Evaluation of clinical efficacy of Ninjin Yoh-eito extract granules with special reference to the...
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Abstracts/Lung Cancer 11 (1994) 423-444 443 IIldcellIlmg-,themlio- modalityi8chemotherapy, unnbii with early thoracic radiation therapy for patients with limited diseasee. The precocity of the rwponse after initiating multimodality beatment is the mia prognosis tbctor. Patients with very limited small cell lung cancer (TNM stage I and II) can be managed by surgery. Association with colony stimulating factors can I- the severity of oeutmpenicandinfectiousepiscdee. Themleofmaintenancetherapyby alpha interfemo in cliically disease tiw patients is suggwted. Recent adv- in diagnosis and treatment of small ceil and non- smnllcelllungcancar Sorensen JB, Hansen HH. Departmentof OncoIogy, lke Finsen Center/ Rigsbospitaler. 9 Blegdamsvej. DK-2100 Copenhagen. Curt Opio Oncol 1994;6: 162-70. Despite much effort and many published reports, pmgrees in diagncsingandtmstinoglungzancer hasbeenslow.Theuseofmonoclonal antibodies for detection of metastasis and oeumendocrine markers for subclassification ofoon-small cell lung cancer into different prognostic groups may be useful in future staging and tmatment. Dose-intensive chemotherapy in small cell lung cancer is still experimental, which is alsothecaseforpmphylacticcranialirradiatioo.Adjuvantchemotherapy for completely rcsccted patients with non- small cell lung cancer may be associated with a marginal survival benefit, which also seems to hold true for patients with advanced disease when compared with untreated control subjects solely receiving supportive care. The modest survival benefit is achieved at the cost of increased toxicity. Neoadjuvant treatmentmmainsacootmversialissue, oneofthemajorpmblemsbeing the lack of an effective standard systemic therapy in non- small cell lung cancer. Reviews Functlonnl status in women with lung cnncer Sarna L. School of Nursing, Uniwrsityof California, 10833 Le Conte Avenue, Los Angeles, CA 900246918. Cancer NW 1994;17:87-93. Lung cancer remains the number one cause of cancer-related death and the third most common csncer for women in the United States. The msjor purpose of this study was to describe physical hmctional status in a sample of women with lung cancer. Functional status was objectively measured by the Karnofsky Performance Status Scale, and subjectively by the Rand Physical Function Scale, and the Physical Function Subscale of the CARES-Short Form. A convenience sample of 69 women participated in a one-time data collection. The typical subject was <65 years of age, had lived with primary or recurrent lung cancer for > 12 months, had non-small cell limited disease, and was not curmntly receiving treatment. The most prevalent disruptions in physical function were reduced energy (59%), difficulty with household chores (33 %), and interference with work (28 46). A third of the sample had serious limitations in three or more activities. Approximately 26% of the sample had severe limitations in moderate activities, 20% in walking short distances, and 16 %in walking one flight of stairs. Only a quarter weresatisfiedwiththeirlevelofactivity. Physical functioowasdifferent by income category (one-way analysis of variance), with those with the lowest income having the poorest function. current status of lung cancer diagno& and mtment in Shawhai Lip0 ML, Yang ZP, Ling ZQ, Gao YT, Gao RN, ZJwo W et al. Shanghai Chest Hospital, 241 Huai-haiRoad, Shanghai 2ooO30. Lung Cancer (Ireland) 1994 10/S-6 (333-338) The status of diagnosis and treatment of lung cancers discovered duringlyeuintheShn~populationue~~.AtotPlof940 lung cancers was detected from inhabitants of 35-64 years of age, with a male/female ratio of 1.8: I. Pathology showed 35.7 %ademxcinoma and 35.1% aquamow c8ll caAnonu.Tbefewaaapredominauceof admocmiiom (47.6%) in femalce and of squammm cell capGoomn (44.6%) in males. Most (68.6%) of the lesions dete&d werealreedy advanced in contrast to 14.7 96of Stage I disease. The need for vigilance oothepartofdoctorswasdemonst&d by the fact that 23.3% of patients were seen by the doctor within 1 month after presenting with symptoms and 44.5 96 of them had their diagnosis suspected within 1 month after their first hospital visit. The treatment consisted of surgery for 33.3 96, chemotherapy for 35 96, traditional Chinese medicine for 20% and symptomatic management for 9.6% of patients. As only 55.8% Stage I patients were treated by surgery, the tmatment pmtocol seemed to be improperly biased. The adcqua@ training ofhealth workers was shown by the t&t that 79.7 46 of these patients were confirmed by