialpruumlfungndashndash NA 062-02-93-AA Photokatalyse AK2 LuftreinhaltungDr Michael Huumlben

DIN NA 119 Normenausschuss Wasserwesen (NAW)ndashndash NA 119-01-02-05 UA Elutions-verfahrenDr Dieter Hennecke

ndashndash NA 119-01-02-02-01 AK Bioverfuumlg-barkeitDr Kerstin Derz

ndashndash NA 119-01-02-02-53 AK Sprengstofftypische VerbindungenDr Dieter Hennecke

ndashndash NA 119-01-02-04 UA Biologische VerfahrenDr Kerstin Hund-Rinke

ndashndash NA 119-01-02 AA Abfall- und Bo-denuntersuchung UA 1 ProbenahmeKarlheinz Weinfurtner

ndashndash NA 119-01-02-06 UA Bodenschutz Entsorgung Altlastensanierung UA 2 EntsorgungKarlheinz Weinfurtner

DIN NA 172-00-10 GA Gemeinschafts-arbeitsausschuss NAGUSNAL Nach-haltigkeitskriterien fuumlr BiomasseKarlheinz Weinfurtner

Dutch NeuroFederationDr Natasja de Bruin

EFSA Scientific Panel on Plant Pro-tection Products and their ResiduesDr Michael Kleinndashndash Working Group on the new gui-dance document about persistence in soilndashndash Working Group on non-target ar-thropods and in-soil risk assessment (Rapporteur)

EU-OPENSCREEN ndash The European Research Infrastructure for Chemical BiologyCoordinator Dr Philip Gribbon

FBU Fachbeirat BodenuntersuchungenDr Dieter Hennecke

Fachbeirat zum Masterstudiengang raquoBoden Gewaumlsser Altlastenlaquo an derHochschuleUniversitaumlt OsnabruumlckDr Kerstin Hund-Rinke

FENS Federation of European Neu-roscience Societies Dr Natasja de Bruin

FET Directorate General for Communications Networks Content and Technology raquoFuture amp Emerging Technologieslaquo Advisory Group European CommissionProf Dr Rainer Fischer

FOCUS (Forum for international coordination of pesticide fate models and their use) Work group ldquoVersion ControlldquoDr Michael Klein

Forschungsausschuss des Fachverban-des raquoAngewandte Photokatalyselaquo im Verband der MineralfarbenindustrieDr Kerstin Hund-Rinke

FPI eV Food-Processing InitiativeVorstandsvorsitzender Dr Mark Buumlcking

Forum Gesundheit der Bundes-regierungProf Dr Rainer Fischer

GDCh Fachgruppe Umweltchemie und Oumlkotoxikologiendashndash Arbeitskreis Bodenchemie und BodenoumlkologieLeitung Dr Dieter Hennecke

ndashndash Arbeitskreis ChemikalienbewertungDr Martin Muumlller

ndashndash Arbeitsgruppe Persistenz und Ab-baubarkeit im Arbeitskreis Chemika-lienbewertungDr Dieter Hennecke Dr Markus Simon

ndashndash Arbeitskreis UmweltmonitoringLeitung Dr Heinz Ruumldel

GDK (Gemeinschaft Deutscher Kryo-banken)Kassenpruumlfer Dr Heinz Ruumldel

Hochschulforum der Hamburger WirtschaftProf Dr Carsten Claussen

House of Pharma and HealthcareVorstandsmitglieder Prof Dr Dr Gerd Geisslinger Dr Frank Behrens

ILSI-HESI ndash Animal Alternatives in Environmental Risk Assessment Technical Committee

Dr Martina Fenske

Industrial Quality and Productivity Centre (IQPC) Pharmaceutical Advisory Board Dr Sheraz Gul

Initiative Gesundheitsindustrie HessenMitglied des Lenkungskreises Prof Dr Dr Gerd Geisslinger

International Association of Inflam-mation Societies (IAIS)Ex-officio Member Prof Dr Michael J Parnham

ISOTC 190 SC2 WG10 Soil quality ndashElaborating general aspects of samplingKarlheinz Weinfurtner

ISOTC 190 SC3 WG11 Explosive compoundsDr Dieter Hennecke

ISOTC 190 SC7 WG6 Leaching testsDr Dieter Hennecke

ISOTC 190 SC7 WG8 BioavailabilityDr Dieter Hennecke

ISPE Community of Practice Process analytical technologies Active Pharmaceutical IngredientsDr Juumlrgen Drossard

IUPAC Division of Chemistry and theEnvironment (DCE)Titular Member Dr Heinz Ruumldel

IUPAC Subcommittee on Chemical and Biophysical Processes in the EnvironmentSecretary Dr Heinz Ruumldel

KGITTC Korean-German Industrial TechnologyCooperation Committee Prof Dr Rainer Fischer

38 39

NETWORKS IN SCIENCE AND INDUSTRY

Kommission Bodenschutz beim UmweltbundesamtDr Kerstin Hund-Rinke

Kommission zur Bewertung wasser-gefaumlhrdender Stoffe (KBwS) des BMUProf Dr Christoph Schaumlfers

LebensmittelwirtschaftWissenschaftlicher Beirat Dr Mark Buumlcking

Lundbeckfonden Center of ExcellenceNanomedicine Research Centerfor Cancer Stem Cell TargetingTherapeutics (NanoCAN) (OdenseDenmark)Scientific advisory board member Dr Ole Pless

NORMAN ndash Network of reference laboratories research centres and related organisations for monitoring of emerging environmental substancesndashndash Working Group ldquoPrioritization of emerging substancesldquoDr Heinz Ruumldel

OECD Expert Group on Fish Bioaccu-mulationProf Dr Christian Schlechtriem

OECD Fish Drafting GroupProf Dr Christoph Schaumlfers Matthias Teigeler

OECD Working Party on Manufac-tured Nanomaterials (WPMN) ndash SG4 Drafting Group for Guidance on Sample Preparation and Dosimetry (DG-GSPD)Dr Kerstin Hund-Rinke

Pharma-Dialog der BundesregierungProf Dr Rainer Fischer

SETAC Europe Advisory Group on Mechanistic Effect Models for Ecological Risk Assessment of Chemicals (MEMoRisk)Co-chair Dr Udo Hommen

SETAC Global Advisory Group on Bioaccumulation ScienceProf Dr Christoph SchaumlfersCo-chair Prof Dr Christian Schlechtriem

SETAC Global Advisory Group on PlantsSteering Committee Dr Udo Hommen SETAC Global Advisory Group on Animal Alternatives in Environmen-tal ScienceDr Martina Fenske Prof Dr Christian Schlechtriem

SETAC Europe 26th Annual Meeting Nantes 2016Scientific Committee Dr Udo Hommen

Single Technologies (Stockholm Sweden)Scientific advisor Dr Sheraz Gul

Society for Neuroscience Dr Natasja de Bruin

Standardisierungsgremium Big Data VDIVDEFounding member Dr Manfred Kohler

Stiftung fuumlr Unternehmensrecht an der Heinrich Heine Universitaumlt DuumlsseldorfKuratoriumsmitglied Prof Dr Carsten Claussen

Stiftungsrat der Dr Robert Pfleger StiftungProf Dr Dr Gerd Geisslinger

Stiftungsrat der Freundlich-StiftungProf Dr Dr Gerd Geisslinger

UBA Arbeitskreis Fortentwicklung von Pruumlfmethoden im Rahmen des Stoffrechts AK Oumlkotoxikologie Akkumulation und Abbau in der UmweltProf Dr Christoph Schaumlfers

VDIVDE raquoDatenmanagement im Bereich Life ScienceslaquoVice chairman Dr Manfred Kohler

Wissenschaftlicher Beirat des Life Science-Center der Universitaumlt HohenheimProf Dr Rainer Fischer

Organization of Scientific Meetings and Courses (Applied Ecology)

Workshop ldquoEnvironmental monitoring of biocides in Europe ndash compartment-specific strategiesrdquoBerlin 25-2662015 carried out by Fraunhofer IME on behalf of the German Federal Environment Agency (Umweltbundesamt) and the NORMAN network

Lehrveranstaltung raquoGrundlagen der Oumlkotoxikologielaquo im Rahmen der Ausbildung zum Fachtoxikologen der DGPT (German Society for Experimental and Clinical Pharmacology and Toxicology) excursion day Fraunhofer IME Schmallenberg 2472015

Summer School WWU MuumlnsterUniversitaumlt Siegen raquoAquatische Oumlko(system)toxikologielaquoFraunhofer IME Schmallenberg 248ndash492015

Scientific Workshop on ldquoIdentifying limitations of the OECD water-sediment test (OECD 308) and developing suitable alternatives to assess persistencerdquoDuumlbendorf Switzerland 6102015 organized by EAWAG in cooperation with Fraunhofer IME ECT and Fraunhofer ITEM

wwwimefraunhoferde

160318_Einleger_Titel_210x277_RZindd 2 180316 1855

30 31

DOCTORAL MASTERrsquoSDIPLOMA AND BACHELORrsquoS THESES

Bachelorrsquos MasterrsquosDiploma and Doctoral Theses

Bacheloracutes Theses (BSc)

19

2

21

Doctoral Theses

16

2

18

Masteracutes (MA) or Diploma Theses

21

3

24

Total

56

7

63

IME-MB

IME-AE

IME

Doctoral Theses

Ahvari HoutanCharacterization and subcellular localization of endomembrane pro-teases from tobacco BY-2 cellsRWTH Aachen University

