exp 11, 12, 13
-
Upload
patrick-libiran -
Category
Documents
-
view
53 -
download
0
description
Transcript of exp 11, 12, 13
![Page 1: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/1.jpg)
CLASSIFICATION TEST FOR AMINES
![Page 2: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/2.jpg)
AMINES
R NH2R1 NH
R2
R1 N
R2
R3
![Page 3: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/3.jpg)
PROPERTIES OF AMINES
• urine-like odor
• Polar
• Basic
![Page 4: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/4.jpg)
HINSBERG TEST
• differentiating test for 10, 20 and 30 amines
• Reagent: benzenesulfonyl chloride/NaOH
SO
ClO
![Page 5: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/5.jpg)
Amine
10 or 20 Amine
30 Amine
10 Amine
20 Amine benzenesulfonylchloride
No ppt
White ppt +NaOH (aq)
Soluble ppt
Insoluble ppt
![Page 6: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/6.jpg)
SYNTHESIS OF ASPIRIN AND METHYL SALICILATE
![Page 7: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/7.jpg)
ASPIRIN
• Acetyl salicylic acid (ASA)
• Analgesic
• Antipyretic
• Slightly soluble in water
OH
O
O
CH3O
![Page 8: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/8.jpg)
SYNTHESIS OF ASPIRIN
OH
O
OH
CH3
O
O
CH3
O+ H2SO4
OH
O
O
CH3O
+ H2O
![Page 9: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/9.jpg)
SYNTHESIS OF MEHYL SALICYLATE
OH
O
OH
+ CH3 OHH2SO4 OH
O
O
CH3
+ H2O
![Page 10: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/10.jpg)
FERRIC CHLORIDE TEST
• Complexation rxn of Fe3+
• Fe3+ forms a complex with aspirin
![Page 11: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/11.jpg)
STARCH TEST
• Role of starch in pharmaceutical preparation:
– Excipient: diluent or binder
• Reagent: I2
• Formation of iodo-starch complex: bluish-black suspension
![Page 12: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/12.jpg)
SYNTHESIS OF SOAP AND DETERGENT
![Page 13: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/13.jpg)
DEFINITION OF TERMS
Soap – sodium salt of fatty acid
Fatty acid – long chain carboxylic acid
Detergent – sodium salt of long HC chain of thioester
![Page 14: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/14.jpg)
AMPHIPATIC NATURE OF SOAPS AND DETERGENTS
![Page 15: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/15.jpg)
SYNTHESIS OF SOAP
+ NaOH
+ H2O
![Page 16: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/16.jpg)
SYNTHESIS OF DETERGENT
+ NaCl
![Page 17: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/17.jpg)
BASIS OF COMPARISON
SOAP DETERGENT
Structure Na+ salt of fatty acid Na+ salt of thioester
Activity in distilled water
Formation of suds Formation of suds
Activity in Hard Water
Minimal to no suds Formation of scums
No effect suds formation
Test for Glycerol Burnt fat odor No burnt fat odor
![Page 18: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/18.jpg)
TEST FOR GLYCEROL (ACROLEIN TEST)
• Dehydration reaction
KHSO4
+ 2H2O
![Page 19: exp 11, 12, 13](https://reader036.fdocuments.net/reader036/viewer/2022073120/55cf8f16550346703b98cc89/html5/thumbnails/19.jpg)
THANK YOU!