pathology and/or cytology and most of the Stage I lesions were diagnosed outside the hospital. Evaluation of clinical elficacy of Ninjin Yoh-eito extract granules with special reference to the quality of life of lung cancer patients TsuburaE, NakajimaS, FuruseK, Iikegami H, FukuokaM, Nishikawa H. Department of Internal Medicine, Osaka Hospital,Antituberculosis Ass. Osaka Branch, Osaka. Tlwr Res 1994;15:487-500. We investigated whether Niojin Yoh-eito, a Chinese medicine is clinically useful in impmving the QOL of lung cancer patients after consolidation chemotherapy. The clinical efficacy of this medication was evaluated by physician assessment of the signs and symptoms of the patients, self-asse3sment of the patients with regard to their symptoms (QOL), and the results of laboratory teats. Whereas the severity of PS, pain, dyspnea, cough, and production of sputa, which were assemed by thephysician-in-charge, worsenedover thecourseoftherapy, symptoms whicbwereammsedbytbepatientsthemselves, sucbasmood,anorexia, and malaise, clearly improved as treatment progressed. Significant increases in the red blood cell count, hemoglobin, and hematocrit were observed in the PS(O-1) group at the 4th, Sth, 16th and 20th week of the administration of Niojin Yoh-eito. Serum pmteins were significantly incmasedatthe4thandl6thweek,whilesemmalbumiowassignificantly increased at the 16th week of the administration of Ninjin Yoh-eito @ < 0.05 and p C 0.01, respectively). Reference values were established with regard to the results of the laboratory teats conducted at the initiation of this investigation. On the basis of these reference values the patients were divided into 2 groups, one showing normal and the other showing abnormal laboratory values. Impmv-ts in red blood cell count, hemoglobin, and hematocrit in the gmup showing abnormal laboratory values were observed after the 4th week. Improvement of the hematological picture noted after the ingestion of Nmjin Yoh-eito invariably leads to improvement of the general condition of the patients. It is further expected that improvement in the QOL will follow these positivechangeeinpati~tsbltusoccWlingasa~ltofUleadrninistration of this Chinese medication. pulmonary cancer from the general prtxtitioner’s point of view: Experience from the health centm area of Kungsbwlca, Sweden M-O J, Ikngtsson C. Heabh Centre of LovgaxIet, Vaniljgotan 28. S-424 45 Angered. Stand J Prim Hcaltb Core l%%l2:39-43. Objecri~ - To study the incidence of pulmonary CpllcBT in a conununity with special reface to the diagnostic procas~ and the mle of the general practitioner. Design - Study of the records of all patimts
Transcript of Evaluation of clinical efficacy of Ninjin Yoh-eito extract granules with special reference to the...
Abstracts/Lung Cancer 11 (1994) 423-444 443
IIldcellIlmg-,themlio- modalityi8chemotherapy, unnbii with early thoracic radiation therapy for patients with limited diseasee. The precocity of the rwponse after initiating multimodality beatment is the mia prognosis tbctor. Patients with very limited small cell lung cancer (TNM stage I and II) can be managed by surgery. Association with colony stimulating factors can I- the severity of oeutmpenicandinfectiousepiscdee. Themleofmaintenancetherapyby alpha interfemo in cliically disease tiw patients is suggwted.
Recent adv- in diagnosis and treatment of small ceil and non- smnllcelllungcancar Sorensen JB, Hansen HH. Department of OncoIogy, lke Finsen Center/ Rigsbospitaler. 9 Blegdamsvej. DK-2100 Copenhagen. Curt Opio Oncol 1994;6: 162-70.
Despite much effort and many published reports, pmgrees in diagncsingandtmstinoglungzancer hasbeenslow.Theuseofmonoclonal antibodies for detection of metastasis and oeumendocrine markers for subclassification ofoon-small cell lung cancer into different prognostic groups may be useful in future staging and tmatment. Dose-intensive chemotherapy in small cell lung cancer is still experimental, which is alsothecaseforpmphylacticcranialirradiatioo.Adjuvantchemotherapy for completely rcsccted patients with non- small cell lung cancer may be associated with a marginal survival benefit, which also seems to hold true for patients with advanced disease when compared with untreated control subjects solely receiving supportive care. The modest survival benefit is achieved at the cost of increased toxicity. Neoadjuvant treatmentmmainsacootmversialissue, oneofthemajorpmblemsbeing the lack of an effective standard systemic therapy in non- small cell lung cancer.
Reviews
Functlonnl status in women with lung cnncer Sarna L. School of Nursing, Uniwrsity of California, 10833 Le Conte Avenue, Los Angeles, CA 900246918. Cancer NW 1994;17:87-93.
