Fact of the Day: Ovarian Cancer Awareness Month
-
Upload
myriadgenetics -
Category
Health & Medicine
-
view
11.786 -
download
0
Transcript of Fact of the Day: Ovarian Cancer Awareness Month
OVARIAN CANCER AWARENESS
MYRIAD GENETICS PRESENTS
OVARIAN CANCER AWARENESS
SEPTEMBER DAILY AWARENESS
SUN MON TUE WED THUR FRI SAT
1 2 4 5
6 7 8 9 10 11 12
13 14 15 16 17 18 19
20 21 22 23 24 25 26
27 28 29 30
3
tweet this
SEPTEMBER 1
1 in 72 women will develop ovarian cancer in their lifetime.1
tweet this
SEPTEMBER 2
1 in 7 ovarian cancers are due to BRCA mutations.2
tweet this
SEPTEMBER 3
Lynparza (olaparib) is the first and only FDA-approved PARP inhibitor for use in patients with ovarian cancer who have a BRCA mutation and have been treated with three or more prior lines of chemotherapy.3 Hear about one patient’s journey with BRCA-associated ovarian cancer: Katya
tweet this
SEPTEMBER 4
Pap tests/cervical smear tests are not a screening test for ovarian cancer.4
tweet this
SEPTEMBER 5
Almost half (44%) of women with BRCA mutation-associated ovarian cancer have NO family history of breast or ovarian cancer.2
44%
tweet this
SEPTEMBER 6
Up to 5% of endometrial cancers are due to a hereditary (inherited) cause. The most common hereditary cause of endometrial cancer is Lynch syndrome, which also increases the risk of developing colorectal and ovarian cancer.5
tweet thistweet this
SEPTEMBER 7
There are other genes that increase the risk of ovarian cancer beyond BRCA1 and BRCA2, such as BRIP1, MSH6, and RAD51D. Learn more about these and other hereditary ovarian cancer genes here.
OVARIAN
BRCA1
BRIPI
MSH2
MSH6
PMS2RAD51D
RAD51C
EPCAM
TP53 BRCA2
MLH1
STK11
tweet this
SEPTEMBER 8
0 20 40 60 80 100
Women with a BRCA mutation have up to a 44% risk of developing ovarian cancer by age 70 (compared to the average woman’s risk of 1.4%.)6
Breast cancer by age 50
Breast cancer by age 70
Ovarian cancer by age 70
tweet this
SEPTEMBER 9
Symptoms of endometrial cancer can include vaginal bleeding, spotting, or discharge that is not normal for you. Any vaginal bleeding occurring after menopause should be further evaluated to rule out endometrial cancer.7
tweet this
SEPTEMBER 10
People who have a first-degree relative (parent, sibling, or child) with a BRCA mutation have a 50% chance to inherit the same mutation.5
tweet this
SEPTEMBER 11
There is no proven early detection test for ovarian cancer. Women at increased risk of developing this cancer, such as those with an inherited gene mutation, may be recommended by their doctor to undergoing screening for certain markers in the blood (such as CA-125) or by ultrasound.8
tweet this
SEPTEMBER 12
The average woman’s risk of developing endometrial cancer is 2.7%. That risk increases to up to 71% in women with a hereditary endometrial cancer syndrome like Lynch syndrome.9
2.7%
71%with hereditary endometrial cancer syndrome
the average woman’s risk
tweet this
SEPTEMBER 13
While ovarian cancer is often called the “silent killer”, there are some symptoms to watch out for. These can include bloating, pelvic or abdominal pain, difficulty eating or feeling full quickly, urinary symptoms such as urgency or frequency, fatigue, indigestion, back pain, pain with intercourse, constipation, and menstrual changes. If these symptoms persist for more than two weeks, see your physician.4
FATIGUE
UPSET STOMACH
BACK PAIN
CONSTIPATION
MENSTRUALCHANGES
ABDOMINALSWELLING WITH
WEIGHT LOSS
RECOGNIZE THE SYMPTOMS
tweet this
SEPTEMBER 14
There are preventive measures available for women at increased risk of ovarian cancer. Oral contraceptives reduce the risk of ovarian cancer by up to 50%, and surgical removal of the ovaries and fallopian tubes reduces risk by up to 96%. Tubal removal alone and breastfeeding may also reduce the risk of developing ovarian cancer.4
50%
oral contraceptives reduce the risk by up to
tweet thistweet this
SEPTEMBER 15
Risk factors for ovarian cancer include: a family history of breast/ovarian cancer, a mutation in a hereditary cancer gene, a personal history of breast cancer, a personal history of colon cancer, having no children, possibly infertility, beginning menstruation at an early age (before age 12), a later age of menopause (after age 55), and increasing age.4
tweet this
SEPTEMBER 16
The National Comprehensive Cancer Network (NCCN) and the Society of Gynecologic Oncology (SGO) recommend that ALL women with ovarian cancer receive genetic testing, regardless of family history.10
tweet this
SEPTEMBER 17
There are 3 major types of ovarian cancer: epithelial, germ cell, and sex-cord stromal cell. Epithelial ovarian cancer represents around 90% of ovarian cancers.4
EPITHELIAL
Represents around 90% of ovarian cancers; common
among women over the age of 60 but can develop at
any age.