Barthelmes Julia (geb Maumlnnich)Die Rolle der Ceramidsynthase 2 bei der Pathogenese von Multipler SkleroseGoethe-Universitaumlt Frankfurt

Busch SaskiaRegulation of the 5-lipoxygenase by miRNAGoethe-Universitaumlt Frankfurt

Delov VeraFluoreszierende Toxizitaumltsendpunkte als vielversprechende Werkzeuge zur Weiterentwicklung des Fischembryo-tests fuumlr praktische Screening-An-wendungenRWTH Aachen University

Fuhrmann DominikChronic hypoxia in human macro-phages - adaption and functional consequencesGoethe-Universitaumlt Frankfurt

Gilbert BiancaDie Charakterisierung der humanen 5-Lipoxygenase als direktes Target-gen des Tumorsuppressors p53 und seine Relevanz fuumlr die TumorgeneseGoethe-Universitaumlt Frankfurt

Henke NinaRole of HIF-1α and HIF-2α in macro-phages during tumor progressionGoethe-Universitaumlt Frankfurt

Ibrahim LaraIdentification and modelling of a representative vulnerable fish species for pesticide risk assessment in EuropeRWTH Aachen University

Kemmerer MarinaElucidation of lipid metabolism pathways mediated by AMPK and nuclear receptors PPARdelta and LXRalpha in human macrophagesGoethe-Universitaumlt Frankfurt

Knape TiloDie Antagonisierung von PPARγ als neues Therapiekonzept bei SepsisGoethe-Universitaumlt Frankfurt

Mora JavierNovel IL-1 family ligands and recep-tors in the interaction of macropha-ges with apoptotic cellsGoethe-Universitaumlt Frankfurt

Salgado DanielaPurification and characterization of the plant-produced human surfac-tant protein D (hSPndashD)RWTH Aachen University

Scherzberg Maria-ChristinaMolecular Characterization of anticancer and metabolic activities of resveratrol analog 34rsquo5-(Z)-trime-thoxystilbene and interaction with AMPK inhibitor compound CGoethe-Universitaumlt Frankfurt

Schmitz KatjaThe role of endocannabinoid mo-dulators on the pathogenesis and therapy in different mouse models of multiple sclerosis and metabolic syndromeGoethe-Universitaumlt Frankfurt

Schroumlder MirjamIsolierung und Charakterisierung der isolierten regulatorischen Domaumlne der humanen 5 LipoxygenaseGoethe-Universitaumlt Frankfurt

Schubert MaxHerstellung und Charakterisierung von rekombinanten scFv-Fusionspro-teinen zur Generierung Aspergillus flavus -resistenter MaispflanzenRWTH Aachen University

Wanger RuthRegulation von Ceramidsynthasen in Kolonkarzinom-ZellenGoethe-Universitaumlt Frankfurt

Wegner Marthe-SusannaHormonelle Regulation von Ceramid-synthasen in BrustkrebszellenGoethe-Universitaumlt Frankfurt

32 33

NETWORKS IN SCIENCE AND INDUSTRY

34 35

NETWORKS IN SCIENCE AND INDUSTRY

Dr Andreas Ernst holds seminars at the Goethe University Hospital Frankfurt

Dr Martina Fenske holds lectures for the Ecotoxicology Post-Gradual Training Program of SETAC-EUROPE (German Language Branch) eV amp Gesellschaft Deutscher Chemiker at the University of Heidelberg

Prof Dr Dr Gerd Geisslinger is director of the Institute for Clinical Pharmacology of the University Medical Center Frankfurt

PD Dr Bruno Oertel holds seminars at the Goethe University Hospital Frankfurt

Prof Dr Michael Parnham is Professor of Pharmacology and Toxicology in the Faculty of Biochemistry Chemistry and Pharmacy at Goethe University Frankfurt

Dr Ole Pless hold lectures seminars and work placements as part of the academic linking of the IME-ScreeningPort to the Faculty of Medicine of the University of Hamburg (UKE)

Prof Dr Dirk Pruumlfer is Professor of Plant Biotechnology at the University of Muumlnster

Dr Nicole Raven Dr Andreas Schiermeyer Holger Spiegel and Prof Dr Stefan Schillberg provide lectures on Plant Biotechnology at the Fachhochschule AachenProf Schillberg is also Honorary Professor at the Justus-Liebig University of Giessen

Prof Dr Christoph Schaumlfers holds an extraordinary professorship for eco(system)toxicology at the University of Muumlnster

PD Dr Susanne Schiffmann holds seminars at the Goethe University Hospital Frankfurt

Prof Dr Christian Schlechtriem is Honorary Professor for Ecotoxicology at the University of Siegen

Matthias Teigeler provides lectures on Ecotoxicology at the Fachhochschule Bingen

Prof Dr Andreas Vilcinskas is Professor for Applied Entomology at the Justus-Liebig University of Giessen

Dr Bjoumlrn Windshuumlgel holds lectures at the Jacobs University of Bremen

International activities and cooperation with the industryThe Fraunhofer IME cooperates with many internationalresearch partners and remains in close contact with universitiesand other research organizations The aim is to recognizetrends and developments as they emerge and to developand implement novel research strategies and technologies

In 2015 the Fraunhofer IME co-operated with around 100national and international industrial clients and several international industrial associations for whom confidential projects were carried out

Lecturing Assignments

Cooperation with RWTH Aachen University

Fraunhofer IME has close ties with RWTH Aachen University in terms of personnel and basic research areas Prof Dr Rainer Fischer is Chair and Director of the Institute for Molecular Biotechnology (IMB) The Fraunhofer IME offers Diploma Bachelors Masters and PhD courses in association with the RWTH Aachen University as well as lectures practical courses and seminars

The Fraunhofer IME Applied Ecology Division also gives lectures in applied ecology and collaborates with the RWTH research institute for ecosystem analysis and assessment (gaiac) performing mesocosm and other ecotoxicological studies for industrial clients

Additional Lecturing Assignments

Dr Mark Buumlcking and Dr Matthias Kotthoff hold lectures in the degree program food chemistry at the University of Wuppertal

Dr Natasja de Bruin holds seminars at the Goethe University Hospital Frankfurt and is guest lecturer at the Donders Institute for Brain Cognition and Behavior MSc Cognitive Neuroscience (Radboud University Nijmegen the Netherlands)

Prof Dr Carsten Claussen is honorary professor for information systems at the Heinz-Nixdorf Institute of the Paderborn UniversityHe also hold lectures seminars and work placements as part of the academic linking of the IME-ScreeningPort to the Faculty of Medicine of the University of Hamburg (UKE)

36 37

NETWORKS IN SCIENCE AND INDUSTRY

Memberships of Editorial Boards and Commitees

Scientific Journals

Current Research in Drug DiscoveryEditorial Board Dr Sheraz Gul

Drug Target ReviewEditor in chief Dr Sheraz Gul

Environmental Science and Pollution Research SpringerCo-editor of the series Chemical and Biological Environmental Monitoring Dr Heinz Ruumldel

Environmental Sciences Europe SpringerAdvisory Board Dr Kerstin Hund-Rinke

European Pharmaceutical ReviewEditorial board Dr Sheraz Gul

Fraunhofer Group for Life SciencesChairman Prof Dr Rainer Fischer

Frontiers in Plant Biotechnology Frontiers Media SAAssociate Editor Prof Dr Dirk Pruumlfer

Handbuch der Bodenuntersuchung Wiley-VCHBeirat Dr Dieter Hennecke

Journal of Applied Ichthyology Wiley-BlackwellEditorial Board Prof Dr Christian Schlechtriem

Journal of PharmaceuticsEditorial Board Dr Sheraz Gul

Plant Cell Reports SpringerEditorial Board Prof Dr Stefan Schillberg

Transgenic Research Kluwer Academic PublishersAssociate Editor Prof Dr Stefan Schillberg

Committees

AltmetricAmbassador Dr Sheraz Gul

Anti-Doping-Beauftragter des Landessportbundes HessenProf Dr Dr Gerd Geisslinger

Assay DepotBusiness Advisory Board Dr Sheraz Gul

Ausschuss fuumlr Innovation Handelskammer HamburgProf Dr Carsten Claussen

BioOumlkonomieRat AG BiotechnologieProf Dr Rainer Fischer

BMELV Wissenschaftlicher Beirat fuumlr DuumlngungsfragenStellvertretende Vorsitzende Dr Kerstin Hund-Rinke

Bundesinstitut fuumlr Risikobewertung (BfR) Kommission fuumlr Kontaminanten und andere gesundheitlich uner-wuumlnschte Stoffe in der Lebensmittel-ketteDr Mark Buumlcking

Bundesinstitut fuumlr Risikobewertung (BfR) Kommission fuumlr Pflanzenschutz-mittel und ihre RuumlckstaumlndeDr Michael Klein

BVL Expertengruppe zur Erstellung einer Richtlinie fuumlr Fischfuumltterungs-studienProf Dr Christian Schlechtriem

COST Action CM1307 1406Management Committee Substitute Dr Sheraz Gul

DAkkS Fachbegutachter bei der Deutschen AkkreditierungsstelleDr Kerstin Hund-Rinke Dr Josef Muumlller

Deutsche Gesellschaft fuumlr industrielle ZelltechnikBoard Dr Mira Graettinger

DFG Steering Group SystembiologieProf Dr Rainer Fischer

DFG Fachkollegium MedizinProf Dr Dr Gerd Geisslinger

DFG Senatskommission fuumlr klinische ForschungProf Dr Dr Gerd Geisslinger

DFG Allianz-AG raquoInfrastrukturen in der terrestrischen ForschunglaquoProf Dr Christoph Schaumlfers

