Ezastatin ( The Art of Combination Therapy)
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Transcript of Ezastatin ( The Art of Combination Therapy)
![Page 1: Ezastatin ( The Art of Combination Therapy)](https://reader034.fdocuments.net/reader034/viewer/2022052523/55507e47b4c905cc0f8b55f8/html5/thumbnails/1.jpg)
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Coronary Artery Disease Risk
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Coronary Artery Disease Risk
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Are LDL-C Goals The Same For All Patients With Dyslipideamia?
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Coronary Artery Disease RiskATP III modification
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Debate
Can we achieve these goals with Statin mono therapy alone ?
At which Statin concentration ? Is it enough to achieve normal lipid
profile only ? what else ? What about increase exogenous
cholesterol absorption in diabetics?
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Coronary Artery Disease RiskStatins monotherapy limitations
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Coronary Artery Disease RiskStatins monotherapy limitations
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Fill the unmet need in lipid lowering managementEzastatin
atorvastatin + ezetimibe
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MANAGEMENT OF DIABETIC DYSLIPIDEMIA: RECENT ADVANCES IN COMBINATION THERAPY
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Fill the unmet need in lipid lowering managementEzastatin
atorvastatin + ezetimibe
![Page 12: Ezastatin ( The Art of Combination Therapy)](https://reader034.fdocuments.net/reader034/viewer/2022052523/55507e47b4c905cc0f8b55f8/html5/thumbnails/12.jpg)
Fill the unmet need in lipid lowering managementEzastatin
atorvastatin + ezetimibe
![Page 13: Ezastatin ( The Art of Combination Therapy)](https://reader034.fdocuments.net/reader034/viewer/2022052523/55507e47b4c905cc0f8b55f8/html5/thumbnails/13.jpg)
Fill the unmet need in lipid lowering managementEzastatin
atorvastatin + ezetimibe
![Page 14: Ezastatin ( The Art of Combination Therapy)](https://reader034.fdocuments.net/reader034/viewer/2022052523/55507e47b4c905cc0f8b55f8/html5/thumbnails/14.jpg)
Fill the unmet need in lipid lowering managementEzastatin
atorvastatin + ezetimibe
![Page 15: Ezastatin ( The Art of Combination Therapy)](https://reader034.fdocuments.net/reader034/viewer/2022052523/55507e47b4c905cc0f8b55f8/html5/thumbnails/15.jpg)
Fill the unmet need in lipid lowering managementEzastatin
atorvastatin + ezetimibe
![Page 16: Ezastatin ( The Art of Combination Therapy)](https://reader034.fdocuments.net/reader034/viewer/2022052523/55507e47b4c905cc0f8b55f8/html5/thumbnails/16.jpg)
Fill the unmet need in lipid lowering managementEzastatin
atorvastatin + ezetimibe
![Page 17: Ezastatin ( The Art of Combination Therapy)](https://reader034.fdocuments.net/reader034/viewer/2022052523/55507e47b4c905cc0f8b55f8/html5/thumbnails/17.jpg)
Fill the unmet need in lipid lowering managementEzastatin
atorvastatin + ezetimibe
![Page 18: Ezastatin ( The Art of Combination Therapy)](https://reader034.fdocuments.net/reader034/viewer/2022052523/55507e47b4c905cc0f8b55f8/html5/thumbnails/18.jpg)
Fill the unmet need in lipid lowering managementEzastatin
atorvastatin + ezetimibe
![Page 19: Ezastatin ( The Art of Combination Therapy)](https://reader034.fdocuments.net/reader034/viewer/2022052523/55507e47b4c905cc0f8b55f8/html5/thumbnails/19.jpg)
Fill the unmet need in lipid lowering managementEzastatin
atorvastatin + ezetimibe
![Page 20: Ezastatin ( The Art of Combination Therapy)](https://reader034.fdocuments.net/reader034/viewer/2022052523/55507e47b4c905cc0f8b55f8/html5/thumbnails/20.jpg)
Fill the unmet need in lipid lowering managementEzastatin
atorvastatin + ezetimibe
![Page 21: Ezastatin ( The Art of Combination Therapy)](https://reader034.fdocuments.net/reader034/viewer/2022052523/55507e47b4c905cc0f8b55f8/html5/thumbnails/21.jpg)
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Fill the unmet need in lipid lowering managementEzastatin
atorvastatin + ezetimibe
![Page 23: Ezastatin ( The Art of Combination Therapy)](https://reader034.fdocuments.net/reader034/viewer/2022052523/55507e47b4c905cc0f8b55f8/html5/thumbnails/23.jpg)
Fill the unmet need in lipid lowering managementEzastatin
atorvastatin + ezetimibe
![Page 24: Ezastatin ( The Art of Combination Therapy)](https://reader034.fdocuments.net/reader034/viewer/2022052523/55507e47b4c905cc0f8b55f8/html5/thumbnails/24.jpg)
Fill the unmet need in lipid lowering managementEzastatin
atorvastatin + ezetimibe
![Page 25: Ezastatin ( The Art of Combination Therapy)](https://reader034.fdocuments.net/reader034/viewer/2022052523/55507e47b4c905cc0f8b55f8/html5/thumbnails/25.jpg)
Fill the unmet need in lipid lowering managementEzastatin
atorvastatin + ezetimibe
![Page 26: Ezastatin ( The Art of Combination Therapy)](https://reader034.fdocuments.net/reader034/viewer/2022052523/55507e47b4c905cc0f8b55f8/html5/thumbnails/26.jpg)
Fill the unmet need in lipid lowering managementEzastatin
atorvastatin + ezetimibe
![Page 27: Ezastatin ( The Art of Combination Therapy)](https://reader034.fdocuments.net/reader034/viewer/2022052523/55507e47b4c905cc0f8b55f8/html5/thumbnails/27.jpg)
Fill the unmet need in lipid lowering managementEzastatin
atorvastatin + ezetimibe
![Page 28: Ezastatin ( The Art of Combination Therapy)](https://reader034.fdocuments.net/reader034/viewer/2022052523/55507e47b4c905cc0f8b55f8/html5/thumbnails/28.jpg)
Why Ezastatin
Ezastatin combines 10 mg ezetimibe with 40 mg atorvastatin
Marked improvement in lipid profile compared to plain Atorvastatin.
Reduction in Oxidized LDL, an effect not achieved by up-titration of statin dose.
Reduces cholesterol absorption specially in diabetic patients with CAD.
Ezastatin with 40 mg atorvastatin concentration to benefit from pleiotropic effects of atorvastatin.
Ezastatin reduces CIMT compared to standard and aggressive therapy.
Higher safety profile than maximizing atorvastatin dose to 80mg.
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Ezastatinatorvastatin + ezetimibe
Fill the unmet need in lipid lowering management
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THANK YOU
Thank YOU