Lung cancer remains the number one cause of cancer-related death and the third most common csncer for women in the United States. The msjor purpose of this study was to describe physical hmctional status in a sample of women with lung cancer. Functional status was objectively measured by the Karnofsky Performance Status Scale, and subjectively by the Rand Physical Function Scale, and the Physical Function Subscale of the CARES-Short Form. A convenience sample of 69 women participated in a one-time data collection. The typical subject was <65 years of age, had lived with primary or recurrent lung cancer for > 12 months, had non-small cell limited disease, and was not curmntly receiving treatment. The most prevalent disruptions in physical function were reduced energy (59%), difficulty with household chores (33 %), and interference with work (28 46). A third of the sample had serious limitations in three or more activities. Approximately 26% of the sample had severe limitations in moderate activities, 20% in walking short distances, and 16 % in walking one flight of stairs. Only a quarter weresatisfiedwiththeirlevelofactivity. Physical functioowasdifferent by income category (one-way analysis of variance), with those with the lowest income having the poorest function.
current status of lung cancer diagno& and mtment in Shawhai Lip0 ML, Yang ZP, Ling ZQ, Gao YT, Gao RN, ZJwo W et al. Shanghai Chest Hospital, 241 Huai-hai Road, Shanghai 2ooO30. Lung Cancer (Ireland) 1994 10/S-6 (333-338)
The status of diagnosis and treatment of lung cancers discovered duringlyeuintheShn~populationue~~.AtotPlof940 lung cancers was detected from inhabitants of 35-64 years of age, with a male/female ratio of 1.8: I. Pathology showed 35.7 % ademxcinoma and 35.1% aquamow c8ll caAnonu.Tbefewaaapredominauceof admocmiiom (47.6%) in femalce and of squammm cell capGoomn (44.6%) in males. Most (68.6%) of the lesions dete&d werealreedy advanced in contrast to 14.7 96 of Stage I disease. The need for vigilance oothepartofdoctorswasdemonst&d by the fact that 23.3% of patients were seen by the doctor within 1 month after presenting with symptoms and 44.5 96 of them had their diagnosis suspected within 1 month after their first hospital visit. The treatment consisted of surgery for 33.3 96, chemotherapy for 35 96, traditional Chinese medicine for 20% and symptomatic management for 9.6% of patients. As only 55.8% Stage I patients were treated by surgery, the tmatment pmtocol seemed to be improperly biased. The adcqua@ training ofhealth workers was shown by the t&t that 79.7 46 of these patients were confirmed by pathology and/or cytology and most of the Stage I lesions were diagnosed outside the hospital.
Evaluation of clinical elficacy of Ninjin Yoh-eito extract granules with special reference to the quality of life of lung cancer patients TsuburaE, NakajimaS, FuruseK, Iikegami H, FukuokaM, Nishikawa H. Department of Internal Medicine, Osaka Hospital, Antituberculosis Ass. Osaka Branch, Osaka. Tlwr Res 1994;15:487-500.
We investigated whether Niojin Yoh-eito, a Chinese medicine is clinically useful in impmving the QOL of lung cancer patients after consolidation chemotherapy. The clinical efficacy of this medication was evaluated by physician assessment of the signs and symptoms of the patients, self-asse3sment of the patients with regard to their symptoms (QOL), and the results of laboratory teats. Whereas the severity of PS, pain, dyspnea, cough, and production of sputa, which were assemed by thephysician-in-charge, worsenedover thecourseoftherapy, symptoms whicbwereammsedbytbepatientsthemselves, sucbasmood,anorexia, and malaise, clearly improved as treatment progressed. Significant increases in the red blood cell count, hemoglobin, and hematocrit were observed in the PS(O-1) group at the 4th, Sth, 16th and 20th week of the administration of Niojin Yoh-eito. Serum pmteins were significantly incmasedatthe4thandl6thweek,whilesemmalbumiowassignificantly increased at the 16th week of the administration of Ninjin Yoh-eito @ < 0.05 and p C 0.01, respectively). Reference values were established with regard to the results of the laboratory teats conducted at the initiation of this investigation. On the basis of these reference values the patients were divided into 2 groups, one showing normal and the other showing abnormal laboratory values. Impmv-ts in red blood cell count, hemoglobin, and hematocrit in the gmup showing abnormal laboratory values were observed after the 4th week. Improvement of the hematological picture noted after the ingestion of Nmjin Yoh-eito invariably leads to improvement of the general condition of the patients. It is further expected that improvement in the QOL will follow these positivechangeeinpati~tsbltusoccWlingasa~ltofUleadrninistration of this Chinese medication.
pulmonary cancer from the general prtxtitioner’s point of view: Experience from the health centm area of Kungsbwlca, Sweden M-O J, Ikngtsson C. Heabh Centre of LovgaxIet, Vaniljgotan 28. S-424 45 Angered. Stand J Prim Hcaltb Core l%%l2:39-43.
Objecri~ - To study the incidence of pulmonary CpllcBT in a conununity with special reface to the diagnostic procas~ and the mle of the general practitioner. Design - Study of the records of all patimts