DIBT Projektgruppe raquoModellierunglaquo des Deutschen Instituts fuumlr BautechnikDr Michael Klein

DIN NA 062 Normenausschuss Materialpruumlfungndashndash NA 062-02-93-AA Photokatalyse AK2 LuftreinhaltungDr Michael Huumlben

DIN NA 119 Normenausschuss Wasserwesen (NAW)ndashndash NA 119-01-02-05 UA Elutions-verfahrenDr Dieter Hennecke

ndashndash NA 119-01-02-02-01 AK Bioverfuumlg-barkeitDr Kerstin Derz

ndashndash NA 119-01-02-02-53 AK Sprengstofftypische VerbindungenDr Dieter Hennecke

ndashndash NA 119-01-02-04 UA Biologische VerfahrenDr Kerstin Hund-Rinke

ndashndash NA 119-01-02 AA Abfall- und Bo-denuntersuchung UA 1 ProbenahmeKarlheinz Weinfurtner

ndashndash NA 119-01-02-06 UA Bodenschutz Entsorgung Altlastensanierung UA 2 EntsorgungKarlheinz Weinfurtner

DIN NA 172-00-10 GA Gemeinschafts-arbeitsausschuss NAGUSNAL Nach-haltigkeitskriterien fuumlr BiomasseKarlheinz Weinfurtner

Dutch NeuroFederationDr Natasja de Bruin

EFSA Scientific Panel on Plant Pro-tection Products and their ResiduesDr Michael Kleinndashndash Working Group on the new gui-dance document about persistence in soilndashndash Working Group on non-target ar-thropods and in-soil risk assessment (Rapporteur)

EU-OPENSCREEN ndash The European Research Infrastructure for Chemical BiologyCoordinator Dr Philip Gribbon

FBU Fachbeirat BodenuntersuchungenDr Dieter Hennecke

Fachbeirat zum Masterstudiengang raquoBoden Gewaumlsser Altlastenlaquo an derHochschuleUniversitaumlt OsnabruumlckDr Kerstin Hund-Rinke

FENS Federation of European Neu-roscience Societies Dr Natasja de Bruin

FET Directorate General for Communications Networks Content and Technology raquoFuture amp Emerging Technologieslaquo Advisory Group European CommissionProf Dr Rainer Fischer

FOCUS (Forum for international coordination of pesticide fate models and their use) Work group ldquoVersion ControlldquoDr Michael Klein

Forschungsausschuss des Fachverban-des raquoAngewandte Photokatalyselaquo im Verband der MineralfarbenindustrieDr Kerstin Hund-Rinke

FPI eV Food-Processing InitiativeVorstandsvorsitzender Dr Mark Buumlcking

Forum Gesundheit der Bundes-regierungProf Dr Rainer Fischer

GDCh Fachgruppe Umweltchemie und Oumlkotoxikologiendashndash Arbeitskreis Bodenchemie und BodenoumlkologieLeitung Dr Dieter Hennecke

ndashndash Arbeitskreis ChemikalienbewertungDr Martin Muumlller

ndashndash Arbeitsgruppe Persistenz und Ab-baubarkeit im Arbeitskreis Chemika-lienbewertungDr Dieter Hennecke Dr Markus Simon

ndashndash Arbeitskreis UmweltmonitoringLeitung Dr Heinz Ruumldel

GDK (Gemeinschaft Deutscher Kryo-banken)Kassenpruumlfer Dr Heinz Ruumldel

Hochschulforum der Hamburger WirtschaftProf Dr Carsten Claussen

House of Pharma and HealthcareVorstandsmitglieder Prof Dr Dr Gerd Geisslinger Dr Frank Behrens

ILSI-HESI ndash Animal Alternatives in Environmental Risk Assessment Technical Committee

Dr Martina Fenske

Industrial Quality and Productivity Centre (IQPC) Pharmaceutical Advisory Board Dr Sheraz Gul

Initiative Gesundheitsindustrie HessenMitglied des Lenkungskreises Prof Dr Dr Gerd Geisslinger

International Association of Inflam-mation Societies (IAIS)Ex-officio Member Prof Dr Michael J Parnham

ISOTC 190 SC2 WG10 Soil quality ndashElaborating general aspects of samplingKarlheinz Weinfurtner

ISOTC 190 SC3 WG11 Explosive compoundsDr Dieter Hennecke

ISOTC 190 SC7 WG6 Leaching testsDr Dieter Hennecke

ISOTC 190 SC7 WG8 BioavailabilityDr Dieter Hennecke

ISPE Community of Practice Process analytical technologies Active Pharmaceutical IngredientsDr Juumlrgen Drossard

IUPAC Division of Chemistry and theEnvironment (DCE)Titular Member Dr Heinz Ruumldel

IUPAC Subcommittee on Chemical and Biophysical Processes in the EnvironmentSecretary Dr Heinz Ruumldel

KGITTC Korean-German Industrial TechnologyCooperation Committee Prof Dr Rainer Fischer

38 39

NETWORKS IN SCIENCE AND INDUSTRY

Kommission Bodenschutz beim UmweltbundesamtDr Kerstin Hund-Rinke

Kommission zur Bewertung wasser-gefaumlhrdender Stoffe (KBwS) des BMUProf Dr Christoph Schaumlfers

LebensmittelwirtschaftWissenschaftlicher Beirat Dr Mark Buumlcking

Lundbeckfonden Center of ExcellenceNanomedicine Research Centerfor Cancer Stem Cell TargetingTherapeutics (NanoCAN) (OdenseDenmark)Scientific advisory board member Dr Ole Pless

NORMAN ndash Network of reference laboratories research centres and related organisations for monitoring of emerging environmental substancesndashndash Working Group ldquoPrioritization of emerging substancesldquoDr Heinz Ruumldel

OECD Expert Group on Fish Bioaccu-mulationProf Dr Christian Schlechtriem

OECD Fish Drafting GroupProf Dr Christoph Schaumlfers Matthias Teigeler

OECD Working Party on Manufac-tured Nanomaterials (WPMN) ndash SG4 Drafting Group for Guidance on Sample Preparation and Dosimetry (DG-GSPD)Dr Kerstin Hund-Rinke

Pharma-Dialog der BundesregierungProf Dr Rainer Fischer

SETAC Europe Advisory Group on Mechanistic Effect Models for Ecological Risk Assessment of Chemicals (MEMoRisk)Co-chair Dr Udo Hommen

SETAC Global Advisory Group on Bioaccumulation ScienceProf Dr Christoph SchaumlfersCo-chair Prof Dr Christian Schlechtriem

SETAC Global Advisory Group on PlantsSteering Committee Dr Udo Hommen SETAC Global Advisory Group on Animal Alternatives in Environmen-tal ScienceDr Martina Fenske Prof Dr Christian Schlechtriem

SETAC Europe 26th Annual Meeting Nantes 2016Scientific Committee Dr Udo Hommen

Single Technologies (Stockholm Sweden)Scientific advisor Dr Sheraz Gul

Society for Neuroscience Dr Natasja de Bruin

Standardisierungsgremium Big Data VDIVDEFounding member Dr Manfred Kohler

Stiftung fuumlr Unternehmensrecht an der Heinrich Heine Universitaumlt DuumlsseldorfKuratoriumsmitglied Prof Dr Carsten Claussen

Stiftungsrat der Dr Robert Pfleger StiftungProf Dr Dr Gerd Geisslinger

Stiftungsrat der Freundlich-StiftungProf Dr Dr Gerd Geisslinger

UBA Arbeitskreis Fortentwicklung von Pruumlfmethoden im Rahmen des Stoffrechts AK Oumlkotoxikologie Akkumulation und Abbau in der UmweltProf Dr Christoph Schaumlfers

VDIVDE raquoDatenmanagement im Bereich Life ScienceslaquoVice chairman Dr Manfred Kohler

Wissenschaftlicher Beirat des Life Science-Center der Universitaumlt HohenheimProf Dr Rainer Fischer

Organization of Scientific Meetings and Courses (Applied Ecology)

Workshop ldquoEnvironmental monitoring of biocides in Europe ndash compartment-specific strategiesrdquoBerlin 25-2662015 carried out by Fraunhofer IME on behalf of the German Federal Environment Agency (Umweltbundesamt) and the NORMAN network

Lehrveranstaltung raquoGrundlagen der Oumlkotoxikologielaquo im Rahmen der Ausbildung zum Fachtoxikologen der DGPT (German Society for Experimental and Clinical Pharmacology and Toxicology) excursion day Fraunhofer IME Schmallenberg 2472015

Summer School WWU MuumlnsterUniversitaumlt Siegen raquoAquatische Oumlko(system)toxikologielaquoFraunhofer IME Schmallenberg 248ndash492015

Scientific Workshop on ldquoIdentifying limitations of the OECD water-sediment test (OECD 308) and developing suitable alternatives to assess persistencerdquoDuumlbendorf Switzerland 6102015 organized by EAWAG in cooperation with Fraunhofer IME ECT and Fraunhofer ITEM

wwwimefraunhoferde

160318_Einleger_Titel_210x277_RZindd 2 180316 1855

32 33

NETWORKS IN SCIENCE AND INDUSTRY

34 35

NETWORKS IN SCIENCE AND INDUSTRY

Dr Andreas Ernst holds seminars at the Goethe University Hospital Frankfurt

Dr Martina Fenske holds lectures for the Ecotoxicology Post-Gradual Training Program of SETAC-EUROPE (German Language Branch) eV amp Gesellschaft Deutscher Chemiker at the University of Heidelberg