GERM CELL
Represents 5% of ovarian cancers; usually only impacts 1 ovary in adolescent and young women.
SEX-CORDSTROMAL CELL
Represents less than 5% of patients; tumors occur with equal
frequency among pre- and post-menopausal women.
tweet this
SEPTEMBER 18
Hereditary cancer genetic testing is broadly covered by the vast majority of health insurance plans. In fact, most patients with ovarian cancer pay $0 out of pocket for genetic testing.11
$0 pay for genetic testing
tweet this
SEPTEMBER 19
BRCA mutations can be inherited from either the mother’s or the father’sside of the family.5
tweet this
SEPTEMBER 20
Risk factors for endometrial cancer include: a family history of endometrial cancer, a mutation in a hereditary cancer gene, increased age, beginning menstruation at an early age (before age 12), a late age of menopause (after age 55), exposure to estrogen-only hormone replacement therapy, obesity, polycystic ovary syndrome (PCOS), and exposure to tamoxifen.9
tweet this
SEPTEMBER 21
Early detection of ovarian cancer is key, and more research is needed to develop effective screening tools. When caught in its early stages, 92% of women with ovarian cancer will survive five years, compared to only 28% of those who are diagnosed after the cancer has spread to other organs. Unfortunately, only 15% of ovarian cancer is currently diagnosed at an early stage.4
92%of women with ovarian cancer will survive 5 years
tweet this
SEPTEMBER 22
Patients with BRCA mutation-associated ovarian cancer may respond better to platinum-based chemotherapy, as well as other classes of drugs; for example, PARP inhibitors.2
tweet this
SEPTEMBER 23
A family history of ovarian cancer is important for men to know about as well. Not only could a hereditary ovarian cancer syndrome impact their female relatives, men with a BRCA mutation are also at increased for cancers of the prostate, pancreas, breast, and melanoma.
tweet this
SEPTEMBER 24
Only 25% of patients newly diagnosed with ovarian cancer know their BRCA status12, even though the National Comprehensive Cancer Network (NCCN) has recommended BRCA1 and BRCA2 testing for all patients with epithelial ovarian cancer since 2008. If you’ve had ovarian cancer, talk to your doctor about whether genetic testing is right for you.
Only 25% of patients newly diagnosed with ovarian cancer know their BRCA status
tweet this
SEPTEMBER 25
Women with Lynch syndrome have a high risk of developing a second cancer such as colon cancer or ovarian cancer. Up to 30% will develop a second cancer within 10 years of their first cancer diagnosis, and up to 50% will within 15 years.13,14
30% will develop a second cancer within 10 years
50% will develop a second cancer within 15 years
tweet this
SEPTEMBER 26
Ovarian cancer is a deadly disease. This year, there will be more than 21,000 new cases of ovarian cancer diagnosed and about 14,000 deaths from ovarian cancer.1
More than 21,000
new cases of ovarian
cancer diagnosed
About 14,000 deaths
each year from
ovarian cancer
tweet this
SEPTEMBER 27
BRCA mutations are not only found in younger patients; 66% of women with BRCA mutation-associated ovarian cancer are diagnosed after the age of 50.15
66%of BRCA-positive women are diagnosed after age 50
tweet this
SEPTEMBER 28
1 in 4 patients with endometrial cancer are at risk for hereditary cancer and should undergo genetic testing. Approximately 24% of patients with endometrial cancer are diagnosed before the age of 50, which is one of the clinical testing criteria recognized by the National Comprehensive Cancer Network (NCCN).9,16
at risk for hereditary cancer
24% with endometrial cancer are diagnosed before the age of 50
tweet this
SEPTEMBER 29
Are you at risk for hereditary gynecologic cancer? Take the hereditary cancer quiz here to find out. Red flags for hereditary cancer include rare cancers (such as ovarian cancer), cancer that occurs at an earlier age than in the general population (such as breast or colon cancer in a 30-year-old), more than one type of cancer occurring in one person (such as a woman experiencing both breast and ovarian cancers or cancer in both breasts), and multiple people on the same side of the family with similar or related types of cancer (for example, several relatives with breast cancer).
tweet this
SEPTEMBER 30
Knowledge is power - talk to your doctor about your personal or family history of ovarian cancer. Find a health care professional here.
View full interactive calendar here.