Extrahepatic manifestations of HCV

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  • 1. Management of Extrahepatic Manifestations of Chronic Hepatitis C Mario U. Mondelli Department of Infectious Diseases, University of Pavia, Fondazione IRCCS Policlinico San MatteoKasr Al-Aini International Post Graduate Course of Hepatology, Cairo University, 10-12 October 2009

2. Chronic Hepatitis C Virus Extrahepatic Manifestations Non organ-specific antibodies Mixed cryoglobulinaemia (Types II & III): Purpura (Leukocytoclastic vasculitis) Glomerulonephritis Peripheral neuropathy Non-Hodgkins lymphoma: low grade, MZ Autoimmune thyroiditis (up to 36% anti-TPO prevalence, CD81 on thyrocytes, IL-8) Porphyria cutanea tarda (Metanalysis showed OR 274.78) Diabetes mellitus (defects in insulin signalling) Lichen planus Sicca (non-Sjgrens syndrome) (SS-A, SS-B neg.; no xerophtalmia) 3. Chronic Hepatitis C Virus Autoantibodies HCV %Control %Rheumatoid factor708Cryoglobulins>50 1:40 > 1:18021 1310 2Antismooth muscle (SMA) > 1:40 > 1:18021 72