Prof Dr Dr Gerd Geisslinger is director of the Institute for Clinical Pharmacology of the University Medical Center Frankfurt

PD Dr Bruno Oertel holds seminars at the Goethe University Hospital Frankfurt

Prof Dr Michael Parnham is Professor of Pharmacology and Toxicology in the Faculty of Biochemistry Chemistry and Pharmacy at Goethe University Frankfurt

Dr Ole Pless hold lectures seminars and work placements as part of the academic linking of the IME-ScreeningPort to the Faculty of Medicine of the University of Hamburg (UKE)

Prof Dr Dirk Pruumlfer is Professor of Plant Biotechnology at the University of Muumlnster

Dr Nicole Raven Dr Andreas Schiermeyer Holger Spiegel and Prof Dr Stefan Schillberg provide lectures on Plant Biotechnology at the Fachhochschule AachenProf Schillberg is also Honorary Professor at the Justus-Liebig University of Giessen

Prof Dr Christoph Schaumlfers holds an extraordinary professorship for eco(system)toxicology at the University of Muumlnster

PD Dr Susanne Schiffmann holds seminars at the Goethe University Hospital Frankfurt

Prof Dr Christian Schlechtriem is Honorary Professor for Ecotoxicology at the University of Siegen

Matthias Teigeler provides lectures on Ecotoxicology at the Fachhochschule Bingen

Prof Dr Andreas Vilcinskas is Professor for Applied Entomology at the Justus-Liebig University of Giessen

Dr Bjoumlrn Windshuumlgel holds lectures at the Jacobs University of Bremen

International activities and cooperation with the industryThe Fraunhofer IME cooperates with many internationalresearch partners and remains in close contact with universitiesand other research organizations The aim is to recognizetrends and developments as they emerge and to developand implement novel research strategies and technologies

In 2015 the Fraunhofer IME co-operated with around 100national and international industrial clients and several international industrial associations for whom confidential projects were carried out

Lecturing Assignments

Cooperation with RWTH Aachen University

Fraunhofer IME has close ties with RWTH Aachen University in terms of personnel and basic research areas Prof Dr Rainer Fischer is Chair and Director of the Institute for Molecular Biotechnology (IMB) The Fraunhofer IME offers Diploma Bachelors Masters and PhD courses in association with the RWTH Aachen University as well as lectures practical courses and seminars

The Fraunhofer IME Applied Ecology Division also gives lectures in applied ecology and collaborates with the RWTH research institute for ecosystem analysis and assessment (gaiac) performing mesocosm and other ecotoxicological studies for industrial clients

Additional Lecturing Assignments

Dr Mark Buumlcking and Dr Matthias Kotthoff hold lectures in the degree program food chemistry at the University of Wuppertal

Dr Natasja de Bruin holds seminars at the Goethe University Hospital Frankfurt and is guest lecturer at the Donders Institute for Brain Cognition and Behavior MSc Cognitive Neuroscience (Radboud University Nijmegen the Netherlands)

Prof Dr Carsten Claussen is honorary professor for information systems at the Heinz-Nixdorf Institute of the Paderborn UniversityHe also hold lectures seminars and work placements as part of the academic linking of the IME-ScreeningPort to the Faculty of Medicine of the University of Hamburg (UKE)

36 37

NETWORKS IN SCIENCE AND INDUSTRY

Memberships of Editorial Boards and Commitees

Scientific Journals

Current Research in Drug DiscoveryEditorial Board Dr Sheraz Gul

Drug Target ReviewEditor in chief Dr Sheraz Gul

Environmental Science and Pollution Research SpringerCo-editor of the series Chemical and Biological Environmental Monitoring Dr Heinz Ruumldel

Environmental Sciences Europe SpringerAdvisory Board Dr Kerstin Hund-Rinke

European Pharmaceutical ReviewEditorial board Dr Sheraz Gul

Fraunhofer Group for Life SciencesChairman Prof Dr Rainer Fischer

Frontiers in Plant Biotechnology Frontiers Media SAAssociate Editor Prof Dr Dirk Pruumlfer

Handbuch der Bodenuntersuchung Wiley-VCHBeirat Dr Dieter Hennecke

Journal of Applied Ichthyology Wiley-BlackwellEditorial Board Prof Dr Christian Schlechtriem

Journal of PharmaceuticsEditorial Board Dr Sheraz Gul

Plant Cell Reports SpringerEditorial Board Prof Dr Stefan Schillberg

Transgenic Research Kluwer Academic PublishersAssociate Editor Prof Dr Stefan Schillberg

Committees

AltmetricAmbassador Dr Sheraz Gul

Anti-Doping-Beauftragter des Landessportbundes HessenProf Dr Dr Gerd Geisslinger

Assay DepotBusiness Advisory Board Dr Sheraz Gul

Ausschuss fuumlr Innovation Handelskammer HamburgProf Dr Carsten Claussen

BioOumlkonomieRat AG BiotechnologieProf Dr Rainer Fischer

BMELV Wissenschaftlicher Beirat fuumlr DuumlngungsfragenStellvertretende Vorsitzende Dr Kerstin Hund-Rinke

Bundesinstitut fuumlr Risikobewertung (BfR) Kommission fuumlr Kontaminanten und andere gesundheitlich uner-wuumlnschte Stoffe in der Lebensmittel-ketteDr Mark Buumlcking

Bundesinstitut fuumlr Risikobewertung (BfR) Kommission fuumlr Pflanzenschutz-mittel und ihre RuumlckstaumlndeDr Michael Klein

BVL Expertengruppe zur Erstellung einer Richtlinie fuumlr Fischfuumltterungs-studienProf Dr Christian Schlechtriem

COST Action CM1307 1406Management Committee Substitute Dr Sheraz Gul

DAkkS Fachbegutachter bei der Deutschen AkkreditierungsstelleDr Kerstin Hund-Rinke Dr Josef Muumlller

Deutsche Gesellschaft fuumlr industrielle ZelltechnikBoard Dr Mira Graettinger

DFG Steering Group SystembiologieProf Dr Rainer Fischer

DFG Fachkollegium MedizinProf Dr Dr Gerd Geisslinger

DFG Senatskommission fuumlr klinische ForschungProf Dr Dr Gerd Geisslinger

DFG Allianz-AG raquoInfrastrukturen in der terrestrischen ForschunglaquoProf Dr Christoph Schaumlfers

DIBT Projektgruppe raquoModellierunglaquo des Deutschen Instituts fuumlr BautechnikDr Michael Klein

DIN NA 062 Normenausschuss Materialpruumlfungndashndash NA 062-02-93-AA Photokatalyse AK2 LuftreinhaltungDr Michael Huumlben

DIN NA 119 Normenausschuss Wasserwesen (NAW)ndashndash NA 119-01-02-05 UA Elutions-verfahrenDr Dieter Hennecke

ndashndash NA 119-01-02-02-01 AK Bioverfuumlg-barkeitDr Kerstin Derz

ndashndash NA 119-01-02-02-53 AK Sprengstofftypische VerbindungenDr Dieter Hennecke

ndashndash NA 119-01-02-04 UA Biologische VerfahrenDr Kerstin Hund-Rinke

ndashndash NA 119-01-02 AA Abfall- und Bo-denuntersuchung UA 1 ProbenahmeKarlheinz Weinfurtner

ndashndash NA 119-01-02-06 UA Bodenschutz Entsorgung Altlastensanierung UA 2 EntsorgungKarlheinz Weinfurtner

DIN NA 172-00-10 GA Gemeinschafts-arbeitsausschuss NAGUSNAL Nach-haltigkeitskriterien fuumlr BiomasseKarlheinz Weinfurtner

Dutch NeuroFederationDr Natasja de Bruin

EFSA Scientific Panel on Plant Pro-tection Products and their ResiduesDr Michael Kleinndashndash Working Group on the new gui-dance document about persistence in soilndashndash Working Group on non-target ar-thropods and in-soil risk assessment (Rapporteur)

EU-OPENSCREEN ndash The European Research Infrastructure for Chemical BiologyCoordinator Dr Philip Gribbon

FBU Fachbeirat BodenuntersuchungenDr Dieter Hennecke

Fachbeirat zum Masterstudiengang raquoBoden Gewaumlsser Altlastenlaquo an derHochschuleUniversitaumlt OsnabruumlckDr Kerstin Hund-Rinke

FENS Federation of European Neu-roscience Societies Dr Natasja de Bruin

FET Directorate General for Communications Networks Content and Technology raquoFuture amp Emerging Technologieslaquo Advisory Group European CommissionProf Dr Rainer Fischer

FOCUS (Forum for international coordination of pesticide fate models and their use) Work group ldquoVersion ControlldquoDr Michael Klein

Forschungsausschuss des Fachverban-des raquoAngewandte Photokatalyselaquo im Verband der MineralfarbenindustrieDr Kerstin Hund-Rinke

FPI eV Food-Processing InitiativeVorstandsvorsitzender Dr Mark Buumlcking

Forum Gesundheit der Bundes-regierungProf Dr Rainer Fischer

GDCh Fachgruppe Umweltchemie und Oumlkotoxikologiendashndash Arbeitskreis Bodenchemie und BodenoumlkologieLeitung Dr Dieter Hennecke

ndashndash Arbeitskreis ChemikalienbewertungDr Martin Muumlller

ndashndash Arbeitsgruppe Persistenz und Ab-baubarkeit im Arbeitskreis Chemika-lienbewertungDr Dieter Hennecke Dr Markus Simon

ndashndash Arbeitskreis UmweltmonitoringLeitung Dr Heinz Ruumldel

GDK (Gemeinschaft Deutscher Kryo-banken)Kassenpruumlfer Dr Heinz Ruumldel

Hochschulforum der Hamburger WirtschaftProf Dr Carsten Claussen

House of Pharma and HealthcareVorstandsmitglieder Prof Dr Dr Gerd Geisslinger Dr Frank Behrens

