Eye selectivity peaks in middle layers of Poster Print ...
Transcript of Eye selectivity peaks in middle layers of Poster Print ...
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• Functionaldataweremotion-anddistortion-correctedusingAFNI8.Distortion-matchedT1-weightedEPI(greenoverlay:GM)guidedthenonlinearwarpingoffunctionaltoanatomicaldata.
• Regressionanalysis(GLM)assessedfMRIresponsemodulationfortwostimulusconditions(allLandallR)ineachvoxel.ControlGLMassessedresponsestoM-andP-targetedstimuli(collapsingacrossLandR).Voxelsnearpialvesselswereexcludedfromanalysis.• GMinreferenceanatomywassegmentedusinganequivolume9solution.Eachfunctionalvoxelwasthenassignedadepth,anddepth-dependentfMRIprofileswereformedbyaveragingresponsein6bins.
• Neuronsinprimaryvisualcortexaredrivenprimarilybyvisualinputfromeithertheleftortherighteye.Theseneuronsareorganizedinalternatingleft-rightstripesknownasoculardominancecolumns(ODCs).
• Inmonkeys,oculardominanceisstrongestinmiddlecorticallayers1.Cellsarelessmonocularinsuperficialanddeeplayers1.
• High-fieldfMRIcanrevealinformationaboutcorticalstructureonthescaleofcolumns2andlayers3.ODCshavebeendemonstratedinhumans2,4,5,6.
• UsingGEEPI,weusedknowncytoarchitectureofODCsandeyeselectivitytotestthefidelityof7TfMRIinhumansubjects.
Participants.Sevenhealthyadults(2male,meanage=33±11years)participatedintwoscanningsessions.
Stimuli.Flickeringcheckerboardswerepresentedtoeitherleft(L)orright(R)eye.Thecheckerboardstargetedeitherparvocellular(P)pathways(0.5Hz,highspatialfrequency,chromaticisoluminant)ormagnocellular(M)pathways(12Hz,lowspatialfrequency,achromatic).Design.Fourstimulusconditions(L/RxM/P)repeated4timesineachscan,randomlyinterleaved.
Dataacquisition.• 7TSiemensscannerwithacustom-made32-channelreceive,4-channeltransmitheadcoil
• GEEPIimagesat0.8mmisotropicresolution(TR/TE:2s/22.6ms;FOV=168x200mm;R=3;echospacing=1.01ms,6/8PartialFourier)
• T1-weighedGEEPIsequences7wereobtainedineachsession.3Tstructuralscanswereacquiredseparately.
Eyeselectivitypeaksinmiddlelayersofhumanvisualcortex:Evidencefrom7TfMRIdata
KimberlyB.Weldon1,MarisaJ.Sanchez1,2,PhilipC.Burton1,3,andCherylA.Olman1,3
1CenterforMagneticResonanceResearch,UniversityofMinnesota;2DepartmentofPsychiatry,UniversityofMinnesota;3DepartmentofPsychology,UniversityofMinnesota
Contact:[email protected]
Results
• Columnarstructurewasevidentineye-selectivitymaps.• EyeselectivityinV1wasenhancedinthemiddlelayers,butnotdeeporsuperficiallayers,comparedtoacontrolanalysisinV2.
• Eyeselectivitywasweakerthanexpected;thiscanbeexplainedbyblurringinthedata.
• IncreasedeyeselectivityindeeperGMwasnotanticipated.Controlanalysisofcolorselectivityindicatesitisnotanon-specifichemodynamicorpartialvolumingeffect.
Discussion
Introduction Analysis
1. Hubel,D.H.,&Wiesel,T.N.(1968).Receptivefieldsandfunctionalarchitectureofmonkeystriatecortex.TheJournalofphysiology,195(1),215-243.2. Nasr,S.,Polimeni,J.R.,&Tootell,R.B.(2016).Interdigitatedcolor-anddisparity-selectivecolumnswithinhumanvisualcorticalareasV2andV3.JournalofNeuroscience,36(6),1841-1857.3. Olman,C.A.,Harel,N.,Feinberg,D.A.,He,S.,Zhang,P.,Ugurbil,K.,&Yacoub,E.(2012).Layer-specificfMRIreflectsdifferentneuronalcomputationsatdifferentdepthsinhumanV1.PloSone,7(3),
e32536.4. Horton,J.C.,&Hedley-Whyte,E.T.(1984).Mappingofcytochromeoxidasepatchesandoculardominancecolumnsinhumanvisualcortex.PhilosophicalTransactionsoftheRoyalSocietyofLondon.B,
BiologicalSciences,304(1119),255-272.5. Yacoub,E.,Shmuel,A.,Logothetis,N.,&Uğurbil,K.(2007).RobustdetectionofoculardominancecolumnsinhumansusingHahnSpinEchoBOLDfunctionalMRIat7Tesla.Neuroimage,37(4),1161-1177.6. Cheng,K.,Waggoner,R.A.,&Tanaka,K.(2001).Humanoculardominancecolumnsasrevealedbyhigh-fieldfunctionalmagneticresonanceimaging.Neuron,32(2),359-374.7. vanderZwaag,W.,Buur,P.F.,Fracasso,A.,vanDoesum,T.,Uludağ,K.,Versluis,M.J.,&Marques,J.P.(2018).Distortion-matchedT1mapsandunbiasedT1-weightedimagesasanatomicalreferencefor
high-resolutionfMRI.NeuroImage,176,41-55.8. Cox,R.W.(1996).AFNI:softwareforanalysisandvisualizationoffunctionalmagneticresonanceneuroimages.ComputersandBiomedicalresearch,29(3),162-173.9. Waehnert,M.D.,Dinse,J.,Weiss,M.,Streicher,M.N.,Waehnert,P.,Geyer,S.,...&Bazin,P.L.(2014).Anatomicallymotivatedmodelingofcorticallaminae.Neuroimage,93,210-220.
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RM LM RP RM LM LPRP RM RP LMLP RM LP RPLM
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MaterialsandMethods
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=Left=Right
Acknowledgements:NIHgrantsR01MH111447,R21EY025731,P41EB015894,P30NS076408,S10RR026783,WMKECKFoundation
ParvocellularSelectivity
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EyeSelectivity(V1) EyeSelectivity(V2) EyeSelectivity
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