Acute Myocardial Infarction Acute Myocardial Infarction (AMI ...
Experimental Acute Myocardial Infarction (AMI)
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Transcript of Experimental Acute Myocardial Infarction (AMI)
CARDIAC ISCHAEMIA
&STEM CELLS
by/ M.Mohsen.ElAlfy M.Fathi
Ischaemic Heart Disease AMI
Def. ?
Ischaemic Heart Disease
AMI13%
12%
6%
5%3%
3%3%3%2%2%
49%
Ischaemic Heart DiseaseStrokeCOPDLower Respiratory InfectionTrachea, Bronchi & Lung cancersHIV/AIDSDiarrhoeal DiseasesDiabetes MellitusRoad InjuryHypertensive Heart DiseaseOthers
Stem Cells
Acute Phase(Inflam
.)1-7 d
Sub-Acute Phase
(Granulation)1-3 wk
Chronic Phase(Scar)1 m
Patho-pysiology of Myocardial Infarction
ModelsSurgica
lLAD
Ligation
Medical IDoxorubicin
Medical II
Isoproterenol
Mechanism
SurgicalLAD Ligation
SimulationEffectivenessReliabilitySurvival
Medical IDoxorubicin
SimulationEffectivenessReliabilitySurvivalO H
Medical IIIsoproterenol
SimulationEffectivenessReliabilitySurvival
O Ca+2
O
ATPO H
Investigations
• Macroscopic: Nitro-blue Tetrazolium
• Microscopic: H&E and Mallory’s Tri-chrome
Macroscopic & Microscopic
• CBC• Kidney functions: urea and
creatinine• Liver enzymes: SGOT and SGPT
Routine lab. Work
• Troponin: TI isozyme• Creatin Phospho-kinase: CPK-MB
isozyme• Lactate Dehydrogenase: LDH Total
Cardiac Enzymes
• Glutathione: GSH Total• Super-oxide Dismutase: SOD Markers of
Oxidative Stress
???Questions
Thank You