ILSI-HESI ndash Animal Alternatives in Environmental Risk Assessment Technical Committee

Dr Martina Fenske

Industrial Quality and Productivity Centre (IQPC) Pharmaceutical Advisory Board Dr Sheraz Gul

Initiative Gesundheitsindustrie HessenMitglied des Lenkungskreises Prof Dr Dr Gerd Geisslinger

International Association of Inflam-mation Societies (IAIS)Ex-officio Member Prof Dr Michael J Parnham

ISOTC 190 SC2 WG10 Soil quality ndashElaborating general aspects of samplingKarlheinz Weinfurtner

ISOTC 190 SC3 WG11 Explosive compoundsDr Dieter Hennecke

ISOTC 190 SC7 WG6 Leaching testsDr Dieter Hennecke

ISOTC 190 SC7 WG8 BioavailabilityDr Dieter Hennecke

ISPE Community of Practice Process analytical technologies Active Pharmaceutical IngredientsDr Juumlrgen Drossard

IUPAC Division of Chemistry and theEnvironment (DCE)Titular Member Dr Heinz Ruumldel

IUPAC Subcommittee on Chemical and Biophysical Processes in the EnvironmentSecretary Dr Heinz Ruumldel

KGITTC Korean-German Industrial TechnologyCooperation Committee Prof Dr Rainer Fischer

38 39

NETWORKS IN SCIENCE AND INDUSTRY

Kommission Bodenschutz beim UmweltbundesamtDr Kerstin Hund-Rinke

Kommission zur Bewertung wasser-gefaumlhrdender Stoffe (KBwS) des BMUProf Dr Christoph Schaumlfers

LebensmittelwirtschaftWissenschaftlicher Beirat Dr Mark Buumlcking

Lundbeckfonden Center of ExcellenceNanomedicine Research Centerfor Cancer Stem Cell TargetingTherapeutics (NanoCAN) (OdenseDenmark)Scientific advisory board member Dr Ole Pless

NORMAN ndash Network of reference laboratories research centres and related organisations for monitoring of emerging environmental substancesndashndash Working Group ldquoPrioritization of emerging substancesldquoDr Heinz Ruumldel

OECD Expert Group on Fish Bioaccu-mulationProf Dr Christian Schlechtriem

OECD Fish Drafting GroupProf Dr Christoph Schaumlfers Matthias Teigeler

OECD Working Party on Manufac-tured Nanomaterials (WPMN) ndash SG4 Drafting Group for Guidance on Sample Preparation and Dosimetry (DG-GSPD)Dr Kerstin Hund-Rinke

Pharma-Dialog der BundesregierungProf Dr Rainer Fischer

SETAC Europe Advisory Group on Mechanistic Effect Models for Ecological Risk Assessment of Chemicals (MEMoRisk)Co-chair Dr Udo Hommen

SETAC Global Advisory Group on Bioaccumulation ScienceProf Dr Christoph SchaumlfersCo-chair Prof Dr Christian Schlechtriem

SETAC Global Advisory Group on PlantsSteering Committee Dr Udo Hommen SETAC Global Advisory Group on Animal Alternatives in Environmen-tal ScienceDr Martina Fenske Prof Dr Christian Schlechtriem

SETAC Europe 26th Annual Meeting Nantes 2016Scientific Committee Dr Udo Hommen

Single Technologies (Stockholm Sweden)Scientific advisor Dr Sheraz Gul

Society for Neuroscience Dr Natasja de Bruin

Standardisierungsgremium Big Data VDIVDEFounding member Dr Manfred Kohler

Stiftung fuumlr Unternehmensrecht an der Heinrich Heine Universitaumlt DuumlsseldorfKuratoriumsmitglied Prof Dr Carsten Claussen

Stiftungsrat der Dr Robert Pfleger StiftungProf Dr Dr Gerd Geisslinger

Stiftungsrat der Freundlich-StiftungProf Dr Dr Gerd Geisslinger

UBA Arbeitskreis Fortentwicklung von Pruumlfmethoden im Rahmen des Stoffrechts AK Oumlkotoxikologie Akkumulation und Abbau in der UmweltProf Dr Christoph Schaumlfers

VDIVDE raquoDatenmanagement im Bereich Life ScienceslaquoVice chairman Dr Manfred Kohler

Wissenschaftlicher Beirat des Life Science-Center der Universitaumlt HohenheimProf Dr Rainer Fischer

Organization of Scientific Meetings and Courses (Applied Ecology)

Workshop ldquoEnvironmental monitoring of biocides in Europe ndash compartment-specific strategiesrdquoBerlin 25-2662015 carried out by Fraunhofer IME on behalf of the German Federal Environment Agency (Umweltbundesamt) and the NORMAN network

Lehrveranstaltung raquoGrundlagen der Oumlkotoxikologielaquo im Rahmen der Ausbildung zum Fachtoxikologen der DGPT (German Society for Experimental and Clinical Pharmacology and Toxicology) excursion day Fraunhofer IME Schmallenberg 2472015

Summer School WWU MuumlnsterUniversitaumlt Siegen raquoAquatische Oumlko(system)toxikologielaquoFraunhofer IME Schmallenberg 248ndash492015

Scientific Workshop on ldquoIdentifying limitations of the OECD water-sediment test (OECD 308) and developing suitable alternatives to assess persistencerdquoDuumlbendorf Switzerland 6102015 organized by EAWAG in cooperation with Fraunhofer IME ECT and Fraunhofer ITEM

wwwimefraunhoferde

160318_Einleger_Titel_210x277_RZindd 2 180316 1855

34 35

NETWORKS IN SCIENCE AND INDUSTRY

Dr Andreas Ernst holds seminars at the Goethe University Hospital Frankfurt

Dr Martina Fenske holds lectures for the Ecotoxicology Post-Gradual Training Program of SETAC-EUROPE (German Language Branch) eV amp Gesellschaft Deutscher Chemiker at the University of Heidelberg

Prof Dr Dr Gerd Geisslinger is director of the Institute for Clinical Pharmacology of the University Medical Center Frankfurt

PD Dr Bruno Oertel holds seminars at the Goethe University Hospital Frankfurt

Prof Dr Michael Parnham is Professor of Pharmacology and Toxicology in the Faculty of Biochemistry Chemistry and Pharmacy at Goethe University Frankfurt

Dr Ole Pless hold lectures seminars and work placements as part of the academic linking of the IME-ScreeningPort to the Faculty of Medicine of the University of Hamburg (UKE)

Prof Dr Dirk Pruumlfer is Professor of Plant Biotechnology at the University of Muumlnster

Dr Nicole Raven Dr Andreas Schiermeyer Holger Spiegel and Prof Dr Stefan Schillberg provide lectures on Plant Biotechnology at the Fachhochschule AachenProf Schillberg is also Honorary Professor at the Justus-Liebig University of Giessen

Prof Dr Christoph Schaumlfers holds an extraordinary professorship for eco(system)toxicology at the University of Muumlnster

PD Dr Susanne Schiffmann holds seminars at the Goethe University Hospital Frankfurt

Prof Dr Christian Schlechtriem is Honorary Professor for Ecotoxicology at the University of Siegen

Matthias Teigeler provides lectures on Ecotoxicology at the Fachhochschule Bingen

Prof Dr Andreas Vilcinskas is Professor for Applied Entomology at the Justus-Liebig University of Giessen

Dr Bjoumlrn Windshuumlgel holds lectures at the Jacobs University of Bremen

International activities and cooperation with the industryThe Fraunhofer IME cooperates with many internationalresearch partners and remains in close contact with universitiesand other research organizations The aim is to recognizetrends and developments as they emerge and to developand implement novel research strategies and technologies

In 2015 the Fraunhofer IME co-operated with around 100national and international industrial clients and several international industrial associations for whom confidential projects were carried out

Lecturing Assignments

Cooperation with RWTH Aachen University

Fraunhofer IME has close ties with RWTH Aachen University in terms of personnel and basic research areas Prof Dr Rainer Fischer is Chair and Director of the Institute for Molecular Biotechnology (IMB) The Fraunhofer IME offers Diploma Bachelors Masters and PhD courses in association with the RWTH Aachen University as well as lectures practical courses and seminars

The Fraunhofer IME Applied Ecology Division also gives lectures in applied ecology and collaborates with the RWTH research institute for ecosystem analysis and assessment (gaiac) performing mesocosm and other ecotoxicological studies for industrial clients

Additional Lecturing Assignments

Dr Mark Buumlcking and Dr Matthias Kotthoff hold lectures in the degree program food chemistry at the University of Wuppertal

Dr Natasja de Bruin holds seminars at the Goethe University Hospital Frankfurt and is guest lecturer at the Donders Institute for Brain Cognition and Behavior MSc Cognitive Neuroscience (Radboud University Nijmegen the Netherlands)

Prof Dr Carsten Claussen is honorary professor for information systems at the Heinz-Nixdorf Institute of the Paderborn UniversityHe also hold lectures seminars and work placements as part of the academic linking of the IME-ScreeningPort to the Faculty of Medicine of the University of Hamburg (UKE)

36 37

NETWORKS IN SCIENCE AND INDUSTRY

Memberships of Editorial Boards and Commitees

Scientific Journals

Current Research in Drug DiscoveryEditorial Board Dr Sheraz Gul

Drug Target ReviewEditor in chief Dr Sheraz Gul

Environmental Science and Pollution Research SpringerCo-editor of the series Chemical and Biological Environmental Monitoring Dr Heinz Ruumldel

Environmental Sciences Europe SpringerAdvisory Board Dr Kerstin Hund-Rinke

European Pharmaceutical ReviewEditorial board Dr Sheraz Gul

Fraunhofer Group for Life SciencesChairman Prof Dr Rainer Fischer

Frontiers in Plant Biotechnology Frontiers Media SAAssociate Editor Prof Dr Dirk Pruumlfer

Handbuch der Bodenuntersuchung Wiley-VCHBeirat Dr Dieter Hennecke

Journal of Applied Ichthyology Wiley-BlackwellEditorial Board Prof Dr Christian Schlechtriem

Journal of PharmaceuticsEditorial Board Dr Sheraz Gul

Plant Cell Reports SpringerEditorial Board Prof Dr Stefan Schillberg

Transgenic Research Kluwer Academic PublishersAssociate Editor Prof Dr Stefan Schillberg

Committees

AltmetricAmbassador Dr Sheraz Gul

Anti-Doping-Beauftragter des Landessportbundes HessenProf Dr Dr Gerd Geisslinger

Assay DepotBusiness Advisory Board Dr Sheraz Gul

Ausschuss fuumlr Innovation Handelskammer HamburgProf Dr Carsten Claussen

BioOumlkonomieRat AG BiotechnologieProf Dr Rainer Fischer

BMELV Wissenschaftlicher Beirat fuumlr DuumlngungsfragenStellvertretende Vorsitzende Dr Kerstin Hund-Rinke

Bundesinstitut fuumlr Risikobewertung (BfR) Kommission fuumlr Kontaminanten und andere gesundheitlich uner-wuumlnschte Stoffe in der Lebensmittel-ketteDr Mark Buumlcking

Bundesinstitut fuumlr Risikobewertung (BfR) Kommission fuumlr Pflanzenschutz-mittel und ihre RuumlckstaumlndeDr Michael Klein

BVL Expertengruppe zur Erstellung einer Richtlinie fuumlr Fischfuumltterungs-studienProf Dr Christian Schlechtriem

COST Action CM1307 1406Management Committee Substitute Dr Sheraz Gul

DAkkS Fachbegutachter bei der Deutschen AkkreditierungsstelleDr Kerstin Hund-Rinke Dr Josef Muumlller

Deutsche Gesellschaft fuumlr industrielle ZelltechnikBoard Dr Mira Graettinger

DFG Steering Group SystembiologieProf Dr Rainer Fischer

DFG Fachkollegium MedizinProf Dr Dr Gerd Geisslinger

DFG Senatskommission fuumlr klinische ForschungProf Dr Dr Gerd Geisslinger

DFG Allianz-AG raquoInfrastrukturen in der terrestrischen ForschunglaquoProf Dr Christoph Schaumlfers

DIBT Projektgruppe raquoModellierunglaquo des Deutschen Instituts fuumlr BautechnikDr Michael Klein

DIN NA 062 Normenausschuss Materialpruumlfungndashndash NA 062-02-93-AA Photokatalyse AK2 LuftreinhaltungDr Michael Huumlben

DIN NA 119 Normenausschuss Wasserwesen (NAW)ndashndash NA 119-01-02-05 UA Elutions-verfahrenDr Dieter Hennecke

ndashndash NA 119-01-02-02-01 AK Bioverfuumlg-barkeitDr Kerstin Derz

ndashndash NA 119-01-02-02-53 AK Sprengstofftypische VerbindungenDr Dieter Hennecke

ndashndash NA 119-01-02-04 UA Biologische VerfahrenDr Kerstin Hund-Rinke

ndashndash NA 119-01-02 AA Abfall- und Bo-denuntersuchung UA 1 ProbenahmeKarlheinz Weinfurtner

ndashndash NA 119-01-02-06 UA Bodenschutz Entsorgung Altlastensanierung UA 2 EntsorgungKarlheinz Weinfurtner

DIN NA 172-00-10 GA Gemeinschafts-arbeitsausschuss NAGUSNAL Nach-haltigkeitskriterien fuumlr BiomasseKarlheinz Weinfurtner

Dutch NeuroFederationDr Natasja de Bruin

EFSA Scientific Panel on Plant Pro-tection Products and their ResiduesDr Michael Kleinndashndash Working Group on the new gui-dance document about persistence in soilndashndash Working Group on non-target ar-thropods and in-soil risk assessment (Rapporteur)

EU-OPENSCREEN ndash The European Research Infrastructure for Chemical BiologyCoordinator Dr Philip Gribbon

FBU Fachbeirat BodenuntersuchungenDr Dieter Hennecke

Fachbeirat zum Masterstudiengang raquoBoden Gewaumlsser Altlastenlaquo an derHochschuleUniversitaumlt OsnabruumlckDr Kerstin Hund-Rinke

FENS Federation of European Neu-roscience Societies Dr Natasja de Bruin

FET Directorate General for Communications Networks Content and Technology raquoFuture amp Emerging Technologieslaquo Advisory Group European CommissionProf Dr Rainer Fischer

FOCUS (Forum for international coordination of pesticide fate models and their use) Work group ldquoVersion ControlldquoDr Michael Klein

Forschungsausschuss des Fachverban-des raquoAngewandte Photokatalyselaquo im Verband der MineralfarbenindustrieDr Kerstin Hund-Rinke

FPI eV Food-Processing InitiativeVorstandsvorsitzender Dr Mark Buumlcking

Forum Gesundheit der Bundes-regierungProf Dr Rainer Fischer

GDCh Fachgruppe Umweltchemie und Oumlkotoxikologiendashndash Arbeitskreis Bodenchemie und BodenoumlkologieLeitung Dr Dieter Hennecke

ndashndash Arbeitskreis ChemikalienbewertungDr Martin Muumlller

ndashndash Arbeitsgruppe Persistenz und Ab-baubarkeit im Arbeitskreis Chemika-lienbewertungDr Dieter Hennecke Dr Markus Simon

ndashndash Arbeitskreis UmweltmonitoringLeitung Dr Heinz Ruumldel

GDK (Gemeinschaft Deutscher Kryo-banken)Kassenpruumlfer Dr Heinz Ruumldel

Hochschulforum der Hamburger WirtschaftProf Dr Carsten Claussen

House of Pharma and HealthcareVorstandsmitglieder Prof Dr Dr Gerd Geisslinger Dr Frank Behrens

ILSI-HESI ndash Animal Alternatives in Environmental Risk Assessment Technical Committee

Dr Martina Fenske

Industrial Quality and Productivity Centre (IQPC) Pharmaceutical Advisory Board Dr Sheraz Gul

Initiative Gesundheitsindustrie HessenMitglied des Lenkungskreises Prof Dr Dr Gerd Geisslinger

International Association of Inflam-mation Societies (IAIS)Ex-officio Member Prof Dr Michael J Parnham

ISOTC 190 SC2 WG10 Soil quality ndashElaborating general aspects of samplingKarlheinz Weinfurtner

ISOTC 190 SC3 WG11 Explosive compoundsDr Dieter Hennecke

ISOTC 190 SC7 WG6 Leaching testsDr Dieter Hennecke

ISOTC 190 SC7 WG8 BioavailabilityDr Dieter Hennecke

ISPE Community of Practice Process analytical technologies Active Pharmaceutical IngredientsDr Juumlrgen Drossard

IUPAC Division of Chemistry and theEnvironment (DCE)Titular Member Dr Heinz Ruumldel

IUPAC Subcommittee on Chemical and Biophysical Processes in the EnvironmentSecretary Dr Heinz Ruumldel

KGITTC Korean-German Industrial TechnologyCooperation Committee Prof Dr Rainer Fischer

38 39

NETWORKS IN SCIENCE AND INDUSTRY

Kommission Bodenschutz beim UmweltbundesamtDr Kerstin Hund-Rinke

Kommission zur Bewertung wasser-gefaumlhrdender Stoffe (KBwS) des BMUProf Dr Christoph Schaumlfers

LebensmittelwirtschaftWissenschaftlicher Beirat Dr Mark Buumlcking

Lundbeckfonden Center of ExcellenceNanomedicine Research Centerfor Cancer Stem Cell TargetingTherapeutics (NanoCAN) (OdenseDenmark)Scientific advisory board member Dr Ole Pless

NORMAN ndash Network of reference laboratories research centres and related organisations for monitoring of emerging environmental substancesndashndash Working Group ldquoPrioritization of emerging substancesldquoDr Heinz Ruumldel

OECD Expert Group on Fish Bioaccu-mulationProf Dr Christian Schlechtriem

OECD Fish Drafting GroupProf Dr Christoph Schaumlfers Matthias Teigeler

OECD Working Party on Manufac-tured Nanomaterials (WPMN) ndash SG4 Drafting Group for Guidance on Sample Preparation and Dosimetry (DG-GSPD)Dr Kerstin Hund-Rinke

Pharma-Dialog der BundesregierungProf Dr Rainer Fischer

SETAC Europe Advisory Group on Mechanistic Effect Models for Ecological Risk Assessment of Chemicals (MEMoRisk)Co-chair Dr Udo Hommen

SETAC Global Advisory Group on Bioaccumulation ScienceProf Dr Christoph SchaumlfersCo-chair Prof Dr Christian Schlechtriem

SETAC Global Advisory Group on PlantsSteering Committee Dr Udo Hommen SETAC Global Advisory Group on Animal Alternatives in Environmen-tal ScienceDr Martina Fenske Prof Dr Christian Schlechtriem

SETAC Europe 26th Annual Meeting Nantes 2016Scientific Committee Dr Udo Hommen

Single Technologies (Stockholm Sweden)Scientific advisor Dr Sheraz Gul

Society for Neuroscience Dr Natasja de Bruin

Standardisierungsgremium Big Data VDIVDEFounding member Dr Manfred Kohler

Stiftung fuumlr Unternehmensrecht an der Heinrich Heine Universitaumlt DuumlsseldorfKuratoriumsmitglied Prof Dr Carsten Claussen

Stiftungsrat der Dr Robert Pfleger StiftungProf Dr Dr Gerd Geisslinger

Stiftungsrat der Freundlich-StiftungProf Dr Dr Gerd Geisslinger

UBA Arbeitskreis Fortentwicklung von Pruumlfmethoden im Rahmen des Stoffrechts AK Oumlkotoxikologie Akkumulation und Abbau in der UmweltProf Dr Christoph Schaumlfers

VDIVDE raquoDatenmanagement im Bereich Life ScienceslaquoVice chairman Dr Manfred Kohler

Wissenschaftlicher Beirat des Life Science-Center der Universitaumlt HohenheimProf Dr Rainer Fischer

Organization of Scientific Meetings and Courses (Applied Ecology)

Workshop ldquoEnvironmental monitoring of biocides in Europe ndash compartment-specific strategiesrdquoBerlin 25-2662015 carried out by Fraunhofer IME on behalf of the German Federal Environment Agency (Umweltbundesamt) and the NORMAN network

Lehrveranstaltung raquoGrundlagen der Oumlkotoxikologielaquo im Rahmen der Ausbildung zum Fachtoxikologen der DGPT (German Society for Experimental and Clinical Pharmacology and Toxicology) excursion day Fraunhofer IME Schmallenberg 2472015

Summer School WWU MuumlnsterUniversitaumlt Siegen raquoAquatische Oumlko(system)toxikologielaquoFraunhofer IME Schmallenberg 248ndash492015

Scientific Workshop on ldquoIdentifying limitations of the OECD water-sediment test (OECD 308) and developing suitable alternatives to assess persistencerdquoDuumlbendorf Switzerland 6102015 organized by EAWAG in cooperation with Fraunhofer IME ECT and Fraunhofer ITEM

wwwimefraunhoferde

160318_Einleger_Titel_210x277_RZindd 2 180316 1855

36 37

NETWORKS IN SCIENCE AND INDUSTRY

Memberships of Editorial Boards and Commitees

Scientific Journals

Current Research in Drug DiscoveryEditorial Board Dr Sheraz Gul

Drug Target ReviewEditor in chief Dr Sheraz Gul

Environmental Science and Pollution Research SpringerCo-editor of the series Chemical and Biological Environmental Monitoring Dr Heinz Ruumldel

Environmental Sciences Europe SpringerAdvisory Board Dr Kerstin Hund-Rinke

European Pharmaceutical ReviewEditorial board Dr Sheraz Gul

Fraunhofer Group for Life SciencesChairman Prof Dr Rainer Fischer

Frontiers in Plant Biotechnology Frontiers Media SAAssociate Editor Prof Dr Dirk Pruumlfer

Handbuch der Bodenuntersuchung Wiley-VCHBeirat Dr Dieter Hennecke

Journal of Applied Ichthyology Wiley-BlackwellEditorial Board Prof Dr Christian Schlechtriem

Journal of PharmaceuticsEditorial Board Dr Sheraz Gul

Plant Cell Reports SpringerEditorial Board Prof Dr Stefan Schillberg

Transgenic Research Kluwer Academic PublishersAssociate Editor Prof Dr Stefan Schillberg

Committees

AltmetricAmbassador Dr Sheraz Gul

Anti-Doping-Beauftragter des Landessportbundes HessenProf Dr Dr Gerd Geisslinger

Assay DepotBusiness Advisory Board Dr Sheraz Gul

Ausschuss fuumlr Innovation Handelskammer HamburgProf Dr Carsten Claussen

BioOumlkonomieRat AG BiotechnologieProf Dr Rainer Fischer

BMELV Wissenschaftlicher Beirat fuumlr DuumlngungsfragenStellvertretende Vorsitzende Dr Kerstin Hund-Rinke

Bundesinstitut fuumlr Risikobewertung (BfR) Kommission fuumlr Kontaminanten und andere gesundheitlich uner-wuumlnschte Stoffe in der Lebensmittel-ketteDr Mark Buumlcking

Bundesinstitut fuumlr Risikobewertung (BfR) Kommission fuumlr Pflanzenschutz-mittel und ihre RuumlckstaumlndeDr Michael Klein

BVL Expertengruppe zur Erstellung einer Richtlinie fuumlr Fischfuumltterungs-studienProf Dr Christian Schlechtriem

COST Action CM1307 1406Management Committee Substitute Dr Sheraz Gul

DAkkS Fachbegutachter bei der Deutschen AkkreditierungsstelleDr Kerstin Hund-Rinke Dr Josef Muumlller

Deutsche Gesellschaft fuumlr industrielle ZelltechnikBoard Dr Mira Graettinger

DFG Steering Group SystembiologieProf Dr Rainer Fischer

DFG Fachkollegium MedizinProf Dr Dr Gerd Geisslinger

DFG Senatskommission fuumlr klinische ForschungProf Dr Dr Gerd Geisslinger

DFG Allianz-AG raquoInfrastrukturen in der terrestrischen ForschunglaquoProf Dr Christoph Schaumlfers

DIBT Projektgruppe raquoModellierunglaquo des Deutschen Instituts fuumlr BautechnikDr Michael Klein

DIN NA 062 Normenausschuss Materialpruumlfungndashndash NA 062-02-93-AA Photokatalyse AK2 LuftreinhaltungDr Michael Huumlben

DIN NA 119 Normenausschuss Wasserwesen (NAW)ndashndash NA 119-01-02-05 UA Elutions-verfahrenDr Dieter Hennecke

ndashndash NA 119-01-02-02-01 AK Bioverfuumlg-barkeitDr Kerstin Derz

ndashndash NA 119-01-02-02-53 AK Sprengstofftypische VerbindungenDr Dieter Hennecke

ndashndash NA 119-01-02-04 UA Biologische VerfahrenDr Kerstin Hund-Rinke

ndashndash NA 119-01-02 AA Abfall- und Bo-denuntersuchung UA 1 ProbenahmeKarlheinz Weinfurtner

ndashndash NA 119-01-02-06 UA Bodenschutz Entsorgung Altlastensanierung UA 2 EntsorgungKarlheinz Weinfurtner

DIN NA 172-00-10 GA Gemeinschafts-arbeitsausschuss NAGUSNAL Nach-haltigkeitskriterien fuumlr BiomasseKarlheinz Weinfurtner

Dutch NeuroFederationDr Natasja de Bruin

EFSA Scientific Panel on Plant Pro-tection Products and their ResiduesDr Michael Kleinndashndash Working Group on the new gui-dance document about persistence in soilndashndash Working Group on non-target ar-thropods and in-soil risk assessment (Rapporteur)

EU-OPENSCREEN ndash The European Research Infrastructure for Chemical BiologyCoordinator Dr Philip Gribbon

FBU Fachbeirat BodenuntersuchungenDr Dieter Hennecke

Fachbeirat zum Masterstudiengang raquoBoden Gewaumlsser Altlastenlaquo an derHochschuleUniversitaumlt OsnabruumlckDr Kerstin Hund-Rinke

FENS Federation of European Neu-roscience Societies Dr Natasja de Bruin

FET Directorate General for Communications Networks Content and Technology raquoFuture amp Emerging Technologieslaquo Advisory Group European CommissionProf Dr Rainer Fischer

FOCUS (Forum for international coordination of pesticide fate models and their use) Work group ldquoVersion ControlldquoDr Michael Klein

Forschungsausschuss des Fachverban-des raquoAngewandte Photokatalyselaquo im Verband der MineralfarbenindustrieDr Kerstin Hund-Rinke

FPI eV Food-Processing InitiativeVorstandsvorsitzender Dr Mark Buumlcking

Forum Gesundheit der Bundes-regierungProf Dr Rainer Fischer

GDCh Fachgruppe Umweltchemie und Oumlkotoxikologiendashndash Arbeitskreis Bodenchemie und BodenoumlkologieLeitung Dr Dieter Hennecke

ndashndash Arbeitskreis ChemikalienbewertungDr Martin Muumlller

ndashndash Arbeitsgruppe Persistenz und Ab-baubarkeit im Arbeitskreis Chemika-lienbewertungDr Dieter Hennecke Dr Markus Simon

ndashndash Arbeitskreis UmweltmonitoringLeitung Dr Heinz Ruumldel

GDK (Gemeinschaft Deutscher Kryo-banken)Kassenpruumlfer Dr Heinz Ruumldel

Hochschulforum der Hamburger WirtschaftProf Dr Carsten Claussen

House of Pharma and HealthcareVorstandsmitglieder Prof Dr Dr Gerd Geisslinger Dr Frank Behrens

ILSI-HESI ndash Animal Alternatives in Environmental Risk Assessment Technical Committee

Dr Martina Fenske

Industrial Quality and Productivity Centre (IQPC) Pharmaceutical Advisory Board Dr Sheraz Gul

Initiative Gesundheitsindustrie HessenMitglied des Lenkungskreises Prof Dr Dr Gerd Geisslinger

International Association of Inflam-mation Societies (IAIS)Ex-officio Member Prof Dr Michael J Parnham

ISOTC 190 SC2 WG10 Soil quality ndashElaborating general aspects of samplingKarlheinz Weinfurtner

ISOTC 190 SC3 WG11 Explosive compoundsDr Dieter Hennecke

ISOTC 190 SC7 WG6 Leaching testsDr Dieter Hennecke

ISOTC 190 SC7 WG8 BioavailabilityDr Dieter Hennecke

ISPE Community of Practice Process analytical technologies Active Pharmaceutical IngredientsDr Juumlrgen Drossard

IUPAC Division of Chemistry and theEnvironment (DCE)Titular Member Dr Heinz Ruumldel

IUPAC Subcommittee on Chemical and Biophysical Processes in the EnvironmentSecretary Dr Heinz Ruumldel

KGITTC Korean-German Industrial TechnologyCooperation Committee Prof Dr Rainer Fischer

38 39

NETWORKS IN SCIENCE AND INDUSTRY

Kommission Bodenschutz beim UmweltbundesamtDr Kerstin Hund-Rinke

Kommission zur Bewertung wasser-gefaumlhrdender Stoffe (KBwS) des BMUProf Dr Christoph Schaumlfers

LebensmittelwirtschaftWissenschaftlicher Beirat Dr Mark Buumlcking

Lundbeckfonden Center of ExcellenceNanomedicine Research Centerfor Cancer Stem Cell TargetingTherapeutics (NanoCAN) (OdenseDenmark)Scientific advisory board member Dr Ole Pless

NORMAN ndash Network of reference laboratories research centres and related organisations for monitoring of emerging environmental substancesndashndash Working Group ldquoPrioritization of emerging substancesldquoDr Heinz Ruumldel

OECD Expert Group on Fish Bioaccu-mulationProf Dr Christian Schlechtriem

OECD Fish Drafting GroupProf Dr Christoph Schaumlfers Matthias Teigeler

OECD Working Party on Manufac-tured Nanomaterials (WPMN) ndash SG4 Drafting Group for Guidance on Sample Preparation and Dosimetry (DG-GSPD)Dr Kerstin Hund-Rinke

Pharma-Dialog der BundesregierungProf Dr Rainer Fischer

SETAC Europe Advisory Group on Mechanistic Effect Models for Ecological Risk Assessment of Chemicals (MEMoRisk)Co-chair Dr Udo Hommen

SETAC Global Advisory Group on Bioaccumulation ScienceProf Dr Christoph SchaumlfersCo-chair Prof Dr Christian Schlechtriem

SETAC Global Advisory Group on PlantsSteering Committee Dr Udo Hommen SETAC Global Advisory Group on Animal Alternatives in Environmen-tal ScienceDr Martina Fenske Prof Dr Christian Schlechtriem

SETAC Europe 26th Annual Meeting Nantes 2016Scientific Committee Dr Udo Hommen

Single Technologies (Stockholm Sweden)Scientific advisor Dr Sheraz Gul

Society for Neuroscience Dr Natasja de Bruin

Standardisierungsgremium Big Data VDIVDEFounding member Dr Manfred Kohler

Stiftung fuumlr Unternehmensrecht an der Heinrich Heine Universitaumlt DuumlsseldorfKuratoriumsmitglied Prof Dr Carsten Claussen

Stiftungsrat der Dr Robert Pfleger StiftungProf Dr Dr Gerd Geisslinger

Stiftungsrat der Freundlich-StiftungProf Dr Dr Gerd Geisslinger

UBA Arbeitskreis Fortentwicklung von Pruumlfmethoden im Rahmen des Stoffrechts AK Oumlkotoxikologie Akkumulation und Abbau in der UmweltProf Dr Christoph Schaumlfers

VDIVDE raquoDatenmanagement im Bereich Life ScienceslaquoVice chairman Dr Manfred Kohler

Wissenschaftlicher Beirat des Life Science-Center der Universitaumlt HohenheimProf Dr Rainer Fischer

Organization of Scientific Meetings and Courses (Applied Ecology)

Workshop ldquoEnvironmental monitoring of biocides in Europe ndash compartment-specific strategiesrdquoBerlin 25-2662015 carried out by Fraunhofer IME on behalf of the German Federal Environment Agency (Umweltbundesamt) and the NORMAN network

Lehrveranstaltung raquoGrundlagen der Oumlkotoxikologielaquo im Rahmen der Ausbildung zum Fachtoxikologen der DGPT (German Society for Experimental and Clinical Pharmacology and Toxicology) excursion day Fraunhofer IME Schmallenberg 2472015

Summer School WWU MuumlnsterUniversitaumlt Siegen raquoAquatische Oumlko(system)toxikologielaquoFraunhofer IME Schmallenberg 248ndash492015

Scientific Workshop on ldquoIdentifying limitations of the OECD water-sediment test (OECD 308) and developing suitable alternatives to assess persistencerdquoDuumlbendorf Switzerland 6102015 organized by EAWAG in cooperation with Fraunhofer IME ECT and Fraunhofer ITEM

wwwimefraunhoferde

160318_Einleger_Titel_210x277_RZindd 2 180316 1855

38 39

NETWORKS IN SCIENCE AND INDUSTRY

Kommission Bodenschutz beim UmweltbundesamtDr Kerstin Hund-Rinke

Kommission zur Bewertung wasser-gefaumlhrdender Stoffe (KBwS) des BMUProf Dr Christoph Schaumlfers

LebensmittelwirtschaftWissenschaftlicher Beirat Dr Mark Buumlcking

Lundbeckfonden Center of ExcellenceNanomedicine Research Centerfor Cancer Stem Cell TargetingTherapeutics (NanoCAN) (OdenseDenmark)Scientific advisory board member Dr Ole Pless

NORMAN ndash Network of reference laboratories research centres and related organisations for monitoring of emerging environmental substancesndashndash Working Group ldquoPrioritization of emerging substancesldquoDr Heinz Ruumldel

OECD Expert Group on Fish Bioaccu-mulationProf Dr Christian Schlechtriem

OECD Fish Drafting GroupProf Dr Christoph Schaumlfers Matthias Teigeler

OECD Working Party on Manufac-tured Nanomaterials (WPMN) ndash SG4 Drafting Group for Guidance on Sample Preparation and Dosimetry (DG-GSPD)Dr Kerstin Hund-Rinke

Pharma-Dialog der BundesregierungProf Dr Rainer Fischer

SETAC Europe Advisory Group on Mechanistic Effect Models for Ecological Risk Assessment of Chemicals (MEMoRisk)Co-chair Dr Udo Hommen

SETAC Global Advisory Group on Bioaccumulation ScienceProf Dr Christoph SchaumlfersCo-chair Prof Dr Christian Schlechtriem

SETAC Global Advisory Group on PlantsSteering Committee Dr Udo Hommen SETAC Global Advisory Group on Animal Alternatives in Environmen-tal ScienceDr Martina Fenske Prof Dr Christian Schlechtriem

SETAC Europe 26th Annual Meeting Nantes 2016Scientific Committee Dr Udo Hommen

Single Technologies (Stockholm Sweden)Scientific advisor Dr Sheraz Gul

Society for Neuroscience Dr Natasja de Bruin

Standardisierungsgremium Big Data VDIVDEFounding member Dr Manfred Kohler

Stiftung fuumlr Unternehmensrecht an der Heinrich Heine Universitaumlt DuumlsseldorfKuratoriumsmitglied Prof Dr Carsten Claussen

Stiftungsrat der Dr Robert Pfleger StiftungProf Dr Dr Gerd Geisslinger

Stiftungsrat der Freundlich-StiftungProf Dr Dr Gerd Geisslinger

UBA Arbeitskreis Fortentwicklung von Pruumlfmethoden im Rahmen des Stoffrechts AK Oumlkotoxikologie Akkumulation und Abbau in der UmweltProf Dr Christoph Schaumlfers

VDIVDE raquoDatenmanagement im Bereich Life ScienceslaquoVice chairman Dr Manfred Kohler

Wissenschaftlicher Beirat des Life Science-Center der Universitaumlt HohenheimProf Dr Rainer Fischer

Organization of Scientific Meetings and Courses (Applied Ecology)

Workshop ldquoEnvironmental monitoring of biocides in Europe ndash compartment-specific strategiesrdquoBerlin 25-2662015 carried out by Fraunhofer IME on behalf of the German Federal Environment Agency (Umweltbundesamt) and the NORMAN network

Lehrveranstaltung raquoGrundlagen der Oumlkotoxikologielaquo im Rahmen der Ausbildung zum Fachtoxikologen der DGPT (German Society for Experimental and Clinical Pharmacology and Toxicology) excursion day Fraunhofer IME Schmallenberg 2472015

Summer School WWU MuumlnsterUniversitaumlt Siegen raquoAquatische Oumlko(system)toxikologielaquoFraunhofer IME Schmallenberg 248ndash492015

Scientific Workshop on ldquoIdentifying limitations of the OECD water-sediment test (OECD 308) and developing suitable alternatives to assess persistencerdquoDuumlbendorf Switzerland 6102015 organized by EAWAG in cooperation with Fraunhofer IME ECT and Fraunhofer ITEM

wwwimefraunhoferde

160318_Einleger_Titel_210x277_RZindd 2 180316 1855

wwwimefraunhoferde

160318_Einleger_Titel_210x277_RZindd 2 180316 1855